LOCUS       NM_001085365             599 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens mitotic spindle organizing protein 2A (MZT2A), mRNA.
ACCESSION   NM_001085365
VERSION     NM_001085365.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 599)
  AUTHORS   Wang,H., Jiang,X., Cheng,Y., Ren,H., Hu,Y., Zhang,Y., Su,H.,
            Zou,Z., Wang,Q., Liu,Z., Zhang,J. and Qiu,X.
  TITLE     MZT2A promotes NSCLC viability and invasion by increasing Akt
            phosphorylation via the MOZART2 domain
  JOURNAL   Cancer Sci 112 (6), 2210-2222 (2021)
   PUBMED   33754417
  REMARK    GeneRIF: MZT2A promotes NSCLC viability and invasion by increasing
            Akt phosphorylation via the MOZART2 domain.
REFERENCE   2  (bases 1 to 599)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 599)
  AUTHORS   Wieczorek,M., Huang,T.L., Urnavicius,L., Hsia,K.C. and Kapoor,T.M.
  TITLE     MZT Proteins Form Multi-Faceted Structural Modules in the
            gamma-Tubulin Ring Complex
  JOURNAL   Cell Rep 31 (13), 107791 (2020)
   PUBMED   32610146
  REMARK    GeneRIF: MZT Proteins Form Multi-Faceted Structural Modules in the
            gamma-Tubulin Ring Complex.
REFERENCE   4  (bases 1 to 599)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   5  (bases 1 to 599)
  AUTHORS   Teixido-Travesa,N., Villen,J., Lacasa,C., Bertran,M.T.,
            Archinti,M., Gygi,S.P., Caelles,C., Roig,J. and Luders,J.
  TITLE     The gammaTuRC revisited: a comparative analysis of interphase and
            mitotic human gammaTuRC redefines the set of core components and
            identifies the novel subunit GCP8
  JOURNAL   Mol Biol Cell 21 (22), 3963-3972 (2010)
   PUBMED   20861304
  REMARK    GeneRIF: Data show that depletion of GCP8 specifically affects the
            organization of the interphase microtubule network.
REFERENCE   6  (bases 1 to 599)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 599)
  AUTHORS   Hutchins,J.R., Toyoda,Y., Hegemann,B., Poser,I., Heriche,J.K.,
            Sykora,M.M., Augsburg,M., Hudecz,O., Buschhorn,B.A., Bulkescher,J.,
            Conrad,C., Comartin,D., Schleiffer,A., Sarov,M., Pozniakovsky,A.,
            Slabicki,M.M., Schloissnig,S., Steinmacher,I., Leuschner,M.,
            Ssykor,A., Lawo,S., Pelletier,L., Stark,H., Nasmyth,K.,
            Ellenberg,J., Durbin,R., Buchholz,F., Mechtler,K., Hyman,A.A. and
            Peters,J.M.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
REFERENCE   8  (bases 1 to 599)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU682101.1 and BM554057.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001085365.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM554057.1, SRR1803612.267831.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309451.7/ ENSP00000311500.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-431               BU682101.1         175-605             c
            432-599             BM554057.1         588-755
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.1"
     gene            1..599
                     /gene="MZT2A"
                     /gene_synonym="FAM128A; MOZART2A"
                     /note="mitotic spindle organizing protein 2A"
                     /db_xref="GeneID:653784"
                     /db_xref="HGNC:HGNC:33187"
                     /db_xref="MIM:613449"
     exon            1..191
                     /gene="MZT2A"
                     /gene_synonym="FAM128A; MOZART2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..498
                     /gene="MZT2A"
                     /gene_synonym="FAM128A; MOZART2A"
                     /note="mitotic-spindle organizing protein associated with
                     a ring of gamma-tubulin 2A; family with sequence
                     similarity 128, member A"
                     /codon_start=1
                     /product="mitotic-spindle organizing protein 2A"
                     /protein_id="NP_001078834.1"
                     /db_xref="CCDS:CCDS42758.1"
                     /db_xref="GeneID:653784"
                     /db_xref="HGNC:HGNC:33187"
                     /db_xref="MIM:613449"
                     /translation="MAAQGVGPGPGSAAPPGLEAARQKLALRRKKVLSTEEMELYELA
                     QAAGGGIDPDVFKILVDLLKLNVAPLAVFQMLKSMCAGQRLASEPQDPAAVSLPTSSV
                     PETRGRDKGSAALGGVLALAERSNHEGSSQRMPRQPSATRLPKGGGPGKSPTQGST"
     exon            192..340
                     /gene="MZT2A"
                     /gene_synonym="FAM128A; MOZART2A"
                     /inference="alignment:Splign:2.1.0"
     exon            341..599
                     /gene="MZT2A"
                     /gene_synonym="FAM128A; MOZART2A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      565..570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MZT2A"
                     /gene_synonym="FAM128A; MOZART2A"
                     /note="hexamer: AATAAA"
     polyA_site      599
                     /gene="MZT2A"
                     /gene_synonym="FAM128A; MOZART2A"
                     /note="major polyA site"
ORIGIN      
        1 acctttcggc gggcctcgcg gatggcggcg cagggcgtag ggcctgggcc ggggtcggcg
       61 gcgcccccgg ggctggaggc ggcccggcag aagctggcgc tgcggcgcaa gaaggtgctg
      121 agcaccgagg agatggagct gtacgagctg gctcaggcgg cgggcggcgg tatcgacccc
      181 gacgtgttca agatcctggt ggacctgctg aagctgaacg tggcccccct cgccgtcttc
      241 cagatgctca agtccatgtg tgccgggcag aggctagcga gcgagcccca ggaccctgcg
      301 gccgtgtctc tgcccacgtc gagcgtgccc gagacccgag ggagagacaa aggcagcgct
      361 gccctcgggg gagtattggc cctggcggaa cgcagcaacc acgagggatc cagccagagg
      421 atgccacgcc agcccagcgc taccaggctg cccaaggggg gcgggcctgg gaagagccct
      481 acgcagggca gcacctagga tggggcagag acttgtcaca tctttgtccc cagcaaaggc
      541 tacatgttac ctccttcagt tgataataaa cctttctgag atgcagaggg tccaggtca
//
