LOCUS       NM_024953               5771 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens N-alpha-acetyltransferase 25, NatB auxiliary subunit
            (NAA25), mRNA.
ACCESSION   NM_024953
VERSION     NM_024953.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5771)
  AUTHORS   Morrison,J., Altuwaijri,N.K., Bronstad,K., Aksnes,H., Alsaif,H.S.,
            Evans,A., Hashem,M., Wheeler,P.G., Webb,B.D., Alkuraya,F.S. and
            Arnesen,T.
  TITLE     Missense NAA20 variants impairing the NatB protein N-terminal
            acetyltransferase cause autosomal recessive developmental delay,
            intellectual disability, and microcephaly
  JOURNAL   Genet Med 23 (11), 2213-2218 (2021)
   PUBMED   34230638
REFERENCE   2  (bases 1 to 5771)
  AUTHORS   Xu,J.K., Li,G.Z., Li,Z., Li,W.J., Chen,R.S., Zhang,B. and
            Zhang,X.J.
  TITLE     Genome-wide long non-coding RNA association study on Han Chinese
            women identifies lncHSAT164 as a novel susceptibility gene for
            breast cancer
  JOURNAL   Chin Med J (Engl) 134 (10), 1138-1145 (2021)
   PUBMED   34018994
  REMARK    GeneRIF: Genome-wide long non-coding RNA association study on Han
            Chinese women identifies lncHSAT164 as a novel susceptibility gene
            for breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5771)
  AUTHORS   Bozpolat,A., Unal,E., Topaloglu,T., Taheri,S., Bayram,A.K.,
            Ozcan,A., Karakukcu,M., Ozdemir,M.A. and Per,H.
  TITLE     The relationship between the prognosis of children with acute
            arterial stroke and polymorphisms of CDKN2B, HDAC9, NINJ2, NAA25
            genes
  JOURNAL   J Thromb Thrombolysis 47 (4), 578-584 (2019)
   PUBMED   30656483
  REMARK    GeneRIF: The relationship between the prognosis of children with
            acute arterial stroke and polymorphisms of CDKN2B, HDAC9, NINJ2,
            NAA25 genes.
REFERENCE   4  (bases 1 to 5771)
  AUTHORS   Yasuda,K., Takahashi,M. and Mori,N.
  TITLE     Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its
            Effect on Rictor Expression
  JOURNAL   PLoS One 10 (11), e0142943 (2015)
   PUBMED   26600389
  REMARK    GeneRIF: Mdm20 acts as a novel regulator of Rictor, thereby
            controlling mTORC2 activity, and leading to the activation of
            PKCalphaS657 and FoxO1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5771)
  AUTHORS   Dichgans,M., Malik,R., Konig,I.R., Rosand,J., Clarke,R.,
            Gretarsdottir,S., Thorleifsson,G., Mitchell,B.D., Assimes,T.L.,
            Levi,C., O'Donnell,C.J., Fornage,M., Thorsteinsdottir,U.,
            Psaty,B.M., Hengstenberg,C., Seshadri,S., Erdmann,J., Bis,J.C.,
            Peters,A., Boncoraglio,G.B., Marz,W., Meschia,J.F., Kathiresan,S.,
            Ikram,M.A., McPherson,R., Stefansson,K., Sudlow,C., Reilly,M.P.,
            Thompson,J.R., Sharma,P., Hopewell,J.C., Chambers,J.C., Watkins,H.,
            Rothwell,P.M., Roberts,R., Markus,H.S., Samani,N.J., Farrall,M. and
            Schunkert,H.
  CONSRTM   METASTROKE Consortium; CARDIoGRAM Consortium; C4D Consortium;
            International Stroke Genetics Consortium
  TITLE     Shared genetic susceptibility to ischemic stroke and coronary
            artery disease: a genome-wide analysis of common variants
  JOURNAL   Stroke 45 (1), 24-36 (2014)
   PUBMED   24262325
  REMARK    Review article
REFERENCE   6  (bases 1 to 5771)
  AUTHORS   Polevoda,B., Arnesen,T. and Sherman,F.
  TITLE     A synopsis of eukaryotic Nalpha-terminal acetyltransferases:
            nomenclature, subunits and substrates
  JOURNAL   BMC Proc 3 Suppl 6 (Suppl 6), S2 (2009)
   PUBMED   19660095
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5771)
  AUTHORS   Prahalad,S., Hansen,S., Whiting,A., Guthery,S.L., Clifford,B.,
            McNally,B., Zeft,A.S., Bohnsack,J.F. and Jorde,L.B.
  TITLE     Variants in TNFAIP3, STAT4, and C12orf30 loci associated with
            multiple autoimmune diseases are also associated with juvenile
            idiopathic arthritis
  JOURNAL   Arthritis Rheum 60 (7), 2124-2130 (2009)
   PUBMED   19565500
  REMARK    GeneRIF: There are associations between juvenile idiopathic
            arthritis and variants in the TNFAIP3, STAT4, and C12orf30 regions
            that have previously shown associations with other autoimmune
            diseases, including rheumatoid arthritis and systemic lupus
            erythematosus.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5771)
  AUTHORS   Cooper,J.D., Smyth,D.J., Smiles,A.M., Plagnol,V., Walker,N.M.,
            Allen,J.E., Downes,K., Barrett,J.C., Healy,B.C., Mychaleckyj,J.C.,
            Warram,J.H. and Todd,J.A.
  TITLE     Meta-analysis of genome-wide association study data identifies
            additional type 1 diabetes risk loci
  JOURNAL   Nat Genet 40 (12), 1399-1401 (2008)
   PUBMED   18978792
REFERENCE   9  (bases 1 to 5771)
  AUTHORS   Starheim,K.K., Arnesen,T., Gromyko,D., Ryningen,A., Varhaug,J.E.
            and Lillehaug,J.R.
  TITLE     Identification of the human N(alpha)-acetyltransferase complex B
            (hNatB): a complex important for cell-cycle progression
  JOURNAL   Biochem J 415 (2), 325-331 (2008)
   PUBMED   18570629
  REMARK    GeneRIF: Human N-acetyltransferase complexe NatB consists of human
            N-acetyltransferase 3 and human MDM20. The hMDM20 knockdown
            decreased the fraction of cells in G(0)/G(1)-phase and increased
            the fraction of cells in the sub-G(0)/G(1)-phase.
            GeneRIF: hMdm20 (C12orf30) is an auxiliary subunit of the human
            NatB N-terminal acetyltransferase complex while hNat3 (NAT5) is the
            catalytic subunit. This ribosome associated complex acetylates
            nascent Met-Asp/Glu- polypeptides.
REFERENCE   10 (bases 1 to 5771)
  AUTHORS   Todd,J.A., Walker,N.M., Cooper,J.D., Smyth,D.J., Downes,K.,
            Plagnol,V., Bailey,R., Nejentsev,S., Field,S.F., Payne,F.,
            Lowe,C.E., Szeszko,J.S., Hafler,J.P., Zeitels,L., Yang,J.H.,
            Vella,A., Nutland,S., Stevens,H.E., Schuilenburg,H., Coleman,G.,
            Maisuria,M., Meadows,W., Smink,L.J., Healy,B., Burren,O.S.,
            Lam,A.A., Ovington,N.R., Allen,J., Adlem,E., Leung,H.T.,
            Wallace,C., Howson,J.M., Guja,C., Ionescu-Tirgoviste,C.,
            Simmonds,M.J., Heward,J.M., Gough,S.C., Dunger,D.B., Wicker,L.S.
            and Clayton,D.G.
  CONSRTM   Genetics of Type 1 Diabetes in Finland; Wellcome Trust Case Control
            Consortium
  TITLE     Robust associations of four new chromosome regions from genome-wide
            analyses of type 1 diabetes
  JOURNAL   Nat Genet 39 (7), 857-864 (2007)
   PUBMED   17554260
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC113587.1, BX647450.1,
            BC047640.1 and AA653507.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024953.3.
            
            Summary: This gene encodes the auxiliary subunit of the heteromeric
            N-terminal acetyltransferase B complex. This complex acetylates
            methionine residues that are followed by acidic or asparagine
            residues.[provided by RefSeq, Mar 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647450.1, SRR1803615.8597.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261745.9/ ENSP00000261745.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3005              BC113587.1         49-3053
            3006-5280           BX647450.1         3007-5281
            5281-5768           BC047640.1         682-1169
            5769-5771           AA653507.1         7-9                 c
FEATURES             Location/Qualifiers
     source          1..5771
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..5771
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /note="N-alpha-acetyltransferase 25, NatB auxiliary
                     subunit"
                     /db_xref="GeneID:80018"
                     /db_xref="HGNC:HGNC:25783"
                     /db_xref="MIM:612755"
     exon            1..68
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2929
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /note="mitochondrial distribution and morphology 20; natB
                     complex subunit MDM20; N-terminal acetyltransferase B
                     complex subunit NAA25"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 25, NatB auxiliary
                     subunit"
                     /protein_id="NP_079229.2"
                     /db_xref="CCDS:CCDS9159.1"
                     /db_xref="GeneID:80018"
                     /db_xref="HGNC:HGNC:25783"
                     /db_xref="MIM:612755"
                     /translation="MATRGHVQDPNDRRLRPIYDYLDNGNNKMAIQQADKLLKKHKDL
                     HCAKVLKAIGLQRTGKQEEAFTLAQEVAALEPTDDNSLQALTILYREMHRPELVTKLY
                     EAAVKKVPNSEEYHSHLFMAYARVGEYKKMQQAGMALYKIVPKNPYYFWSVMSLIMQS
                     ISAQDENLSKTMFLPLAERMVEKMVKEDKIEAEAEVELYYMILERLGKYQEALDVIRG
                     KLGEKLTSEIQSRENKCMAMYKKLSRWPECNALSRRLLLKNSDDWQFYLTYFDSVFRL
                     IEEAWSPPAEGEHSLEGEVHYSAEKAVKFIEDRITEESKSSRHLRGPHLAKLELIRRL
                     RSQGCNDEYKLGDPEELMFQYFKKFGDKPCCFTDLKVFVDLLPATQCTKFINQLLGVV
                     PLSTPTEDKLALPADIRALQQHLCVVQLTRLLGLYHTMDKNQKLSVVRELMLRYQHGL
                     EFGKTCLKTELQFSDYYCLLAVHALIDVWRETGDETTVWQALTLLEEGLTHSPSNAQF
                     KLLLVRIYCMLGAFEPVVDLYSSLDAKHIQHDTIGYLLTRYAESLGQYAAASQSCNFA
                     LRFFHSNQKDTSEYIIQAYKYGAFEKIPEFIAFRNRLNNSLHFAQVRTERMLLDLLLE
                     ANISTSLAESIKSMNLRPEEDDIPWEDLRDNRDLNVFFSWDPKDRDVSEEHKKLSLEE
                     ETLWLRIRSLTLRLISGLPSLNHPVEPKNSEKTAENGVSSRIDILRLLLQQLEATLET
                     GKRFIEKDIQYPFLGPVPTRMGGFFNSGCSQCQISSFYLVNDIYELDTSGLEDTMEIQ
                     ERIENSFKSLLDQLKDVFSKCKGDLLEVKDGNLKTHPTLLENLVFFVETISVILWVSS
                     YCESVLRPYKLNLQKKKKKKKETSIIMPPVFTSFQDYVTGLQTLISNVVDHIKGLETH
                     LIALKLEELILEDTSLSPEERKFSKTVQGKVQSSYLHSLLEMGELLKKRLETTKKLKI
                     "
     exon            69..154
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            155..293
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            294..412
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..487
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            488..595
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..674
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..786
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..876
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1046
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1159
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1367
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1457
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1638
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1738
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1890
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2016
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2260
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2384
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2450
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2548
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2659
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2806
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..5771
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4649..4654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /note="hexamer: CATAAA"
     polyA_site      4677
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /note="major polyA site"
     regulatory      5600..5605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /note="hexamer: TATAAA"
     polyA_site      5621
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /note="major polyA site"
     regulatory      5745..5750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
                     /note="hexamer: TATAAA"
     polyA_site      5771
                     /gene="NAA25"
                     /gene_synonym="C12orf30; MDM20; NAP1"
ORIGIN      
        1 gcttgtcatc atggcgacgc ggggccatgt gcaggaccct aacgacaggc gcctccggcc
       61 catttacgat tatcttgaca atggtaataa taaaatggca attcagcaag cagataaact
      121 gttgaagaaa cataaggatc ttcattgtgc taaggtttta aaggcaattg gtttacagag
      181 aactggaaag caagaggaag cctttactct tgcacaggag gtggcagccc ttgaacccac
      241 agatgacaac tcactgcagg cactgactat cctttaccgg gagatgcacc gaccggagtt
      301 agttacaaaa ctttatgagg cagctgtgaa gaaagttccc aatagtgagg agtatcactc
      361 tcacctcttc atggcctatg ccagagtggg tgaatacaag aaaatgcaac aggctggcat
      421 ggctctatat aagattgtcc ccaaaaatcc ctactacttt tggtctgtga tgagcttaat
      481 tatgcaatct atatcggcac aggatgaaaa cctctcaaaa acaatgtttc tgccccttgc
      541 tgagagaatg gtcgaaaaaa tggtgaaaga ggacaagata gaagctgagg ctgaagttga
      601 actttattat atgatcctgg aacgtttggg aaagtaccag gaggccttgg atgtcatcag
      661 agggaaatta ggagagaagt tgacaagtga gattcagagt cgggaaaata aatgcatggc
      721 tatgtacaag aagctgagca ggtggccaga gtgcaatgcc ctttcccggc gcctcttact
      781 aaaaaactca gatgactggc agttctatct gacttatttc gattctgtct ttcgactgat
      841 tgaagaggcc tggagtcctc ctgctgaagg tgaacactct ttagaaggag aagtacatta
      901 ttctgcagaa aaagctgtga agtttataga agatcggata acggaagaat ctaaaagttc
      961 tcgccatctc cgaggaccac atctagctaa attggagctg attaggcgtt tacgaagtca
     1021 aggttgtaac gatgagtaca aactgggtga tccagaagaa ttaatgttcc agtattttaa
     1081 aaagtttggc gataaacctt gttgttttac agaccttaag gtgtttgttg acctcttacc
     1141 tgctacacag tgtacaaaat ttattaatca gttacttgga gttgttcctt tgtcgacacc
     1201 aacagaggat aagctggcac tgcctgctga catcagagct ctgcagcaac atttgtgtgt
     1261 ggtgcagctg acgaggttac ttggcttgta ccacaccatg gataaaaatc agaaattgag
     1321 tgtggtcaga gaattgatgt taaggtacca gcatggactg gaatttggga aaacctgttt
     1381 gaaaacagaa ttgcaatttt ctgactatta ctgtctcctt gctgtccatg cgcttattga
     1441 tgtatggagg gaaacaggtg atgagaccac tgtgtggcag gccctgactt tgctggaaga
     1501 gggattaacc catagccctt ccaatgctca gttcaaattg ctgcttgttc gaatctactg
     1561 tatgctgggt gcatttgaac cagtggtgga tctttactcc agcctcgatg ctaagcatat
     1621 ccagcatgat accattggtt atcttttgac ccgatatgct gaatctctag gtcagtatgc
     1681 tgctgcgtcc caatcctgta acttcgcact caggtttttt cactccaacc agaaagatac
     1741 ctcagaatat attattcaag cttacaaata tggtgcattt gagaagatcc cagagtttat
     1801 cgcttttagg aacaggctga ataattctct tcattttgca caagtccgta ctgaacggat
     1861 gctgttagac cttctacttg aagcaaatat atcaaccagt ttagcagaaa gtataaagtc
     1921 aatgaacctt aggccagaag aagatgacat tccatgggaa gatttgcgag acaacagaga
     1981 cttaaatgtt tttttcagct gggatccaaa agacagggac gtttctgaag aacataagaa
     2041 actttcctta gaggaggaga ccttgtggtt aagaatccga tccttaacat tgaggctgat
     2101 aagtggactt ccaagtctca accaccctgt ggagccaaag aactcggaga agactgccga
     2161 gaatggggta tcctcccgga ttgatattct tcgtttgctc cttcaacagc tggaggcaac
     2221 cctggagaca ggaaagcgat ttattgagaa ggatattcag tatcctttcc ttggtcctgt
     2281 acctaccaga atgggtggat tctttaattc tggctgttct cagtgccaga taagctcttt
     2341 ttatcttgtc aatgatattt atgagctgga taccagtggt ttagaggata caatggagat
     2401 tcaggaacga atagaaaata gttttaagtc tttactagac cagttaaaag atgtcttcag
     2461 taaatgtaaa ggtgacctct tagaagttaa agatggtaac ttgaaaacac atcctactct
     2521 tttagaaaat ctagttttct ttgttgagac tatttctgtt atcctttggg tatccagtta
     2581 ctgtgagagt gtcctacgac catacaaact aaatttacag aaaaagaaaa agaagaaaaa
     2641 agaaaccagc atcatcatgc cacctgtctt taccagtttc caagactatg ttactgggct
     2701 tcagacttta atttccaatg ttgtggatca tattaaaggg cttgaaacac atctaattgc
     2761 acttaaactt gaagaactta ttttagaaga cacttctctc tcaccggaag agagaaaatt
     2821 ttcaaagact gtgcaaggga aggtgcagag cagttatctg cactcacttc tggaaatggg
     2881 ggagctgctg aaaaaaagac ttgagaccac aaagaaacta aaaatttaag gaagtatcta
     2941 tcatgggcac tgatgactct gcaacagaat atgacaccat cttcccaggc aaaagcaaca
     3001 tctggttgac catgatttta atccagaact tcctcataaa atgcatgaag gactttgatc
     3061 gtgaattttt ttaggtgtta aatatataca actgattaaa ttattgtata taaaccagaa
     3121 gcgggaccct catctgggtt tgaccacttt ttatacatgt tcatatgcat atggcagcaa
     3181 caagagaacc ctacttttct tcttcccatc accagaaaca tcttttcagg ggagcggggg
     3241 gtctataaaa acagcaatag aaattaagca taaagcatca acctcatagc aactgaatag
     3301 cccttccatt ataaataaca ttgagagttt ttggtctggt ccttgagcca caagaagtgg
     3361 aggggagacc atgcctggga acagaccccc ttttcacagc agtaagtttg ttttgaggct
     3421 ttctcagcta cttggctccc acagaaccca aggcaggtac acaaaggacc ttagatgaga
     3481 tctggcatat gcacccgcaa tagaagggca ccacttggat gaccacaggc acttagtttt
     3541 tggctagttt ttgtctgata gttaagacat ccccatccta gcttctgtga gagttaaaaa
     3601 tctcaggtaa gaaggcaagg aaggctctgt taatttatag ctgtttagag gggaaagcag
     3661 tgcagaccac ttattaagcc cgctgaggac tagctttctg tctttcatac atttgggaaa
     3721 gataggaatg actgtttcaa agaagagagg tgcacataat ttatgcaggc aagtatgata
     3781 cttatttcat tggttttgtg agtcatatat atacatatat atatatacac atatatatat
     3841 gacttgaaaa ttaagattta atactttaat gttttaagtg tggggggttt gggaaggaag
     3901 gaatgtaata ttatggattt agccttaggc tttaagtttt aggctggcaa aagaaatgtt
     3961 attcagtggg tttgaggttt ggactacttt cttcaaactt agagaattat aacaggatgg
     4021 tgtttacttt gttcacctgg atgtccccaa gactctagct tcttctatca gtggttggtc
     4081 tgatagaaga ggtaaaaatt gctcttgaaa atgtcctaca atttatgcag tttctttgat
     4141 aatatttttc tgtttaaatc cctgcttctg tttttggtct gttacctaaa tatagttcaa
     4201 gtttaattct gtaagagcaa agaaatgaat ttgatgagga aattaagcat ccaatggagg
     4261 attggtcttg aagaccttaa aggtgctttc caacctgcac tgctccagtg aaatgtggta
     4321 cttttttctt ttaaaagcaa ccaagagagc tgggaatatc tgtgtacgca aagtaattgc
     4381 attttgtccc ttcattttga ctttcttaga ttcataattt gatacagtgc ttaaacttcc
     4441 aaggaaattt taaacaatta ctacattacc tgttcaaaat aaggcttgtt ggaaatccta
     4501 gtccatcaac taatttcaaa aatttatttt tgatatgagt agcaacagct ggtcatatac
     4561 cctatcccaa aaggaagaac tgtcttgaac aagatgaatg gaaaattgtg gttaattctg
     4621 aatttcatgt aatgacaaca tattctttca taaaactatg gcctgtttaa gatggaactt
     4681 tgtgtgtgtc tgctggggag ggtggggtac atgtgtatgg cgtgtgttct tgaaatgatg
     4741 tctctctgaa tatccaaaaa agtactgtac tgtagaaatg ctctttgaaa aagtctatcg
     4801 actgaccatg atcaatctag catatgtatg ttcagtgggc tagccttggt cctcagggac
     4861 agtgtgtgac tctagtggtc ttcctaacca gtctcttgcc taaagatatc tgggacctct
     4921 actggcttta atgacaaata atgttatgtt gaggttatgc ttcctttgtt atttgctgat
     4981 tttcctacta aatgtagcat ttcaattaga tccagctttc acattttgag ataattgtaa
     5041 aaagaatgaa attatgcaga aatggccaat atctcttatc aatctgttct tttggaaacc
     5101 ctcatgtact ataaattgtg tacagttaaa aaaatatata tatatatata ttcttacatg
     5161 agtaaaaagc accctctccc agcaatcgta tgccattggt atttgaagag aattcccaaa
     5221 taacccattg ctgctgctgc tgtttttgat ttgtatgggt ttttttgttt tgtttgtttt
     5281 tgtgtggtaa actgatattt aaaaaaggaa aggagaaaaa tcacgactac tgtttacaga
     5341 ctgaaaaatt attgcttttt atactactga gatcctaagt taagactctc caaagcaaac
     5401 atttggttta aatcatttat ctgatgtaga taaaaggtag agaaacttgt agtgttctcc
     5461 acataatgga aaatgtacaa atgcctagtt gtgttgccca tcaattttgt atattttcat
     5521 aattttaatt gttgaaaatt gcattatatt ttgcaatcac tatgttcaat ctggatttgt
     5581 ctttcatttt aacttttaat ataaaaaggg gtttcaatgt atctacaggc ttgttattga
     5641 aacttcctac ttatttgatg tgatttatta atataggaag tatatattct tccttaagta
     5701 agtgaagcat agcaaatcta ctttaaactg gatgggttaa tttatataaa cattttcatt
     5761 ttaagttggc a
//
