LOCUS       NM_025146               6112 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens N-alpha-acetyltransferase 50, NatE catalytic subunit
            (NAA50), transcript variant 1, mRNA.
ACCESSION   NM_025146 XR_108467 XR_112516 XR_113578
VERSION     NM_025146.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6112)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 6112)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 6112)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 6112)
  AUTHORS   Reddi,R., Saddanapu,V., Chinthapalli,D.K., Sankoju,P., Sripadi,P.
            and Addlagatta,A.
  TITLE     Human Naa50 Protein Displays Broad Substrate Specificity for
            Amino-terminal Acetylation: DETAILED STRUCTURAL AND BIOCHEMICAL
            ANALYSIS USING TETRAPEPTIDE LIBRARY
  JOURNAL   J Biol Chem 291 (39), 20530-20538 (2016)
   PUBMED   27484799
  REMARK    GeneRIF: Because Naa10 is reported to acetylate all amino termini
            that are devoid of methionine and Naa50 acetylates all other
            peptides that are followed by methionine
REFERENCE   5  (bases 1 to 6112)
  AUTHORS   Rong,Z., Ouyang,Z., Magin,R.S., Marmorstein,R. and Yu,H.
  TITLE     Opposing Functions of the N-terminal Acetyltransferases Naa50 and
            NatA in Sister-chromatid Cohesion
  JOURNAL   J Biol Chem 291 (36), 19079-19091 (2016)
   PUBMED   27422821
  REMARK    GeneRIF: co-depletion of NatA, a heterodimeric NAT complex that
            physically interacts with Naa50, rescues the sister-chromatid
            cohesion defects and the resulting mitotic arrest caused by Naa50
            depletion, indicating that NatA and Naa50 play antagonistic roles
            in cohesion.
REFERENCE   6  (bases 1 to 6112)
  AUTHORS   Starheim,K.K., Gromyko,D., Evjenth,R., Ryningen,A., Varhaug,J.E.,
            Lillehaug,J.R. and Arnesen,T.
  TITLE     Knockdown of human N alpha-terminal acetyltransferase complex C
            leads to p53-dependent apoptosis and aberrant human Arl8b
            localization
  JOURNAL   Mol Cell Biol 29 (13), 3569-3581 (2009)
   PUBMED   19398576
  REMARK    GeneRIF: Data show that with MAK3 knockdown, p53 is stabilized and
            phosphorylated and there is a significant transcriptional
            activation of proapoptotic genes downstream of p53, and that
            localization of Arl8b is altered, suggesting that Arl8b is a Mak3
            substrate.
REFERENCE   7  (bases 1 to 6112)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 6112)
  AUTHORS   Hou,F., Chu,C.W., Kong,X., Yokomori,K. and Zou,H.
  TITLE     The acetyltransferase activity of San stabilizes the mitotic
            cohesin at the centromeres in a shugoshin-independent manner
  JOURNAL   J Cell Biol 177 (4), 587-597 (2007)
   PUBMED   17502424
  REMARK    GeneRIF: May be specifically required for the maintenance of
            centromeric cohesion in mitosis.
REFERENCE   9  (bases 1 to 6112)
  AUTHORS   Arnesen,T., Anderson,D., Torsvik,J., Halseth,H.B., Varhaug,J.E. and
            Lillehaug,J.R.
  TITLE     Cloning and characterization of hNAT5/hSAN: an evolutionarily
            conserved component of the NatA protein N-alpha-acetyltransferase
            complex
  JOURNAL   Gene 371 (2), 291-295 (2006)
   PUBMED   16507339
  REMARK    GeneRIF: The first description of the human homologue of Nat5p/San,
            hNAT5, the third component of the human NatA
            N-alpha-acetyltransferase complex
REFERENCE   10 (bases 1 to 6112)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM831426.1, BC012731.2, DB198553.1, DB096143.1, DA408894.1,
            DA599265.1, HX784836.1, AW954963.1, H15889.1, H39948.1, BX102492.1
            and AC108693.5.
            
            On Nov 22, 2018 this sequence version replaced NM_025146.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023256.1, SRR1803612.19842.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000240922.8/ ENSP00000240922.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               BM831426.1         25-432
            409-3577            BC012731.2         398-3566
            3578-4050           DB198553.1         16-488
            4051-4255           DB096143.1         355-559
            4256-4718           DA408894.1         195-657
            4719-4864           DA599265.1         405-550
            4865-5033           HX784836.1         12-180
            5034-5292           AW954963.1         162-420
            5293-5365           H15889.1           393-465
            5366-5561           HX784836.1         513-708
            5562-5638           H39948.1           321-397
            5639-6110           BX102492.1         14-485              c
            6111-6112           AC108693.5         75502-75503
FEATURES             Location/Qualifiers
     source          1..6112
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.31"
     gene            1..6112
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
                     /note="N-alpha-acetyltransferase 50, NatE catalytic
                     subunit"
                     /db_xref="GeneID:80218"
                     /db_xref="HGNC:HGNC:29533"
                     /db_xref="MIM:610834"
     exon            1..308
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..810
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
                     /EC_number="2.3.1.258"
                     /note="isoform 1 is encoded by transcript variant 1;
                     N-acetyltransferase 5; N-acetyltransferase 13
                     (GCN5-related); N-acetyltransferase san homolog; natE
                     catalytic subunit; N-epsilon-acetyltransferase 50"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 50 isoform 1"
                     /protein_id="NP_079422.1"
                     /db_xref="CCDS:CCDS2975.1"
                     /db_xref="GeneID:80218"
                     /db_xref="HGNC:HGNC:29533"
                     /db_xref="MIM:610834"
                     /translation="MKGSRIELGDVTPHNIKQLKRLNQVIFPVSYNDKFYKDVLEVGE
                     LAKLAYFNDIAVGAVCCRVDHSQNQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNICEK
                     DGTFDNIYLHVQISNESAIDFYRKFGFEIIETKKNYYKRIEPADAHVLQKNLKVPSGQ
                     NADVQKTDN"
     exon            309..445
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
                     /inference="alignment:Splign:2.1.0"
     exon            446..565
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
                     /inference="alignment:Splign:2.1.0"
     exon            566..632
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
                     /inference="alignment:Splign:2.1.0"
     exon            633..6112
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3553..3558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
                     /note="hexamer: AATAAA"
     polyA_site      3577
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
                     /note="major polyA site"
     regulatory      3710..3715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
                     /note="hexamer: ATTAAA"
     polyA_site      3730
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
     regulatory      6091..6096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
                     /note="hexamer: AATAAA"
     polyA_site      6112
                     /gene="NAA50"
                     /gene_synonym="hNaa50p; MAK3; NAT13; NAT13P; NAT5; NAT5P;
                     SAN"
ORIGIN      
        1 gaaaggtcac agcgcggcag cgggtctggc tggcggcagc ggcgggaggg agccgagaga
       61 cccgagtgca cgtgtggaga agcggcggca caagcgcggc ggcgggagac actcccgccc
      121 ccaccagact caagccctca ctcgactctc gcggccttcg ttgctcgcac agctccctgc
      181 ccaggctagg aggccggctt gcggggttga gtggcccgag ctaagggtgc ggagacctaa
      241 gggcggcgac tacgacggcg ttgatatcgg tggtaacgac ggcctcagca ggcggggaag
      301 atgaaaggta gccggatcga gctgggagat gtgacaccac acaatattaa acagttgaaa
      361 agattgaatc aggtcatctt tccagtcagc tacaatgaca agttctacaa ggatgtgctg
      421 gaggttggcg agctagcaaa acttgcctat ttcaatgata ttgctgtagg tgcagtatgc
      481 tgtagggtgg atcattcaca gaatcagaag agactttaca tcatgacact aggatgtctg
      541 gcaccttacc gaaggctagg aataggaact aaaatgttaa atcatgtctt aaacatctgt
      601 gaaaaagatg gtacttttga caacatttat ctgcatgtcc agatcagcaa tgagtcggca
      661 attgacttct acaggaagtt tggctttgag attattgaga caaagaagaa ctactataag
      721 aggatagagc ccgcagatgc tcatgtgctg cagaaaaacc tcaaagttcc ttctggtcag
      781 aatgcagatg tgcaaaagac agacaactga acaaattaca aatgaacttt cttgcacttg
      841 cttgtcgcca aataaaagag aggcccattg attcctcccc caccccaaca cttttctttt
      901 aaagcttttc tccctccttg ttcttgtttt tctttcttcc tttccttttc tctgagagtt
      961 ttaatacttt caaggacttt aaaaaaataa tcatgtttga attgttttct cttatttttg
     1021 tgaggtggtt tgaaggaagg acaaggtaga tctgtttagt tttgcagttg aagttagatg
     1081 gtcctaaaca tttaattgtc aaataatttc aaatttaatg tcctgctttc acattgaagg
     1141 gcagagccta caaaacattg tatatttcaa aagacaaaaa gaagcagcag cagtatcttg
     1201 ttctctaatt catagacaag ttgagtgtgt ttgtggtact ttgggttttt aaacactttg
     1261 ggatactaat ccctagacat tgccttcact ccacctttag tccttctgag cactctctcg
     1321 ggagttggaa cattgttatc cttgtaagaa atactaagct tatgttgatt tttaagtaat
     1381 tatatcttct cttcttgctg gtgggtgggg cagtttggtt tagtgttata ctttggtcta
     1441 agtatttgag ttaaactgct tttttgctaa tgagtgggct ggttgttagc aggtttgttt
     1501 ttcctgctgt tgattgttac tagtggcatt aacttttaga atttgggctg gtgagattaa
     1561 ttttttttaa tatcccagct agagatatgg cctttaactg acctaaagag gtgtgttgtg
     1621 atttaatttt ttcccgttcc tttttcttca gtaaacccaa caatagtcta accttaaaaa
     1681 ttgagttgat gtccttatag gtcactaccc ctaaataaac ctgaagcagg tgttttctct
     1741 tggacatact aaaaaatacc taaaaggaag cttagatggg ctgtgacaca aaaaattcaa
     1801 ttactgtcat ctaatgccag ctgttaaaag tgtggccact gagcatttga ttttatagga
     1861 aaaaatagta tttttgagaa taacatagct gtgctattgc acatctgttg gaggacatcc
     1921 cagatttgct tatactcagt gcctgtgata ttgagtttaa ggatttgagg caggggtaat
     1981 tattaaacat attgcttcta ttcttggaaa aatagaagtg taaaatgtta ataatacaaa
     2041 tgtcactgtg acctcctcca ctgagaggac tggtttatgc cagatcattt tccggcacac
     2101 acggagtggc tttgacagat tgataacttt gtaagatggg agacatctga aatattcatg
     2161 ttttcctttt gtagtcccat ctccactatt tagaaatgtt ctcagacttt aaaataatgc
     2221 acagggcttg agctttctgt catttgactt taaaaggaag tttcattcat atttatcctc
     2281 ttatgtaaaa ttgcggtata aagtctcatt tccaaatatg ttaaatgaca aaattatttt
     2341 ataaaatgtt tatgcacact ttataacctt aagtttttat ttgagaatgt gaaagtacaa
     2401 agtgcagtag acttcaacaa tcttgagtgc caagaataat acagaaaaag aagacagttg
     2461 atgaatgagt ttatagggtt ctaatcttaa gatggtaaaa atgtagaaag accttgctgg
     2521 ttttttgggg gtattcgttt cttaaacaat ccaaatctaa gcttagaaga aaagtttagc
     2581 gttaagcacc tttatcttca tgaataagct tcagcttgct cttggcaaga gaagagtgct
     2641 tgagttacag aaggcataag tagtttgaag aatgcagcag cctttttgta aacttcccag
     2701 atatcaaaat agactttgat atataaatgg ttttctgaga tgacactgcc tctatttcta
     2761 taaccatttc acctggacta tctaatcagt cctatgaatg tatccctaaa tgtggttatt
     2821 gaaaacctaa tagctgcctc atgacaagta catgttattt aaggaggaaa aaatattaaa
     2881 ttttgaattg agtgtgtagg ctccctatca ttatatatag agtttctttt tccacggtag
     2941 tcagtgactt aacctgaatt gtaaatgttt gtaaagggtt aattgtccta catcaaactt
     3001 agttaaataa ttccatccac ttatggagga ggaggagaat gtggaagagg taaaaagctg
     3061 ggcacaagtt catatgccta tgagtcagta aagactgaag taatgtccta tgttgagctg
     3121 gttattttga tatatgataa taattatctt tgaagtagaa caattctgtt aactggaaaa
     3181 tcacaggata tatccatcat atttttcagg acagatagtt tttactgtgg ggcaaatagg
     3241 ttaaaattac actatgttag ttgcatttag gttttaaagc aaagaatctg tagagaaatc
     3301 tatgcaatat atagtttgtc cagattagct ttcatttggg gaatgaagtt ctgaaatatc
     3361 taaagcagtt tactcatcaa ttgaaaagtc ctccaaaaag agaactattg ggaaaccatg
     3421 gtgtggtggt ggaaaagaaa agctccctca gttttttgga gggaataact taaaaaaata
     3481 cttaaatggc taagtttact tggtgcagtt aagaattaaa cttgtcaatt ttaacattgc
     3541 tgttacatct gaaataaact tatgtgatgt tctggtagtg atctgtgata tctgtaaatg
     3601 tcaaaactgt attgttgaat tctgcagcca gcaaccgtac atactcattg tgtagtgttt
     3661 cccttactgc ttttatttac tttcacattt aagatctaat tttaaaatca ttaaaatagg
     3721 ccaagtgtaa ttaaggcatc ctaattcaga tcttctgtga cttgctaggt acagtgccca
     3781 atatctacaa ttcagttcca atgagaggga aaaagtaaga tccaaggaac tgtcttgctg
     3841 ctgtattttt aatgtaatta ttagaaatac ttgacacttt aggctgcaat ctagttagta
     3901 atgtttattg gctacagaca acatattcag gtgttttgtt tttcttcctt gtaaggaagg
     3961 agtacggtag ttcaatgagt tgggaattgg cttttaagct ttttatcaaa catgaattta
     4021 agattttttc tttaacagaa ttcagtattt aatatttcta gtcaaaattg ttataattag
     4081 atttttgctt ttttcattta agaagcaatg agtgatcctt gtctagtgtg tctcagttat
     4141 tactgtagtt taaaacaaca aacaagtatt accttccaca gttctggatc aggaatctag
     4201 gagctgctta actgggtggt tctgtcttga gatctcagaa ggttgcagtc aagctgttag
     4261 ccaggactgt accatcttga agcttgacaa ggctagagga gccatttcca agatgtcttg
     4321 cttacgtggc tcttgggctt ctgttcctca ctgtgtgggt atcacacaca gtgcctgatg
     4381 ctcacgtggc tcttgggctt cagttccttg ggcaccagtt gcctggtgga caactggtat
     4441 gtggcttccc ctagagcagg tgatataaga aagtgagcag aaaccatact tttttatgac
     4501 gtagcctcag gtgacattat ttctgccata ttccatgagt cacacagacc aaccattgaa
     4561 tcagcttggt atagtgtggg aggggactgc acaaggatgt gaatactggg aggtggatat
     4621 cattgggccc tctaggagac tggctatcac tgctcagaga agatgctggg cttcgttgac
     4681 tcccaaggtc agggtagttt tggttaggtt gtgttttatt agtctctaaa aggagtagtt
     4741 ttctaaatga gggttataaa gcactgcact ttacagttat tcgggatata aaagaaatag
     4801 tgggtctaaa ggctgtgctc ttgtggttgg gttttcagtg gggaggggag actagtctgt
     4861 ctcagactga tgctgttctc actgatttga atatttctgg gaaattggat actacagtca
     4921 caaataggaa cagtaagcct atagaagttt ttcagggagt aaatattttc tatggcagtg
     4981 tcctgaattg gttctccctt gcaagactga actgtaggaa cttagtccta gtttatgata
     5041 cagccaagta acatagtcac atgggaaaaa gagcttgagt cagatttctt aatgtgtgtt
     5101 gttaacttgg tagaacattg agaattattt aagtcagaga acgatctgtt actggggcag
     5161 aaattctcaa ccttttcagt tctccaaaat ttaagatact tgatttctta ggtaaaatgt
     5221 ttttgttttt gttttggaga cagagtctcg ctctgtcgcc caggctggag tgcagtggcg
     5281 cgatcttggc tcactgcaaa ctccgcctcc cagattcaag caattctgcc tgagcctccc
     5341 aagtagctgc gactagaaag cgcatgccac cacgcctggc taattttttg tattttagta
     5401 gagatggggg tttcaccgtg ttgcccaggc tggtctcaaa ctcctgagct taggcaatcc
     5461 tcctggggca gcctcccaaa gtgctaggat tacaggcgag ccatggcgcc tggccagtaa
     5521 aatgttttct atctagaatg aatcaaggta ttttccttgc tcagtagctt ctagaataag
     5581 aaaaaaatag cagcaagatc tgattcagaa atagttggga gcagaaagtt aatatgaagg
     5641 agttgctact tgttaacagc ctagagttga gatctagaag aattattacc tttttaaatt
     5701 tgtgatgaaa gcttaaatcc agcatttggg aagttactct attggctgaa ctattttgga
     5761 gtttgtaagc tttgtattag atattcctga tttaactgaa actaatttgc cacatagctt
     5821 taatttcatc ccagttttac ttgttttact gtcctcaaaa actcaagaca tctgaactca
     5881 aaggatctaa gcagtataaa ttaaagcaca tgttgaatca ctgtagcttt cgtaggacat
     5941 ctgattataa tgcttttctt tgtttctttg tccatactga acttgtctag tttatctttg
     6001 agaaacattt gctagtatca aaaatcttct gtaaagattt gaacaatctt gaattctcct
     6061 tgtcactagc catctcttcc cctaaagtat aataaaactg tcaggtacta ta
//
