LOCUS       NM_032693               2031 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens N-alpha-acetyltransferase 11, NatA catalytic subunit
            (NAA11), mRNA.
ACCESSION   NM_032693 XM_496704 XM_938471
VERSION     NM_032693.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2031)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2031)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2031)
  AUTHORS   Pang,A.L., Clark,J., Chan,W.Y. and Rennert,O.M.
  TITLE     Expression of human NAA11 (ARD1B) gene is tissue-specific and is
            regulated by DNA methylation
  JOURNAL   Epigenetics 6 (11), 1391-1399 (2011)
   PUBMED   22048246
  REMARK    GeneRIF: NAA11 expression is tissue-specific and is epigenetically
            regulated by DNA methylation.
REFERENCE   4  (bases 1 to 2031)
  AUTHORS   Wang,Z.H., Gong,J.L., Yu,M., Yang,H., Lai,J.H., Ma,M.X., Wu,H.,
            Li,L. and Tan,D.Y.
  TITLE     Up-regulation of human arrest-defective 1 protein is correlated
            with metastatic phenotype and poor prognosis in breast cancer
  JOURNAL   Asian Pac J Cancer Prev 12 (8), 1973-1977 (2011)
   PUBMED   22292636
  REMARK    GeneRIF: ARD1 protein was observed at 61.0% (50/82), 54.7%
            (87/159), 37.9% (25/66), 36.8% (7/19) in IDC, fibroadenoma,
            hyperplasia, and inflammation, respectively.
REFERENCE   5  (bases 1 to 2031)
  AUTHORS   Huang,G.L., Li,B.K., Zhang,M.Y., Zhang,H.Z., Wei,R.R., Yuan,Y.F.,
            Shi,M., Chen,X.Q., Huang,L., Li,A.H., Huang,B.J., Li,H.H. and
            Wang,H.Y.
  TITLE     LOH analysis of genes around D4S2964 identifies ARD1B as a
            prognostic predictor of hepatocellular carcinoma
  JOURNAL   World J Gastroenterol 16 (16), 2046-2054 (2010)
   PUBMED   20419844
  REMARK    GeneRIF: LOH in genes around D4S2964, including ARD1B and SEPT11
            may play an important role in hepatocellular carcinoma development
            and progression
REFERENCE   6  (bases 1 to 2031)
  AUTHORS   Polevoda,B., Arnesen,T. and Sherman,F.
  TITLE     A synopsis of eukaryotic Nalpha-terminal acetyltransferases:
            nomenclature, subunits and substrates
  JOURNAL   BMC Proc 3 Suppl 6 (Suppl 6), S2 (2009)
   PUBMED   19660095
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2031)
  AUTHORS   Arnesen,T., Gromyko,D., Kagabo,D., Betts,M.J., Starheim,K.K.,
            Varhaug,J.E., Anderson,D. and Lillehaug,J.R.
  TITLE     A novel human NatA Nalpha-terminal acetyltransferase complex:
            hNaa16p-hNaa10p (hNat2-hArd1)
  JOURNAL   BMC Biochem 10, 15 (2009)
   PUBMED   19480662
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2031)
  AUTHORS   Arnesen,T., Betts,M.J., Pendino,F., Liberles,D.A., Anderson,D.,
            Caro,J., Kong,X., Varhaug,J.E. and Lillehaug,J.R.
  TITLE     Characterization of hARD2, a processed hARD1 gene duplicate,
            encoding a human protein N-alpha-acetyltransferase
  JOURNAL   BMC Biochem 7, 13 (2006)
   PUBMED   16638120
  REMARK    GeneRIF: hARD2, an N-alpha-acetyltransferase has 81 % sequence
            identity to hARD1. Its gene may originate from a
            eutherian-mammal-specific retrotransposition event. hARD2-NATH
            complexes may be responsible for protein N-alpha-acetylation in
            human cells.
            GeneRIF: hARD2 (MGC10646) is a novel human protein N-alpha
            acetyltransferase
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023277.5 and BC004552.2.
            
            On May 17, 2019 this sequence version replaced NM_032693.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063623.1, SRR5189661.155165.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000286794.5/ ENSP00000286794.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AC023277.5         82321-82364         c
            45-1560             BC004552.2         1-1516
            1561-2031           AC023277.5         72950-73420         c
FEATURES             Location/Qualifiers
     source          1..2031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.21"
     gene            1..2031
                     /gene="NAA11"
                     /gene_synonym="ARD1B; ARD2; hARD2"
                     /note="N-alpha-acetyltransferase 11, NatA catalytic
                     subunit"
                     /db_xref="GeneID:84779"
                     /db_xref="HGNC:HGNC:28125"
                     /db_xref="MIM:619432"
     exon            1..886
                     /gene="NAA11"
                     /gene_synonym="ARD1B; ARD2; hARD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..874
                     /gene="NAA11"
                     /gene_synonym="ARD1B; ARD2; hARD2"
                     /EC_number="2.3.1.255"
                     /note="N-terminal acetyltransferase complex ARD1 subunit
                     homolog B; human arrest defective 2; =N-terminal
                     acetyltransferase complex ARD1 subunit homolog B; ARD1
                     homolog B; natA catalytic subunit Naa11"
                     /codon_start=1
                     /product="N-alpha-acetyltransferase 11"
                     /protein_id="NP_116082.1"
                     /db_xref="CCDS:CCDS47084.1"
                     /db_xref="GeneID:84779"
                     /db_xref="HGNC:HGNC:28125"
                     /db_xref="MIM:619432"
                     /translation="MNIRNAQPDDLMNMQHCNLLCLPENYQMKYYLYHGLSWPQLSYI
                     AEDEDGKIVGYVLAKMEEEPDDVPHGHITSLAVKRSHRRLGLAQKLMDQASRAMIENF
                     NAKYVSLHVRKSNRPALHLYSNTLNFQISEVEPKYYADGEDAYAMKRDLSQMADELRR
                     QMDLKKGGYVVLGSRENQETQGSTLSDSEEACQQKNPATEESGSDSKEPKESVESTNV
                     QDSSESSDSTS"
     exon            887..2031
                     /gene="NAA11"
                     /gene_synonym="ARD1B; ARD2; hARD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1542..1547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="NAA11"
                     /gene_synonym="ARD1B; ARD2; hARD2"
                     /note="hexamer: ATTAAA"
     polyA_site      1564
                     /gene="NAA11"
                     /gene_synonym="ARD1B; ARD2; hARD2"
                     /note="major polyA site"
ORIGIN      
        1 agtttggcac catcttttcc atctcctgct ccttccgcct tcccgccatc cgccctccac
       61 acgattcagc ccggtggtgt tagccccctg gactcgattc ctgaggcaaa cagtgcccct
      121 taaggtcggc gacagcctct tctgggttca ctgcagtcca accggttccc taccctctgc
      181 cattatgaac atccgcaacg ctcagccaga cgacctgatg aatatgcaac actgcaacct
      241 cctttgcctt cctgagaact accagatgaa atactattta tatcatggcc tttcctggcc
      301 ccagctttct tacatcgctg aggatgagga cgggaagatt gtgggctatg ttctggccaa
      361 aatggaggag gaaccagatg atgtcccgca tggccatatc acctcactgg ccgtgaagcg
      421 ttcacaccgg cgcctcggcc tggcccagaa gctgatggac caggcctcca gggccatgat
      481 agagaacttt aacgccaaat acgtgtctct gcacgtcagg aagagtaacc ggccagcctt
      541 gcacctttat tctaacaccc tcaactttca gattagtgag gtggaaccta aatactatgc
      601 agatggggaa gatgcttatg ctatgaagcg ggatctctcg cagatggcag atgagctgag
      661 acgacaaatg gacctgaaga agggcgggta tgtggtcctg ggctccaggg agaaccagga
      721 gacccagggc agcacacttt ctgattctga agaggcctgt cagcaaaaga acccggctac
      781 cgaagaaagt ggcagtgaca gcaaagaacc taaggagtct gtggagagca ccaacgtcca
      841 ggacagctca gaaagctcgg attccacctc ctagagcatg cttaagcatt tcaggtcctc
      901 atgtctcaac cacatctact ctgtgaaccc tggcttagtc tgtctgctct gcagcatctg
      961 ctgtggggat catctcacag tgaccagaat ggcttctcac tcttaactct ataaacaacc
     1021 acctttcaca tatcctgctg ggatcatgaa ggaatacctg gacacaagag ccactgcaca
     1081 acagccaagg aactttgaga cctgccatta cagaaccttt cttggcctac tcacactacg
     1141 ctgccatttt attctgtttg tagtagtcct ctgttgggtg tggttatcct gcaagttttt
     1201 ctccttttag aatgatgaac aggaagcagg gcaaactctt gaagatttcc agctttcagt
     1261 ttttgttttt gttttttaac cattatttac ctgagttttc atccttgagg aggtgaagta
     1321 gtcaggacca tgaagtcaga cctcatgccc tcttcctcct ctttcctgga agaagtattc
     1381 agtttccttt tcctttctct ggtaactcct cctttatact attcccccct cccttttttt
     1441 tgaggaggag ggcatcacct tcccagtggg aaaaggtgtt aagttaggag cttctactgt
     1501 acaatcagaa cttggagatt ttaagaaaag gacaaacggt aattaaattg gaatctctaa
     1561 tgtgcttgtt tgtgttagtt tttttgtgat tatgtcactt ggcatttatt gagtacctgc
     1621 agtgttcaca cacaatgctg gagccttcat tagttacata tttaaccctc tcagcaaccc
     1681 tgtaaagtag gtagtattat ccctgtttta cagatgagga aactgaagct cagagaagtg
     1741 aattaaatat cctggatctg aacccaattc tgtttgaatt caaagccaaa gttccttcta
     1801 cttttctgtt cctactcttt gcattttatt tataaatgtg ttaaaatttt agcaaaaatg
     1861 gagaatctgc tgtttaaaaa tgtgtttgct taatacatgg ctactgtatg tcaattgtaa
     1921 atatttatat aacctacaat tataatctat ttttattatt tttctctagt aaaaataagt
     1981 gaagacaaag taccttgacc tctgcagtaa aagttaccag ataaatccag a
//
