LOCUS       NM_015111               5985 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens NEDD4 binding protein 3 (N4BP3), mRNA.
ACCESSION   NM_015111 XM_038920
VERSION     NM_015111.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5985)
  AUTHORS   Luo,M., Li,J., Yang,Q., Xu,S., Zhang,K., Chen,J., Zhang,S.,
            Zheng,S. and Zhou,J.
  TITLE     N4BP3 promotes breast cancer metastasis via NEDD4-mediated
            E-cadherin ubiquitination and degradation
  JOURNAL   Cancer Lett 550, 215926 (2022)
   PUBMED   36162713
  REMARK    GeneRIF: N4BP3 promotes breast cancer metastasis via NEDD4-mediated
            E-cadherin ubiquitination and degradation.
REFERENCE   2  (bases 1 to 5985)
  AUTHORS   Han,H., Zhu,W., Lin,T., Liu,C. and Zhai,H.
  TITLE     N4BP3 promotes angiogenesis in hepatocellular carcinoma by binding
            with KAT2B
  JOURNAL   Cancer Sci 113 (10), 3390-3404 (2022)
   PUBMED   35848906
  REMARK    GeneRIF: N4BP3 promotes angiogenesis in hepatocellular carcinoma by
            binding with KAT2B.
REFERENCE   3  (bases 1 to 5985)
  AUTHORS   Wang,C., Ling,T., Zhong,N. and Xu,L.G.
  TITLE     N4BP3 Regulates RIG-I-Like Receptor Antiviral Signaling Positively
            by Targeting Mitochondrial Antiviral Signaling Protein
  JOURNAL   Front Microbiol 12, 770600 (2021)
   PUBMED   34880843
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5985)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5985)
  AUTHORS   Zhou,J., Liu,X., Wang,C. and Li,C.
  TITLE     The correlation analysis of miRNAs and target genes in metastasis
            of cervical squamous cell carcinoma
  JOURNAL   Epigenomics 10 (3), 259-275 (2018)
   PUBMED   29343084
  REMARK    GeneRIF: N4BP3 was associated with the survival time of cervical
            squamous cell carcinoma patients. mir-451 and mir-486 were related
            to tumor differentiation stage.
REFERENCE   6  (bases 1 to 5985)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   7  (bases 1 to 5985)
  AUTHORS   Liu,S., Chen,J., Cai,X., Wu,J., Chen,X., Wu,Y.T., Sun,L. and
            Chen,Z.J.
  TITLE     MAVS recruits multiple ubiquitin E3 ligases to activate antiviral
            signaling cascades
  JOURNAL   Elife 2, e00785 (2013)
   PUBMED   23951545
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5985)
  AUTHORS   Murillas,R., Simms,K.S., Hatakeyama,S., Weissman,A.M. and
            Kuehn,M.R.
  TITLE     Identification of developmentally expressed proteins that
            functionally interact with Nedd4 ubiquitin ligase
  JOURNAL   J Biol Chem 277 (4), 2897-2907 (2002)
   PUBMED   11717310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136632.3.
            
            On Nov 23, 2018 this sequence version replaced NM_015111.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053323.1, SRR1163657.454904.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274605.6/ ENSP00000274605.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               AC136632.3         104796-105035
            241-600             AC136632.3         110818-111177
            601-1122            AC136632.3         111442-111963
            1123-1377           AC136632.3         112362-112616
            1378-5985           AC136632.3         112738-117345
FEATURES             Location/Qualifiers
     source          1..5985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..5985
                     /gene="N4BP3"
                     /gene_synonym="LZTS4"
                     /note="NEDD4 binding protein 3"
                     /db_xref="GeneID:23138"
                     /db_xref="HGNC:HGNC:29852"
                     /db_xref="MIM:619140"
     exon            1..240
                     /gene="N4BP3"
                     /gene_synonym="LZTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            241..600
                     /gene="N4BP3"
                     /gene_synonym="LZTS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..1905
                     /gene="N4BP3"
                     /gene_synonym="LZTS4"
                     /codon_start=1
                     /product="NEDD4-binding protein 3"
                     /protein_id="NP_055926.1"
                     /db_xref="CCDS:CCDS34307.1"
                     /db_xref="GeneID:23138"
                     /db_xref="HGNC:HGNC:29852"
                     /db_xref="MIM:619140"
                     /translation="MATAPGPAGIAMGSVGSLLERQDFSPEELRAALAGSRGSRQPDG
                     LLRKGLGQREFLSYLHLPKKDSKSTKNTKRAPRNEPADYATLYYREHSRAGDFSKTSL
                     PERGRFDKCRIRPSVFKPTAGNGKGFLSMQSLASHKGQKLWRSNGSLHTLACHPPLSP
                     GPRASQARAQLLHALSLDEGGPEPEPSLSDSSSGGSFGRSPGTGPSPFSSSLGHLNHL
                     GGSLDRASQGPKEAGPPAVLSCLPEPPPPYEFSCSSAEEMGAVLPETCEELKRGLGDE
                     DGSNPFTQVLEERQRLWLAELKRLYVERLHEVTQKAERSERNLQLQLFMAQQEQRRLR
                     KELRAQQGLAPEPRAPGTLPEADPSARPEEEARWEVCQKTAEISLLKQQLREAQAELA
                     QKLAEIFSLKTQLRGSRAQAQAQDAELVRLREAVRSLQEQAPREEAPGSCETDDCKSR
                     GLLGEAGGSEARDSAEQLRAELLQERLRGQEQALRFEQERRTWQEEKERVLRYQREIQ
                     GGYMDMYRRNQALEQELRALREPPTPWSPRLESSKI"
     exon            601..1122
                     /gene="N4BP3"
                     /gene_synonym="LZTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1377
                     /gene="N4BP3"
                     /gene_synonym="LZTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..5985
                     /gene="N4BP3"
                     /gene_synonym="LZTS4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2287..2292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="N4BP3"
                     /gene_synonym="LZTS4"
                     /note="hexamer: AATAAA"
     polyA_site      2310
                     /gene="N4BP3"
                     /gene_synonym="LZTS4"
                     /note="major polyA site"
     regulatory      5966..5971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="N4BP3"
                     /gene_synonym="LZTS4"
                     /note="hexamer: AATAAA"
     polyA_site      5985
                     /gene="N4BP3"
                     /gene_synonym="LZTS4"
                     /note="major polyA site"
ORIGIN      
        1 gttttccctc cgcctttggg gcaggcgatc gagcgccgcg gagcgcgtcc ctccctcgcc
       61 aatccggctc cggcgccggc gcccgcccgc gttttcccgg cgcctgccgc tccgccgctc
      121 cgacccggca cgcagtcccg gcccgagccg acgccttgca ggagggttca aatccgcgcg
      181 ggggagctgc gacgcgcaag ggctgcggag ccgcgggccg gcgagcgcgt cgccaccatg
      241 aagcagctgc ctgtaccctg ttgaaacttc atggccacag ccccaggccc tgctggcatt
      301 gccatgggca gcgtgggcag cctgttggaa cggcaggact tctcccctga agagctgcgg
      361 gcggcacttg ccgggtctcg gggctcccgc cagcctgatg ggctcctccg gaagggcttg
      421 ggccagcgtg agttcctcag ctacctgcac ctccccaaga aggacagcaa gagcaccaag
      481 aacaccaagc gggcccctcg gaacgagcct gccgactatg ccaccctcta ctaccgggaa
      541 cattctcgcg cgggtgactt cagcaagacc tcgctgccag aacggggtcg ctttgacaag
      601 tgccgcattc gcccctcagt gttcaagcct acggcgggca acgggaaagg cttcctatcc
      661 atgcaaagtc tggcgtccca caaaggccag aagctgtggc gcagcaatgg cagcctgcac
      721 acgctggcct gccacccgcc cctgagcccc gggccccggg ccagccaggc ccgggcacag
      781 ctgctgcacg ccctcagcct agatgagggc ggccctgagc ccgagcccag cctgtccgac
      841 tcctccagtg ggggtagttt tggtcgcagt cctggtactg gccctagccc cttcagctcc
      901 tcccttggcc accttaacca cctcgggggc tccctggacc gggcctctca aggacccaag
      961 gaggctgggc caccagctgt gctgagctgc ctgcccgagc caccaccccc ctacgagttc
     1021 tcctgctcct ctgccgagga aatgggagcc gtgctgcccg agacctgtga ggagctcaag
     1081 aggggccttg gcgatgagga cggctccaac cccttcacgc aggtgctgga ggagcgccag
     1141 cggctgtggc tggctgagct gaagcgcctg tatgtggagc ggctgcacga ggtgacccag
     1201 aaggctgagc gcagcgagcg caacctccag ctgcagctgt ttatggctca gcaggagcag
     1261 cggcgcctgc gcaaggagct gcgggctcag cagggcctgg ctccggagcc tcgggccccc
     1321 ggcaccctcc cagaggctga ccccagtgca cgaccagagg aggaagcccg atgggaggtg
     1381 tgccagaaga cagcagagat tagcctcttg aagcagcagc tgcgtgaagc ccaggcggaa
     1441 ctggcccaga agctggcgga gatcttcagt ctgaagacac aacttcgggg cagccgggca
     1501 caagcccagg ctcaggacgc agagctggtc cggctgcgcg aggctgtgcg cagcctgcag
     1561 gagcaggccc ctcgggagga agccccaggc agctgtgaga ctgatgactg caagagcagg
     1621 ggcctgctag gggaggcagg aggcagcgag gccagagaca gtgctgagca gctgcgggct
     1681 gagctgctgc aggagcgact tcggggccag gagcaggcgc tgcgctttga gcaggagcgg
     1741 cggacttggc aggaggagaa ggagcgcgtg ctgcgctacc agcgggagat ccagggaggg
     1801 tacatggaca tgtaccgccg caaccaggca ctggagcagg aactgcgggc actgcgggag
     1861 ccccccacac cctggagtcc ccggctcgag tcctccaaga tctgaggcca gcagagcgag
     1921 ctgacagcag caacactgtc agaaggtgcc ctgagacggc cggctcagcc ttcccttgca
     1981 ctggttgggg tggaacctgc agaggccagc ccggggctgg ggaggcgcaa ggagaggagg
     2041 gatccagtgg ggccgtgggc tgggtagggt gccttggcag gagccaggac aaggccctcc
     2101 tggcagagga gcacctaggc agggcccagc cctgcttcct ggagtggatg tggcccagag
     2161 aaggaggctg ggggatcacc agccccaagg tcccgaaggg caggtcagag ggagagaggc
     2221 tggagacctg ggctggggcc ttcctccagg gaaggaggct ggggtgggaa cactggcctc
     2281 ccccagaata aaaccatgtt ttctaccaga ggctcagaat acgctgagcc tgtgaccaga
     2341 ggatgatgga tggtcgggat tgaggctgtt gacctgggca gtagctcctc ccatggccag
     2401 tggtcagtgg gagggtgtgc cctgcgcctg tctgcatggc cactgggcat gtgtgttggg
     2461 agcagaggag tcctactcct tgcctcagcc ccacacggtt ccttagctgc cgtgtgggct
     2521 gaaattcctt tctttagcac cagtggagtt ttcagaagga acaacaccag ggaatgccaa
     2581 aaaaacaaag ggcaagtcaa ccaaggcatt ttgagaacat gaaatgtctt cttggtggga
     2641 aggctgggcc ccaggagtat ccacaggctc aggccatgcc cctccccgca cccacctcct
     2701 gtctccctcc ctccctccat aggagtgggg ggcccctaga agtgctctgc ctcattccct
     2761 gttcgtagga aggtgcagga gaggaggtgg gcaagcttat gggtttcttg gtaaagagcc
     2821 tttaccacag caaggaatgg gaacatttcc ccatcagcaa cggggctcta gggcattatt
     2881 aagtaggggt gaaatatgat tgatttgcat tctggaaagc tctcccagga ggaagcattc
     2941 cccaccccac cttgcctctg tcctgcgctg ggctccagga cggtcagtcc tcccggatcc
     3001 ctgctctcag ctaaggctgg tccctaaaac ccacacctgc ctttggtctc tcagaggcct
     3061 ggcttgccct ctgggccttt gctcccccgc tgggtgcccg gcctggaaca caggttctgt
     3121 ctggctgtgt gagtggcgtc tctcccttcc tttgagggaa gctcagcttt cttacgcgct
     3181 catcgttgga cgggctgcca tgcattgcgt gcttactggg cgccaggtgc tgtgctgggc
     3241 ccttgtgagt gtgggggcac aggctgaatt agatgagctc ctgccgcagg gggccctgca
     3301 cactgatgtc agctcaccag tctcttccct gacagggcag ctcagggaac ttctgagaag
     3361 ttatctgcag agagccccac ctcactccct ttggctaccc tggccgtgcc tggcagcccc
     3421 tcaggcccca caggtgggtc ctggttgtga agtggagtta gtgcacatgg atgtcagggg
     3481 acgggtgtga ggcatgagct gggggggccc cctttttcag ggcagagaat gaggcgtgtg
     3541 cactgtctgc tgtggggatg gtgtgtttat ggccatgtaa gtggcaggtg tgtgtaaaga
     3601 tgtgcttgtg ggtggtgggt gtgtctgagg gggtgtgttt gggagcctgg cctccaaaag
     3661 ccagtgtctg ggttggagac agtgcaggcc ccttcttggc cccaccctct accccattcc
     3721 ttcctgtcag ccccagtctg tcttggcact ggccaggctt gggtggagcc tgtgtcccag
     3781 acagatcccc taggcctatc tgagacccat acaggcccac acctgagctc ctgtctgcct
     3841 gaggagggaa agggggagtg gccaggtcag gcaggccagt cgtctacaca cccccttggt
     3901 acccattccc atttcacaaa ctcctccaaa ccccaaaccc caaacggaaa tctctgggac
     3961 aatggctcct ccagagggcc cctcagagcc aggtgctggc cagatgcctt gatcacagcc
     4021 tccatggcca ggggcctgtc aagccagggg cccacacacc tggtgccagg gtccaccttg
     4081 gtataccagc tcggcagaac agttccccac ccagcgatta gggagctggg ctggccagta
     4141 cagccagtgg ggagtgggtg ggaggcacca aaacttggca gctgtgccag aaaccaaagc
     4201 caggcccaga tgtaggggga gggcacgaga gctgaacctg agcctggggc gtctcggagc
     4261 tggatccccg tcagctcatc caggctggac aaaccagttc ctgggtcccc cagccggctg
     4321 ggtggctctg gggccaaccg accacaggtg tcactgatca caggtgtcac cgtagtggct
     4381 accacctcag ggcagcccct ccctccagct ggcggggcct cagcttccca gctgccctgg
     4441 cttagccttc cctgcagccc ctccccaaca ggcttggtcc gggcagcctg ctctgcggaa
     4501 ggtggcagcc tcctggtgct gggctccctg cctctggggc ctccagtcct tcactcagtg
     4561 tcatcccttc cagcagctcc ctgggcctct tggtccatcc cttcaggctt ctgacacact
     4621 agtggcctcg agtcactgat agtggtgcct cctccttacc ttggcaagcc cttgtagccc
     4681 tctgagccct catcctgcag gcagagcccc tcagtgctct gagaaacctg ccctgaactc
     4741 accgcctccc ctgcctgggc actccctcct ccctgcgccc acagccccca tgccaatctc
     4801 cgtcagctct ttctgtgctg ctgtaattgt tggtttgcct gtctcctttg agctgtgggc
     4861 attgccgggg tagggtggtg tcttcaccac agctccagaa ggcactggtg ggatgtggag
     4921 tcaggagcaa ccagagaccc cccaatacta gaatgggttt gagcttgggg tggggtggat
     4981 ggggaagact tactctgaat gttcgttcac catccgtggg caccaggtct gtgccaagca
     5041 cagggactcc aggggcagct gccattcgtt ccagtgatgt atttggggcc ttctcaggtg
     5101 aggaagccaa ggtggccaag gccctcggtc ccctgccctg atagggctta cctgtgggtg
     5161 ggggagggag accacacatg tcagaggtag tgaaggccgc tccaaatagt gactggggcc
     5221 aggcaggcgg aaaagagaac agaagagaat ccagaagtgt tcagacagaa ctagggacaa
     5281 cagaggggcc tccatggtgg catgggtcag cagagcatgg agcaggcaga ggaagcctat
     5341 ctgtggggct gggtacattt ctctgagact cacggaatgt aagtgttgag gtttctgcaa
     5401 agagggcgca ggccctgcag tgacggttca gatattgata acccatcccc cttggcaggt
     5461 gggggcttag gcatccatat tggattcaga aaagaaaaag aatgatgctt cttgcaacaa
     5521 aaacaaaagt gattatgtca cgagaggaga ggctggaggg ccatgggagt tcccagctgg
     5581 ctcactcatc cgtccaggag gtgggtctca tggtttcatt ttgctttggg cttacttaga
     5641 gttttggcaa atgcagagtt atgtaacgaa cccaacaatg aagatacagt tctgtcaccc
     5701 ccccagcatt ctcctgtggc cctctagtcc accccccgcc ccaccccagc ccctggcaac
     5761 cactgatctg ctttcacaat aaccgtatgg ggttttttct ctttcctttt ttgtgagcgg
     5821 tatttaattc ctttgctcta atatgtaata ttagaacata ttacaaagta gcaagaaaaa
     5881 tacgacattg gtgtaaaaat aatctacacc tcatggaaag aatgaagagc cagaaataga
     5941 ttctattctg tagaaaatct tacacaataa aggacttcaa aataa
//
