LOCUS       NM_024561               4285 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens N-alpha-acetyltransferase 16, NatA auxiliary subunit
            (NAA16), transcript variant 1, mRNA.
ACCESSION   NM_024561
VERSION     NM_024561.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4285)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4285)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 4285)
  AUTHORS   Polevoda,B., Arnesen,T. and Sherman,F.
  TITLE     A synopsis of eukaryotic Nalpha-terminal acetyltransferases:
            nomenclature, subunits and substrates
  JOURNAL   BMC Proc 3 Suppl 6 (Suppl 6), S2 (2009)
   PUBMED   19660095
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4285)
  AUTHORS   Arnesen,T., Gromyko,D., Kagabo,D., Betts,M.J., Starheim,K.K.,
            Varhaug,J.E., Anderson,D. and Lillehaug,J.R.
  TITLE     A novel human NatA Nalpha-terminal acetyltransferase complex:
            hNaa16p-hNaa10p (hNat2-hArd1)
  JOURNAL   BMC Biochem 10, 15 (2009)
   PUBMED   19480662
  REMARK    GeneRIF: hNaa16p (NARG1L) interacts with hNaa10p (hArd1) making a
            distinct ribosome associated human NatA N-terminal
            acetyltransferase complex. hNAA16 is expressed in a variety of
            human cell lines and specific knockdown of hNAA16 induces cell
            death.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4285)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 4285)
  AUTHORS   Arnesen,T., Betts,M.J., Pendino,F., Liberles,D.A., Anderson,D.,
            Caro,J., Kong,X., Varhaug,J.E. and Lillehaug,J.R.
  TITLE     Characterization of hARD2, a processed hARD1 gene duplicate,
            encoding a human protein N-alpha-acetyltransferase
  JOURNAL   BMC Biochem 7, 13 (2006)
   PUBMED   16638120
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4285)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   8  (bases 1 to 4285)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB078940.1, AK097224.1, AL590665.9, AL833341.1 and AL731858.10.
            
            On Nov 22, 2018 this sequence version replaced NM_024561.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.213027.1,
                                           SRR1803611.169579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379406.8/ ENSP00000368716.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                DB078940.1         64-126
            64-1032             AK097224.1         36-1004
            1033-1033           AL590665.9         9035-9035
            1034-1672           AK097224.1         1006-1644
            1673-2922           AL833341.1         712-1961
            2923-3762           AL731858.10        5142-5981
            3763-4285           AL833341.1         2802-3324
FEATURES             Location/Qualifiers
     source          1..4285
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..4285
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /note="N-alpha-acetyltransferase 16, NatA auxiliary
                     subunit"
                     /db_xref="GeneID:79612"
                     /db_xref="HGNC:HGNC:26164"
                     /db_xref="MIM:619497"
     exon            1..316
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..2857
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /note="isoform 1 is encoded by transcript variant 1; NMDA
                     receptor-regulated 1-like protein; NARG1-like protein"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 16, NatA auxiliary
                     subunit isoform 1"
                     /protein_id="NP_078837.3"
                     /db_xref="CCDS:CCDS9379.1"
                     /db_xref="GeneID:79612"
                     /db_xref="HGNC:HGNC:26164"
                     /db_xref="MIM:619497"
                     /translation="MPNVLLPPKESNLFKRILKCYEQKQYKNGLKFCKMILSNPKFAE
                     HGETLAMKGLTLNCLGKKEEAYEFVRKGLRNDVKSHVCWHVYGLLQRSDKKYDEAIKC
                     YRNALKLDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPTQRASWIGYAIAYHL
                     LKDYDMALKLLEEFRQTQQVPPNKIDYEYSELILYQNQVMREADLLQESLEHIEMYEK
                     QICDKLLVEEIKGEILLKLGRLKEASEVFKNLIDRNAENWCYYEGLEKALQISTLEER
                     LQIYEEISKQHPKAITPRRLPLTLVPGERFRELMDKFLRVNFSKGCPPLFTTLKSLYY
                     NTEKVSIIQELVTNYEASLKTCDFFSPYENGEKEPPTTLLWVQYFLAQHFDKLGQYSL
                     ALDYINAAIASTPTLIELFYMKAKIYKHIGNLKEAAKWMDEAQSLDTADRFINSKCAK
                     YMLRANMIKEAEEMCSKFTREGTSAMENLNEMQCMWFQTECISAYQRLGRYGDALKKC
                     HEVERHFFEITDDQFDFHTYCMRKMTLRAYVDLLRLEDILRRHAFYFKAARSAIEIYL
                     KLYDNPLTNESKQQEINSENLSAKELKKMLSKQRRAQKKAKLEEERKHAERERQQKNQ
                     KKKRDEEEEEASGLKEELIPEKLERVENPLEEAVKFLIPLKNLVADNIDTHLLAFEIY
                     FRKGKFLLMLQSVKRAFAINSNNPWLHECLIRFSKSVSNHSNLPDIVSKVLSQEMQKI
                     FVKKDLESFNEDFLKRNATSLQHLLSGAKMMYFLDKSRQEKAIAIATRLDETIKDKDV
                     KTLIKVSEALLDGSFGNCSSQYEEYRMACHNLLPFTSAFLPAVNEVDNPNVALNHTAN
                     YDVLANEI"
     exon            317..401
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            402..506
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            507..664
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            665..799
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            800..953
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1073
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1169
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1276
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..1349
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1519
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1672
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1801
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..2015
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2209
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2318
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2417
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2561
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2659
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..4285
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4263..4268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /note="hexamer: AATAAA"
     polyA_site      4285
                     /gene="NAA16"
                     /gene_synonym="NARG1L"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcgcg ggaaccgccg ccgccgccgc tggccaaaaa gcggagccca ggggaagcgt
       61 gtcctgctca gaccgccttc cttctccatt gccacccgtg ccgaacagcc aggctgccca
      121 attgcaactg tagaccaatg aactaatcca tcgcccgcag cccgactctc agcagcggtt
      181 cgtcccggtg cccacccccg cgaagcggag cgcccgggca cctagcctcc ctgccggcca
      241 cctagcctcc ctgccggcca cgatgccgaa cgtgctgctg ccgcccaagg agagcaacct
      301 cttcaaacgc atcttgaaat gttatgaaca gaagcagtac aaaaatggcc tcaagttttg
      361 caagatgatt ctgtcgaacc caaaatttgc tgaacatgga gagactttgg ctatgaaagg
      421 attaacactg aactgtttag gaaaaaaaga agaagcttat gagtttgttc gtaaaggact
      481 tcgtaatgat gtcaagagtc atgtctgttg gcatgtatat ggactcttgc agcgttctga
      541 taaaaaatat gatgaagcta taaaatgtta ccgaaatgcc ctcaaattag ataaagataa
      601 cctgcaaatt ttgagggatc tctcactgtt gcagatccaa atgagagacc ttgaaggtta
      661 ccgagagaca agataccagc ttcttcagtt gcgccccaca cagcgtgcct cctggattgg
      721 atatgctatt gcataccatt tgctgaaaga ttatgatatg gccctaaaac tgttggaaga
      781 atttagacaa actcagcaag ttcctccaaa caaaatagat tatgaatata gtgaattgat
      841 attataccag aatcaagtga tgagagaggc agatctgttg caggaatctt tggaacatat
      901 agaaatgtat gagaaacaaa tatgtgataa acttttggtg gaagaaatta aaggggaaat
      961 actgttgaaa ttgggaagat taaaagaagc cagtgaagtg ttcaaaaact tgattgatcg
     1021 aaatgcagaa aattggtgtt attatgaagg cttggaaaaa gctctacaaa ttagcacttt
     1081 agaagagagg cttcaaattt atgaagaaat tagtaagcag caccccaaag caattacacc
     1141 cagaagatta cctttgactc ttgtcccagg tgaaagattt agagaactaa tggataagtt
     1201 cctgagggtt aacttcagta aaggctgccc acccttgttt actactttga aatctttata
     1261 ttacaataca gaaaaggttt ctataatcca ggaacttgtt actaattatg aagcctctct
     1321 taaaacgtgt gactttttta gcccatatga gaatggggag aaggaacccc cgacaacact
     1381 actctgggtt cagtatttcc tggcacagca ctttgataaa cttggacagt attctttggc
     1441 tttggattat attaatgctg caattgctag tactccaact ctaatagaat tattctatat
     1501 gaaagcaaaa atttacaagc atataggtaa tctcaaagaa gctgcaaagt ggatggatga
     1561 agcacagtct ttggacacag ctgatagatt catcaattcc aaatgtgcaa aatacatgct
     1621 tcgagcaaat atgataaaag aagcagagga aatgtgctcc aagttcacaa gggaaggaac
     1681 atctgccatg gaaaatctaa atgaaatgca gtgtatgtgg tttcagacag aatgcatttc
     1741 agcttatcag cgtctgggga gatacgggga tgccttgaaa aaatgtcatg aagtagaaag
     1801 gcattttttt gagataactg atgaccaatt cgacttccat acatactgca tgagaaagat
     1861 gacccttcgt gcctatgttg accttttgag attagaagat atactcagaa gacatgcctt
     1921 ttatttcaag gctgctagat cagcgattga aatatacttg aaattgtatg ataatccctt
     1981 aaccaatgaa agcaaacaac aagaaataaa ctcagaaaac ttgtcagcca aagaattgaa
     2041 gaaaatgctt agcaagcaga gaagagctca gaaaaaggct aaactagaag aagaaagaaa
     2101 gcatgcagaa agagaacgtc aacagaaaaa tcaaaagaaa aaaagagatg aagaagaaga
     2161 agaagccagt ggccttaagg aagaacttat acctgaaaaa ttagaaaggg tagaaaatcc
     2221 attagaggaa gccgttaagt tccttatacc tcttaagaac cttgttgctg ataacattga
     2281 cactcatctg ttagcatttg aaatatattt tagaaaagga aagtttctgt taatgctgca
     2341 gtctgtcaaa cgagcttttg ccattaacag taataaccca tggttacatg aatgtttaat
     2401 tagattttct aaatctgtgt ctaatcatag taatcttcca gacattgtga gcaaagttct
     2461 atctcaagaa atgcagaaaa tatttgtcaa aaaggatttg gaaagtttta atgaggattt
     2521 tctgaaacgt aacgctacct ctcttcagca tctactttca ggtgctaaaa tgatgtattt
     2581 tctggacaag tcaaggcagg agaaagcaat tgctatagcc actagactag atgaaactat
     2641 aaaagataaa gatgtaaaga cattaataaa ggtttctgaa gcactgcttg atggcagctt
     2701 tgggaactgt agttcccaat atgaagaata taggatggcc tgtcataacc tgcttccttt
     2761 tacatctgcc ttcttgcctg ctgtgaatga agtcgacaat cctaatgtgg cactgaacca
     2821 tacagctaat tatgatgtct tggcaaatga aatttgaaat cttctagaaa gtagactcct
     2881 atagactcaa agctgaattg agatcagggt ttcttttcca gggtgcattt taatatacgt
     2941 atgaaatgaa atatttggtt aggattttta aatggcatat tctgtaagct tattttgttc
     3001 tttacccgac ctgccaattt acataaccat ctgttaaaat tacctgttta ttcttacaca
     3061 gttttgtggt agctccgatc gcttctgtat aattataatt tcttactaag ctaagttgta
     3121 tacaacccca ctgtattatt ttctttagat tctgatttca ggatctgtgc tttgattcct
     3181 tgtctgtttt atcgtatatt tgcttgcttt ttaattaaag cacatcagtt ttaaagtgtt
     3241 aactatatgt taacaatatg gaggctgggc gtggtggctc acacctgtaa tcccagcact
     3301 ttgggaggcc cagactggcg gatcacctga ggtcaggaga tcgagatcag cctggccaac
     3361 atggtgaaac cccttctcta ctgaaaatac aaaaattagc cagacgtgat ggcacatacc
     3421 tgtaatccaa gctgcccagg agctgaggcc ggagaatcgc ttgaacctgg gaggtggagg
     3481 ttgcagtgag ccgagatcat gccactgcac tccagcctgg gcaacagagc aagactccat
     3541 ctcgaaaaaa aggaattcct cttggcagat attgaagttt atttgaaaat ttaattcgtc
     3601 cttttttcat tgtaatattt catggtttac tatttccttt tagtattcat gaaaatggta
     3661 ttttctggtt gaataagggt actctagttt tatgtagatg atttcagaat gtgaaggctg
     3721 gtttgcctgt cagtcatgga aattcactgg taaaattgtt gaatatttct ctctcccagt
     3781 cttaaaagcc cacaggcaag aattaatgct ttcttaacta agttactttg agtattaaca
     3841 agtagcttat actgaggtgt gcttcaaggg agcattatag ggcagaaaac aaattaaaat
     3901 gaaatgttgt tgttatagcc atgcattgac cattaaatgc attttaatat ctcggcaaaa
     3961 tgagatttga aactcattag tttaactctt aaaacatagt gttgttaaac agtatttttt
     4021 gggggcgggt ggatagcttt ttgttctatc ttgtacagaa aacagtaatg gaatcactca
     4081 tgttcagaac cttgtaaata tgtctgtaat attaatgctt ccctttatta agacaaatat
     4141 acattcaaaa agggagattt tatttagaca cacattttct tttcacccta atctatttag
     4201 attcatactt attgagacgg gaaaaactcg ctgtaaaata atgccaacct agataatgct
     4261 ataataaatt attttgtaca cagtt
//
