LOCUS       NM_025029                599 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitotic spindle organizing protein 2B (MZT2B),
            transcript variant 2, mRNA.
ACCESSION   NM_025029
VERSION     NM_025029.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 599)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 599)
  AUTHORS   Wieczorek,M., Huang,T.L., Urnavicius,L., Hsia,K.C. and Kapoor,T.M.
  TITLE     MZT Proteins Form Multi-Faceted Structural Modules in the
            gamma-Tubulin Ring Complex
  JOURNAL   Cell Rep 31 (13), 107791 (2020)
   PUBMED   32610146
  REMARK    GeneRIF: MZT Proteins Form Multi-Faceted Structural Modules in the
            gamma-Tubulin Ring Complex.
REFERENCE   3  (bases 1 to 599)
  AUTHORS   Liu,X., Salokas,K., Tamene,F., Jiu,Y., Weldatsadik,R.G., Ohman,T.
            and Varjosalo,M.
  TITLE     An AP-MS- and BioID-compatible MAC-tag enables comprehensive
            mapping of protein interactions and subcellular localizations
  JOURNAL   Nat Commun 9 (1), 1188 (2018)
   PUBMED   29568061
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 599)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 599)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   6  (bases 1 to 599)
  AUTHORS   Hutchins,J.R., Toyoda,Y., Hegemann,B., Poser,I., Heriche,J.K.,
            Sykora,M.M., Augsburg,M., Hudecz,O., Buschhorn,B.A., Bulkescher,J.,
            Conrad,C., Comartin,D., Schleiffer,A., Sarov,M., Pozniakovsky,A.,
            Slabicki,M.M., Schloissnig,S., Steinmacher,I., Leuschner,M.,
            Ssykor,A., Lawo,S., Pelletier,L., Stark,H., Nasmyth,K.,
            Ellenberg,J., Durbin,R., Buchholz,F., Mechtler,K., Hyman,A.A. and
            Peters,J.M.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018804.9 and BC014255.2.
            
            On Jun 2, 2019 this sequence version replaced NM_025029.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ057792.1, BC014255.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281871.11/ ENSP00000281871.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC018804.9         56143-56166         c
            25-599              BC014255.2         1-575
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     gene            1..599
                     /gene="MZT2B"
                     /gene_synonym="FAM128B; MOZART2B"
                     /note="mitotic spindle organizing protein 2B"
                     /db_xref="GeneID:80097"
                     /db_xref="HGNC:HGNC:25886"
                     /db_xref="MIM:613450"
     exon            1..191
                     /gene="MZT2B"
                     /gene_synonym="FAM128B; MOZART2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..498
                     /gene="MZT2B"
                     /gene_synonym="FAM128B; MOZART2B"
                     /note="isoform 2 is encoded by transcript variant 2;
                     mitotic-spindle organizing protein associated with a ring
                     of gamma-tubulin 2B; family with sequence similarity 128,
                     member B"
                     /codon_start=1
                     /product="mitotic-spindle organizing protein 2B isoform 2"
                     /protein_id="NP_079305.2"
                     /db_xref="CCDS:CCDS2157.1"
                     /db_xref="GeneID:80097"
                     /db_xref="HGNC:HGNC:25886"
                     /db_xref="MIM:613450"
                     /translation="MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELA
                     QAAGGAIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQDPAAVSLPTSSV
                     PETRGRNKGSAALGGALALAERSSREGSSQRMPRQPSATRLPKGGGPGKSPTRGST"
     exon            192..340
                     /gene="MZT2B"
                     /gene_synonym="FAM128B; MOZART2B"
                     /inference="alignment:Splign:2.1.0"
     exon            341..599
                     /gene="MZT2B"
                     /gene_synonym="FAM128B; MOZART2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      565..570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MZT2B"
                     /gene_synonym="FAM128B; MOZART2B"
                     /note="hexamer: AATAAA"
     polyA_site      599
                     /gene="MZT2B"
                     /gene_synonym="FAM128B; MOZART2B"
                     /note="major polyA site"
ORIGIN      
        1 acctttccgc gggccgcggg gatggcggcg cagggcgtag ggcctgggcc ggggtcggcg
       61 gcgcccccgg ggctggaggc ggcccggcag aagctggcgc tgcggcggaa gaaggtgctg
      121 agcaccgagg agatggagct gtacgagctg gcgcaggcgg cgggcggcgc tatcgacccc
      181 gacgtgttca agatcctggt ggacctgctg aagctgaacg tggcccccct cgccgtcttc
      241 cagatgctca agtccatgtg tgccgggcag aggctagcga gcgagcccca ggaccctgcg
      301 gccgtgtctc tgcccacgtc gagcgtgccc gagacccgag ggagaaacaa aggcagcgct
      361 gccctcgggg gagcattggc cctggcggaa cgcagcagcc gcgaaggatc cagccagagg
      421 atgccacgcc agcccagcgc taccaggctg cccaaggggg gcgggcctgg gaagagccct
      481 acacggggca gcacctagga tggggcagag acttgttgca tctttgtccc cagcaaaggc
      541 tacatgttac ctccttcaat tgataataaa cctttctgag atgcagaggg tccaggtca
//
