LOCUS       NM_001083601            2656 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens N-alpha-acetyltransferase 60, NatF catalytic subunit
            (NAA60), transcript variant 1, mRNA.
ACCESSION   NM_001083601 XR_243313
VERSION     NM_001083601.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2656)
  AUTHORS   Chelban,V., Aksnes,H., Maroofian,R., LaMonica,L.C., Seabra,L.,
            Siggervag,A., Devic,P., Shamseldin,H.E., Vandrovcova,J., Murphy,D.,
            Richard,A.C., Quenez,O., Bonnevalle,A., Zanetti,M.N.,
            Kaiyrzhanov,R., Salpietro,V., Efthymiou,S., Schottlaender,L.V.,
            Morsy,H., Scardamaglia,A., Tariq,A., Pagnamenta,A.T.,
            Pennavaria,A., Krogstad,L.S., Bekkelund,A.K., Caiella,A.,
            Glomnes,N., Bronstad,K.M., Tury,S., Moreno De Luca,A.,
            Boland-Auge,A., Olaso,R., Deleuze,J.F., Anheim,M., Cretin,B.,
            Vona,B., Alajlan,F., Abdulwahab,F., Battini,J.L., Ipek,R.,
            Bauer,P., Zifarelli,G., Gungor,S., Kurul,S.H., Lochmuller,H.,
            Da'as,S.I., Fakhro,K.A., Gomez-Pascual,A., Botia,J.A., Wood,N.W.,
            Horvath,R., Ernst,A.M., Rothman,J.E., McEntagart,M., Crow,Y.J.,
            Alkuraya,F.S., Nicolas,G., Arnesen,T. and Houlden,H.
  CONSRTM   SYNaPS Study Group
  TITLE     Biallelic NAA60 variants with impaired n-terminal acetylation
            capacity cause autosomal recessive primary familial brain
            calcifications
  JOURNAL   Nat Commun 15 (1), 2269 (2024)
   PUBMED   38480682
  REMARK    GeneRIF: Biallelic NAA60 variants with impaired n-terminal
            acetylation capacity cause autosomal recessive primary familial
            brain calcifications.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2656)
  AUTHORS   Donnarumma,F., Tucci,V., Ambrosino,C., Altucci,L. and Carafa,V.
  TITLE     NAA60 (HAT4): the newly discovered bi-functional Golgi member of
            the acetyltransferase family
  JOURNAL   Clin Epigenetics 14 (1), 182 (2022)
   PUBMED   36539894
  REMARK    GeneRIF: NAA60 (HAT4): the newly discovered bi-functional Golgi
            member of the acetyltransferase family.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2656)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2656)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2656)
  AUTHORS   Aksnes,H., Goris,M., Stromland,O., Drazic,A., Waheed,Q., Reuter,N.
            and Arnesen,T.
  TITLE     Molecular determinants of the N-terminal acetyltransferase Naa60
            anchoring to the Golgi membrane
  JOURNAL   J Biol Chem 292 (16), 6821-6837 (2017)
   PUBMED   28196861
  REMARK    GeneRIF: analysis of the mode of cytosolic Naa60 anchoring to the
            Golgi apparatus, most likely occurring post-translationally and
            specifically facilitating post-translational N-terminal acetylation
            of many transmembrane proteins
REFERENCE   6  (bases 1 to 2656)
  AUTHORS   Aksnes,H., Marie,M. and Arnesen,T.
  TITLE     Holding it together: Naa60 at the Golgi
  JOURNAL   Oncotarget 6 (18), 15726-15727 (2015)
   PUBMED   26164078
  REMARK    GeneRIF: Knockdown of the N-terminal acetyltransferase Naa60
            compromises Golgi ribbon integrity.
REFERENCE   7  (bases 1 to 2656)
  AUTHORS   Aksnes,H., Van Damme,P., Goris,M., Starheim,K.K., Marie,M.,
            Stove,S.I., Hoel,C., Kalvik,T.V., Hole,K., Glomnes,N., Furnes,C.,
            Ljostveit,S., Ziegler,M., Niere,M., Gevaert,K. and Arnesen,T.
  TITLE     An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic
            N termini of transmembrane proteins and maintains Golgi integrity
  JOURNAL   Cell Rep 10 (8), 1362-1374 (2015)
   PUBMED   25732826
  REMARK    GeneRIF: Naa60 is necessary for maintenance of the Golgi ribbon
            through its Nt-acetylation of substrate protein(s) that is/are
            involved in Golgi ribbon structural and/or functional organization.
REFERENCE   8  (bases 1 to 2656)
  AUTHORS   Yang,X., Yu,W., Shi,L., Sun,L., Liang,J., Yi,X., Li,Q., Zhang,Y.,
            Yang,F., Han,X., Zhang,D., Yang,J., Yao,Z. and Shang,Y.
  TITLE     HAT4, a Golgi apparatus-anchored B-type histone acetyltransferase,
            acetylates free histone H4 and facilitates chromatin assembly
  JOURNAL   Mol Cell 44 (1), 39-50 (2011)
   PUBMED   21981917
  REMARK    GeneRIF: HAT4 is an important player in the organization and
            function of the genome and may contribute to the diversity and
            complexity of higher eukaryotic organisms [HAT4]
REFERENCE   9  (bases 1 to 2656)
  AUTHORS   Nakabayashi,K., Trujillo,A.M., Tayama,C., Camprubi,C., Yoshida,W.,
            Lapunzina,P., Sanchez,A., Soejima,H., Aburatani,H., Nagae,G.,
            Ogata,T., Hata,K. and Monk,D.
  TITLE     Methylation screening of reciprocal genome-wide UPDs identifies
            novel human-specific imprinted genes
  JOURNAL   Hum Mol Genet 20 (16), 3188-3197 (2011)
   PUBMED   21593219
REFERENCE   10 (bases 1 to 2656)
  AUTHORS   Van Damme,P., Hole,K., Pimenta-Marques,A., Helsens,K.,
            Vandekerckhove,J., Martinho,R.G., Gevaert,K. and Arnesen,T.
  TITLE     NatF contributes to an evolutionary shift in protein N-terminal
            acetylation and is important for normal chromosome segregation
  JOURNAL   PLoS Genet 7 (7), e1002169 (2011)
   PUBMED   21750686
  REMARK    GeneRIF: Naa60 is an N-terminal acetyltransferase defined as NatF.
            Human and Drosophila melanogaster Naa60 acetylate Met-Lys- and
            other Met-starting N-termini. In Drosophila cells, NAA60 knockdown
            induced chromosomal segregation defects.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC401343.1, AL833594.1,
            BG472911.1, AC004224.1 and BC011267.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001083601.2.
            
            Summary: This gene encodes an enzyme that localizes to the Golgi
            apparatus, where it transfers an acetyl group to the N-terminus of
            free proteins. This enzyme acts on histones, and its activity is
            important for chromatin assembly and chromosome integrity.
            Alternative splicing and the use of alternative promoters results
            in multiple transcript variants. The upstream promoter is located
            in a differentially methylated region (DMR) and undergoes
            imprinting; transcript variants originating from this position are
            expressed from the maternal allele. [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. This variant may be expressed predominantly from the
            maternal allele (PMID:21593219). Variants 1, 2, and 3 encode the
            same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833594.1, SRR1660807.111728.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 21593219
            MANE Ensembl match     :: ENST00000407558.9/ ENSP00000385903.4
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                DC401343.1         70-124
            56-785              AL833594.1         2-731
            786-1251            BG472911.1         80-545
            1252-2575           AC004224.1         33801-35124         c
            2576-2656           BC011267.1         2358-2438
FEATURES             Location/Qualifiers
     source          1..2656
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2656
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /note="N-alpha-acetyltransferase 60, NatF catalytic
                     subunit"
                     /db_xref="GeneID:79903"
                     /db_xref="HGNC:HGNC:25875"
                     /db_xref="MIM:614246"
     exon            1..158
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     exon            159..228
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     exon            229..344
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..963
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /EC_number="2.3.1.48"
                     /EC_number="2.3.1.259"
                     /note="isoform a is encoded by transcript variant 1;
                     N-acetyltransferase 15 (GCN5-related, putative); histone
                     acetyltransferase type B protein 4;
                     N-alpha-acetyltransferase F; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 60 isoform a"
                     /protein_id="NP_001077070.1"
                     /db_xref="CCDS:CCDS45396.1"
                     /db_xref="GeneID:79903"
                     /db_xref="HGNC:HGNC:25875"
                     /db_xref="MIM:614246"
                     /translation="MTEVVPSSALSEVSLRLLCHDDIDTVKHLCGDWFPIEYPDSWYR
                     DITSNKKFFSLAATYRGAIVGMIVAEIKNRTKIHKEDGDILASNFSVDTQVAYILSLG
                     VVKEFRKHGIGSLLLESLKDHISTTAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHY
                     LPYYYSIRGVLKDGFTYVLYINGGHPPWTILDYIQHLGSALASLSPCSIPHRVYRQAH
                     SLLCSFLPWSGISSKSGIEYSRTM"
     exon            345..474
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     exon            475..571
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     exon            572..806
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1169
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..2656
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2636..2641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /note="hexamer: AATAAA"
     polyA_site      2656
                     /gene="NAA60"
                     /gene_synonym="HAT4; hNaa60; IBGC9; NAT15; NatF"
                     /note="major polyA site"
ORIGIN      
        1 ccgcttccgc tggcggggtc tcctccgtga gctccgggcc tgtttgcctg ctgaagtaga
       61 gtcttagggt gaccccaggg ggacgtaatg tttccgagaa gaaggacaga aagaagactg
      121 ggagacaccg gaactcgaaa gaaaatcggt aacaaaatca tacagaaagg ctgtacctgg
      181 aggaaggaag tgcggagcca gcctgagttg ggagaagagc tccagagagt gtgaatgaca
      241 gaggtggtgc catccagcgc gctcagcgag gtcagcctgc gcctcctctg ccacgatgac
      301 atagacactg tgaagcacct gtgtggcgac tggttcccca tcgagtaccc agactcatgg
      361 tatcgtgata tcacatccaa caagaagttc ttttcccttg ctgcaaccta cagaggtgcc
      421 attgtgggaa tgatagtagc tgaaattaag aacaggacca aaatacataa agaggatgga
      481 gatattctag catccaactt ctctgttgac acacaagtcg cgtacatcct aagtctgggc
      541 gtcgtgaaag agttcaggaa gcacggcata ggttccctct tacttgaaag tttaaaggat
      601 cacatatcaa ccaccgccca ggaccactgc aaagccattt acctgcatgt cctcaccacc
      661 aacaacacag caataaactt ctatgaaaac agagacttca agcagcacca ctatctcccc
      721 tattactact ccattcgagg ggtcctcaaa gatggcttca cctatgtcct ctacatcaac
      781 ggcggccacc ctccctggac gattttggac tacatccagc acctgggctc tgcactagcc
      841 agcctgagcc cctgctccat tccgcacaga gtctaccgcc aggcccacag cctgctctgc
      901 agcttcctgc catggtcggg catctcttcc aagagtggca tcgagtacag ccggaccatg
      961 tgatgtcggc tgggcagccg ccaccaggcc ccacccttcg gccgcccgca gagcccgcct
     1021 tcctgtccat ctgacccctt ctgttttctg caaggagctg ccagccatct aactgggctc
     1081 gtcggcctgc cccagctgca ggcccggtgc tacacgggct cgggaacaga acatcgtggg
     1141 catgcgcaga gcatgcccat ccgtggcagg ctcttcagct cccctccctg cttctggaaa
     1201 cctctgcctg ctgccctggc cctgcccccc tgcgcatgca ccgtccccag ggctgaccca
     1261 gtgtggctgc attcactggg aggggcctgc cctcactggg cctctcccac tccgctgcct
     1321 gttcttgcag ctccttcctg gaaagctgga ggggactttc tcctgcaagg gaggaacgca
     1381 agtattatgg acacacttga ccgtaaaggc acaggagcct cggaacaagg gggcgcaata
     1441 aagggaatgg cccgtcccct tccagaacca gcccaaagaa gcctgggggg tgaggagtgg
     1501 cccccactcc tccatgaggg gctgatgagg ggtgggcagc ctgggggagg ctttcctcgc
     1561 aagcacagag ctctgaggct cagccccctg gcacaggcgg tcacgcatca ggacggttcc
     1621 tactcctcag caccttccgt gcagttacca gtgccctggg aggtcacact gcccgtcgga
     1681 ccttggcatg ctccattcag ctgacctgct gaggacaggc atcgccgaga ctccttgggt
     1741 cctccccgcc ctccctcatg ctgccacaag ctgctgctcc aaggcctggc cacatgcaga
     1801 caggaggaag ctgagctcga cattaggcct caaggctgcc atctgtcttg tagggcctgg
     1861 ccttgtgggc agggggcagt cctgtgcctt gtgggccctc agcctctgag ggcagagatg
     1921 ctgtcagtgc cgcaggtgca tcacatactt ctagcatcct ctccaccctg cattccaaat
     1981 gctgcttgct gcctgccctg ccctccgatg caggggtggg gtggggggcg gagtcccgcc
     2041 cagcatagct gcagtgtcac aaagccatgg cagagggtcc tagcggcgcc accctgcccc
     2101 agcctgagga ggagggagag ggaggaacaa ccctgggcag acggggcctc agggacctgt
     2161 gtccttccgc ctccagagct gcccagccac gggctctcag ggtgctgggg cagccccagg
     2221 tcccctcttg aactcagctg gggccagggg ccctcagaat gaaggcaggc accaggcagg
     2281 agcagcatcc ccctccttga cggtgctggc aggagggccg cgccatgctg actgcttgaa
     2341 cctctgctga cctgacagtg ctggcgggag ggccgcacca tgctgactgc ctgaatctct
     2401 gctgaggctg cctgcctgcc gggcccagct cagcgccctc tccactgcga atcagtggcg
     2461 atcatgtgat ttctatttct gccccacagg gtaagggacg agtcttctgg aaggctctgc
     2521 catggacatt tgtcctcggg ctcagaggcc ccaccctgcc ccacacctgc ccctgatcac
     2581 tgcagtgtcc agcccagtgt tgaacagatt gtagcgttct gtctcattac gagcaaataa
     2641 atagactttc attgga
//
