LOCUS       NM_016459                925 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens marginal zone B and B1 cell specific protein (MZB1),
            mRNA.
ACCESSION   NM_016459
VERSION     NM_016459.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 925)
  AUTHORS   Xu,M., Feng,Y., Xiang,X., Liu,L. and Tang,G.
  TITLE     MZB1 regulates cellular proliferation, mitochondrial dysfunction,
            and inflammation and targets the PI3K-Akt signaling pathway in
            acute pancreatitis
  JOURNAL   Cell Signal 118, 111143 (2024)
   PUBMED   38508349
  REMARK    GeneRIF: MZB1 regulates cellular proliferation, mitochondrial
            dysfunction, and inflammation and targets the PI3K-Akt signaling
            pathway in acute pancreatitis.
REFERENCE   2  (bases 1 to 925)
  AUTHORS   Huang,Y., Xu,Z., Holtappels,G., Shen,Y., Van Zele,T., Wen,W.,
            Zhang,L., Zhang,N. and Bachert,C.
  TITLE     MZB1-expressing cells are essential for local immunoglobulin
            production in chronic rhinosinusitis with nasal polyps
  JOURNAL   Ann Allergy Asthma Immunol 132 (2), 198-207 (2024)
   PUBMED   37852603
  REMARK    GeneRIF: MZB1-expressing cells are essential for local
            immunoglobulin production in chronic rhinosinusitis with nasal
            polyps.
REFERENCE   3  (bases 1 to 925)
  AUTHORS   Sunnetci-Akkoyunlu,D., Guzeldemir-Akcakanat,E., Alkan,B., Gurel,B.,
            Balta-Uysal,V.M., Akgun,E., Baykal,A.T. and Olgac,V.
  TITLE     Altered expression of MZB1 in periodontitis: A possible link to
            disease pathogenesis
  JOURNAL   J Periodontol 94 (11), 1285-1294 (2023)
   PUBMED   37332260
  REMARK    GeneRIF: Altered expression of MZB1 in periodontitis: A possible
            link to disease pathogenesis.
REFERENCE   4  (bases 1 to 925)
  AUTHORS   Li,D., Zhu,Y., Zhang,L., Shi,L., Deng,L., Ding,Z., Ai,R., Zhang,X.
            and He,Y.
  TITLE     MZB1 targeted by miR-185-5p inhibits the migration of human
            periodontal ligament cells through NF-kappaB signaling and promotes
            alveolar bone loss
  JOURNAL   J Periodontal Res 57 (4), 811-823 (2022)
   PUBMED   35653494
  REMARK    GeneRIF: MZB1 targeted by miR-185-5p inhibits the migration of
            human periodontal ligament cells through NF-kappaB signaling and
            promotes alveolar bone loss.
REFERENCE   5  (bases 1 to 925)
  AUTHORS   Sowa,S.T., Moilanen,A., Biterova,E., Saaranen,M.J., Lehtio,L. and
            Ruddock,L.W.
  TITLE     High-resolution Crystal Structure of Human pERp1, A Saposin-like
            Protein Involved in IgA, IgM and Integrin Maturation in the
            Endoplasmic Reticulum
  JOURNAL   J Mol Biol 433 (5), 166826 (2021)
   PUBMED   33453188
  REMARK    GeneRIF: High-resolution Crystal Structure of Human pERp1, A
            Saposin-like Protein Involved in IgA, IgM and Integrin Maturation
            in the Endoplasmic Reticulum.
REFERENCE   6  (bases 1 to 925)
  AUTHORS   Flach,H., Rosenbaum,M., Duchniewicz,M., Kim,S., Zhang,S.L.,
            Cahalan,M.D., Mittler,G. and Grosschedl,R.
  TITLE     Mzb1 protein regulates calcium homeostasis, antibody secretion, and
            integrin activation in innate-like B cells
  JOURNAL   Immunity 33 (5), 723-735 (2010)
   PUBMED   21093319
REFERENCE   7  (bases 1 to 925)
  AUTHORS   Shimizu,Y., Meunier,L. and Hendershot,L.M.
  TITLE     pERp1 is significantly up-regulated during plasma cell
            differentiation and contributes to the oxidative folding of
            immunoglobulin
  JOURNAL   Proc Natl Acad Sci U S A 106 (40), 17013-17018 (2009)
   PUBMED   19805157
REFERENCE   8  (bases 1 to 925)
  AUTHORS   van Anken,E., Pena,F., Hafkemeijer,N., Christis,C., Romijn,E.P.,
            Grauschopf,U., Oorschot,V.M., Pertel,T., Engels,S., Ora,A.,
            Lastun,V., Glockshuber,R., Klumperman,J., Heck,A.J., Luban,J. and
            Braakman,I.
  TITLE     Efficient IgM assembly and secretion require the plasma cell
            induced endoplasmic reticulum protein pERp1
  JOURNAL   Proc Natl Acad Sci U S A 106 (40), 17019-17024 (2009)
   PUBMED   19805154
REFERENCE   9  (bases 1 to 925)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     MGC29506 gene, frequently down-regulated in intestinal-type gastric
            cancer, encodes secreted-type protein with conserved cysteine
            residues
  JOURNAL   Int J Oncol 23 (1), 235-241 (2003)
   PUBMED   12792799
  REMARK    GeneRIF: MGC29506 gene, frequently down-regulated in
            intestinal-type gastric cancer, was found to encode secreted-type
            protein with six conserved cysteine residues [MGC29506]
REFERENCE   10 (bases 1 to 925)
  AUTHORS   Bonfoco,E., Li,E., Kolbinger,F. and Cooper,N.R.
  TITLE     Characterization of a novel proapoptotic caspase-2- and
            caspase-9-binding protein
  JOURNAL   J Biol Chem 276 (31), 29242-29250 (2001)
   PUBMED   11350957
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU601458.1, BC021275.2 and AC135457.2.
            
            On May 17, 2019 this sequence version replaced NM_016459.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.80593.1,
                                           DRR138524.460867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2155628
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302125.9/ ENSP00000303920.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BU601458.1         6-21
            17-824              BC021275.2         1-808
            825-925             AC135457.2         23809-23909         c
FEATURES             Location/Qualifiers
     source          1..925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..925
                     /gene="MZB1"
                     /gene_synonym="MEDA-7; PACAP; pERp1"
                     /note="marginal zone B and B1 cell specific protein"
                     /db_xref="GeneID:51237"
                     /db_xref="HGNC:HGNC:30125"
                     /db_xref="MIM:609447"
     exon            1..234
                     /gene="MZB1"
                     /gene_synonym="MEDA-7; PACAP; pERp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..627
                     /gene="MZB1"
                     /gene_synonym="MEDA-7; PACAP; pERp1"
                     /note="plasma cell-induced ER protein 1; proapoptotic
                     caspase adaptor protein; caspase-2 binding protein;
                     HSPC190; proapoptotic caspase adapter protein; plasma
                     cell-induced resident endoplasmic reticulum protein;
                     plasma cell-induced resident ER protein; mesenteric
                     oestrogen-dependent adipose gene- 7; mesenteric
                     estrogen-dependent adipose 7"
                     /codon_start=1
                     /product="marginal zone B- and B1-cell-specific protein
                     precursor"
                     /protein_id="NP_057543.2"
                     /db_xref="CCDS:CCDS47273.1"
                     /db_xref="GeneID:51237"
                     /db_xref="HGNC:HGNC:30125"
                     /db_xref="MIM:609447"
                     /translation="MRLSLPLLLLLLGAWAIPGGLGDRAPLTATAPQLDDEEMYSAHM
                     PAHLRCDACRAVAYQMWQNLAKAETKLHTSNSGGRRELSELVYTDVLDRSCSRNWQDY
                     GVREVDQVKRLTGPGLSEGPEPSISVMVTGGPWPTRLSRTCLHYLGEFGEDQIYEAHQ
                     QGRGALEALLCGGPQGACSEKVSATREEL"
     exon            235..359
                     /gene="MZB1"
                     /gene_synonym="MEDA-7; PACAP; pERp1"
                     /inference="alignment:Splign:2.1.0"
     exon            360..470
                     /gene="MZB1"
                     /gene_synonym="MEDA-7; PACAP; pERp1"
                     /inference="alignment:Splign:2.1.0"
     exon            471..925
                     /gene="MZB1"
                     /gene_synonym="MEDA-7; PACAP; pERp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      805..810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MZB1"
                     /gene_synonym="MEDA-7; PACAP; pERp1"
                     /note="hexamer: AATAAA"
     polyA_site      824
                     /gene="MZB1"
                     /gene_synonym="MEDA-7; PACAP; pERp1"
                     /note="major polyA site"
ORIGIN      
        1 acacacacat ctgcacctca accacagact acacttgctg aactggctcc tggggccatg
       61 aggctgtcac tgccactgct gctgctgctg ctgggagcct gggccatccc agggggcctc
      121 ggggacaggg cgccactcac agccacagcc ccacaactgg atgatgagga gatgtactca
      181 gcccacatgc ccgctcacct gcgctgtgat gcctgcagag ctgtggctta ccagatgtgg
      241 caaaatctgg caaaggcaga gaccaaactt catacctcaa actctggggg gcggcgggag
      301 ctgagcgagt tggtctacac ggatgtcctg gaccggagct gctcccggaa ctggcaggac
      361 tacggagttc gagaagtgga ccaagtgaaa cgtctcacag gcccaggact tagcgagggg
      421 ccagagccaa gcatcagcgt gatggtcaca gggggcccct ggcctaccag gctctccagg
      481 acatgtttgc actacttggg ggagtttgga gaagaccaga tctatgaagc ccaccaacaa
      541 ggccgagggg ctctggaggc attgctatgt gggggacccc agggggcctg ctcagagaag
      601 gtgtcagcca caagagaaga gctctagtcc tggactctac cctcctctga aagaagctgg
      661 ggcttgctct gacggtctcc actcccgtct gcaggcagcc aggagggcag gaagcccttg
      721 ctctgtgctg ccatcctgcc tccctcctcc agcctcaggg cactcgggcc tgggtgggag
      781 tcaacgcctt cccctctgga ctcaaataaa acccagtgac ctcacttctt ttctctgcaa
      841 aaggtgcttg tggggctggg agtgcagaca ttggtgtttc tgctgatgtc ccttgtgaaa
      901 aaaaaaaaaa aactctcaaa atcaa
//
