LOCUS       NP_055926                544 aa            linear   PRI 03-OCT-2024
DEFINITION  NEDD4-binding protein 3 [Homo sapiens].
ACCESSION   NP_055926 XP_038920
VERSION     NP_055926.1
DBSOURCE    REFSEQ: accession NM_015111.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 544)
  AUTHORS   Luo,M., Li,J., Yang,Q., Xu,S., Zhang,K., Chen,J., Zhang,S.,
            Zheng,S. and Zhou,J.
  TITLE     N4BP3 promotes breast cancer metastasis via NEDD4-mediated
            E-cadherin ubiquitination and degradation
  JOURNAL   Cancer Lett 550, 215926 (2022)
   PUBMED   36162713
  REMARK    GeneRIF: N4BP3 promotes breast cancer metastasis via NEDD4-mediated
            E-cadherin ubiquitination and degradation.
REFERENCE   2  (residues 1 to 544)
  AUTHORS   Han,H., Zhu,W., Lin,T., Liu,C. and Zhai,H.
  TITLE     N4BP3 promotes angiogenesis in hepatocellular carcinoma by binding
            with KAT2B
  JOURNAL   Cancer Sci 113 (10), 3390-3404 (2022)
   PUBMED   35848906
  REMARK    GeneRIF: N4BP3 promotes angiogenesis in hepatocellular carcinoma by
            binding with KAT2B.
REFERENCE   3  (residues 1 to 544)
  AUTHORS   Wang,C., Ling,T., Zhong,N. and Xu,L.G.
  TITLE     N4BP3 Regulates RIG-I-Like Receptor Antiviral Signaling Positively
            by Targeting Mitochondrial Antiviral Signaling Protein
  JOURNAL   Front Microbiol 12, 770600 (2021)
   PUBMED   34880843
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 544)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (residues 1 to 544)
  AUTHORS   Zhou,J., Liu,X., Wang,C. and Li,C.
  TITLE     The correlation analysis of miRNAs and target genes in metastasis
            of cervical squamous cell carcinoma
  JOURNAL   Epigenomics 10 (3), 259-275 (2018)
   PUBMED   29343084
  REMARK    GeneRIF: N4BP3 was associated with the survival time of cervical
            squamous cell carcinoma patients. mir-451 and mir-486 were related
            to tumor differentiation stage.
REFERENCE   6  (residues 1 to 544)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   7  (residues 1 to 544)
  AUTHORS   Liu,S., Chen,J., Cai,X., Wu,J., Chen,X., Wu,Y.T., Sun,L. and
            Chen,Z.J.
  TITLE     MAVS recruits multiple ubiquitin E3 ligases to activate antiviral
            signaling cascades
  JOURNAL   Elife 2, e00785 (2013)
   PUBMED   23951545
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 544)
  AUTHORS   Murillas,R., Simms,K.S., Hatakeyama,S., Weissman,A.M. and
            Kuehn,M.R.
  TITLE     Identification of developmentally expressed proteins that
            functionally interact with Nedd4 ubiquitin ligase
  JOURNAL   J Biol Chem 277 (4), 2897-2907 (2002)
   PUBMED   11717310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136632.3.
            
            On Apr 4, 2005 this sequence version replaced XP_038920.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053323.1, SRR1163657.454904.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274605.6/ ENSP00000274605.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..544
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     Protein         1..544
                     /product="NEDD4-binding protein 3"
                     /calculated_mol_wt=60339
     Region          61..84
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15049.3)"
     Region          116..252
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15049.3)"
     Site            176
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (O15049.3)"
     Region          260..>438
                     /region_name="YhaN"
                     /note="Uncharacterized conserved protein YhaN, contains
                     AAA domain [Function unknown]; COG4717"
                     /db_xref="CDD:443752"
     Region          335..365
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15049.3)"
     Region          368..526
                     /region_name="Fez1"
                     /note="pfam06818"
                     /db_xref="CDD:462015"
     Region          430..465
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O15049.3)"
     CDS             1..544
                     /gene="N4BP3"
                     /gene_synonym="LZTS4"
                     /coded_by="NM_015111.2:271..1905"
                     /db_xref="CCDS:CCDS34307.1"
                     /db_xref="GeneID:23138"
                     /db_xref="HGNC:HGNC:29852"
                     /db_xref="MIM:619140"
ORIGIN      
        1 matapgpagi amgsvgslle rqdfspeelr aalagsrgsr qpdgllrkgl gqreflsylh
       61 lpkkdskstk ntkraprnep adyatlyyre hsragdfskt slpergrfdk crirpsvfkp
      121 tagngkgfls mqslashkgq klwrsngslh tlachpplsp gprasqaraq llhalsldeg
      181 gpepepslsd sssggsfgrs pgtgpspfss slghlnhlgg sldrasqgpk eagppavlsc
      241 lpeppppyef scssaeemga vlpetceelk rglgdedgsn pftqvleerq rlwlaelkrl
      301 yverlhevtq kaersernlq lqlfmaqqeq rrlrkelraq qglapeprap gtlpeadpsa
      361 rpeeearwev cqktaeisll kqqlreaqae laqklaeifs lktqlrgsra qaqaqdaelv
      421 rlreavrslq eqapreeapg scetddcksr gllgeaggse ardsaeqlra ellqerlrgq
      481 eqalrfeqer rtwqeekerv lryqreiqgg ymdmyrrnqa leqelralre pptpwsprle
      541 sski
//
