LOCUS       NM_198055               2666 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens myeloid zinc finger 1 (MZF1), transcript variant 2,
            mRNA.
ACCESSION   NM_198055
VERSION     NM_198055.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2666)
  AUTHORS   Jiang,J., Dong,W., Zhang,W., Wang,Q., Wang,R., Wang,J., Wu,H.,
            Dong,H., Zhao,R.C., Wang,J. and Li,Z.
  TITLE     LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant
            Progression of Hepatocellular Carcinoma
  JOURNAL   Discov Med 35 (179), 995-1014 (2023)
   PUBMED   38058065
  REMARK    GeneRIF: LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant
            Progression of Hepatocellular Carcinoma.
REFERENCE   2  (bases 1 to 2666)
  AUTHORS   Wu,D., Tan,H., Su,W., Cheng,D., Wang,G., Wang,J., Ma,D.A.,
            Dong,G.M. and Sun,P.
  TITLE     MZF1 mediates oncogene-induced senescence by promoting the
            transcription of p16INK4A
  JOURNAL   Oncogene 41 (3), 414-426 (2022)
   PUBMED   34773072
  REMARK    GeneRIF: MZF1 mediates oncogene-induced senescence by promoting the
            transcription of p16(INK4A).
            Erratum:[Oncogene. 2025 Feb;44(4):272-275. doi:
            10.1038/s41388-024-03229-4.. PMID: 39613935]
REFERENCE   3  (bases 1 to 2666)
  AUTHORS   Zhang,J., Chai,W., Xiang,Z., Zhou,X. and Zhang,P.
  TITLE     MZF1 alleviates oxidative stress and apoptosis induced by rotenone
            in SH-SY5Y cells by promoting RBM3 transcription
  JOURNAL   J Toxicol Sci 46 (10), 477-486 (2021)
   PUBMED   34602532
  REMARK    GeneRIF: MZF1 alleviates oxidative stress and apoptosis induced by
            rotenone in SH-SY5Y cells by promoting RBM3 transcription.
REFERENCE   4  (bases 1 to 2666)
  AUTHORS   Kruger,M., Metzger,C., Al-Nawas,B., Kammerer,P.W. and Brieger,J.
  TITLE     Cigarette smoke modulates binding of the transcription factor MZF1
            to the VEGF promoter and regulates VEGF expression in dependence of
            genetic variation SNP 405
  JOURNAL   J Oral Pathol Med 49 (8), 780-786 (2020)
   PUBMED   32449233
  REMARK    GeneRIF: Cigarette smoke modulates binding of the transcription
            factor MZF1 to the VEGF promoter and regulates VEGF expression in
            dependence of genetic variation SNP 405.
REFERENCE   5  (bases 1 to 2666)
  AUTHORS   Yue,C.H., Liu,J.Y., Chi,C.S., Hu,C.W., Tan,K.T., Huang,F.M.,
            Pan,Y.R., Lin,K.I. and Lee,C.J.
  TITLE     Myeloid Zinc Finger 1 (MZF1) Maintains the Mesenchymal Phenotype by
            Down-regulating IGF1R/p38 MAPK/ERalpha Signaling Pathway in
            High-level MZF1-expressing TNBC cells
  JOURNAL   Anticancer Res 39 (8), 4149-4164 (2019)
   PUBMED   31366500
  REMARK    GeneRIF: Exogenous expression of the acidic domain of MZF1
            repressed the binding of endogenous MZF1 to IGF1R promoter via
            blocking the interaction with ETS-like gene 1 (ELK1). This blockage
            not only caused MZF1 protein degradation, but also restrained ELK1
            nuclear localization in high-level MZF1-expressing TNBC cells.
            MZF1, but not ELK1, was necessary for the retention of mesenchymal
            phenotype by repressing IGF1R promoter activity
REFERENCE   6  (bases 1 to 2666)
  AUTHORS   Peterson,M.J. and Morris,J.F.
  TITLE     Human myeloid zinc finger gene MZF produces multiple transcripts
            and encodes a SCAN box protein
  JOURNAL   Gene 254 (1-2), 105-118 (2000)
   PUBMED   10974541
REFERENCE   7  (bases 1 to 2666)
  AUTHORS   Sander,T.L., Haas,A.L., Peterson,M.J. and Morris,J.F.
  TITLE     Identification of a novel SCAN box-related protein that interacts
            with MZF1B. The leucine-rich SCAN box mediates hetero- and
            homoprotein associations
  JOURNAL   J Biol Chem 275 (17), 12857-12867 (2000)
   PUBMED   10777584
REFERENCE   8  (bases 1 to 2666)
  AUTHORS   Morris,J.F., Rauscher,F.J. 3rd, Davis,B., Klemsz,M., Xu,D.,
            Tenen,D. and Hromas,R.
  TITLE     The myeloid zinc finger gene, MZF-1, regulates the CD34 promoter in
            vitro
  JOURNAL   Blood 86 (10), 3640-3647 (1995)
   PUBMED   7579328
REFERENCE   9  (bases 1 to 2666)
  AUTHORS   Bavisotto,L., Kaushansky,K., Lin,N. and Hromas,R.
  TITLE     Antisense oligonucleotides from the stage-specific myeloid zinc
            finger gene MZF-1 inhibit granulopoiesis in vitro
  JOURNAL   J Exp Med 174 (5), 1097-1101 (1991)
   PUBMED   1719120
REFERENCE   10 (bases 1 to 2666)
  AUTHORS   Hromas,R., Collins,S.J., Hickstein,D., Raskind,W., Deaven,L.L.,
            O'Hara,P., Hagen,F.S. and Kaushansky,K.
  TITLE     A retinoic acid-responsive human zinc finger gene, MZF-1,
            preferentially expressed in myeloid cells
  JOURNAL   J Biol Chem 266 (22), 14183-14187 (1991)
   PUBMED   1860835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF055078.1 and BC007777.2.
            
            On May 17, 2019 this sequence version replaced NM_198055.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.757480.1, AF055078.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215057.7/ ENSP00000215057.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-472               AF055078.1         241-712
            473-2666            BC007777.2         371-2564
FEATURES             Location/Qualifiers
     source          1..2666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..2666
                     /gene="MZF1"
                     /gene_synonym="MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6"
                     /note="myeloid zinc finger 1"
                     /db_xref="GeneID:7593"
                     /db_xref="HGNC:HGNC:13108"
                     /db_xref="MIM:194550"
     exon            1..281
                     /gene="MZF1"
                     /gene_synonym="MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6"
                     /inference="alignment:Splign:2.1.0"
     exon            282..717
                     /gene="MZF1"
                     /gene_synonym="MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..2526
                     /gene="MZF1"
                     /gene_synonym="MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6"
                     /note="isoform 1 is encoded by transcript variant 2; zinc
                     finger protein 42 (myeloid-specific retinoic
                     acid-responsive); zinc finger and SCAN domain-containing
                     protein 6"
                     /codon_start=1
                     /product="myeloid zinc finger 1 isoform 1"
                     /protein_id="NP_932172.1"
                     /db_xref="CCDS:CCDS12988.1"
                     /db_xref="GeneID:7593"
                     /db_xref="HGNC:HGNC:13108"
                     /db_xref="MIM:194550"
                     /translation="MRPAVLGSPDRAPPEDEGPVMVKLEDSEEEGEAALWDPGPEAAR
                     LRFRCFRYEEATGPQEALAQLRELCRQWLRPEVRSKEQMLELLVLEQFLGALPPEIQA
                     RVQGQRPGSPEEAAALVDGLRREPGGPRRWVTVQVQGQEVLSEKMEPSSFQPLPETEP
                     PTPEPGPKTPPRTMQESPLGLQVKEESEVTEDSDFLESGPLAATQESVPTLLPEEAQR
                     CGTVLDQIFPHSKTGPEGPSWREHPRALWHEEAGGIFSPGFALQLGSISAGPGSVSPH
                     LHVPWDLGMAGLSGQIQSPSREGGFAHALLLPSDLRSEQDPTDEDPCRGVGPALITTR
                     WRSPRGRSRGRPSTGGGVVRGGRCDVCGKVFSQRSNLLRHQKIHTGERPFVCSECGRS
                     FSRSSHLLRHQLTHTEERPFVCGDCGQGFVRSARLEEHRRVHTGEQPFRCAECGQSFR
                     QRSNLLQHQRIHGDPPGPGAKPPAPPGAPEPPGPFPCSECRESFARRAVLLEHQAVHT
                     GDKSFGCVECGERFGRRSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQHRRIHTGE
                     RPFACAECGKAFRQRPTLTQHLRVHTGEKPFACPECGQRFSQRLKLTRHQRTHTGEKP
                     YHCGECGLGFTQVSRLTEHQRIHTGERPFACPECGQSFRQHANLTQHRRIHTGERPYA
                     CPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQSTKLIQHQRVHSAE"
     exon            718..901
                     /gene="MZF1"
                     /gene_synonym="MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6"
                     /inference="alignment:Splign:2.1.0"
     exon            902..972
                     /gene="MZF1"
                     /gene_synonym="MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1093
                     /gene="MZF1"
                     /gene_synonym="MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..2666
                     /gene="MZF1"
                     /gene_synonym="MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2648..2653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MZF1"
                     /gene_synonym="MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6"
                     /note="hexamer: AATAAA"
     polyA_site      2666
                     /gene="MZF1"
                     /gene_synonym="MZF-1; MZF1B; ZFP98; ZNF42; ZSCAN6"
                     /note="major polyA site"
ORIGIN      
        1 aggcggtgct gccgtctgtt gtacctgaga ggcttgcgca tgccgacgca cggattcgag
       61 gcggggagca tgggaagaag cggccaggag tatgacctga tcattgcgac caccgctagg
      121 ggaagggagg agagggtgta gaaacgggga cgagggtggg ggaagggcaa ggaggcgctc
      181 gagctggtgc gcggagcatc ctgggagacg tagtccagcg ggagggggaa gtcgaagact
      241 gcgcgtgctc aggagcgcgg agcggcccgc tgagcgcaga ggggcagaca ctggcctcag
      301 atacctgacc tggtaccctc tatgaggcct gcggtgctgg gctccccaga ccgagcaccc
      361 ccagaagatg aggggcctgt catggtgaag ctagaggact ctgaggagga gggtgaggct
      421 gccttatggg acccaggccc tgaagctgca cgcctgcgtt tccggtgctt ccgctatgag
      481 gaggccacag ggccccaaga ggccctggcc cagctccgag agctgtgtcg ccagtggctg
      541 cgtccagagg tacgctccaa ggagcagatg ctggagctgt tggtgctgga gcagttcctg
      601 ggcgcactgc cccctgagat ccaggcccgt gtgcaggggc agcggccagg cagccccgag
      661 gaggctgctg ccctagtaga tgggctgcgc cgggagccgg gcggaccccg gagatgggtc
      721 acagtccagg tgcagggcca ggaggtccta tcagagaaga tggagccctc cagtttccag
      781 cccctacctg aaactgagcc tccaactcca gagcctgggc ccaagacacc tcctaggact
      841 atgcaggaat caccactggg cctgcaggtg aaagaggagt cagaggttac agaggactca
      901 gatttcctgg agtctgggcc tctagctgcc acccaggagt ctgtacccac cctcctgcct
      961 gaggaggccc agagatgtgg gaccgtgctg gaccagatct ttccccacag caagactggg
     1021 cctgagggtc cctcatggag ggagcacccc agggccctgt ggcatgagga agctgggggc
     1081 atcttctccc cagggttcgc gctgcagcta ggcagcatct ccgcaggtcc aggtagtgta
     1141 agccctcacc tccacgtccc ctgggacctc ggcatggctg gcctttctgg ccagatccaa
     1201 tcaccctccc gcgaaggtgg ctttgcgcat gcgcttctgc tccccagcga tctgaggagt
     1261 gaacaggacc ccacggacga ggatccctgc cggggtgtgg gccctgctct gatcaccacc
     1321 cgctggcgct cccccagggg ccggagccgg ggccgcccca gcactggggg cggggtggtt
     1381 aggggcggcc gttgcgatgt atgtggcaag gtgttcagcc aacgcagcaa cctgctgagg
     1441 caccagaaga tccacacggg tgagcgacca ttcgtgtgca gcgagtgcgg ccgcagcttc
     1501 agccgcagct cgcacctgct gcgccaccag cttacgcaca ccgaggagcg gccgttcgtg
     1561 tgcggcgact gtggccaggg cttcgtgcgc agcgcgcgcc tggaagagca tcggagagtg
     1621 cacacgggcg aacagccttt ccgttgcgct gagtgcggcc agagcttccg gcagcgctcc
     1681 aatctgctgc agcaccagcg catccacggc gatcccccgg gccctggcgc taagcccccg
     1741 gcccctcctg gtgcgcccga gcctcccggc ccctttccgt gcagcgagtg ccgcgagagc
     1801 ttcgcgcggc gcgccgtgct gctggagcac caggcggtac acacgggcga caagtccttt
     1861 ggctgcgtcg agtgcggcga gcgcttcggc cgccgctcag tgctgctgca gcaccggcgc
     1921 gtgcacagtg gcgagcggcc cttcgcctgt gccgagtgcg gccagagctt ccggcagcgc
     1981 tccaacctga cgcagcaccg gcgcatccac accggggagc ggcccttcgc ctgcgccgag
     2041 tgtggcaagg ccttccgcca gcggcctacg ctcacgcagc atctccgcgt acacacgggc
     2101 gagaaaccct ttgcctgccc cgagtgtggc cagcgcttca gccagcgcct caagctcacg
     2161 cgtcatcaga ggacacacac cggcgaaaag ccctaccact gcggtgagtg cggcctgggc
     2221 ttcacgcagg tctcgcggct caccgagcac cagcgcatcc acacgggcga acggcccttc
     2281 gcctgccccg agtgcggcca gagctttcgg cagcacgcca acctcaccca gcaccggcgc
     2341 atccacacgg gtgaacggcc ctacgcatgc cctgagtgtg gcaaggcctt ccgccagcgg
     2401 cccacgctca cgcagcatct gcgcacccac cgacgagaga agcccttcgc ctgccaggac
     2461 tgtggccgcc gcttccacca gagcaccaag ctcattcagc accagcgcgt ccacagcgcc
     2521 gagtagctcc agccgggacg cactgtgtcc gccatggtca gaacacctac ctcccctggt
     2581 tattgtgagg ctggcgatta cataagtata agcaggtccg cccagggctt ggctactgta
     2641 ggtgtccaat aaacagtaga tggaaa
//
