LOCUS       NM_001303052            7144 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens myelin transcription factor 1 like (MYT1L), transcript
            variant 1, mRNA.
ACCESSION   NM_001303052 XM_006711866
VERSION     NM_001303052.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7144)
  AUTHORS   Bouassida,M., Egloff,M., Levy,J., Chatron,N., Bernardini,L., Le
            Guyader,G., Tabet,A.C., Schluth-Bolard,C., Brancati,F.,
            Giuffrida,M.G., Dard,R., Clorennec,J., Coursimault,J., Vialard,F.
            and Herve,B.
  TITLE     2p25.3 microduplications involving MYT1L: further phenotypic
            characterization through an assessment of 16 new cases and a
            literature review
  JOURNAL   Eur J Hum Genet 31 (8), 895-904 (2023)
   PUBMED   37188826
  REMARK    GeneRIF: 2p25.3 microduplications involving MYT1L: further
            phenotypic characterization through an assessment of 16 new cases
            and a literature review.
            Review article
REFERENCE   2  (bases 1 to 7144)
  AUTHORS   Weigel,B., Tegethoff,J.F., Grieder,S.D., Lim,B., Nagarajan,B.,
            Liu,Y.C., Truberg,J., Papageorgiou,D., Adrian-Segarra,J.M.,
            Schmidt,L.K., Kaspar,J., Poisel,E., Heinzelmann,E., Saraswat,M.,
            Christ,M., Arnold,C., Ibarra,I.L., Campos,J., Krijgsveld,J.,
            Monyer,H., Zaugg,J.B., Acuna,C. and Mall,M.
  TITLE     MYT1L haploinsufficiency in human neurons and mice causes
            autism-associated phenotypes that can be reversed by genetic and
            pharmacologic intervention
  JOURNAL   Mol Psychiatry 28 (5), 2122-2135 (2023)
   PUBMED   36782060
  REMARK    GeneRIF: MYT1L haploinsufficiency in human neurons and mice causes
            autism-associated phenotypes that can be reversed by genetic and
            pharmacologic intervention.
REFERENCE   3  (bases 1 to 7144)
  AUTHORS   Coursimault,J., Guerrot,A.M., Morrow,M.M., Schramm,C., Zamora,F.M.,
            Shanmugham,A., Liu,S., Zou,F., Bilan,F., Le Guyader,G., Bruel,A.L.,
            Denomme-Pichon,A.S., Faivre,L., Tran Mau-Them,F., Tessarech,M.,
            Colin,E., El Chehadeh,S., Gerard,B., Schaefer,E., Cogne,B.,
            Isidor,B., Nizon,M., Doummar,D., Valence,S., Heron,D., Keren,B.,
            Mignot,C., Coutton,C., Devillard,F., Alaix,A.S., Amiel,J.,
            Colleaux,L., Munnich,A., Poirier,K., Rio,M., Rondeau,S., Barcia,G.,
            Callewaert,B., Dheedene,A., Kumps,C., Vergult,S., Menten,B.,
            Chung,W.K., Hernan,R., Larson,A., Nori,K., Stewart,S., Wheless,J.,
            Kresge,C., Pletcher,B.A., Caumes,R., Smol,T., Sigaudy,S.,
            Coubes,C., Helm,M., Smith,R., Morrison,J., Wheeler,P.G.,
            Kritzer,A., Jouret,G., Afenjar,A., Deleuze,J.F., Olaso,R.,
            Boland,A., Poitou,C., Frebourg,T., Houdayer,C., Saugier-Veber,P.,
            Nicolas,G. and Lecoquierre,F.
  TITLE     MYT1L-associated neurodevelopmental disorder: description of 40 new
            cases and literature review of clinical and molecular aspects
  JOURNAL   Hum Genet 141 (1), 65-80 (2022)
   PUBMED   34748075
  REMARK    GeneRIF: MYT1L-associated neurodevelopmental disorder: description
            of 40 new cases and literature review of clinical and molecular
            aspects.
REFERENCE   4  (bases 1 to 7144)
  AUTHORS   Tabolacci,E., Pomponi,M.G., Remondini,L., Pietrobono,R.,
            Orteschi,D., Nobile,V., Pucci,C., Musto,E., Pane,M., Mercuri,E.M.,
            Neri,G., Genuardi,M., Chiurazzi,P. and Zollino,M.
  TITLE     Co-Occurrence of Fragile X Syndrome with a Second Genetic
            Condition: Three Independent Cases of Double Diagnosis
  JOURNAL   Genes (Basel) 12 (12), 1909 (2021)
   PUBMED   34946857
  REMARK    GeneRIF: Co-Occurrence of Fragile X Syndrome with a Second Genetic
            Condition: Three Independent Cases of Double Diagnosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7144)
  AUTHORS   Hu,J., Ho,A.L., Yuan,L., Hu,B., Hua,S., Hwang,S.S., Zhang,J.,
            Hu,T., Zheng,H., Gan,B., Wu,G., Wang,Y.A., Chin,L. and DePinho,R.A.
  TITLE     From the Cover: Neutralization of terminal differentiation in
            gliomagenesis
  JOURNAL   Proc Natl Acad Sci U S A 110 (36), 14520-14527 (2013)
   PUBMED   23918370
  REMARK    GeneRIF: Data indicate that reintroduction of A2BP1 or Myt1L in
            glioblastoma multiforme (GBM) cell lines and glioma stem cells
            profoundly inhibited tumorigenesis.
REFERENCE   6  (bases 1 to 7144)
  AUTHORS   Pang,Z.P., Yang,N., Vierbuchen,T., Ostermeier,A., Fuentes,D.R.,
            Yang,T.Q., Citri,A., Sebastiano,V., Marro,S., Sudhof,T.C. and
            Wernig,M.
  TITLE     Induction of human neuronal cells by defined transcription factors
  JOURNAL   Nature 476 (7359), 220-223 (2011)
   PUBMED   21617644
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7144)
  AUTHORS   Wang,T., Zeng,Z., Li,T., Liu,J., Li,J., Li,Y., Zhao,Q., Wei,Z.,
            Wang,Y., Li,B., Feng,G., He,L. and Shi,Y.
  TITLE     Common SNPs in myelin transcription factor 1-like (MYT1L):
            association with major depressive disorder in the Chinese Han
            population
  JOURNAL   PLoS One 5 (10), e13662 (2010)
   PUBMED   21048971
  REMARK    GeneRIF: results indicate that MYT1L may be a potential risk gene
            for major depressive disorder in the Chinese Han population
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7144)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 7144)
  AUTHORS   Vrijenhoek,T., Buizer-Voskamp,J.E., van der Stelt,I., Strengman,E.,
            Sabatti,C., Geurts van Kessel,A., Brunner,H.G., Ophoff,R.A. and
            Veltman,J.A.
  CONSRTM   Genetic Risk and Outcome in Psychosis (GROUP) Consortium
  TITLE     Recurrent CNVs disrupt three candidate genes in schizophrenia
            patients
  JOURNAL   Am J Hum Genet 83 (4), 504-510 (2008)
   PUBMED   18940311
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 7144)
  AUTHORS   Kim,J.G., Armstrong,R.C., v Agoston,D., Robinsky,A., Wiese,C.,
            Nagle,J. and Hudson,L.D.
  TITLE     Myelin transcription factor 1 (Myt1) of the oligodendrocyte
            lineage, along with a closely related CCHC zinc finger, is
            expressed in developing neurons in the mammalian central nervous
            system
  JOURNAL   J Neurosci Res 50 (2), 272-290 (1997)
   PUBMED   9373037
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA248951.1, BC137272.1,
            AC011301.9, AF036943.1, BC150281.1 and BC042833.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001303052.1.
            
            Summary: This gene encodes a member of the zinc finger superfamily
            of transcription factors whose expression, thus far, has been found
            only in neuronal tissues. The encoded protein belongs to a novel
            class of cystein-cystein-histidine-cystein zinc finger proteins
            that function in the developing mammalian central nervous system.
            Forced expression of this gene in combination with the basic
            helix-loop-helix transcription factor NeuroD1 and the transcription
            factors POU class 3 homeobox 2 and achaete-scute family basic
            helix-loop-helix transcription factor 1 can convert fetal and
            postnatal human fibroblasts into induced neuronal cells, which are
            able to generate action potentials. Mutations in this gene have
            been associated with an autosomal dominant form of cognitive
            disability and with autism spectrum disorder. Alternative splicing
            results in multiple variants. [provided by RefSeq, Jul 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF036943.1, SRR1803616.47495.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000647738.2/ ENSP00000497479.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               DA248951.1         39-197
            160-1932            BC137272.1         1-1773
            1933-1933           AC011301.9         30007-30007         c
            1934-2306           BC137272.1         1775-2147
            2307-2312           AF036943.1         2240-2245
            2313-5015           BC137272.1         2148-4850
            5016-7137           BC150281.1         4833-6954
            7138-7144           BC042833.1         933-939
FEATURES             Location/Qualifiers
     source          1..7144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.3"
     gene            1..7144
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /note="myelin transcription factor 1 like"
                     /db_xref="GeneID:23040"
                     /db_xref="HGNC:HGNC:7623"
                     /db_xref="MIM:613084"
     exon            1..309
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            310..409
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            410..526
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            527..672
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            673..829
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             830..4390
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neural zinc finger transcription factor 1; myelin
                     transcription factor 1-like protein"
                     /codon_start=1
                     /product="myelin transcription factor 1-like protein
                     isoform 1"
                     /protein_id="NP_001289981.1"
                     /db_xref="CCDS:CCDS77378.1"
                     /db_xref="GeneID:23040"
                     /db_xref="HGNC:HGNC:7623"
                     /db_xref="MIM:613084"
                     /translation="MEVDTEEKRHRTRSKGVRVPVEPAIQELFSCPTPGCDGSGHVSG
                     KYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEK
                     EEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEE
                     EEEEEEENEDHQMNCHNTRIMQDTEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYR
                     ARTESEMNSNTSNSLEDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQGHGVVL
                     SENMNDRNYADSMSQQDSRNMNYVMLGKPMNNGLMEKMVEESDEEVCLSSLECLRNQC
                     FDLARKLSETNPQERNPQQNMNIRQHVRPEEDFPGRTPDRNYSDMLNLMRLEEQLSPR
                     SRVFASCAKEDGCHERDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMRE
                     KMAMEAGRRDNMRSYEDQSPRQLPGEDRKPKSSDSHVKKPYYGKDPSRTEKKESKCPT
                     PGCDGTGHVTGLYPHHRSLSGCPHKDRVPPEILAMHESVLKCPTPGCTGRGHVNSNRN
                     SHRSLSGCPIAAAEKLAKAQEKHQSCDVSKSSQASDRVLRPMCFVKQLEIPQYGYRNN
                     VPTTTPRSNLAKELEKYSKTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYC
                     KDPSPSSSSTSSYAPSSSSNLSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLS
                     TRCREMPQNLSTKPQDLCATRNPDMEVDENGTLDLSMNKQRPRDSCCPILTPLEPMSP
                     QQQAVMNNRCFQLGEGDCWDLPVDYTKMKPRRIDEDESKDITPEDLDPFQEALEERRY
                     PGEVTIPSPKPKYPQCKESKKDLITLSGCPLADKSIRSMLATSSQELKCPTPGCDGSG
                     HITGNYASHRSLSGCPRAKKSGIRIAQSKEDKEDQEPIRCPVPGCDGQGHITGKYASH
                     RSASGCPLAAKRQKDGYLNGSQFSWKSVKTEGMSCPTPGCDGSGHVSGSFLTHRSLSG
                     CPRATSAMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIK
                     LRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQSLIHSLANIQLPHMDPINEQ
                     NFDAYVTTLTEMYTNQDRYQSPENKALLENIKQAVRGIQV"
     exon            830..884
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            885..918
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            919..981
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1334
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..2312
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2447
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2538
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2646
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2647..2861
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..3112
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3113..3349
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3471
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3472..3540
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3541..3603
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3604..3687
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..3909
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            3910..4001
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            4002..4105
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            4106..4249
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     exon            4250..7144
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7101..7106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /note="hexamer: AATAAA"
     regulatory      7105..7110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /note="hexamer: AACAAG"
     polyA_site      7121
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
                     /note="major polyA site"
     polyA_site      7144
                     /gene="MYT1L"
                     /gene_synonym="MRD39; myT1-L; NZF1; ZC2H2C2; ZC2HC4B"
ORIGIN      
        1 cctaagctac tgcacactaa acagtgagag agcttttccc tgcagtcttg ttgaagcacc
       61 ccgggttttt tgctcattgt tggtgggtgc attttaattt tttcattccc tggactatgg
      121 gttatgatat ccatactcac tgaagacaaa aagccacctt ttctgcgtct tggtggcatg
      181 catgtgtctc atcatccttt caaacttgtg gtggaacagg gttttcttcc ctgtctgtgt
      241 attttgagcc agcacagtta ccaaaattga acttgtcttt cgcttgtgag cggttgtggt
      301 cattgtgagg gcgggtcatg aggaggctgt agccaaggac gaggtgtgtg cggctgttgc
      361 ctggacgttt gtccaatcca cgttgacatt tgagggatca cagcgtgtga aaatgaactc
      421 agaggagaat tggtgaattc ctatccagtg ggcatcttca aaccctggtc gacggcggaa
      481 gaatatcagg tcctgagatc acccacccgg cgcggcaaca gtgcagagtg gccacatctg
      541 gtggaagaag aaaaaaatgt agttattgaa ttcaatcaag tgtttgcatc tttcaagcta
      601 tcaacaaaat tccatcaaga aaggttccag ttggtctcac agacgtatgg atatccgagg
      661 agccacctaa agatggagaa atcaaggcat agagagatta agtgactttg ccacagtcac
      721 aagctggaga ggaccaggag tagagcttag agcgagcccc tgactctggg cctgcgtcct
      781 gccaggagtc acgctgcctc cgttcctagg agagaagact tcctgtaaga tggaggtgga
      841 caccgaggag aagcggcatc gcacgcggtc caaaggggtt cgagttcccg tggaaccagc
      901 catacaagag ctgttcagct gtcccacccc tggctgtgac ggcagtggtc atgtcagtgg
      961 caaatatgca agacacagaa gtgtatatgg ttgtcccttg gcgaaaaaaa gaaaaacaca
     1021 agataaacag ccccaggaac ctgctcctaa acgaaagcca tttgccgtga aagcagacag
     1081 ctcctcagtg gatgagtgtg acgacagtga tgggactgag gacatggatg agaaggagga
     1141 ggatgagggg gaggagtact ccgaggacaa tgatgagcca ggggatgagg acgaggagga
     1201 cgaggagggg gaccgggagg aggaggagga gatcgaggag gaggatgagg acgatgacga
     1261 ggatggagaa gatgtggagg atgaagaaga ggaagaggag gaggaggagg aggaggaaga
     1321 ggaagaagaa aacgaagacc atcaaatgaa ttgtcacaat actcgaataa tgcaagacac
     1381 agaaaaggat gataacaata atgacgaata tgacaattac gatgaactgg tggccaagtc
     1441 attgttaaac ctcggcaaaa tcgctgagga tgcagcctac cgggccagga ctgagtcaga
     1501 aatgaacagc aatacctcca atagtctgga agacgatagt gacaaaaacg aaaacctggg
     1561 tcggaaaagt gagttgagtt tagacttaga cagtgatgtt gttagagaaa cagtggactc
     1621 ccttaaacta ttagcccaag gacacggtgt tgtgctctca gaaaacatga atgacagaaa
     1681 ttatgcagac agcatgtcgc agcaagacag tagaaatatg aattacgtca tgttggggaa
     1741 gcccatgaac aacggactca tggaaaagat ggtggaggag agcgatgagg aggtgtgtct
     1801 gagcagtctg gagtgtttga ggaatcagtg cttcgacctg gccaggaagc tcagtgagac
     1861 caacccgcag gagaggaatc cgcagcagaa catgaacatc cgtcagcatg tccggccaga
     1921 agaggacttc cccggaagga cgccggacag aaactactcg gacatgctga acctcatgcg
     1981 gctggaggag cagttgagcc cccggtcgag agtgtttgcc agctgtgcga aggaggatgg
     2041 gtgtcatgag cgggacgacg ataccacctc tgtgaactcg gacaggtctg aagaggtgtt
     2101 cgacatgacc aaggggaacc tgaccctgct ggagaaagcc atcgctttgg aaacggaaag
     2161 agcaaaggcc atgagggaga agatggccat ggaagctggg aggagggaca atatgaggtc
     2221 atatgaggac cagtctccga gacaacttcc cggggaggac agaaagccta aatccagtga
     2281 cagccatgtc aaaaagccat actatggtaa agatccctca agaacagaaa agaaagagag
     2341 caagtgtcca acccccgggt gtgatggaac cggccacgta actgggctgt acccacatca
     2401 ccgcagcctg tccggatgcc cgcacaaaga tagggtccct ccagaaatcc ttgccatgca
     2461 tgaaagtgtc ctcaagtgcc ccactccggg ctgcacgggg cgcgggcatg tcaacagcaa
     2521 caggaactcc caccgaagcc tctccggatg cccgatcgct gcagcagaga aactggccaa
     2581 ggcacaggaa aagcaccaga gctgcgacgt gtccaagtcc agccaggcct cggaccgcgt
     2641 gctcaggcca atgtgctttg tgaagcagct ggagattcct cagtatggct acagaaacaa
     2701 tgtccccaca actacgccgc gttccaacct ggccaaggag ctcgagaaat attccaagac
     2761 ctcgtttgaa tacaacagtt acgacaacca tacttatggc aagcgagcca tagctcccaa
     2821 ggtgcaaacc agggatatat cccccaaagg atatgatgat gcgaagcggt actgcaagga
     2881 ccccagcccc agcagcagca gcaccagcag ctacgcgccc agcagcagca gcaacctgag
     2941 ctgcggcggg ggcagcagcg ccagcagcac gtgcagcaag agcagcttcg actacacgca
     3001 cgacatggag gcggcccaca tggcggccac cgccatcctc aacctgtcca cgcgctgccg
     3061 cgagatgccg cagaacctga gcaccaagcc gcaggacctg tgcgccacgc ggaaccctga
     3121 catggaggtg gatgagaacg ggaccctgga cctcagcatg aacaagcaga ggccgcggga
     3181 cagctgctgc cccatcctga cccctctgga gcccatgtcc ccccagcagc aggcagtgat
     3241 gaacaaccgg tgtttccagc tgggcgaggg cgactgctgg gacttgcccg tagactacac
     3301 caaaatgaaa ccccggagga tagacgagga cgagtccaaa gacattactc cagaagactt
     3361 ggacccattc caggaggctc tagaagaaag acggtatccc ggggaggtga ccatcccaag
     3421 tcccaaaccc aagtaccctc agtgcaagga gagcaaaaag gacttaataa ctctgtctgg
     3481 ctgccccctg gcggacaaaa gcattcgaag tatgctggcc accagctccc aagaactcaa
     3541 gtgccccacg cctggctgtg atggttctgg acatatcacc ggcaattatg cttctcatcg
     3601 gagcctttca ggttgcccaa gagcaaagaa aagtggtatc aggatagcac agagcaaaga
     3661 agataaagaa gatcaagaac ccatcaggtg tccggtcccc gggtgcgacg gccagggcca
     3721 catcactggg aagtacgcgt cccatcgcag cgcctccggg tgccccttgg cggccaagag
     3781 gcagaaagac gggtacctga atggctccca gttctcctgg aagtcggtca agacggaagg
     3841 catgtcctgc cccacgccag gatgcgacgg ctcaggccac gtcagcggca gcttcctcac
     3901 acaccgcagc ttgtcaggat gcccgagagc cacgtcagcg atgaagaagg caaagctttc
     3961 tggagagcag atgctgacca tcaaacagcg ggccagcaac ggtatagaaa atgatgaaga
     4021 aatcaaacag ttagatgaag aaatcaagga gctaaatgaa tccaattccc agatggaagc
     4081 cgatatgatt aaactcagaa ctcagattac cacgatggag agcaacctga agaccatcga
     4141 agaggagaac aaagtgattg agcagcagaa cgagtctctc ctccacgagc tggcgaacct
     4201 gagccagtct ctgatccaca gcctggctaa catccagctg ccgcacatgg atccaatcaa
     4261 tgaacaaaat tttgatgctt acgtgactac tttgacggaa atgtatacaa atcaagatcg
     4321 ttatcagagt ccagaaaata aagccctact ggaaaatata aagcaggctg tgagaggaat
     4381 tcaggtctga acagctgctg tagtgatgaa actcttgctt aaaaaggatg cctcttgttt
     4441 tttgctgctg taacttacca gaaagtgttc tatatttatt tctgtttgaa tttgaaacag
     4501 tgttatgctt acaagacttc ataatgattt tatgtcttgc tttaaagata gtacctgcag
     4561 aatagttttt gaatacaccc acattttgta cgtttccatg taagctgaca tagtgttctg
     4621 ccatgtaatg tttatagctg ctgatgtatg cacatttggg ggtatatcta tttctgaaga
     4681 ggtaagctga tcaaaataaa tagagtgtaa attcttttta atgctttagt gattaaatgt
     4741 tttagtattt tgaactgaaa tggacacaca aacacacaca cgcacacaca gacccacagc
     4801 tttgaatgat catgttgtgg ctgagcagcc gctttttaga cgttatcatt ttgcctcatg
     4861 ttggaggact ttatggaatt taagaaatac attttgtgtg catattgttt catagcaaga
     4921 attcgttgca aaaatgcttt atttttgaac aatgcttgga aatattatgt gacttttttg
     4981 tttgtttgtt ttaggaggat ggtgtatggt gggggcaata aatgaggttt tttgcattcc
     5041 aaggaaatgg catatggatt aactgtaaga aatgaaataa gtaatttatt gtaagacaac
     5101 atcaagccat ggaaacttgg cagaagattc aaagcagctt aaacagcact tttaaattaa
     5161 ctcctaagcg ttacatggtt gtgactatgg aaactccagt taagacagga tcttatcaga
     5221 ggtggacaac gtgaagattt ccttttccat tttcaataaa ctttggaaca accttctcgt
     5281 atctccccta gagtttcgtg cccctctgaa ctgtctgtta ttgcaatgta gtttatcaac
     5341 agaatttgtg tgttttcgat ttaagctaaa agataattta agaacattta tttccccttt
     5401 tcactttaaa aaattatgat tattcctatt attgttatga accttcttat tttacatttg
     5461 agggataaag gcaaatgatt tgtgagtctt ctagttactg gaccgagttt tctgctggat
     5521 ctggtgggaa ggcagctcgg taaagtttcc ctcctgctcc ccccgcccga ctttgactct
     5581 gaatcagcat ttggtcctat tcagaggact cttaccacga cgtttctgtt ctacacttgg
     5641 gtggagacca gttgaccata gagcatttgc agagcctcat tgtttgattt cttgtgacta
     5701 ttctaagaat gaatgcaatc agattttaaa agtaactaaa tatacttcag cacttttttg
     5761 ctttaaacta gatcatctta gacttgttta taccttccag atttgattgt tttactccca
     5821 atgactgcac tatatgtatg cataagacca cttttgagcg ctgtgttccc ccttctgagt
     5881 agtcctttga cgacgtgttg tgttttctga tgttgacttg agttccattt agtagcatct
     5941 cttccttcca tgtcttgatg ttatgcagga agtacagacg tactttaaat ttttgttatg
     6001 aaataaaaaa aagatgggtt ttgtaaaaat aaaaaaaaaa tatttttagc agaacaggac
     6061 ttacagggtc attgtcccca caatgtgcca gtcgactatt tgcacttacc ttgtcctata
     6121 tatccgtacg gaggtgtgca attcctcgtg tcagtagcct tgtgacactg aacctggatg
     6181 gattatagag gagccctcac ggctgatcaa taatgttgca aagggagact acagggatct
     6241 cacgacgaat attctgatac aatactcaac ctcggtatat atatatgtgt ataaatatat
     6301 gtatatccca gcggcacttt atactgttca ctgtacaaaa gcttacagtt ttccacaagg
     6361 actttaataa ctagctggga aaagacgatg taattatttc ggggctctgc ggaaccttct
     6421 ctgtacagcg ccccctttct gttgtgctat tggttgcagc tgccatgctc agaatgcgtt
     6481 ttgagagctg aagcaaggtg cttgcagtca cctgaggccg tccgtgtggc ccagggcccc
     6541 agctgccttt agggccccca ttgttcataa cagcatatgc atttccccac cgcgttgtgt
     6601 ctgcagcttc tttgccaata tagtaatgct tttagtagag tactagatag tatcagtttt
     6661 ggattcttat tgttatcacc tatgtacaat ggaaagggat tttaagcaca aacctgctgc
     6721 tcatctaacg ttggtacata atctcaaatc aaaagttatc tgtgactatt atatagggat
     6781 cacaaaagtg tcacatatta gaatgctgac ctttcatatg gattattgtg agtcatcaga
     6841 gtttattata acttattgtt catattcatt tctaagttaa tttaagtaat catttattaa
     6901 gacagaattt tgtataaact atttattgtg ctctctgtgg aactgaagtt tgatttattt
     6961 ttgtactaca cggcatgggt ttgttgacac tttaattttg ctataaatgt gtggaatcac
     7021 aagttgctgt gatacttcat ttttaaattg tgaactttgt acaaattttg tcatgctgga
     7081 tgttaacaca tcttactcta aataaacaag gtgttgccac atttgtagca cgaaggatct
     7141 ctaa
//
