LOCUS       NM_001317096            2360 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens N-alpha-acetyltransferase 60, NatF catalytic subunit
            (NAA60), transcript variant 7, mRNA.
ACCESSION   NM_001317096
VERSION     NM_001317096.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Chelban,V., Aksnes,H., Maroofian,R., LaMonica,L.C., Seabra,L.,
            Siggervag,A., Devic,P., Shamseldin,H.E., Vandrovcova,J., Murphy,D.,
            Richard,A.C., Quenez,O., Bonnevalle,A., Zanetti,M.N.,
            Kaiyrzhanov,R., Salpietro,V., Efthymiou,S., Schottlaender,L.V.,
            Morsy,H., Scardamaglia,A., Tariq,A., Pagnamenta,A.T.,
            Pennavaria,A., Krogstad,L.S., Bekkelund,A.K., Caiella,A.,
            Glomnes,N., Bronstad,K.M., Tury,S., Moreno De Luca,A.,
            Boland-Auge,A., Olaso,R., Deleuze,J.F., Anheim,M., Cretin,B.,
            Vona,B., Alajlan,F., Abdulwahab,F., Battini,J.L., Ipek,R.,
            Bauer,P., Zifarelli,G., Gungor,S., Kurul,S.H., Lochmuller,H.,
            Da'as,S.I., Fakhro,K.A., Gomez-Pascual,A., Botia,J.A., Wood,N.W.,
            Horvath,R., Ernst,A.M., Rothman,J.E., McEntagart,M., Crow,Y.J.,
            Alkuraya,F.S., Nicolas,G., Arnesen,T. and Houlden,H.
  CONSRTM   SYNaPS Study Group
  TITLE     Biallelic NAA60 variants with impaired n-terminal acetylation
            capacity cause autosomal recessive primary familial brain
            calcifications
  JOURNAL   Nat Commun 15 (1), 2269 (2024)
   PUBMED   38480682
  REMARK    GeneRIF: Biallelic NAA60 variants with impaired n-terminal
            acetylation capacity cause autosomal recessive primary familial
            brain calcifications.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   Donnarumma,F., Tucci,V., Ambrosino,C., Altucci,L. and Carafa,V.
  TITLE     NAA60 (HAT4): the newly discovered bi-functional Golgi member of
            the acetyltransferase family
  JOURNAL   Clin Epigenetics 14 (1), 182 (2022)
   PUBMED   36539894
  REMARK    GeneRIF: NAA60 (HAT4): the newly discovered bi-functional Golgi
            member of the acetyltransferase family.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2360)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2360)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2360)
  AUTHORS   Aksnes,H., Goris,M., Stromland,O., Drazic,A., Waheed,Q., Reuter,N.
            and Arnesen,T.
  TITLE     Molecular determinants of the N-terminal acetyltransferase Naa60
            anchoring to the Golgi membrane
  JOURNAL   J Biol Chem 292 (16), 6821-6837 (2017)
   PUBMED   28196861
  REMARK    GeneRIF: analysis of the mode of cytosolic Naa60 anchoring to the
            Golgi apparatus, most likely occurring post-translationally and
            specifically facilitating post-translational N-terminal acetylation
            of many transmembrane proteins
REFERENCE   6  (bases 1 to 2360)
  AUTHORS   Aksnes,H., Marie,M. and Arnesen,T.
  TITLE     Holding it together: Naa60 at the Golgi
  JOURNAL   Oncotarget 6 (18), 15726-15727 (2015)
   PUBMED   26164078
  REMARK    GeneRIF: Knockdown of the N-terminal acetyltransferase Naa60
            compromises Golgi ribbon integrity.
REFERENCE   7  (bases 1 to 2360)
  AUTHORS   Aksnes,H., Van Damme,P., Goris,M., Starheim,K.K., Marie,M.,
            Stove,S.I., Hoel,C., Kalvik,T.V., Hole,K., Glomnes,N., Furnes,C.,
            Ljostveit,S., Ziegler,M., Niere,M., Gevaert,K. and Arnesen,T.
  TITLE     An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic
            N termini of transmembrane proteins and maintains Golgi integrity
  JOURNAL   Cell Rep 10 (8), 1362-1374 (2015)
   PUBMED   25732826
  REMARK    GeneRIF: Naa60 is necessary for maintenance of the Golgi ribbon
            through its Nt-acetylation of substrate protein(s) that is/are
            involved in Golgi ribbon structural and/or functional organization.
REFERENCE   8  (bases 1 to 2360)
  AUTHORS   Yang,X., Yu,W., Shi,L., Sun,L., Liang,J., Yi,X., Li,Q., Zhang,Y.,
            Yang,F., Han,X., Zhang,D., Yang,J., Yao,Z. and Shang,Y.
  TITLE     HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase,
            acetylates free histone H4 and facilitates chromatin assembly
  JOURNAL   Mol Cell 44 (1), 39-50 (2011)
   PUBMED   21981917
  REMARK    GeneRIF: HAT4 is an important player in the organization and
            function of the genome and may contribute to the diversity and
            complexity of higher eukaryotic organisms [HAT4]
REFERENCE   9  (bases 1 to 2360)
  AUTHORS   Nakabayashi,K., Trujillo,A.M., Tayama,C., Camprubi,C., Yoshida,W.,
            Lapunzina,P., Sanchez,A., Soejima,H., Aburatani,H., Nagae,G.,
            Ogata,T., Hata,K. and Monk,D.
  TITLE     Methylation screening of reciprocal genome-wide UPDs identifies
            novel human-specific imprinted genes
  JOURNAL   Hum Mol Genet 20 (16), 3188-3197 (2011)
   PUBMED   21593219
REFERENCE   10 (bases 1 to 2360)
  AUTHORS   Van Damme,P., Hole,K., Pimenta-Marques,A., Helsens,K.,
            Vandekerckhove,J., Martinho,R.G., Gevaert,K. and Arnesen,T.
  TITLE     NatF contributes to an evolutionary shift in protein N-terminal
            acetylation and is important for normal chromosome segregation
  JOURNAL   PLoS Genet 7 (7), e1002169 (2011)
   PUBMED   21750686
  REMARK    GeneRIF: Naa60 is an N-terminal acetyltransferase defined as NatF.
            Human and Drosophila melanogaster Naa60 acetylate Met-Lys- and
            other Met-starting N-termini. In Drosophila cells, NAA60 knockdown
            induced chromosomal segregation defects.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC339939.1, AK298566.1,
            BU501490.1, AC004224.1 and BC011267.1.
            
            On May 31, 2019 this sequence version replaced NM_001317096.1.
            
            Summary: This gene encodes an enzyme that localizes to the Golgi
            apparatus, where it transfers an acetyl group to the N-terminus of
            free proteins. This enzyme acts on histones, and its activity is
            important for chromatin assembly and chromosome integrity.
            Alternative splicing and the use of alternative promoters results
            in multiple transcript variants. The upstream promoter is located
            in a differentially methylated region (DMR) and undergoes
            imprinting; transcript variants originating from this position are
            expressed from the maternal allele. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (7) represents use of an alternate
            promoter and contains multiple differences in both UTRs and in the
            coding region, resulting in a frameshift, compared to variant 1.
            The encoded isoform (e) has a distinct C-terminus and is shorter
            than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145122, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene :: PMID: 21593219
            NMD candidate  :: translation inferred from conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DC339939.1         61-91
            32-681              AK298566.1         1-650
            682-980             BU501490.1         319-617
            981-2279            AC004224.1         33801-35099         c
            2280-2360           BC011267.1         2358-2438
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2360
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /note="N-alpha-acetyltransferase 60, NatF catalytic
                     subunit"
                     /db_xref="GeneID:79903"
                     /db_xref="HGNC:HGNC:25875"
                     /db_xref="MIM:614246"
     exon            1..137
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     exon            138..253
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..716
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /EC_number="2.3.1.48"
                     /EC_number="2.3.1.259"
                     /note="isoform e is encoded by transcript variant 7;
                     N-acetyltransferase 15 (GCN5-related, putative); histone
                     acetyltransferase type B protein 4;
                     N-alpha-acetyltransferase F; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 60 isoform e"
                     /protein_id="NP_001304025.1"
                     /db_xref="CCDS:CCDS81938.1"
                     /db_xref="GeneID:79903"
                     /db_xref="HGNC:HGNC:25875"
                     /db_xref="MIM:614246"
                     /translation="MTEVVPSSALSEVSLRLLCHDDIDTVKHLCGDWFPIEYPDSWYR
                     DITSNKKFFSLAATYRGAIVGMIVAEIKNRTKIHKEDGDILASNFSVDTQVAYILSLG
                     VVKEFRKHGIEPHGLHPAPGLCTSQPEPLLHSAQSLPPGPQPALQLPAMVGHLFQEWH
                     RVQPDHVMSAGQPPPGPTLRPPAEPAFLSI"
     exon            254..383
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     exon            384..480
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     exon            481..873
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     exon            874..2360
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /note="hexamer: AATAAA"
     polyA_site      2360
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /note="major polyA site"
ORIGIN      
        1 gcctccgtcc cggctgcggc ccctgccggt tacataactc gttgcgggct ccgcgcggtc
       61 ccacttcccg gctcccttcg cctccaggat gcgctgagcc ctacaacacc cccagcggcc
      121 gccggctccc ccacgaggtg tgaatgacag aggtggtgcc atccagcgcg ctcagcgagg
      181 tcagcctgcg cctcctctgc cacgatgaca tagacactgt gaagcacctg tgtggcgact
      241 ggttccccat cgagtaccca gactcatggt atcgtgatat cacatccaac aagaagttct
      301 tttcccttgc tgcaacctac agaggtgcca ttgtgggaat gatagtagct gaaattaaga
      361 acaggaccaa aatacataaa gaggatggag atattctagc atccaacttc tctgttgaca
      421 cacaagtcgc gtacatccta agtctgggcg tcgtgaaaga gttcaggaag cacggcatag
      481 agccccacgg actacatcca gcacctgggc tctgcactag ccagcctgag cccctgctcc
      541 attccgcaca gagtctaccg ccaggcccac agcctgctct gcagcttcct gccatggtcg
      601 ggcatctctt ccaagagtgg catcgagtac agccggacca tgtgatgtcg gctgggcagc
      661 cgccaccagg ccccaccctt cggccgcccg cagagcccgc cttcctgtcc atctgacccc
      721 ttctgttttc tgcaaggagc tgccagccat ctaactgggc tcgtcggcct gccccagctg
      781 caggcccggt gctacacggg ctcgggaaca gaacatcgtg ggcatgcgca gagcatgccc
      841 atccgtggca ggtacgccac agcagacaca aaggctcttc agctcccctc cctgcttctg
      901 gaaacctctg cctgctgccc tggccctgcc cccctgcgca tgcaccgtcc ccagggctga
      961 cccagtgtgg ctgcattcac tgggaggggc ctgccctcac tgggcctctc ccactccgct
     1021 gcctgttctt gcagctcctt cctggaaagc tggaggggac tttctcctgc aagggaggaa
     1081 cgcaagtatt atggacacac ttgaccgtaa aggcacagga gcctcggaac aagggggcgc
     1141 aataaaggga atggcccgtc cccttccaga accagcccaa agaagcctgg ggggtgagga
     1201 gtggccccca ctcctccatg aggggctgat gaggggtggg cagcctgggg gaggctttcc
     1261 tcgcaagcac agagctctga ggctcagccc cctggcacag gcggtcacgc atcaggacgg
     1321 ttcctactcc tcagcacctt ccgtgcagtt accagtgccc tgggaggtca cactgcccgt
     1381 cggaccttgg catgctccat tcagctgacc tgctgaggac aggcatcgcc gagactcctt
     1441 gggtcctccc cgccctccct catgctgcca caagctgctg ctccaaggcc tggccacatg
     1501 cagacaggag gaagctgagc tcgacattag gcctcaaggc tgccatctgt cttgtagggc
     1561 ctggccttgt gggcaggggg cagtcctgtg ccttgtgggc cctcagcctc tgagggcaga
     1621 gatgctgtca gtgccgcagg tgcatcacat acttctagca tcctctccac cctgcattcc
     1681 aaatgctgct tgctgcctgc cctgccctcc gatgcagggg tggggtgggg ggcggagtcc
     1741 cgcccagcat agctgcagtg tcacaaagcc atggcagagg gtcctagcgg cgccaccctg
     1801 ccccagcctg aggaggaggg agagggagga acaaccctgg gcagacgggg cctcagggac
     1861 ctgtgtcctt ccgcctccag agctgcccag ccacgggctc tcagggtgct ggggcagccc
     1921 caggtcccct cttgaactca gctggggcca ggggccctca gaatgaaggc aggcaccagg
     1981 caggagcagc atccccctcc ttgacggtgc tggcaggagg gccgcgccat gctgactgct
     2041 tgaacctctg ctgacctgac agtgctggcg ggagggccgc accatgctga ctgcctgaat
     2101 ctctgctgag gctgcctgcc tgccgggccc agctcagcgc cctctccact gcgaatcagt
     2161 ggcgatcatg tgatttctat ttctgcccca cagggtaagg gacgagtctt ctggaaggct
     2221 ctgccatgga catttgtcct cgggctcaga ggccccaccc tgccccacac ctgcccctga
     2281 tcactgcagt gtccagccca gtgttgaaca gattgtagcg ttctgtctca ttacgagcaa
     2341 ataaatagac tttcattgga
//
