LOCUS       NM_001200016            1464 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens N-alpha-acetyltransferase 80, NatH catalytic subunit
            (NAA80), transcript variant 2, mRNA.
ACCESSION   NM_001200016
VERSION     NM_001200016.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1464)
  AUTHORS   Yang,H., Fan,T., Xun,M., Wu,B., Guo,S., Li,X., Zhao,X., Yao,H. and
            Wang,H.
  TITLE     N-terminal acetyltransferase 6 facilitates enterovirus 71
            replication by regulating PI4KB expression and replication
            organelle biogenesis
  JOURNAL   J Virol 98 (2), e0174923 (2024)
   PUBMED   38189249
  REMARK    GeneRIF: N-terminal acetyltransferase 6 facilitates enterovirus 71
            replication by regulating PI4KB expression and replication
            organelle biogenesis.
REFERENCE   2  (bases 1 to 1464)
  AUTHORS   Drazic,A., Timmerman,E., Kajan,U., Marie,M., Varland,S., Impens,F.,
            Gevaert,K. and Arnesen,T.
  TITLE     The Final Maturation State of beta-actin Involves N-terminal
            Acetylation by NAA80, not N-terminal Arginylation by ATE1
  JOURNAL   J Mol Biol 434 (2), 167397 (2022)
   PUBMED   34896361
  REMARK    GeneRIF: The Final Maturation State of beta-actin Involves
            N-terminal Acetylation by NAA80, not N-terminal Arginylation by
            ATE1.
REFERENCE   3  (bases 1 to 1464)
  AUTHORS   Ree,R., Kind,L., Kaziales,A., Varland,S., Dai,M., Richter,K.,
            Drazic,A. and Arnesen,T.
  TITLE     PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of
            actin
  JOURNAL   J Biol Chem 295 (49), 16713-16731 (2020)
   PUBMED   32978259
  REMARK    GeneRIF: PFN2 and NAA80 cooperate to efficiently acetylate the
            N-terminus of actin.
REFERENCE   4  (bases 1 to 1464)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1464)
  AUTHORS   Drazic,A., Aksnes,H., Marie,M., Boczkowska,M., Varland,S.,
            Timmerman,E., Foyn,H., Glomnes,N., Rebowski,G., Impens,F.,
            Gevaert,K., Dominguez,R. and Arnesen,T.
  TITLE     NAA80 is actin's N-terminal acetyltransferase and regulates
            cytoskeleton assembly and cell motility
  JOURNAL   Proc Natl Acad Sci U S A 115 (17), 4399-4404 (2018)
   PUBMED   29581253
  REMARK    GeneRIF: the results demonstrate NAA80's role as actin's NAT and
            reveal a crucial role for actin Nt-acetylation in the control of
            cytoskeleton structure and dynamics.
            GeneRIF: NAT6/FUS-2 is the N-alpha acetyltransferase 80
            (NAA80/NatH) acting post-translationally and specifically on
            processed animal actins. This NAA80 mediated actin N-terminal
            acetylation is crucial for actin polymerization and
            depolymerization, and regulates the actin cytoskeleton and cell
            motility.
REFERENCE   6  (bases 1 to 1464)
  AUTHORS   Yi Lo,P.H., Chung Leung,A.C., Xiong,W., Law,S., Duh,F.M.,
            Lerman,M.I., Stanbridge,E.J. and Lung,M.L.
  TITLE     Expression of candidate chromosome 3p21.3 tumor suppressor genes
            and down-regulation of BLU in some esophageal squamous cell
            carcinomas
  JOURNAL   Cancer Lett 234 (2), 184-192 (2006)
   PUBMED   15885884
REFERENCE   7  (bases 1 to 1464)
  AUTHORS   Duh,F.M., Fivash,M., Moody,M., Li Lung,M., Guo,X., Stanbridge,E.,
            Dean,M., Voevoda,M., Hu,L.F., Kashuba,V., Zabarovsky,E.R.,
            Qian,C.N., Godbole,S., Tean Teh,B. and Lerman,M.I.
  TITLE     Characterization of a new SNP c767A/T (Arg222Trp) in the candidate
            TSG FUS2 on human chromosome 3p21.3: prevalence in Asian
            populations and analysis of association with nasopharyngeal cancer
  JOURNAL   Mol Cell Probes 18 (1), 39-44 (2004)
   PUBMED   15036368
  REMARK    GeneRIF: newly identified polymorphism leads to a non-conservative
            amino acid change (R222W) located between the acetyltransferase and
            the proline-rich domains; analysis suggests no likely association
            between nasopharyngeal cancer and the FUS2 gene polymorphism
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1464)
  AUTHORS   Shuttleworth,T.L., Wilson,M.D., Wicklow,B.A., Wilkins,J.A. and
            Triggs-Raine,B.L.
  TITLE     Characterization of the murine hyaluronidase gene region reveals
            complex organization and cotranscription of Hyal1 with downstream
            genes, Fus2 and Hyal3
  JOURNAL   J Biol Chem 277 (25), 23008-23018 (2002)
   PUBMED   11929860
  REMARK    GeneRIF: Characterization of the murine hyaluronidase gene region
            reveals complex organization and cotranscription of Hyal1 with
            downstream genes, Fus2 and Hyal3.
REFERENCE   9  (bases 1 to 1464)
  AUTHORS   Lerman,M.I. and Minna,J.D.
  TITLE     The 630-kb lung cancer homozygous deletion region on human
            chromosome 3p21.3: identification and evaluation of the resident
            candidate tumor suppressor genes. The International Lung Cancer
            Chromosome 3p21.3 Tumor Suppressor Gene Consortium
  JOURNAL   Cancer Res 60 (21), 6116-6133 (2000)
   PUBMED   11085536
REFERENCE   10 (bases 1 to 1464)
  AUTHORS   Zegerman,P., Bannister,A.J. and Kouzarides,T.
  TITLE     The putative tumour suppressor Fus-2 is an N-acetyltransferase
  JOURNAL   Oncogene 19 (1), 161-163 (2000)
   PUBMED   10644992
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313803.1 and BM989194.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001200016.1.
            
            Summary: This gene encodes a member of the N-acetyltransferase
            family. N-acetyltransferases modify proteins by transferring acetyl
            groups from acetyl CoA to the N-termini of protein substrates. The
            encoded protein is a cytoplasmic N-acetyltransferase with a
            substrate specificity for proteins with an N-terminal methionine.
            This gene is located in the tumor suppressor gene region on
            chromosome 3p21.3 and the encoded protein may play a role in
            cancer. Alternatively spliced transcript variants encoding multiple
            isoforms have been observed. This gene overlaps and is on the same
            strand as hyaluronoglucosaminidase 3, and some transcripts of each
            gene share a portion of the first exon. [provided by RefSeq, Jan
            2011].
            
            Transcript Variant: This variant (2) contains an alternate splice
            site in the 5' UTR and initiates translation at a downstream start
            codon, compared to variant 1. The encoded isoform (2) has a shorter
            N-terminus, compared to isoform 1. Variants 2 and 3 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.296280.1,
                                           SRR3476690.679049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443094.3/ ENSP00000410610.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1263              AK313803.1         17-1279
            1264-1464           BM989194.1         18-218              c
FEATURES             Location/Qualifiers
     source          1..1464
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1464
                     /gene="NAA80"
                     /gene_synonym="ANDS; FUS-2; FUS2; HsNAAA80; NAT6"
                     /note="N-alpha-acetyltransferase 80, NatH catalytic
                     subunit"
                     /db_xref="GeneID:24142"
                     /db_xref="HGNC:HGNC:30252"
                     /db_xref="MIM:607073"
     exon            1..193
                     /gene="NAA80"
                     /gene_synonym="ANDS; FUS-2; FUS2; HsNAAA80; NAT6"
                     /inference="alignment:Splign:2.1.0"
     exon            194..1464
                     /gene="NAA80"
                     /gene_synonym="ANDS; FUS-2; FUS2; HsNAAA80; NAT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..1263
                     /gene="NAA80"
                     /gene_synonym="ANDS; FUS-2; FUS2; HsNAAA80; NAT6"
                     /EC_number="2.3.1.-"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein fusion-2; N-acetyltransferase 6 (GCN5-related)"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 80 isoform 2"
                     /protein_id="NP_001186945.1"
                     /db_xref="CCDS:CCDS56258.1"
                     /db_xref="GeneID:24142"
                     /db_xref="HGNC:HGNC:30252"
                     /db_xref="MIM:607073"
                     /translation="MELILSTSPAELTLDPACQPKLPLDSTCQPEMTFNPGPTELTLD
                     PEHQPEETPAPSLAELTLEPVHRRPELLDACADLINDQWPRSRTSRLHSLGQSSDAFP
                     LCLMLLSPHPTLEAAPVVVGHARLSRVLNQPQSLLVETVVVARALRGRGFGRRLMEGL
                     EVFARARGFRKLHLTTHDQVHFYTHLGYQLGEPVQGLVFTSRRLPATLLNAFPTAPSP
                     RPPRKAPNLTAQAAPRGPKGPPLPPPPPLPECLTISPPVPSGPPSKSLLETQYQNVRG
                     RPIFWMEKDI"
     regulatory      1445..1450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA80"
                     /gene_synonym="ANDS; FUS-2; FUS2; HsNAAA80; NAT6"
                     /note="hexamer: AATAAA"
     polyA_site      1464
                     /gene="NAA80"
                     /gene_synonym="ANDS; FUS-2; FUS2; HsNAAA80; NAT6"
                     /note="major polyA site"
ORIGIN      
        1 ctaagcggcg acgcgcgggt gctgggaggc cttagaacgc cgtggcgtgc cgcaggacgc
       61 gacggctgca gaacatccgc cgcaccgctg ggggccaacg ttgtcggacc gaggagtccg
      121 aggtggcgac tgagtgagat acccagctgt gcggagctag gacgcggaac atcccagagg
      181 ccagcatcaa catgaggaga gccactgtgg tctgaagaga tgctactgcc tggagactgg
      241 ggtcttaacc tccagcctgg cactgagcca cctgcaacct agcagcaggt gaccttggct
      301 cccagcctga ctcagctgaa cctggatcct gtgcataggc aagagctgac tctgagccct
      361 ggcccagcca agctgacccc tacactagac cctacacacc ggatggagct gatcctgagt
      421 accagcccag ctgagctgac tctggatcct gcgtgccagc caaagctgcc cctggattcc
      481 acatgccaac cagagatgac cttcaatcct ggtccaactg agcttaccct ggatcctgaa
      541 caccagccag aggagacccc agctcctagc ctggctgagt tgaccctgga gcctgtgcac
      601 cgccgacccg agctcctgga tgcttgtgct gacctcatca atgatcagtg gccccgcagc
      661 cgcacctccc gcctgcactc cctgggccag tcctcagatg ccttccccct ctgcctgatg
      721 ctgctaagcc cccaccccac acttgaagca gcacccgttg tggtgggcca tgcccgcctg
      781 tcacgggtgc tgaaccagcc ccagagcctc ttagtggaga cagtggtggt ggcccgggcc
      841 ctgaggggcc gtggctttgg ccgccgcctc atggagggcc tggaggtctt tgctcgggcc
      901 cggggcttcc gcaagctgca tctcaccacc catgaccagg tgcacttcta tacccacctg
      961 ggctaccagc tgggtgagcc tgtgcagggc ctggtcttca ccagcagacg gctgcctgcc
     1021 accctgctta atgccttccc cacagccccc tctccccggc cacccaggaa ggccccaaac
     1081 ctgactgccc aagctgcccc aaggggtccc aagggacctc cattgccacc accccctccc
     1141 ctacctgagt gcctgaccat ctcaccccca gttccatcag ggcccccttc aaaaagcctg
     1201 ctggagacac aatatcaaaa tgtgaggggg cgccccatat tctggatgga aaaagacatc
     1261 tgaggccatc cagggcaagg aactgtcttt ctggttcaat agactgcccc gacagtctac
     1321 aagcctcagc ccactgacca tacctcagcc cctagcccct ggggggcagc tttaacctgg
     1381 gcatgtttcc tgggtaccag tggggccagg aggtggctct ggctcagagc cgtcagtgtg
     1441 gctgaataaa ggctctcttg ggta
//
