LOCUS       NM_001300800            3752 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens N-alpha-acetyltransferase 40, NatD catalytic subunit
            (NAA40), transcript variant 2, mRNA.
ACCESSION   NM_001300800 XM_005274296
VERSION     NM_001300800.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3752)
  AUTHORS   Ho,Y.H. and Huang,R.
  TITLE     Effects of Oncohistone Mutations and PTM Crosstalk on the
            N-Terminal Acetylation Activities of NatD
  JOURNAL   ACS Chem Biol 18 (4), 693-700 (2023)
   PUBMED   35044762
  REMARK    GeneRIF: Effects of Oncohistone Mutations and PTM Crosstalk on the
            N-Terminal Acetylation Activities of NatD.
REFERENCE   2  (bases 1 to 3752)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3752)
  AUTHORS   Demetriadou,C., Pavlou,D., Mpekris,F., Achilleos,C.,
            Stylianopoulos,T., Zaravinos,A., Papageorgis,P. and Kirmizis,A.
  TITLE     NAA40 contributes to colorectal cancer growth by controlling PRMT5
            expression
  JOURNAL   Cell Death Dis 10 (3), 236 (2019)
   PUBMED   30858358
  REMARK    GeneRIF: The findings strengthen the importance of NAA40 to
            maintain colorectal cancer cell growth. We show that NAA40
            oncogenic properties stimulate the global levels of H4R3me2s by
            transcriptionally activating PRMT5 methyltransferase which in turn
            modulates the expression of key downstream cancer-related genes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3752)
  AUTHORS   Ju,J., Chen,A., Deng,Y., Liu,M., Wang,Y., Wang,Y., Nie,M., Wang,C.,
            Ding,H., Yao,B., Gui,T., Li,X., Xu,Z., Ma,C., Song,Y.,
            Kvansakul,M., Zen,K., Zhang,C.Y., Luo,C., Fang,M., Huang,D.C.S.,
            Allis,C.D., Tan,R., Zeng,C.K., Wei,J. and Zhao,Q.
  TITLE     NatD promotes lung cancer progression by preventing histone H4
            serine phosphorylation to activate Slug expression
  JOURNAL   Nat Commun 8 (1), 928 (2017)
   PUBMED   29030587
  REMARK    GeneRIF: NatD-mediated acetylation of histone H4 serine 1 competes
            with phosphorylation by CK2alpha at the same residue, leading to
            the upregulation of Slug and lung cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3752)
  AUTHORS   Pavlou,D. and Kirmizis,A.
  TITLE     Depletion of histone N-terminal-acetyltransferase Naa40 induces
            p53-independent apoptosis in colorectal cancer cells via the
            mitochondrial pathway
  JOURNAL   Apoptosis 21 (3), 298-311 (2016)
   PUBMED   26666750
  REMARK    GeneRIF: findings reveal an anti-apoptotic role for Naa40 and
            exhibit its potential as a therapeutic target in colorectal
            cancers.
REFERENCE   6  (bases 1 to 3752)
  AUTHORS   Jedrzejewski,R.P. and Kazmierkiewicz,R.
  TITLE     Structure of Patt1 human proapoptotic histone acetyltransferase
  JOURNAL   J Mol Model 19 (12), 5533-5538 (2013)
   PUBMED   24248912
  REMARK    GeneRIF: The knowledge of detailed molecular architecture of Patt1
            is not only the key to understanding its mechanistic functional
            properties but it also opens the possibility of rational drug and
            protein design experiments
REFERENCE   7  (bases 1 to 3752)
  AUTHORS   Hole,K., Van Damme,P., Dalva,M., Aksnes,H., Glomnes,N.,
            Varhaug,J.E., Lillehaug,J.R., Gevaert,K. and Arnesen,T.
  TITLE     The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved
            from yeast and N-terminally acetylates histones H2A and H4
  JOURNAL   PLoS One 6 (9), e24713 (2011)
   PUBMED   21935442
  REMARK    GeneRIF: Results strongly suggest that human Naa40p/NatD is
            conserved from yeast. Thus, the NATs of all classes of N-terminally
            acetylated proteins in humans now appear to be accounted for.
REFERENCE   8  (bases 1 to 3752)
  AUTHORS   Liu,Z., Liu,Y., Wang,H., Ge,X., Jin,Q., Ding,G., Hu,Y., Zhou,B.,
            Chen,Z., Ge,X., Zhang,B., Man,X. and Zhai,Q.
  TITLE     Patt1, a novel protein acetyltransferase that is highly expressed
            in liver and downregulated in hepatocellular carcinoma, enhances
            apoptosis of hepatoma cells
  JOURNAL   Int J Biochem Cell Biol 41 (12), 2528-2537 (2009)
   PUBMED   19695338
  REMARK    GeneRIF: a novel protein acetyltransferase Patt1 might be involved
            in the development of hepatocellular carcinoma
REFERENCE   9  (bases 1 to 3752)
  AUTHORS   Polevoda,B., Arnesen,T. and Sherman,F.
  TITLE     A synopsis of eukaryotic Nalpha-terminal acetyltransferases:
            nomenclature, subunits and substrates
  JOURNAL   BMC Proc 3 Suppl 6 (Suppl 6), S2 (2009)
   PUBMED   19660095
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3752)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY009487.1, AP003780.3, DC307984.1 and BC041617.1.
            
            On Jul 12, 2014 this sequence version replaced XM_005274296.1.
            
            Transcript Variant: This variant (2) uses an alternate exon in
            place of the first exon compared to variant 1. The resulting
            isoform (2) is shorter at the N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299041.1, SRR5189667.154241.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                HY009487.1         1-40
            41-41               AP003780.3         100367-100367
            42-473              DC307984.1         125-556
            474-2241            BC041617.1         332-2099
            2242-3260           AP003780.3         116805-117823
            3261-3261           BC041617.1         3119-3119
            3262-3752           AP003780.3         117825-118315
FEATURES             Location/Qualifiers
     source          1..3752
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..3752
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /note="N-alpha-acetyltransferase 40, NatD catalytic
                     subunit"
                     /db_xref="GeneID:79829"
                     /db_xref="HGNC:HGNC:25845"
                     /db_xref="MIM:619999"
     exon            1..204
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /inference="alignment:Splign:2.1.0"
     exon            205..300
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..912
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /EC_number="2.3.1.257"
                     /note="isoform 2 is encoded by transcript variant 2;
                     N-acetyltransferase 11 (GCN5-related, putative); N-alpha
                     acetyl transferase 40; natD catalytic subunit;
                     N(alpha)-acetyltransferase 40, NatD catalytic subunit,
                     homolog; N-alpha-acetyltransferase D; protein
                     acetyltransferase 1"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 40 isoform 2"
                     /protein_id="NP_001287729.1"
                     /db_xref="CCDS:CCDS73311.1"
                     /db_xref="GeneID:79829"
                     /db_xref="HGNC:HGNC:25845"
                     /db_xref="MIM:619999"
                     /translation="MDAVCAKVDAANRLGDPLEAFPVFKKYDRNGLNVSIECKRVSGL
                     EPATVDWAFDLTKTNMQTMYEQSEWGWKDREKREEMTDDRAWYLIAWENSSVPVAFSH
                     FRFDVECGDEVLYCYEVQLESKVRRKGLGKFLIQILQLMANSTQMKKVMLTVFKHNHG
                     AYQFFREALQFEIDDSSPSMSGCCGEDCSYEILSRRTKFGDSHHSHAGGHCGGCCH"
     exon            301..353
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..449
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..608
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..692
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..770
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..3752
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3733..3738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /note="hexamer: AATAAA"
     polyA_site      3752
                     /gene="NAA40"
                     /gene_synonym="hNatD; NAT11; NatD; PATT1"
                     /note="major polyA site"
ORIGIN      
        1 agcgtcacgc ccgccccttc ctgcttcgcg gacccgttac tggcctcccc accaccgtcc
       61 cccgcgggga ccctggggtt agcttcccgc tcccccaggg tcactcatca cctggctgtc
      121 accagcttcg tcgcttttca catccgaggt caaccctggc ttggagggaa ttgaggccca
      181 gaggaaagaa ggcgcctagc caagagaaag tcaagcaaag ccaaggagaa gaagcagaag
      241 cggttggagg agcgagcagc catggatgcc gtttgtgcca aagtggacgc tgccaacagg
      301 cttggagacc ctctggaggc tttcccagtg ttcaagaaat atgatagaaa cgggttgaat
      361 gtctccattg aatgtaagcg agtgtctgga ctggagccag ccaccgtgga ttgggccttc
      421 gacctgacca aaacgaatat gcaaaccatg tatgagcaga gcgagtgggg ctggaaggac
      481 cgagagaaac gggaggaaat gacagatgac cgagcctggt acctcatcgc gtgggaaaac
      541 agctccgtcc ctgttgcctt ttctcacttc cggtttgacg tggagtgtgg ggatgaagtc
      601 ctgtactgct atgaagtgca gttggaaagc aaggtgcggc ggaaaggcct ggggaagttc
      661 ctcatacaga tcctgcagct catggccaac agcacacaga tgaagaaggt tatgttaaca
      721 gtatttaaac acaatcatgg tgcctaccag ttcttcagag aagcgttgca atttgaaatt
      781 gatgactctt cccccagcat gtccggttgc tgtggggagg attgctccta tgagatcctg
      841 agccggagga ccaagtttgg ggacagccat cactcccacg cgggtgggca ctgtggtggc
      901 tgctgccact gaactctcag agccactttc aagtcacaat gctctctcct aaggcctttc
      961 ctctttcctg gtctcactgt tcaccgggtg tcctcagagc tgtggcctcc ccagccctgc
     1021 acgtgccagg ctgcgccctg agagcacaga accctgggga gaagtggtat cagctgctcc
     1081 tcctctccta ggagaccaga gtgctagaag ggaatgaaag ggagagggaa gagtaggtgg
     1141 ggccgggcag tgaagctcat cctccacagt ggctgcctcc tcatttggct cctggggcct
     1201 gcagtggagg ttctcgcacc tctgcagccc ctagattcct ggcaacctcc cctcccctga
     1261 cacatacaca cttggacaaa tggaatgttt atgtccacct ttatgaaagt tctggagtcc
     1321 tgggtctggg gtttgctggt ccccaaagag gaacacactg ggtgtaagat ctgggtgtag
     1381 agggcggctt cagagagact cacgcttgcg cagttggaat tgctgttaac ggagactggg
     1441 aagatctttt gtgccaagat gcagggaaat gaagaaagct ctttccagct gtttttatgg
     1501 attcatggag tgggctcatg ttgggaccag ctgactctgg gaggaagact gcctctccat
     1561 cgctgtcaga gagcctgaaa ggaccaacaa tgaggtgttc ttgggacccg ccatggggat
     1621 gattgcttct ctaggctcct ggatgttgct gcattctaag cttaacctcc tggtctcatg
     1681 gcagtgactt gagcttttga ttcatagaag aaagccagag gttctgcttg ttcttgtctg
     1741 ccagccctcg tcgttctttc tcctctgcct ctcacctcta ccccaaatac ctctgttctt
     1801 agtctcaagg ggagaataac atcagggagc ccctcatctt ccccagaagg acttctcgtt
     1861 cctcatgtag ttaactccat tgattttcct atcttggtgc tgatagctct ctaagggtag
     1921 ggcacacctc cccacagcca ccctccctct tcagagagcc cccagccagc agcaggcccc
     1981 tctgcctgca ctcctcaggc ttgcccctcg ctgcctcagt gaggcactag tgccactgcc
     2041 gtggcccagc cgggccatag ctcaggctgc agcagaaatg cctctcagtg gccaacagtt
     2101 gcttttctct ctggtgtcac cctgtggcaa caggctggag caggggaagg agaaagcctt
     2161 cctcttctct cataggatag aaaggcaggc tcagaactaa tgctcatcct gatctctagg
     2221 ccttgttcct cttccaggga agaaaagcca aatccttatc aaggaaaaag cacctaacag
     2281 ctccctttgg atatccctga gctctgctgt ggggagtatc ataaaggttc tagccttcgt
     2341 gaagttgttc tcgtggaggt ctgttggtcc ctctgacctc agcatctgct cacatcccac
     2401 cctctgccca actctggcag tctctcctgg cagatctccc cagagtggtc cttgcttctc
     2461 acctggattc ctgcttgtgc aggagcctgt gtacacaggg cctccctcac ccagcctggc
     2521 ccctctgctg agcactttgc gctgctcttg atgggcagca gtgggactgg gaactcctta
     2581 gagagggcct tgcagcttta cactggaata agtctgcctc tgcctctgcc tcaccctgct
     2641 ggctcctggt gggtttcatc ccaggcagag ttgacattgc tggaggggtt tggtggactc
     2701 ctaagaatca tgaaaccaca ggagcatgtt taggaagaga tttgtctctg gtccctgtct
     2761 ctgaaaggac acagatgcta aatatttatt gtcttagatc atggattcct gatacctctc
     2821 actcaagggg accaaaaggg acccccccgt gttcatccct tgtaaggtga gttcagtcta
     2881 cgttgtctct ttccagtcac tggatacgtg gcaccaactg gtcaatgggt gcttggtgcc
     2941 ataccctgct caccctagtc tctgcaggcc atgtcctgaa gggttcctca ggaggtcggg
     3001 actagggtgg gagaggcact atctgagacc tgcaatcact cttgttggtc ttgagcccat
     3061 tcatttccaa aacatccatc tttctccact tcccccaggt cttggttttg agaaacagca
     3121 ggcatggctg agtgcggtgg cttacacctg taatcccagc actttgggag gctgaggcag
     3181 gcgggtcacc tgaggtcagg agttcaagac cagcctggtc aacatggcaa aagcccatct
     3241 ctactaaaaa atacaaaaat tagccaggcg tggttgtggc ctgtaatccc agctactcgg
     3301 gaggctgagg caggagactc gcttgaaccc aggaggtgga ggttgtggtg agctgagatc
     3361 acgccattgc actccagcct aggcgacaga gtgagactcc atctcaaaaa aaaaaaaaag
     3421 agaaacatag caggcctttt ttaccaggct ttttgtgttt tgtttgtttg tttggagcat
     3481 gttaagattt ttttaagatt tttaaaattt tagttatatc caccctattt caggttattt
     3541 ttgttggtgt caagtatgta taggacatgt gaatggttct ttttaatttt tttttaagag
     3601 gaaatttgga agataaactc cttgatatat atatatatat atatattttt ttttttcttt
     3661 agcagcttgt tatcactgga atcaaaggga aaaagtgatc tcttcttgca ttggttgtat
     3721 ttgtatgtca caaataaaag acactttggt ca
//
