LOCUS       NM_001071775            2231 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitotic spindle organizing protein 1 (MZT1), mRNA.
ACCESSION   NM_001071775 XM_495961 XM_936836
VERSION     NM_001071775.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2231)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2231)
  AUTHORS   Wieczorek,M., Huang,T.L., Urnavicius,L., Hsia,K.C. and Kapoor,T.M.
  TITLE     MZT Proteins Form Multi-Faceted Structural Modules in the
            gamma-Tubulin Ring Complex
  JOURNAL   Cell Rep 31 (13), 107791 (2020)
   PUBMED   32610146
  REMARK    GeneRIF: MZT Proteins Form Multi-Faceted Structural Modules in the
            gamma-Tubulin Ring Complex.
REFERENCE   3  (bases 1 to 2231)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2231)
  AUTHORS   Cukier,C.D., Tourdes,A., El-Mazouni,D., Guillet,V., Nomme,J.,
            Mourey,L., Milon,A., Merdes,A. and Gervais,V.
  TITLE     NMR secondary structure and interactions of recombinant human
            MOZART1 protein, a component of the gamma-tubulin complex
  JOURNAL   Protein Sci 26 (11), 2240-2248 (2017)
   PUBMED   28851027
  REMARK    GeneRIF: NMR secondary structure and interactions of recombinant
            human MOZART1 protein with its binding partner, GCP3, has been
            presented.
REFERENCE   5  (bases 1 to 2231)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2231)
  AUTHORS   Cota,R.R., Teixido-Travesa,N., Ezquerra,A., Eibes,S., Lacasa,C.,
            Roig,J. and Luders,J.
  TITLE     MZT1 regulates microtubule nucleation by linking gammaTuRC assembly
            to adapter-mediated targeting and activation
  JOURNAL   J Cell Sci 130 (2), 406-419 (2017)
   PUBMED   27852835
  REMARK    GeneRIF: MZT1 is a 'priming factor' for gamma-tubulin ring complex
            that allows spatial regulation of nucleation.
REFERENCE   7  (bases 1 to 2231)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   8  (bases 1 to 2231)
  AUTHORS   Stewart,S.E., Yu,D., Scharf,J.M., Neale,B.M., Fagerness,J.A.,
            Mathews,C.A., Arnold,P.D., Evans,P.D., Gamazon,E.R., Davis,L.K.,
            Osiecki,L., McGrath,L., Haddad,S., Crane,J., Hezel,D., Illman,C.,
            Mayerfeld,C., Konkashbaev,A., Liu,C., Pluzhnikov,A., Tikhomirov,A.,
            Edlund,C.K., Rauch,S.L., Moessner,R., Falkai,P., Maier,W.,
            Ruhrmann,S., Grabe,H.J., Lennertz,L., Wagner,M., Bellodi,L.,
            Cavallini,M.C., Richter,M.A., Cook,E.H. Jr., Kennedy,J.L.,
            Rosenberg,D., Stein,D.J., Hemmings,S.M., Lochner,C., Azzam,A.,
            Chavira,D.A., Fournier,E., Garrido,H., Sheppard,B., Umana,P.,
            Murphy,D.L., Wendland,J.R., Veenstra-VanderWeele,J., Denys,D.,
            Blom,R., Deforce,D., Van Nieuwerburgh,F., Westenberg,H.G.,
            Walitza,S., Egberts,K., Renner,T., Miguel,E.C., Cappi,C.,
            Hounie,A.G., Conceicao do Rosario,M., Sampaio,A.S., Vallada,H.,
            Nicolini,H., Lanzagorta,N., Camarena,B., Delorme,R., Leboyer,M.,
            Pato,C.N., Pato,M.T., Voyiaziakis,E., Heutink,P., Cath,D.C.,
            Posthuma,D., Smit,J.H., Samuels,J., Bienvenu,O.J., Cullen,B.,
            Fyer,A.J., Grados,M.A., Greenberg,B.D., McCracken,J.T.,
            Riddle,M.A., Wang,Y., Coric,V., Leckman,J.F., Bloch,M.,
            Pittenger,C., Eapen,V., Black,D.W., Ophoff,R.A., Strengman,E.,
            Cusi,D., Turiel,M., Frau,F., Macciardi,F., Gibbs,J.R.,
            Cookson,M.R., Singleton,A., Hardy,J., Crenshaw,A.T., Parkin,M.A.,
            Mirel,D.B., Conti,D.V., Purcell,S., Nestadt,G., Hanna,G.L.,
            Jenike,M.A., Knowles,J.A., Cox,N. and Pauls,D.L.
  CONSRTM   North American Brain Expression Consortium; UK Brain Expression
            Database
  TITLE     Genome-wide association study of obsessive-compulsive disorder
  JOURNAL   Mol Psychiatry 18 (7), 788-798 (2013)
   PUBMED   22889921
  REMARK    Erratum:[Mol Psychiatry. 2013 Jul;18(7):843. Davis, L K [added]]
REFERENCE   9  (bases 1 to 2231)
  AUTHORS   Janski,N., Masoud,K., Batzenschlager,M., Herzog,E., Evrard,J.L.,
            Houlne,G., Bourge,M., Chaboute,M.E. and Schmit,A.C.
  TITLE     The GCP3-interacting proteins GIP1 and GIP2 are required for
            gamma-tubulin complex protein localization, spindle integrity, and
            chromosomal stability
  JOURNAL   Plant Cell 24 (3), 1171-1187 (2012)
   PUBMED   22427335
REFERENCE   10 (bases 1 to 2231)
  AUTHORS   Hutchins,J.R., Toyoda,Y., Hegemann,B., Poser,I., Heriche,J.K.,
            Sykora,M.M., Augsburg,M., Hudecz,O., Buschhorn,B.A., Bulkescher,J.,
            Conrad,C., Comartin,D., Schleiffer,A., Sarov,M., Pozniakovsky,A.,
            Slabicki,M.M., Schloissnig,S., Steinmacher,I., Leuschner,M.,
            Ssykor,A., Lawo,S., Pelletier,L., Stark,H., Nasmyth,K.,
            Ellenberg,J., Durbin,R., Buchholz,F., Mechtler,K., Hyman,A.A. and
            Peters,J.M.
  TITLE     Systematic analysis of human protein complexes identifies
            chromosome segregation proteins
  JOURNAL   Science 328 (5978), 593-599 (2010)
   PUBMED   20360068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC125183.1, AK025522.1 and AL356754.18.
            
            On Nov 22, 2018 this sequence version replaced NM_001071775.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.198352.1,
                                           SRR1660805.180025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377818.4/ ENSP00000367049.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BC125183.1         175-213
            40-991              AK025522.1         84-1035
            992-2231            AL356754.18        166620-167859       c
FEATURES             Location/Qualifiers
     source          1..2231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q21.33"
     gene            1..2231
                     /gene="MZT1"
                     /gene_synonym="C13orf37; MOZART1"
                     /note="mitotic spindle organizing protein 1"
                     /db_xref="GeneID:440145"
                     /db_xref="HGNC:HGNC:33830"
                     /db_xref="MIM:613448"
     exon            1..106
                     /gene="MZT1"
                     /gene_synonym="C13orf37; MOZART1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..276
                     /gene="MZT1"
                     /gene_synonym="C13orf37; MOZART1"
                     /note="mitotic-spindle organizing protein associated with
                     a ring of gamma-tubulin 1"
                     /codon_start=1
                     /product="mitotic-spindle organizing protein 1"
                     /protein_id="NP_001065243.1"
                     /db_xref="CCDS:CCDS31990.1"
                     /db_xref="GeneID:440145"
                     /db_xref="HGNC:HGNC:33830"
                     /db_xref="MIM:613448"
                     /translation="MASSSGAGAAAAAAAANLNAVRETMDVLLEISRILNTGLDMETL
                     SICVRLCEQGINPEALSSVIKELRKATEALKAAENMTS"
     exon            107..252
                     /gene="MZT1"
                     /gene_synonym="C13orf37; MOZART1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..2231
                     /gene="MZT1"
                     /gene_synonym="C13orf37; MOZART1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2211..2216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MZT1"
                     /gene_synonym="C13orf37; MOZART1"
                     /note="hexamer: AATAAA"
     polyA_site      2231
                     /gene="MZT1"
                     /gene_synonym="C13orf37; MOZART1"
                     /note="major polyA site"
ORIGIN      
        1 cttctcccgc ctccctcggc cttagccatg gcgagtagca gcggtgctgg ggcggcggcg
       61 gcggccgcgg cggcgaatct gaatgcggtg cgggagacca tggacgttct gcttgagatt
      121 tcaagaattt tgaatactgg cttagatatg gaaactctgt ctatttgtgt acggctttgt
      181 gaacaaggaa ttaacccaga agctttatca tcggttatta aggagcttcg caaggctact
      241 gaagcactga aggctgctga aaatatgaca agctgacttt ctggagaaat tctgatgaga
      301 tatgtcaagc tctgcaagag ggtttgaaga ttgcattgta gttgagaatg tacaatgaaa
      361 ttactgcatg cagcagtgta gaaaaatttt actttttaaa agaattataa aaccatagct
      421 ttataaatca gtggaaagtg gcttacagag agaactatca gatgtgttta catcacatct
      481 tattcacttt ttttaacagc tctaatgctt tggcattgct atgttcatat ttatgtattc
      541 cttatttata gctctgatag ctttaatttt ctaagcagtc tgtctatcag atgtgcacat
      601 ctgctgtgcc aggttgaagt atagtggaac ccatcagtag taatgtgtag tagttatgac
      661 ttgttgacat ttccattata aactttaatt ttgaattgtt tatgcattat aactgtggat
      721 ttatattgta ttgggctgaa agttgacagg atttcagcca ccacttgtga atttttattt
      781 agattcatta tgtatatcag aatcttgttt tttgaaataa gagcatggaa aacatttctt
      841 gtaatctact cttgaacaaa gaatatttag tttttcaaac agtttgttgg gcagctaata
      901 gtgtgaacca ggtcattttt gtattgagta aaaaaatcaa actttgagaa acttggattt
      961 taaaagtaat gacaatgctt aggttagtat tatttgtaat ttgaatcatt tacatctaat
     1021 gagaatgtta gttgagaatg ttttcttaaa gttttatatc ctataaataa cggaataaaa
     1081 aaatttgtaa aatgaaacaa caaacatgca aaattcctat ttacttttat tacataaaag
     1141 taattttagt gcttacctaa taaatcttga atggttattt aataaattat tagatgggtg
     1201 atgtgtttca aaagatactt gctatttttt gaagaaataa ggatttccag tcattaaaca
     1261 aaactaaaca atcttattag atgggtgatg tgtttcaaag gatacttgct attttttgaa
     1321 gaaataagga tttccagtca ttaaacaaaa ctaaacaatc aaatgttcta tattaggaat
     1381 ctcaagtatg gcttttttta aaaaaccttt ttaacatctt gatgtcaagg attataagta
     1441 tggcttttca gaattgtttt gtttgtcatt attcttgcct ttaaaatttt aactcatcaa
     1501 agtgaagatt agaaataaat tttagaaaat gtagaatagt attgattctg ttcctgtaat
     1561 agaatctcag tggagttttt ttgcaaaact aatatggatt tcatctgatt ttattatttc
     1621 ttaaatttta gattttattg agtaccattt atatgattgt acaagcattc actctttact
     1681 agcatttttt gtttttcaga caagctgaag tggttttatt aagatttggt aatatttaaa
     1741 tagcaacctt ctctgccttt tttttttttt aatatagaat tttgaccatt ttgacttttt
     1801 aaatgcctgg catctttacc aaccaagtaa actggaagat ctgttactgg tagaacaggt
     1861 tgaggagaca gtaggaattt gtaaaaagtc atttgattta taatcaacac tacaaatact
     1921 atgtgttatt tataaaatca taaagaacac ttttgtcaga ctccaaaatt tgtatatact
     1981 tccaggccat aagagttgat agtattattt atgactttgt agattaagtt atttatgtat
     2041 gaaacaaagc aggaaaatat attgagaagg gatcgtgttt acagaggact tctttaaagt
     2101 gtcacatttt taaaatgtaa acatattttt aatgcatact taagtaatat ttaagaaact
     2161 aaacaaaata atgatacaat tgcagtgttg tgcttgttgt caatgacaaa aataaaacca
     2221 ttttggtggt a
//
