LOCUS       NM_052818               2999 bp    mRNA    linear   PRI 20-DEC-2024
DEFINITION  Homo sapiens NEDD4 binding protein 2 like 1 (N4BP2L1), transcript
            variant 1, mRNA.
ACCESSION   NM_052818
VERSION     NM_052818.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2999)
  AUTHORS   Rao,P., Li,J., Xiong,J., Shen,S., Zeng,J. and Zhao,H.
  TITLE     MicroRNA-150-5p-mediated Inhibition of Cell Proliferation, G1/S
            Transition, and Migration in Bladder Cancer through Targeting
            NEDD4-binding Protein 2-like 1 Gene
  JOURNAL   J Physiol Investig 67 (3), 118-128 (2024)
   PUBMED   38910572
  REMARK    GeneRIF: MicroRNA-150-5p-mediated Inhibition of Cell Proliferation,
            G1/S Transition, and Migration in Bladder Cancer through Targeting
            NEDD4-binding Protein 2-like 1 Gene.
REFERENCE   2  (bases 1 to 2999)
  AUTHORS   Sasahira,T., Kurihara,M., Nishiguchi,Y., Fujiwara,R., Kirita,T. and
            Kuniyasu,H.
  TITLE     NEDD 4 binding protein 2-like 1 promotes cancer cell invasion in
            oral squamous cell carcinoma
  JOURNAL   Virchows Arch 469 (2), 163-172 (2016)
   PUBMED   27184799
  REMARK    GeneRIF: Cox proportional hazards analysis identified N4BP2L1
            expression as an independent predictor of disease-free survival
REFERENCE   3  (bases 1 to 2999)
  AUTHORS   Couch,F.J., Rommens,J.M., Neuhausen,S.L., Belanger,C., Dumont,M.,
            Abel,K., Bell,R., Berry,S., Bogden,R., Cannon-Albright,L.,
            Farid,L., Frye,C., Hattier,T., Janecki,T., Jiang,P., Kehrer,R.,
            Leblanc,J.F., McArthur-Morrison,J., Meney,D., Miki,Y., Peng,Y.,
            Samson,C., Schroeder,M., Snyder,S.C., Simard,J. et al.
  TITLE     Generation of an integrated transcription map of the BRCA2 region
            on chromosome 13q12-q13
  JOURNAL   Genomics 36 (1), 86-99 (1996)
   PUBMED   8812419
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI551105.1, AL137247.14 and AI783635.1.
            
            On Nov 23, 2018 this sequence version replaced NM_052818.2.
            
            Transcript Variant: This variant (1) encodes isoform 1. Variants 1
            and 3 both encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.158658.1,
                                           SRR1660809.62060.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380130.7/ ENSP00000369473.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-642               BI551105.1         54-695
            643-2668            AL137247.14        2685-4710           c
            2669-2999           AI783635.1         5-335               c
FEATURES             Location/Qualifiers
     source          1..2999
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.1"
     gene            1..2999
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /note="NEDD4 binding protein 2 like 1"
                     /db_xref="GeneID:90634"
                     /db_xref="HGNC:HGNC:25037"
                     /db_xref="MIM:621053"
     exon            1..227
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..780
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hypothetical gene CG018"
                     /codon_start=1
                     /product="NEDD4-binding protein 2-like 1 isoform 1"
                     /protein_id="NP_438169.2"
                     /db_xref="CCDS:CCDS9345.2"
                     /db_xref="GeneID:90634"
                     /db_xref="HGNC:HGNC:25037"
                     /db_xref="MIM:621053"
                     /translation="MEDSFLQSFGRLSLQPQQQQQRQRPPRPPPRGTPPRRHSFRKHL
                     YLLRGLPGSGKTTLARQLQHDFPRALIFSTDDFFFREDGAYEFNPDFLEEAHEWNQKR
                     ARKAMRNGISPIIIDNTNLHAWEMKPYAVMALENNYEVIFREPDTRWKFNVQELARRN
                     IHGVSREKIHRMKERYEHDVTFHSVLHAEKPSRMNRNQDRNNALPSNNARYWNSYTEF
                     PNRRAHGGFTNESSYHRRGGCHHGY"
     exon            228..355
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /inference="alignment:Splign:2.1.0"
     exon            356..444
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /inference="alignment:Splign:2.1.0"
     exon            445..521
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /inference="alignment:Splign:2.1.0"
     exon            522..2999
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1962..1967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /note="hexamer: ATTAAA"
     polyA_site      1990
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /note="major polyA site"
     regulatory      2026..2031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /note="hexamer: AATAAA"
     polyA_site      2049
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /note="major polyA site"
     regulatory      2066..2071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /note="hexamer: AATATA"
     polyA_site      2085
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
     regulatory      2115..2120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /note="hexamer: AATAAA"
     polyA_site      2146
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
     regulatory      2973..2978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
                     /note="hexamer: AATAAA"
     polyA_site      2999
                     /gene="N4BP2L1"
                     /gene_synonym="CG018"
ORIGIN      
        1 gacttcagta aagggaaccc ggggctctcg cagccagccc tcctgcccat ggaggacagt
       61 ttccttcaat cttttgggag gctgagcctc cagccccagc agcagcagca gcggcagcgg
      121 ccgccccggc cgcccccgcg ggggacacct cctcgccgcc acagctttag gaaacacctc
      181 tacctcctgc gaggcctccc gggctccggg aaaactacac tggccagaca attgcagcat
      241 gactttccca gggccctgat tttcagcacg gatgattttt tcttcaggga agatggtgcc
      301 tatgagttca atcctgactt cctggaggaa gctcatgaat ggaaccaaaa aagagcaaga
      361 aaagcaatga ggaatggcat atcccccatt attattgata ataccaacct ccacgcctgg
      421 gaaatgaagc cctatgcagt catggcactt gaaaataact atgaagttat attccgagaa
      481 cctgacactc gctggaaatt caacgttcaa gagttagcaa gaagaaacat tcatggtgtc
      541 tcaagagaaa aaatccaccg aatgaaagaa cggtatgaac acgatgttac ttttcacagt
      601 gtgcttcatg cagaaaagcc aagcagaatg aacagaaacc aggacaggaa taatgcattg
      661 ccttccaaca atgccagata ctggaattcc tacacagagt ttccaaaccg gagggcccac
      721 ggtggattta caaatgagag ctcctatcac agaaggggcg gttgtcacca tggatattag
      781 aggcctatct tacagccagg cagaattttc ctaagtcagt ttctacttca gtttttgtta
      841 ttttttgttg cattttagtc agagctccaa ttccagtgta aatagctgaa ctcaaaagtt
      901 tctgagcaaa gtcattatat tcactttctt caccaaaatt tgttaaagtg cttctatatg
      961 catggtctga tgctgggaat tctgcagatt tgagtaaaca gtctctttct ctagggtaag
     1021 aatttgaaac caaaacttga gaacacaccc aagaatatat ttacataggt tcatagatga
     1081 aataaagtgt ttatattata tataagcttc agtaccattt gctctgaagt gatctattta
     1141 ttttttcagg aaattcatct ccatcggtaa agttgggaag gtggagagaa gtggtggggg
     1201 ggcattgcta cttatcaaag tgccattgct actttgataa tctatgtatc taaaaatgtg
     1261 agatgtgcga ctcttatgat actgattttc ctttaatgtt aatatgccag aaagcataca
     1321 tctaagggaa cattgtcctt caaagtagac actttgggaa gttatttctt tattttaatg
     1381 atgtatcatt gttaaaaatg ctgtcaaatc cttaatagct acaggagcta ctgagggaaa
     1441 tcagtgtcat tatttaaagt cacgccttgt gtttttacta ctttattcag caggattaaa
     1501 cctgaataac ttttggctgt tgtgctaata gtgtaaataa aataagcctg ccttcataaa
     1561 acactaactt ttaaaaggaa taaacgactt ctaaaattat gcctattaac atgtgtaatt
     1621 agtcggcagc tcaaatgttt gggagtgcaa gaaattaggc accccaggat ataggtcata
     1681 cagggatata taaaagccat gctcattaca aaatgagcag ttgatgtttt atgtggcatt
     1741 aagacaatca agtcctcaca actctggaat gtcttcttat actgatgctg aatttatgaa
     1801 tccaaattaa tttccaacag gttggaatca gatttaatgt gagatcatga tagacaagac
     1861 cacagaggac gtatgctcta tttcttgttg gccaacagct tctttctaat gttctgtgaa
     1921 aaattatttt aagtgtctta tataatggtg cttttatggt tattaaaaat tgtaaatggt
     1981 atcacattta tatggatttg tcattggatc tttttttggt tcaacaataa aaaaatttaa
     2041 ttacctaaat gccaagaaac tcaacaatat accagttttt ctgtatcaca ggcttattta
     2101 ccagtctttt ttttaataaa taggaatcgt aaaggtaatg acaaaagcag ccttataatt
     2161 tagttgctta tatatttgat ctgtgtacat gagactgttt taacgttatc tgacactact
     2221 gaaacctgct cgacatctcc atgactacca acaccatgtg taatgttttc ttcactaaca
     2281 ttttaaaaac tggtatctcc tttgagtaag tttggctgac aatagtaaat cccaatgaat
     2341 ctaaggtgtt atcagctttg ctaacttctg tatctccaag cacaacataa aataatctcc
     2401 taatgatcta cttaataatg ctcccatttt ccaggcccag gtagtcctgg gtatcttggt
     2461 tgatagggtg gtggcataac cagctcaata tggatggctt gactcgtctg ggctggtaga
     2521 ggggagaaat gtcagagagc tcaaagtgga aattaccatc ctttgatttc acatgagcgg
     2581 ttcaaaggac cagattcaag ccctcctgac ttggctggct ccctgcttta gggtttttgg
     2641 ctcacttggg ttaagtgagt gaccactatg gagaagtggc tctgggttac ataacttttc
     2701 tagagctcta aagaatagtt tcctggccta tttaatgtct cttctttccc tagctgaccc
     2761 ctgaaatatt tggtttgtaa accataaaaa ttgattaaat gccatcaact ttatcccctg
     2821 tagaagtgat ctgtttttca actcccatgg cttctgattt gtgtaactct ttgaacaccc
     2881 aatattgact tgtattgtgt tcgctgtttg catcattcat agaactggca aatgctcttt
     2941 atgggcaata gggtctcatt aaatgattgc tgaataaata acacaaattt ttaccatta
//
