LOCUS       NM_001320925             520 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens N-alpha-acetyltransferase 38, NatC auxiliary subunit
            (NAA38), transcript variant 3, mRNA.
ACCESSION   NM_001320925 XM_005256823
VERSION     NM_001320925.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 520)
  AUTHORS   Varland,S., Silva,R.D., Kjosas,I., Faustino,A., Bogaert,A.,
            Billmann,M., Boukhatmi,H., Kellen,B., Costanzo,M., Drazic,A.,
            Osberg,C., Chan,K., Zhang,X., Tong,A.H.Y., Andreazza,S., Lee,J.J.,
            Nedyalkova,L., Usaj,M., Whitworth,A.J., Andrews,B.J., Moffat,J.,
            Myers,C.L., Gevaert,K., Boone,C., Martinho,R.G. and Arnesen,T.
  TITLE     N-terminal acetylation shields proteins from degradation and
            promotes age-dependent motility and longevity
  JOURNAL   Nat Commun 14 (1), 6774 (2023)
   PUBMED   37891180
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 520)
  AUTHORS   Deng,S., Gardner,S.M., Gottlieb,L., Pan,B., Petersson,E.J. and
            Marmorstein,R.
  TITLE     Molecular role of NAA38 in thermostability and catalytic activity
            of the human NatC N-terminal acetyltransferase
  JOURNAL   Structure 31 (2), 166-173 (2023)
   PUBMED   36638802
  REMARK    GeneRIF: Molecular role of NAA38 in thermostability and catalytic
            activity of the human NatC N-terminal acetyltransferase.
REFERENCE   3  (bases 1 to 520)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 520)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 520)
  AUTHORS   Polevoda,B., Arnesen,T. and Sherman,F.
  TITLE     A synopsis of eukaryotic Nalpha-terminal acetyltransferases:
            nomenclature, subunits and substrates
  JOURNAL   BMC Proc 3 Suppl 6 (Suppl 6), S2 (2009)
   PUBMED   19660095
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 520)
  AUTHORS   Starheim,K.K., Gromyko,D., Evjenth,R., Ryningen,A., Varhaug,J.E.,
            Lillehaug,J.R. and Arnesen,T.
  TITLE     Knockdown of human N alpha-terminal acetyltransferase complex C
            leads to p53-dependent apoptosis and aberrant human Arl8b
            localization
  JOURNAL   Mol Cell Biol 29 (13), 3569-3581 (2009)
   PUBMED   19398576
REFERENCE   7  (bases 1 to 520)
  AUTHORS   Wenzlau,J.M., Garl,P.J., Simpson,P., Stenmark,K.R., West,J.,
            Artinger,K.B., Nemenoff,R.A. and Weiser-Evans,M.C.
  TITLE     Embryonic growth-associated protein is one subunit of a novel
            N-terminal acetyltransferase complex essential for embryonic
            vascular development
  JOURNAL   Circ Res 98 (6), 846-855 (2006)
   PUBMED   16484612
REFERENCE   8  (bases 1 to 520)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104581.22.
            
            On Nov 19, 2020 this sequence version replaced NM_001320925.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051846.1, BM703886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000575771.6/ ENSP00000460172.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               AC104581.22        20620-20796         c
            178-361             AC104581.22        20252-20435         c
            362-520             AC104581.22        19922-20080         c
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..520
                     /gene="NAA38"
                     /gene_synonym="LSMD1; MAK31; PFAAP2"
                     /note="N-alpha-acetyltransferase 38, NatC auxiliary
                     subunit"
                     /db_xref="GeneID:84316"
                     /db_xref="HGNC:HGNC:28212"
                     /db_xref="MIM:617990"
     exon            1..177
                     /gene="NAA38"
                     /gene_synonym="LSMD1; MAK31; PFAAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..474
                     /gene="NAA38"
                     /gene_synonym="LSMD1; MAK31; PFAAP2"
                     /note="isoform 3 is encoded by transcript variant 3; LSM
                     domain-containing protein 1; phosphonoformate
                     immuno-associated protein 2; LSM domain containing 1"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 38, NatC auxiliary
                     subunit isoform 3"
                     /protein_id="NP_001307854.1"
                     /db_xref="CCDS:CCDS82060.1"
                     /db_xref="GeneID:84316"
                     /db_xref="HGNC:HGNC:28212"
                     /db_xref="MIM:617990"
                     /translation="MAGAGPTMLLREENGCCSRRQSSSSAGDSDGEREDSAAERARQQ
                     LEALLNKTMRIRMTDGRTLVGCFLCTDRDCNVILGSAQEFLKPSDSFSAGEPRVLGLA
                     MVPGHHIVSIEVQRESLTGPPYL"
     exon            178..361
                     /gene="NAA38"
                     /gene_synonym="LSMD1; MAK31; PFAAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            362..520
                     /gene="NAA38"
                     /gene_synonym="LSMD1; MAK31; PFAAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      503..508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA38"
                     /gene_synonym="LSMD1; MAK31; PFAAP2"
                     /note="hexamer: ATTAAA"
     polyA_site      517
                     /gene="NAA38"
                     /gene_synonym="LSMD1; MAK31; PFAAP2"
     polyA_site      520
                     /gene="NAA38"
                     /gene_synonym="LSMD1; MAK31; PFAAP2"
                     /note="major polyA site"
ORIGIN      
        1 gaaaggaaag aggtcgggag cgctcgcgag atctcggacc acccaacctg aaaggtgctt
       61 aggaagttga aaggcccaga ggaggcctcc gggcaaatgg ccggagctgg accgaccatg
      121 ctgctacgag aagagaatgg ctgttgcagt cggcgtcaga gcagctccag tgctggggat
      181 tcggacggag agcgcgagga ctcggcggct gagcgcgccc gacagcagct agaggcgctg
      241 ctcaacaaga ctatgcgcat tcgcatgaca gatggacgga cactggtcgg ctgcttcctc
      301 tgcactgacc gtgactgcaa tgtcatcctg ggctcggcgc aggagttcct caagccgtcg
      361 gattccttct ctgccgggga gccccgtgtg ctgggcctgg ccatggtacc cggacaccac
      421 atcgtttcca ttgaggtgca gagggagagt ctgaccgggc ctccgtatct ctgaccacga
      481 tggcgcttac ctttcagact tcattaaact tatgaccgaa
//
