LOCUS       NM_153029               7077 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens NEDD4 binding protein 1 (N4BP1), mRNA.
ACCESSION   NM_153029
VERSION     NM_153029.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7077)
  AUTHORS   Wu,C., Guo,X., Zheng,W., Sun,R., Chen,L., Shen,Y., Chen,M.,
            Song,Y., Mao,R., Chen,X. and Fan,Y.
  TITLE     N4BP1 regulates keratinocytes development and plays protective role
            in burn- and adhesive-related skin injury via MMP9
  JOURNAL   Cell Signal 110, 110850 (2023)
   PUBMED   37579928
  REMARK    GeneRIF: N4BP1 regulates keratinocytes development and plays
            protective role in burn- and adhesive-related skin injury via MMP9.
REFERENCE   2  (bases 1 to 7077)
  AUTHORS   Zhao,D., Wang,C., Liu,X., Liu,N., Zhuang,S., Zhang,Q., Bao,X.,
            Xu,S., Zhou,X., Meng,Q., Li,S. and Tang,L.
  TITLE     CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress
            Syndrome through Mediating Macrophage Polarization via the
            miR-138-5p/EZH2 Axis
  JOURNAL   Mediators Inflamm 2021, 7858746 (2021)
   PUBMED   35002536
  REMARK    GeneRIF: CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory
            Distress Syndrome through Mediating Macrophage Polarization via the
            miR-138-5p/EZH2 Axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7077)
  AUTHORS   Gitlin,A.D., Heger,K., Schubert,A.F., Reja,R., Yan,D., Pham,V.C.,
            Suto,E., Zhang,J., Kwon,Y.C., Freund,E.C., Kang,J., Pham,A.,
            Caothien,R., Bacarro,N., Hinkle,T., Xu,M., McKenzie,B.S., Haley,B.,
            Lee,W.P., Lill,J.R., Roose-Girma,M., Dohse,M., Webster,J.D.,
            Newton,K. and Dixit,V.M.
  TITLE     Integration of innate immune signalling by caspase-8 cleavage of
            N4BP1
  JOURNAL   Nature 587 (7833), 275-280 (2020)
   PUBMED   32971525
  REMARK    GeneRIF: Integration of innate immune signalling by caspase-8
            cleavage of N4BP1.
REFERENCE   4  (bases 1 to 7077)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 7077)
  AUTHORS   Nepravishta,R., Ferrentino,F., Mandaliti,W., Mattioni,A., Weber,J.,
            Polo,S., Castagnoli,L., Cesareni,G., Paci,M. and Santonico,E.
  TITLE     CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1
  JOURNAL   Biomolecules 9 (7), 284 (2019)
   PUBMED   31319543
  REMARK    Erratum:[Biomolecules. 2019 Nov 28;9(12):E803. doi:
            10.3390/biom9120803.. PMID: 31795258]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7077)
  AUTHORS   Li,S., Wang,L., Berman,M., Kong,Y.Y. and Dorf,M.E.
  TITLE     Mapping a dynamic innate immunity protein interaction network
            regulating type I interferon production
  JOURNAL   Immunity 35 (3), 426-440 (2011)
   PUBMED   21903422
  REMARK    Erratum:[Immunity. 2011 Oct 28;35(4):647-8]
REFERENCE   7  (bases 1 to 7077)
  AUTHORS   Enjuanes,A., Benavente,Y., Bosch,F., Martin-Guerrero,I.,
            Colomer,D., Perez-Alvarez,S., Reina,O., Ardanaz,M.T., Jares,P.,
            Garcia-Orad,A., Pujana,M.A., Montserrat,E., de Sanjose,S. and
            Campo,E.
  TITLE     Genetic variants in apoptosis and immunoregulation-related genes
            are associated with risk of chronic lymphocytic leukemia
  JOURNAL   Cancer Res 68 (24), 10178-10186 (2008)
   PUBMED   19074885
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 7077)
  AUTHORS   Oberst,A., Malatesta,M., Aqeilan,R.I., Rossi,M., Salomoni,P.,
            Murillas,R., Sharma,P., Kuehn,M.R., Oren,M., Croce,C.M.,
            Bernassola,F. and Melino,G.
  TITLE     The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the
            E3 ligase Itch
  JOURNAL   Proc Natl Acad Sci U S A 104 (27), 11280-11285 (2007)
   PUBMED   17592138
REFERENCE   9  (bases 1 to 7077)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     The NYN domains: novel predicted RNAses with a PIN domain-like fold
  JOURNAL   RNA Biol 3 (1), 18-27 (2006)
   PUBMED   17114934
REFERENCE   10 (bases 1 to 7077)
  AUTHORS   Murillas,R., Simms,K.S., Hatakeyama,S., Weissman,A.M. and
            Kuehn,M.R.
  TITLE     Identification of developmentally expressed proteins that
            functionally interact with Nedd4 ubiquitin ligase
  JOURNAL   J Biol Chem 277 (4), 2897-2907 (2002)
   PUBMED   11717310
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB014515.1, BC051897.1, AK026937.1, AK124782.1, AK056383.1 and
            AL831882.1.
            
            On Nov 24, 2018 this sequence version replaced NM_153029.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.845067.1, BC152472.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262384.4/ ENSP00000262384.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-392               AB014515.1         30-421
            393-1301            BC051897.1         390-1298
            1302-3290           AB014515.1         1331-3319
            3291-3313           AK026937.1         2411-2433
            3314-4127           AK124782.1         29-842
            4128-4157           AK056383.1         180-209
            4158-5307           AK124782.1         873-2022
            5308-6877           AK056383.1         1360-2929
            6878-7077           AL831882.1         634-833
FEATURES             Location/Qualifiers
     source          1..7077
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..7077
                     /gene="N4BP1"
                     /note="NEDD4 binding protein 1"
                     /db_xref="GeneID:9683"
                     /db_xref="HGNC:HGNC:29850"
                     /db_xref="MIM:619138"
     exon            1..406
                     /gene="N4BP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..2899
                     /gene="N4BP1"
                     /codon_start=1
                     /product="NEDD4-binding protein 1"
                     /protein_id="NP_694574.3"
                     /db_xref="CCDS:CCDS45479.1"
                     /db_xref="GeneID:9683"
                     /db_xref="HGNC:HGNC:29850"
                     /db_xref="MIM:619138"
                     /translation="MAARAVLDEFTAPAEKAELLEQSRGRIEGLFGVSLAVLGALGAE
                     EPLPARIWLQLCGAQEAVHSAKEYIKGICEPELEERECYPKDMHCIFVGAESLFLKSL
                     IQDTCADLCILDIGLLGIRGSAEAVVMARSHIQQFVKLFENKENLPSSQKESEVKREF
                     KQFVEAHADNYTMDLLILPTSLKKELLTLTQGEENLFETGDDEVIEMRDSQQTEFTQN
                     AATGLNISRDETVLQEEARNKAGTPVSELTKQMDTVLSSSPDVLFDPINGLTPDEEAL
                     SNERICQKRRFSDSEERHTKKQFSLENVQEGEILHDAKTLAGNVIADLSDSSADSENL
                     SPDIKETTEEMEYNILVNFFKTMGYSQEIVEKVIKVYGPSTEPLLLLEEIEKENKRFQ
                     EDREFSAGTVYPETNKTKNKGVYSSTNELTTDSTPKKTQAHTQQNMVEKFSQLPFKVE
                     AKPCTSNCRINTFRTVPIEQKHEVWGSNQNYICNTDPETDGLSPSVASPSPKEVNFVS
                     RGASSHQPRVPLFPENGLHQQPEPLLPNNMKSACEKRLGCCSSPHSKPNCSTLSPPMP
                     LPQLLPSVTDARSAGPSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRTDLKHIVIDG
                     SNVAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTRRDPNVTEQHFLTQLQ
                     ELGILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVNESVSWREIIT
                     KRLLQYTFVGDIFMVPDDPLGRSGPRLEEFLQKEVCLRDMQPLLSALPNVGMFDPSFR
                     VPGTQAASTSHQPPTRIQGAPSSHWLPQQPHFPLLPALPSLQQNLPMPAQRSSAETNE
                     LREALLKIFPDSEQRLKIDQILVAHPYMKDLNALSAMVLD"
     exon            407..2097
                     /gene="N4BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2228
                     /gene="N4BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2325
                     /gene="N4BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2326..2433
                     /gene="N4BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2541
                     /gene="N4BP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..7077
                     /gene="N4BP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7056..7061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="N4BP1"
                     /note="hexamer: AATAAA"
     polyA_site      7077
                     /gene="N4BP1"
                     /note="major polyA site"
ORIGIN      
        1 ggaggggttc gctgccagca attgccaagc tgctgcggtc gtggcgggat ggtatagccg
       61 ggcctgaggg cgggcggcgg ggcgcgggcg ggggcgaggc ggccgggaag ggccgacgcc
      121 gcctgactgg cttgggagca gcggcagcaa gctgaggggg cgtcgccgcc gccggccccc
      181 ggcgccgccg cgggaggccg cgcccgccat ggcggcccgg gcggtgctgg acgagttcac
      241 tgcgccagct gagaaggcgg agctgctgga gcagagccgc ggccgtatcg agggcctgtt
      301 tggcgtgagc ctagccgtgc tcggcgcgct aggggctgag gagccgctgc ccgcgcgcat
      361 ctggctgcag ctctgcgggg cgcaggaggc ggtgcacagc gccaaggaat atattaaagg
      421 aatctgtgaa cctgaactag aagaaagaga atgttacccc aaggacatgc actgcatttt
      481 tgttggggca gagagcctgt ttctgaaaag cttgattcag gatacttgtg ctgacctctg
      541 cattctggac attggccttc ttggcatcag aggaagtgct gaggctgtgg tcatggctag
      601 gagtcacatt caacaatttg taaagctctt tgaaaataaa gagaacctac ccagtagtca
      661 gaaagaatca gaggtgaaaa gggaattcaa acaatttgtt gaagcccatg cagacaatta
      721 cacaatggat ttgttgattt tgcccacttc cttgaaaaaa gaacttttga cactcacaca
      781 aggtgaggag aatctctttg aaacaggaga tgatgaggtt attgaaatga gagattctca
      841 acaaacagag tttacacaga atgctgccac agggctgaat atttctagag atgaaactgt
      901 tttgcaggaa gaggcaagaa ataaagctgg gactcctgtt tctgagctta caaaacaaat
      961 ggacacagtc ctttctagct caccagatgt gctttttgat ccaataaatg gtctaacccc
     1021 agatgaagag gcactttcca atgagagaat ttgtcagaaa aggagatttt ctgattctga
     1081 agaaaggcat acgaagaagc agttttcttt ggaaaatgtt caggaggggg agattttaca
     1141 cgatgctaag acattggctg gaaatgtaat agctgaccta tctgattctt ctgctgattc
     1201 tgaaaattta agtccagata taaaagaaac tactgaggaa atggaataca acatcctcgt
     1261 aaactttttt aaaaccatgg gctactccca agaaattgtt gaaaaggtca ttaaggtgta
     1321 tggaccatct actgaaccat tattgctctt agaggaaatt gaaaaagaaa ataaaagatt
     1381 ccaagaagac agagaatttt cagctggtac agtgtatcca gagaccaaca aaaccaaaaa
     1441 taaaggtgtt tatagcagca caaatgagct tacaactgat tccactccaa agaaaacaca
     1501 ggctcacaca cagcaaaata tggtagaaaa attttctcag ttaccattca aagtggaagc
     1561 taaaccatgt acctcaaatt gtagaattaa tactttcaga acagtgccaa tagaacagaa
     1621 acatgaagtc tggggttcaa accagaacta catttgtaac acagaccctg aaactgatgg
     1681 cctttcacct tctgttgcct ctccaagtcc caaagaagtc aattttgttt caaggggagc
     1741 ttcaagtcac cagcccagag ttccactttt tcctgaaaat ggtttacacc agcagccaga
     1801 acccttgctt ccaaataata tgaaatctgc ctgtgaaaaa cgtttaggat gttgtagttc
     1861 tcctcattct aagccaaatt gctcaaccct ttctccacca atgccactgc cccagctgtt
     1921 accttcggtt actgatgcaa ggtcggcagg accttctgat catattgatt cctcagttac
     1981 tggggttcaa aggtttcgag atactctaaa aataccctac aagctggaat taaaaaatga
     2041 accagggaga acggatttga aacacattgt tatagatggg agcaatgttg caattaccca
     2101 tggtctgaaa aagttctttt cttgtcgtgg aattgcaatt gcagttgaat atttttggaa
     2161 gcttggcaac agaaacatca ctgtatttgt ccctcagtgg agaacaaggc gtgatcctaa
     2221 tgtcacagaa cagcacttct taacccagct ccaggagctc ggaatattat ctttaactcc
     2281 tgcccggatg gtctttggag aaagaattgc ttctcatgat gacaggtttc tactacactt
     2341 agcggacaaa actggtggca taattgtgac aaatgataat ttcagagaat ttgtgaatga
     2401 gtcagtctct tggagagaaa ttattacaaa aaggctgctg cagtacacgt tcgtggggga
     2461 catatttatg gttcccgatg atcctctggg aagaagtgga cctcgattag aggagtttct
     2521 tcagaaggaa gtctgtctta gagatatgca gcccctactc agtgccctgc caaatgtggg
     2581 catgtttgac cccagcttca gagtccctgg cacccaggca gccagcacca gccaccagcc
     2641 tccgacccgg attcagggag ccccttcaag ccactggctc cctcagcagc cccacttccc
     2701 actgctgcca gccctcccca gtctccagca gaacctgccc atgccagctc agagatcttc
     2761 tgcagaaacc aacgagctga gggaagccct tctgaagatc ttccctgact cagagcaaag
     2821 actgaaaata gaccagatct tggtggccca cccatacatg aaagatctaa atgcgctttc
     2881 tgccatggtg ttggattgaa gattgtgctg agcgctgagc ttgcgctcag ggctggctga
     2941 tcaaactcaa gctcacacct gtacctgatg ggaatgaaca taatgtgaag aaacttattt
     3001 cccagtgtaa acgcagttgt acagaaaaaa aatgttttgg gtataaatct gggttttcaa
     3061 aaccagcttt tttctatata taaattatgc tgctattaca gatttaacat tttctgttaa
     3121 aggaaagtct acattttctg cctgttcaga actgtttaat agcagttact cttgagtgta
     3181 tttacctttt tatgtttttt aaactatttt ccttaaagcc gaaaatattg acaaatggat
     3241 atggttagcc tttataaata aataaaaaaa aaagtgttgc tttcttaagg aaagcaagac
     3301 gtcttaaagt atattttctt gagatgagta tgtcccatca ctaccatgaa gtgtgctcac
     3361 ccttccagcc tcctctgccc tcacccccgg agttaaagtg ggtaagagtt ggtttgttct
     3421 gcagtctttg gttggagtgt tgtgaaagtg gacccgcggt gccactagat ggcacttggt
     3481 gcctagccat ggtgaatgac cagggcgaag ttagtctcac agaataccag ggctagaaga
     3541 catcgtggag cccatggagt cccaccctcc ttcccccttc caccctgcgc aaaaggggac
     3601 ggcccagtgt gcacgccgtc cggccatgcc cacagccaca gccacagctg aggagtggcc
     3661 gggcaggcag caggctcccc agccagggct tgacacgccc acagtcaggg gcctccacat
     3721 gcctggcctg gctctggaag tcacgtctta gcttctgaac accgtagcgg gttatgagga
     3781 agtttaatga agagcccggt cactgtggcc atcttgtgtc cccaactgca ggagacgccc
     3841 tgatgtggag tttgtacagc tttgccaaaa aatggttttc tattctcaaa agtgacccaa
     3901 gccaataaat agcattagta gcttctgtgg ggggatccca gagcccctgt atttattttc
     3961 cctgtgtttg tctctagtgt cctcctaaac agcctttcct gtgagtcttt ctcagaattg
     4021 atatcttaat attgtctgtt ctaggtgttg cccaaattca gtgtcagtga agttcttttc
     4081 ctgggcaatc ttaacatctt tactcttatt gtctggacct tcaaagggct ttgtatttta
     4141 cacctgcgcc cccaggctgc tcacagtcgg cttgctgcct gtcctgcctg tccggatctt
     4201 gtctcctagt cctgaggagc ggaggctgag aactcagtgc tggtttgtaa atggtgaggg
     4261 gacttggggg catcccagag tgctccctcc aggcctgctt cttggttttg tttgatcact
     4321 gcgttcttca agggatgaat ccagagccct ccatgaggcc aagcttgtcc ttcaatcatg
     4381 tttcctctca gatgcgtccg tgatgcctcc taatgtggaa ctggttgtcc attgtttggg
     4441 cctatggcca agtcacccag ctgtggaagc agaggtagaa gacgaggcca gccaggaggg
     4501 cgacttcagt cacagctccc atgcctcagc tttgtacctg ttttcaaaag cacaactgag
     4561 gtgtgcgggc tggagctgtc ttgcagtgat tctggccttc tggctcatgg ttcagtccag
     4621 cagcctggct gacccactat ttctcctctg cttcagagga aacccaggaa atgcccttac
     4681 tgccaggctg agtctccacc catgctggtt ggtgctggct aggctgaggg ggccaccact
     4741 tttcctggct agaagctact tgacctttga tgtttgagtt ctgtaagtct tcgtgttctg
     4801 acttactgct tcagagggat tggcctgtcc cctttccctt tctcggctat gggaaggaag
     4861 gattgctcat tggttgcctt catcagttac agcatgagac ggaattcatc attccttccg
     4921 aaacccctga tatttaatat ttaatattta aaaacccaaa ttatcaaacc attaagaact
     4981 cattactggt tctcagcctc ctccagtact agcctcagtg tggctgctgc ataagtatct
     5041 gtagcctgtc tacctcctgc agtggggccg ctcgcctctt ccctgtctac tgctcaggct
     5101 ctcccacttc gtggcatcca tgtaaagtag gtggcagggc agagatgtca ctctcattca
     5161 acagggagga tgtctgttgc tcagagaggt tgtcctgagg ggctgggtga ttcctgggcc
     5221 tacattcttc ccgaggctcc aggccgctgt ctctggaagt aaaagagcct tgtctgacct
     5281 taatgcaagc agtctgtttg aacccctgta ggctgcattc aggagacaga aggtgtctgg
     5341 gccatcctgg gcggccggtc agcgttgcta ggcaggctcg gctgtctggc cgggacttgg
     5401 gcctgggtgg cttttgagac cagtgaagaa gggagagccg gcctcatgcc gatgcggctt
     5461 gtggcacggc tgggatgtga gggaggactc agatctacac acagaaaccc ctcttctccc
     5521 cgccctcccc cagctcctac ctgcctccca cgcctcaggt gtggctgcct gtgggaccat
     5581 cccccaaccc ctttcctcgc acctccttgt cctcacccag ttcctgcagt gtctctgacc
     5641 cacgcctccc gcctcctggc cgacttgccc aggaggtgtc tctggctcac ctccgtctgt
     5701 tcatcacctt cctccccagt gtttccactt atcttggatg ttttagattg aaacagcctg
     5761 attcccggaa gaatcctctt cattcattgc tagtgcttcc cctcacctcc cactctccac
     5821 ttcccagttt gcaaatgtgg ctttcgccca ccaagtgaaa gcggactgag agcagccctt
     5881 ggggacggcc cggtgcctgg ctgcaaggcc gcgctggggc tctgtcttgg tgcacatggc
     5941 ttgaccggac tttccctgct tcccaccact tccctcactc ccagacctcc ctcattcttt
     6001 ttgtctcttc tttttgccta aagccagtcc ttaacaccct attcttcctc tgcaggtggc
     6061 ttgcagactt ttccccacct ttggggctcg tggtggtgga gagggcagct ggtgttaaga
     6121 atgtaggtta ccgggcatga cccggcagat gcttgcccag tagttctgga ggaaggcccg
     6181 ggaatctgca aatgagcgca ttccccaggc agttcccatg caggtgatcc acggaccaca
     6241 tgttgagaaa ctgcagtcac ccttagggcc acaccgtccc tctcctcgct gtcccctctc
     6301 tgtagtgact ggccctgacc ttcaggagtg cactttccac tctaccagga agccctatga
     6361 catcctcagg ctccccagac ctgcagcttg catggggccc ctcccttctt ccacacccac
     6421 cctccgtatg gtcccctgct ctgccctcgt gctttgctgg cccctgcccg ctactcccac
     6481 tctcagacac ccaggggtgg tgggccctaa ctggctggcc cctcccagcg ctgccctctg
     6541 ccgtccagat gctgcagtgt ggccagattt accttccagt aacatacttc tagtcacccc
     6601 tcctcctgcg aagtgatctg cagtggctgt ttgaccagac cacaaagttc acatctcctg
     6661 agcttagtgt ccgtggctgt ccacctccca gccatacttg actgtcccca aactctccct
     6721 gcagccacat gtttcccatg acctgtgggc tctgcagatg gacctctctc cgctagagat
     6781 gcccttctcc caaatggctt ccctcctgga aggcccagcc tgagtcctcg tctcctttcc
     6841 agtgcttctg ccagaagcat ccccatgatg ttgtgaccgc acagcacttt gtgtctcgct
     6901 ttgagcactt gccactctgg ctggtgctgc tgccactgat tgtgtactgt cttgctgccc
     6961 tttctagact gtgagctcct cgtgggcagg gaccgcctgt gttctctgta tttcccacgg
     7021 cgcctagcac agtgccttgc acttgatagg tgcttaataa atgtctgctc aactgaa
//
