LOCUS       NM_057175               6174 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens N-alpha-acetyltransferase 15, NatA auxiliary subunit
            (NAA15), transcript variant 1, mRNA.
ACCESSION   NM_057175 NM_025085
VERSION     NM_057175.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6174)
  AUTHORS   Lyon,G.J., Vedaie,M., Beisheim,T., Park,A., Marchi,E., Gottlieb,L.,
            Hsieh,T.C., Klinkhammer,H., Sandomirsky,K., Cheng,H., Starr,L.J.,
            Preddy,I., Tseng,M., Li,Q., Hu,Y., Wang,K., Carvalho,A.,
            Martinez,F., Caro-Llopis,A., Gavin,M., Amble,K., Krawitz,P.,
            Marmorstein,R. and Herr-Israel,E.
  TITLE     Expanding the phenotypic spectrum of NAA10-related
            neurodevelopmental syndrome and NAA15-related neurodevelopmental
            syndrome
  JOURNAL   Eur J Hum Genet 31 (7), 824-833 (2023)
   PUBMED   37130971
  REMARK    GeneRIF: Expanding the phenotypic spectrum of NAA10-related
            neurodevelopmental syndrome and NAA15-related neurodevelopmental
            syndrome.
REFERENCE   2  (bases 1 to 6174)
  AUTHORS   Tian,Y., Xie,H., Yang,S., Shangguan,S., Wang,J., Jin,C., Zhang,Y.,
            Cui,X., Lyu,Y., Chen,X. and Wang,L.
  TITLE     Possible Catch-Up Developmental Trajectories for Children with Mild
            Developmental Delay Caused by NAA15 Pathogenic Variants
  JOURNAL   Genes (Basel) 13 (3), 536 (2022)
   PUBMED   35328089
  REMARK    GeneRIF: Possible Catch-Up Developmental Trajectories for Children
            with Mild Developmental Delay Caused by NAA15 Pathogenic Variants.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6174)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6174)
  AUTHORS   Ward,T., Tai,W., Morton,S., Impens,F., Van Damme,P., Van Haver,D.,
            Timmerman,E., Venturini,G., Zhang,K., Jang,M.Y., Willcox,J.A.L.,
            Haghighi,A., Gelb,B.D., Chung,W.K., Goldmuntz,E., Porter,G.A. Jr.,
            Lifton,R.P., Brueckner,M., Yost,H.J., Bruneau,B.G., Gorham,J.,
            Kim,Y., Pereira,A., Homsy,J., Benson,C.C., DePalma,S.R.,
            Varland,S., Chen,C.S., Arnesen,T., Gevaert,K., Seidman,C. and
            Seidman,J.G.
  TITLE     Mechanisms of Congenital Heart Disease Caused by NAA15
            Haploinsufficiency
  JOURNAL   Circ Res 128 (8), 1156-1169 (2021)
   PUBMED   33557580
  REMARK    GeneRIF: Mechanisms of Congenital Heart Disease Caused by NAA15
            Haploinsufficiency.
REFERENCE   5  (bases 1 to 6174)
  AUTHORS   Ritter,A., Berger,J.H., Deardorff,M., Izumi,K., Lin,K.Y., Medne,L.
            and Ahrens-Nicklas,R.C.
  TITLE     Variants in NAA15 cause pediatric hypertrophic cardiomyopathy
  JOURNAL   Am J Med Genet A 185 (1), 228-233 (2021)
   PUBMED   33103328
  REMARK    GeneRIF: Variants in NAA15 cause pediatric hypertrophic
            cardiomyopathy.
REFERENCE   6  (bases 1 to 6174)
  AUTHORS   Fluge,O., Bruland,O., Akslen,L.A., Varhaug,J.E. and Lillehaug,J.R.
  TITLE     NATH, a novel gene overexpressed in papillary thyroid carcinomas
  JOURNAL   Oncogene 21 (33), 5056-5068 (2002)
   PUBMED   12140756
  REMARK    GeneRIF: NATH, a novel gene overexpressed in papillary thyroid
            carcinomas.
REFERENCE   7  (bases 1 to 6174)
  AUTHORS   Line,A., Stengrevics,A., Slucka,Z., Li,G., Jankevics,E. and
            Rees,R.C.
  TITLE     Serological identification and expression analysis of gastric
            cancer-associated genes
  JOURNAL   Br J Cancer 86 (11), 1824-1830 (2002)
   PUBMED   12087473
REFERENCE   8  (bases 1 to 6174)
  AUTHORS   He,Y.G., Xie,Y.F., Chen,Y., Qian,W., Lai,J.H. and Tan,D.Y.
  TITLE     [Cloning and analysis of a novel gene encoding N-terminal
            acetyltransferase subunit]
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34 (3),
            353-357 (2002)
   PUBMED   12019451
REFERENCE   9  (bases 1 to 6174)
  AUTHORS   Gendron,R.L., Good,W.V., Adams,L.C. and Paradis,H.
  TITLE     Suppressed expression of tubedown-1 in retinal neovascularization
            of proliferative diabetic retinopathy
  JOURNAL   Invest Ophthalmol Vis Sci 42 (12), 3000-3007 (2001)
   PUBMED   11687548
REFERENCE   10 (bases 1 to 6174)
  AUTHORS   Choi,S.C., Chang,J.Y. and Han,J.K.
  TITLE     A novel Xenopus acetyltransferase with a dynamic expression in
            early development
  JOURNAL   Biochem Biophys Res Commun 285 (5), 1338-1343 (2001)
   PUBMED   11478804
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY039242.1, BX499137.1 and
            AC097376.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_057175.4.
            
            Summary: N-alpha-acetylation is among the most common
            post-translational protein modifications in eukaryotic cells. This
            process involves the transfer of an acetyl group from
            acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide
            and is essential for normal cell function. This gene encodes the
            auxillary subunit of the N-terminal acetyltransferase A (NatA)
            complex. [provided by RefSeq, Jan 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.167745.1, AJ314788.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296543.10/ ENSP00000296543.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2420              AY039242.1         9-2428
            2421-2428           BX499137.1         133-140
            2429-3076           AY039242.1         2437-3084
            3077-6174           AC097376.3         94370-97467
FEATURES             Location/Qualifiers
     source          1..6174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..6174
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /note="N-alpha-acetyltransferase 15, NatA auxiliary
                     subunit"
                     /db_xref="GeneID:80155"
                     /db_xref="HGNC:HGNC:30782"
                     /db_xref="MIM:608000"
     exon            1..327
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..2874
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcriptional coactivator tubedown-100; NMDA receptor
                     regulated 1; NMDA receptor-regulated protein 1; gastric
                     cancer antigen Ga19; protein tubedown-1; N-terminal
                     acetyltransferase"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 15, NatA auxiliary
                     subunit isoform 1"
                     /protein_id="NP_476516.1"
                     /db_xref="CCDS:CCDS43270.1"
                     /db_xref="GeneID:80155"
                     /db_xref="HGNC:HGNC:30782"
                     /db_xref="MIM:608000"
                     /translation="MPAVSLPPKENALFKRILRCYEHKQYRNGLKFCKQILSNPKFAE
                     HGETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKC
                     YRNALKWDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHL
                     LEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLLYQNQVLREAGLYREALEHLCTYEK
                     QICDKLAVEETKGELLLQLCRLEDAADVYRGLQERNPENWAYYKGLEKALKPANMLER
                     LKIYEEAWTKYPRGLVPRRLPLNFLSGEKFKECLDKFLRMNFSKGCPPVFNTLRSLYK
                     DKEKVAIIEELVVGYETSLKSCRLFNPNDDGKEEPPTTLLWVQYYLAQHYDKIGQPSI
                     ALEYINTAIESTPTLIELFLVKAKIYKHAGNIKEAARWMDEAQALDTADRFINSKCAK
                     YMLKANLIKEAEEMCSKFTREGTSAVENLNEMQCMWFQTECAQAYKAMNKFGEALKKC
                     HEIERHFIEITDDQFDFHTYCMRKITLRSYVDLLKLEDVLRQHPFYFKAARIAIEIYL
                     KLHDNPLTDENKEHEADTANMSDKELKKLRNKQRRAQKKAQIEEEKKNAEKEKQQRNQ
                     KKKKDDDDEEIGGPKEELIPEKLAKVETPLEEAIKFLTPLKNLVKNKIETHLFAFEIY
                     FRKEKFLLMLQSVKRAFAIDSSHPWLHECMIRLFNTAVCESKDLSDTVRTVLKQEMNR
                     LFGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDPSSQKRAIELATTLDESLTNRN
                     LQTCMEVLEALYDGSLGDCKEAAEIYRANCHKLFPYALAFMPPGYEEDMKITVNGDSS
                     AEAEELANEI"
     exon            328..412
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            413..517
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            518..675
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            676..810
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            811..964
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1084
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1180
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1287
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1360
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1530
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1683
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1812
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2026
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2220
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2329
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2428
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2575
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2673
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..6174
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4091..4096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /note="hexamer: AATAAA"
     polyA_site      4111
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /note="major polyA site"
     regulatory      5067..5072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /note="hexamer: AATAAA"
     polyA_site      5095
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
     regulatory      5401..5406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /note="hexamer: AGTAAA"
     polyA_site      5426
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
     regulatory      5555..5560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /note="hexamer: AATAAA"
     polyA_site      5575
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
     regulatory      6153..6158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
                     /note="hexamer: AATAAA"
     polyA_site      6174
                     /gene="NAA15"
                     /gene_synonym="Ga19; MRD50; NARG1; NAT1P; NATH; TBDN;
                     TBDN100"
ORIGIN      
        1 ggctgcctct gtcggtctgt tcagttacca cgtgaaccgc cgacggagac ccgtagtggg
       61 ggaggcggcg gcagcgttaa gtgagaaagg aaaaaagaca acgaggaaaa aggaggtgtc
      121 cgggtagggc aacgcggcga cacccgaggc ctggtggtgg cggcggatcg agatattcaa
      181 ggctgaagca gctacggaac ggcagcggcg gcggtcggac aaactgactg accgagccgg
      241 gtggtggcgg gagcagcggg agcagccgga acgatgccgg ccgtgagcct cccgcccaag
      301 gagaatgcgc tcttcaagcg gatcttgagg tgttatgaac ataaacagta tagaaatgga
      361 ttgaaattct gtaaacaaat actttctaat cccaaatttg cagagcatgg agaaaccttg
      421 gctatgaaag gattaacatt gaactgtttg gggaaaaagg aagaagctta tgaattggtt
      481 cgtagaggtt tgagaaatga cttgaagagt catgtgtgtt ggcacgttta tggccttctt
      541 cagaggtcag acaagaagta tgatgaagcc attaagtgtt acagaaatgc actaaaatgg
      601 gataaagaca atcttcaaat cttaagggac ctttccttac tacagattca aatgcgagat
      661 cttgagggtt acagggaaac gaggtatcag ttacttcagc ttcgacctgc gcagagagca
      721 tcatggattg gttatgctat tgcttaccat ttattagaag attatgaaat ggcagcaaag
      781 attttagaag aatttaggaa aacacaacag acatcccctg acaaggtgga ttatgaatat
      841 agtgaactac tcttatatca gaatcaagtt cttcgggaag caggtctcta tagagaagct
      901 ttggaacatc tttgtaccta tgaaaagcag atttgtgata aacttgctgt agaagaaacc
      961 aaaggggaac ttctgttgca actatgtcgt ttggaagatg ctgcagatgt ttatagagga
     1021 ttgcaagaga gaaatcctga aaactgggcc tattacaaag gcttggaaaa agcactcaag
     1081 ccagctaata tgttagaacg gctaaaaatt tatgaggaag cctggactaa atatcccagg
     1141 ggactggtgc caagaaggct gccgttaaac tttttatctg gtgagaagtt taaagaatgt
     1201 ttggataagt tcctaaggat gaatttcagc aagggttgcc caccagtctt caatacttta
     1261 agatcattat acaaagacaa agaaaaggtg gcaatcatag aagagttagt agtaggttat
     1321 gaaacctctc taaaaagctg ccggttattt aaccccaatg atgatggaaa ggaggaacca
     1381 ccaaccacat tactttgggt ccagtactac ttggcacaac attatgacaa aattggtcag
     1441 ccatctattg ctttggagta cataaatact gctattgaaa gtacacctac attaatagaa
     1501 ctctttctcg tgaaagctaa aatctataag catgctggaa atattaaaga agctgcaagg
     1561 tggatggatg aggcccaggc cttggacaca gcagacagat ttatcaactc caaatgtgca
     1621 aaatacatgc taaaagccaa cctgattaaa gaagctgaag aaatgtgctc aaagtttaca
     1681 agggaaggaa catcagcggt agagaatttg aatgaaatgc agtgcatgtg gttccaaaca
     1741 gaatgtgccc aggcttataa agcaatgaat aaatttggtg aagcacttaa gaaatgtcat
     1801 gagattgaga gacattttat agaaatcact gatgaccagt ttgactttca tacatactgt
     1861 atgaggaaga ttacccttag atcatatgtg gacttattaa aactagaaga tgtacttcga
     1921 cagcatccat tttacttcaa ggcagcaaga attgctatag agatctattt gaagcttcat
     1981 gacaaccccc ttacagatga gaataaagaa cacgaagctg atacagcaaa catgtctgac
     2041 aaagagctaa agaagctacg taataaacaa agaagagctc aaaagaaagc ccagatagaa
     2101 gaagagaaaa aaaatgcaga aaaagaaaag cagcagagaa atcagaaaaa gaagaaggat
     2161 gatgatgatg aggagatagg aggtccaaaa gaagaactta ttccagagaa actggccaag
     2221 gttgaaactc cattggaaga agctattaaa tttttaacac cgttgaagaa cttggtgaag
     2281 aacaagatag agactcatct ttttgccttt gagatttact ttaggaaaga aaagtttctt
     2341 ttgatgctac aatcagtaaa gagggcattt gctattgatt ctagtcatcc ctggcttcat
     2401 gagtgtatga ttcgtctctt taatactgca gtgtgtgaaa gtaaagattt atctgataca
     2461 gttagaacag tattaaaaca agaaatgaat cgtctttttg gagcaacgaa tccaaagaat
     2521 tttaatgaaa cttttctgaa aaggaattct gattcattgc cacacagatt atcagctgcc
     2581 aaaatggtat attacttaga tccttctagt cagaagcgag ctatagagtt ggcaacaaca
     2641 cttgatgaat ctctcactaa cagaaacctc cagacatgta tggaggtatt ggaagccttg
     2701 tatgatggta gcctaggaga ctgtaaagaa gctgctgaaa tttatagagc aaattgtcat
     2761 aagcttttcc cttatgcttt ggctttcatg cctcctggat atgaagagga tatgaagatc
     2821 acagttaatg gagatagttc tgcagaagct gaagaactgg ccaatgaaat ttgaacatca
     2881 ctaaacaagc aaatggaatg actttggacc atatctagta tataatattt ttgtcacgca
     2941 cctgctgcat tgctctaact tacacagaat gagaggagta aatgttcttg ccttcaaata
     3001 gtgttttacg ttttttatcc tgctgaaaaa gtatatataa aatatctaac attacaggat
     3061 agaggttcag tttcttaaaa aattaaagct gctaaaattg agtggttaaa aaagatacct
     3121 tatcctattc ctccccaccc acccatgttt ttaaactaat ttatataaaa tctggaggct
     3181 gttacagcta acaaagcagg tgtgtggcag aaatattact ttaaatttgt cttgtgagat
     3241 tttactatat ctcagacagc ataaatgctg ttttagcact ggattctttc actgagcaca
     3301 aagagttgtt ggggctttag catctgactg attttgttac ggggttgatt ctgaccatag
     3361 gaagtatgca atgtgaatca ctatttacag agaaacctac aacagatgct tgatgttgta
     3421 gaaactggga catatagata ccaagcaaaa ttataagaaa cctataaggt gttcaatacg
     3481 cttgtgtttc caaaattcac tgtacatgat cagtttggtg ttcttgtacc acagttttta
     3541 actgaaggaa ccagttgtaa cagtctcaat tttaactaaa acttgaagaa ctaaaacaac
     3601 aatgcaaacc tttcagcatt gtttggccaa acttgttaaa actgtaatgc aagaaccaaa
     3661 tgcactgtga tgtggcacca actaattagc aagcatgaat ttttcaccca agagtgaaaa
     3721 aaggaaaatc taccatggct tgaagttaaa gagcagaact cctgactacc attctatgac
     3781 tgatcaaaag actaatagtt aaaaacctca gcaggccttg ttcacgatat gcagaaaaaa
     3841 aagtgctgca gtttagatac ctctggaatt tttccacagt gtcacaggtt tgtaatactt
     3901 gaagccctac atttctaaga atatatttct tgctcagttg tttcaggcaa gcccaagact
     3961 ttgtaatttt taaagggccc aagatttttt tttttttttt ttttttcaaa taacagacca
     4021 gcttcttttt cttgcagtta cagatgtaat ttcctttttg ttgtcaaaca taaggtacca
     4081 aatatgatgc aataaattgt tttgaaaaac agttgtgtga atatttcaac taatctgtgt
     4141 tgggcttctg tgaaatacac aggtggaaac agaggtgcaa gccagaggca atgtaatatg
     4201 ctgtaaggct agtgcagatg ggagcttttt agaaggggct aagtgctggt gtcagggaaa
     4261 ttccataatg aagtagaatg ctgctcctgc attaagattt cattgagggc aaggctggtg
     4321 gcaggtacta tgaatgtaat tcataattta aaaggaaaac taaaaactat tttgatttgg
     4381 gaaaatgagc cttaatttgt taaacctata cactgagaac tagcctcagg cttaatattc
     4441 tcattgcatt tgcaagatct gagcaaataa gattaagtaa aacaaatcaa ttgtatatat
     4501 aattgacctt tttgtggaac atgtagttta tagaaagtat actctaaagg gaatttgccg
     4561 aagacctttt actgattgaa cagttgtgct acaatcaact tttcatagta catgacctgc
     4621 attccacatc tcagtctaac agtttagtag tgatgtaaag agaagtacaa accgaactcc
     4681 agtgctttgt tatgttttat taactggccc tgtctcagga acatcttaac agatggcaaa
     4741 aaaacaaaaa ctttttttca actcctatga gtggcaactg aagttcttat tgttgggaaa
     4801 gaacactagt cctacctctg ccactaatga ggtgtttgga ggaggtacca gccatataat
     4861 agggggtgta tgtgtgaatt ttgtttaaac tctactgtat attgaaatga aattcattta
     4921 tttgtcttga caatgttcaa atgatgtaga ttgtcttaga atgaatattc ataagtactc
     4981 agaactctta agatgcagat gccacccgtg aggagctaaa ttcctaatgt gtattgtatt
     5041 ccaacccaat tttactggaa ctattgaata aatcttttat tttctttcag gtttacttga
     5101 tagtggatac attggtgtca gaggaccttg actgggttca ttttatgtcc agacatcacc
     5161 cctgaaacac tgtactgtac tatcttgctc tgagtagtat caactggatc gtctcatatt
     5221 tgcctcattc atcctattaa tttcaaatga tactgtgggg gaaaaacagg gttagaaaaa
     5281 caagtggaaa aaatggagtg atgttgtaat ctaaacaagt gccttatgtt tattgctaag
     5341 aactggtgtt accaaccctt ttgagaagaa agggtctctt gacctgtatt aacataggaa
     5401 agtaaagttc tttttgtttt tctttatatt cagctactct tgtcatttct cgttgaaaaa
     5461 ctaaaatctg actaggttag tttactcagc tttaattaga tagttgagtc atatattttc
     5521 aacatttttc tgtatcgtat ttattatgca caaaaataaa gtgtgatctc taatagcatg
     5581 gctaaaggta atgccaatat tagtgaatag ctttgctgtg ggctttatca ggcccttgtt
     5641 tttcacagtg ttgtttgtac tccatggtgt attgctatta gagctgtgaa atgaaagctg
     5701 tgactttatg aagagatcaa aaaaagtgtg gtccagattc aggtaggttg tggtaagttc
     5761 agggaagtct tgtatgattt ctaagaatat ttcagttacc atgtatagta tttgggaaaa
     5821 gctgtaatgt aaaatattgg actttgttgc aagataggta tatacttgtg tcagataatt
     5881 aaagccttaa attttgaaat gaatctttga gatttcaaag aaagactgac ctttcaaata
     5941 gaaggcggtc tttctattct agctaatgcc ccacttcttt aagttataaa caaagtttca
     6001 tgataccatt ctgctatcat ctaaactttg ctgaactcta ctgccaacct acattaaaaa
     6061 caaagtccca cgaaatggct gtgttacacc atagtgagca gaaacttaaa ttttgttcta
     6121 attttgatgg ttgaaaaatt tcaacctgta gcaataaaac atttttggaa aaga
//
