LOCUS       NM_004535               5557 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens myelin transcription factor 1 (MYT1), mRNA.
ACCESSION   NM_004535
VERSION     NM_004535.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5557)
  AUTHORS   Ghanbarirad,M., Hashemi,M., Saberi,S.M. and Majd,A.
  TITLE     Dysregulation of Myt1 expression acts as a potential peripheral
            biomarker for major depressive disorder and bipolar disorder
  JOURNAL   J Neurogenet 35 (4), 381-386 (2021)
   PUBMED   34011236
  REMARK    GeneRIF: Dysregulation of Myt1 expression acts as a potential
            peripheral biomarker for major depressive disorder and bipolar
            disorder.
REFERENCE   2  (bases 1 to 5557)
  AUTHORS   Zamariolli,M., Burssed,B., Moyses-Oliveira,M., Colovati,M.,
            Bellucco,F.T.D.S., Dos Santos,L.C., Alvarez Perez,A.B.,
            Bragagnolo,S. and Melaragno,M.I.
  TITLE     Novel MYT1 variants expose the complexity of
            oculo-auriculo-vertebral spectrum genetic mechanisms
  JOURNAL   Am J Med Genet A 185 (7), 2056-2064 (2021)
   PUBMED   33880880
  REMARK    GeneRIF: Novel MYT1 variants expose the complexity of
            oculo-auriculo-vertebral spectrum genetic mechanisms.
REFERENCE   3  (bases 1 to 5557)
  AUTHORS   Luquetti,D.V., Heike,C.L., Zarante,I., Timms,A.E., Gustafson,J.,
            Pachajoa,H., Porras-Hurtado,G.L., Ayala-Ramirez,P.,
            Duenas-Roque,M.M., Jimenez,N., Ibanez,L.M. and Hurtado-Villa,P.
  TITLE     MYT1 role in the microtia-craniofacial microsomia spectrum
  JOURNAL   Mol Genet Genomic Med 8 (10), e1401 (2020)
   PUBMED   32871052
  REMARK    GeneRIF: MYT1 role in the microtia-craniofacial microsomia
            spectrum.
REFERENCE   4  (bases 1 to 5557)
  AUTHORS   Chen,K., Cai,Y., Cheng,C., Zhang,J., Lv,F., Xu,G., Duan,P., Wu,Y.
            and Wu,Z.
  TITLE     MYT1 attenuates neuroblastoma cell differentiation by interacting
            with the LSD1/CoREST complex
  JOURNAL   Oncogene 39 (21), 4212-4226 (2020)
   PUBMED   32251364
  REMARK    GeneRIF: MYT1 attenuates neuroblastoma cell differentiation by
            interacting with the LSD1/CoREST complex.
REFERENCE   5  (bases 1 to 5557)
  AUTHORS   Pandya,P., Pasvolsky,R., Babichev,Y., Braiman,A., Witte,S.,
            Altman,A. and Isakov,N.
  TITLE     PICOT binding to the polycomb group protein, EED, alters H3K27
            methylation at the MYT1 PRC2 target gene
  JOURNAL   Biochem Biophys Res Commun 509 (2), 469-475 (2019)
   PUBMED   30595380
  REMARK    GeneRIF: PICOT knock-down in Jurkat T cells resulted in a reduced
            histone H3 lysine 27 trimethylation (H3K27me3) at the PRC2 target
            gene, myelin transcription factor 1 (MYT1), suggesting that PICOT
            binding to EED alters PRC2-regulated transcriptional repression,
            and potentially contributes to the epigenetic regulation of
            chromatin silencing and remodeling.
REFERENCE   6  (bases 1 to 5557)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   7  (bases 1 to 5557)
  AUTHORS   Kim,J.G., Armstrong,R.C., v Agoston,D., Robinsky,A., Wiese,C.,
            Nagle,J. and Hudson,L.D.
  TITLE     Myelin transcription factor 1 (Myt1) of the oligodendrocyte
            lineage, along with a closely related CCHC zinc finger, is
            expressed in developing neurons in the mammalian central nervous
            system
  JOURNAL   J Neurosci Res 50 (2), 272-290 (1997)
   PUBMED   9373037
REFERENCE   8  (bases 1 to 5557)
  AUTHORS   Armstrong,R.C., Kim,J.G. and Hudson,L.D.
  TITLE     Expression of myelin transcription factor I (MyTI), a 'zinc-finger'
            DNA-binding protein, in developing oligodendrocytes
  JOURNAL   Glia 14 (4), 303-321 (1995)
   PUBMED   8530187
REFERENCE   9  (bases 1 to 5557)
  AUTHORS   Gogate,N., Verma,L., Zhou,J.M., Milward,E., Rusten,R., O'Connor,M.,
            Kufta,C., Kim,J., Hudson,L. and Dubois-Dalcq,M.
  TITLE     Plasticity in the adult human oligodendrocyte lineage
  JOURNAL   J Neurosci 14 (8), 4571-4587 (1994)
   PUBMED   7519254
REFERENCE   10 (bases 1 to 5557)
  AUTHORS   Kim,J.G. and Hudson,L.D.
  TITLE     Novel member of the zinc finger superfamily: A C2-HC finger that
            recognizes a glia-specific gene
  JOURNAL   Mol Cell Biol 12 (12), 5632-5639 (1992)
   PUBMED   1280325
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121581.41, AB020642.1 and
            BC053638.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004535.2.
            
            Summary: The protein encoded by this gene is a member of a family
            of neural specific, zinc finger-containing DNA-binding proteins.
            The protein binds to the promoter regions of proteolipid proteins
            of the central nervous system and plays a role in the developing
            nervous system. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB020642.1, SRR1660807.200069.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMEA2162841
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328439.6/ ENSP00000327465.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL121581.41        69498-69519
            23-3902             AB020642.1         1-3880
            3903-5557           BC053638.1         2693-4347
FEATURES             Location/Qualifiers
     source          1..5557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..5557
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /note="myelin transcription factor 1"
                     /db_xref="GeneID:4661"
                     /db_xref="HGNC:HGNC:7622"
                     /db_xref="MIM:600379"
     exon            1..288
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            289..386
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..3752
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /note="proteolipid protein binding protein; myelin
                     transcription factor I; neural zinc finger transcription
                     factor 2"
                     /codon_start=1
                     /product="myelin transcription factor 1"
                     /protein_id="NP_004526.1"
                     /db_xref="CCDS:CCDS13558.1"
                     /db_xref="GeneID:4661"
                     /db_xref="HGNC:HGNC:7622"
                     /db_xref="MIM:600379"
                     /translation="MSLENEDKRARTRSKALRGPPETTAADLSCPTPGCTGSGHVRGK
                     YSRHRSLQSCPLAKKRKLEGAEAEHLVSKRKSHPLKLALDEGYGVDSDGSEDTEVKDA
                     SVSDESEGTLEGAEAETSGQDEIHRPETAEGRSPVKSHFGSNPIGSATASSKGSYSSY
                     QGIIATSLLNLGQIAEETLVEEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQP
                     EDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEE
                     EEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESP
                     SPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDESEMQDMMTRGNLGLLEQAIALKAEQV
                     RTVCEPGCPPAEQSQLGLGEPGKAAKPLDTVRKSYYSKDPSRAEKREIKCPTPGCDGT
                     GHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLS
                     GCPIAAAEKLAKSHEKQQPQTGDPSKSSSNSDRILRPMCFVKQLEVPPYGSYRPNVAP
                     ATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSQDAE
                     AAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVDIEVDENGTLDLSMHKHRKRENA
                     FPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRL
                     REEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELL
                     TCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHIT
                     GNYASHRSLSGCPRAKKSGVKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSA
                     SGCPLAARRQKEGSLNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPR
                     ATFAGKKGKLSGDEVLSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQS
                     QISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFD
                     AYVSTLTDMYSNQDPENKDLLESIKQAVRGIQV"
     exon            387..441
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            442..472
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            473..535
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            536..783
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            784..1677
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1812
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1903
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2017
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2232
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2357
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2627
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2782
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..2845
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2846..2914
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2915..2977
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3061
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3283
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3375
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3479
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3480..3623
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..5557
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5533..5538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /note="hexamer: AATAAA"
     polyA_site      5557
                     /gene="MYT1"
                     /gene_synonym="C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2H2C1;
                     ZC2HC4A"
                     /note="major polyA site"
ORIGIN      
        1 agcgtattta caaaggagcc tcctccgcca gcccgtgcca ccgctgctaa tgagagcagt
       61 cattaagtaa atgagacgtc gcctttagct ggcttaggag ttcgcacact aaggggagaa
      121 gatatttaat tgaaacccgc acgcaggctt ccccacatgt gaccgctgta cgggaggcag
      181 ctgccttccc tctcctcccc cagtccaccc tgcacccccc atgtaaattt catgattgct
      241 ttccgtgatg tcattttgaa agaggacaga caatagctgt ggggaaagaa aatgagttcc
      301 gaggtgagct gttaaatcag aggtggacac acggaggcaa ggccagcagc tgcaggacct
      361 caagacacct gggcagacac tgcaagatga gcttagaaaa tgaagacaag cgagctcgca
      421 cccgatccaa ggccctgcga ggacccccag agaccacagc tgcagacctc agctgcccca
      481 ccccaggatg cacaggctca gggcacgtcc ggggcaagta ctccaggcac cgaagtttac
      541 agagctgccc cctggccaag aagaggaagc tggagggcgc tgaggctgag cacctggtgt
      601 ccaagaggaa gtcacacccc ctgaagctgg ctctggacga gggctatggt gtggacagcg
      661 acggcagtga ggacactgag gtgaaggacg cctctgtttc ggatgaatcg gaaggaactc
      721 tggagggggc cgaggctgag acgtcaggac aggacgagat tcatcgcccc gagacagctg
      781 aaggaaggag ccccgtcaag tcccattttg gatccaaccc catcggcagc gccactgcct
      841 cctccaaggg cagctacagc agctaccagg gaatcatcgc aacttctctc ctgaacttgg
      901 gtcaaattgc tgaagagacc ctggtggaag aggacttggg ccaggcggcc aagccaggtc
      961 ctggcattgt gcacctgctt caggaggctg cagagggagc tgccagcgag gagggtgaaa
     1021 agggcctctt catccagcca gaggatgccg aggaggtcgt cgaagtcacc accgagcgct
     1081 cccaggacct gtgtccccag tccctggagg atgcagccag tgaggagtcc agcaagcaga
     1141 aaggcatcct gagtcacgaa gaggaggacg aggaggagga ggaggaggaa gaggaggagg
     1201 aggaggatga agaagaggaa gaggaagagg aggaggaaga ggaagaggag gaggaggaag
     1261 aggaagagga ggaggaagag gaagaggaag aggaggagga ggaggcagct cctgatgtga
     1321 tctttcagga agacacctct cacacctctg cccagaaggc ccctgagctc cggggcccag
     1381 aatcacccag tcccaagcct gagtactctg ttattgtgga ggtccgctcg gatgatgaca
     1441 aggacgagga cacccactcc cggaagtcaa cagtcactga cgagtcggag atgcaggaca
     1501 tgatgacccg gggaaacctg ggcctcctgg agcaggccat cgccctgaag gctgaacagg
     1561 tgcgcacagt ctgcgagccg ggctgcccgc ctgccgagca gagccagctg ggcctgggag
     1621 agccagggaa ggcagcaaag cccctggaca ctgtgcggaa gagttactac agtaaagatc
     1681 cttcaagagc tgagaagcgt gagatcaagt gtccaacacc aggctgtgat ggcactggcc
     1741 acgttaccgg gttgtaccct caccaccgca gcctttctgg ctgtccccac aaggatagga
     1801 tccccccaga gatcttagcc atgcatgaga acgtgctgaa gtgccccact cctggctgca
     1861 caggccaggg tcacgtgaac agcaaccgca acacgcacag aagtttgtct gggtgtccca
     1921 ttgctgccgc cgaaaaatta gccaaatccc atgagaagca gcagccgcag acaggagatc
     1981 cttccaagag tagctccaat tccgatcgga tcctcaggcc catgtgcttc gtgaagcagc
     2041 tcgaggtccc tccatatggg agctaccggc ccaacgtggc ccccgccaca cccagggcca
     2101 acttggccaa ggagctggag aagttctcca aggtcacctt tgactacgca agtttcgatg
     2161 ctcaggtttt tggcaaacgc atgcttgccc caaagattca gaccagcgaa acctcaccta
     2221 aagcctttca atgctttgac tactcgcagg acgccgaggc tgcacacatg gctgccactg
     2281 ccatcctgaa cctctccacg cgctgctggg agatgcctga gaacctcagc acgaagccac
     2341 aggacctccc cagcaagtct gtggatatcg aggtagacga aaatggaacc ctggacttga
     2401 gcatgcacaa acaccgcaaa cgagaaaatg ctttccccag cagcagcagc tgcagcagca
     2461 gccccggtgt gaagtctccc gacgcctccc agcgccacag cagcaccagc gcccccagca
     2521 gctccatgac ctctccccag tccagccagg cctcccgcca ggacgagtgg gaccggcccc
     2581 tggactacac caagcctagc cgcctgagag aggaggaacc tgaggagtca gagccagcag
     2641 cccattcttt tgcttcttct gaagcagatg accaggaagt gtcggaagag aattttgagg
     2701 agcggaagta tccgggggaa gtcaccctga ccaactttaa gctgaagttt ctctccaagg
     2761 acataaagaa ggagctgctc acctgtccca cccctggctg tgacggcagc ggccacatca
     2821 ccgggaacta cgcctcccac cgcagcctct ctggttgccc tcttgctgac aagagcctca
     2881 gaaacctcat ggctgcccac tctgctgacc tcaagtgccc cacgcccggc tgtgacggct
     2941 ctggccacat cacagggaac tacgcttcac accggagctt gtccggctgc cctcgtgcaa
     3001 agaaaagtgg agtcaaggtg gcacccacca aggacgacaa ggaggacccc gagctgatga
     3061 agtgcccagt tccaggctgt gtggggctcg gtcacatcag cgggaaatac gcctctcaca
     3121 ggagcgcatc cggctgccca ctggccgccc gcaggcagaa ggaagggtcc ctcaatggct
     3181 cgtcattctc ctggaagtcc ctgaagaatg aaggaccgac ctgccccacc ccgggctgtg
     3241 acggctctgg ccacgccaat gggagtttcc tcacccaccg gagtttgtca ggctgtccca
     3301 gagcaacctt tgctggaaag aagggaaaac tgtcagggga tgaggtcctc agtccaaagt
     3361 tcaagactag cgacgtgttg gagaatgatg aggagatcaa gcagctgaac caggagatcc
     3421 gagacctgaa cgagtccaac tcggagatgg aggctgccat ggtgcagctg cagtcccaga
     3481 tctcctccat ggagaagaac ctgaagaaca tcgaggagga gaacaagctc attgaggagc
     3541 agaatgaagc cctgtttctg gagctgtccg gcctgagcca ggccctcatc caaagtctcg
     3601 ccaatatccg ccttccgcac atggagccaa tatgcgaaca gaatttcgat gcctatgtga
     3661 gcaccctcac cgacatgtac tccaaccagg acccggagaa caaggacctc ctggagagca
     3721 tcaagcaggc tgtgaggggc atccaggtct aggccgtgtg gtacccagaa gtgtcccagc
     3781 ccaccacacc gtttacctcc ctcgccctgc cccgcaccgt ggggatgccc aactcacagt
     3841 gacttcccgt ttggggcccg gtgtggccgc gggcgggttt atccaaaggg atggctggaa
     3901 attggccgct cccacgaggc tccctccagg cttggggccg tggtggccct atctgtgtgc
     3961 ataggggcac tgaagaatta caaagtgatt tatttttgtt ttctgaaaga aatctgaaga
     4021 gcagctcaaa gtctccagtg gaagctcatg gacaaggttc tcagggaagt tttggagttt
     4081 gcaaccacag tattcctttg tctgtcgagg ctgggagggt agccgtgagc gtggtgggtg
     4141 ggtggtgtga gtggcatctt ggcctggagg acacgcctgg ggcagcgtgt ctgtgctcag
     4201 tgagggccga tgaagaaagt gcgttttctg ttttcattta attcagtttt gtgttaaggg
     4261 tggaacaaag ctctgttcta gagggaaagt taggaatagg cctcccagag gatactccag
     4321 acagttgaca agcatcgcag cccctgtcag gtcaaggaat tttaacctgg gagactcctg
     4381 aaaatcagcc taatgtctgg gggcagctgg cgctgaggct gtgcagatgt gtatggcctt
     4441 gggtcacagc tccctactgg ggctgcagcc tttagaccct gggtctggga tccacgtcta
     4501 gggaccactc tggcttctgt gcatccaccc aggcccccga cccatcactg ccacattctc
     4561 cgggtcatgg ccgagcttga cctctgcatc catggtgacg gaggtggcaa tgacatcatc
     4621 aaggtcagag ggtaaattcc taacaggaga ccacaaaggt ttcacttctt ttagatccat
     4681 ccaatatgcg aaaaaagggt acattttaat ttaatgtgtt aaaaacacaa tgtccctacc
     4741 gtgtaaatag aatccaagtc aattgtgact gcaattccaa gttagtattt aaaaatagag
     4801 aaattgcact tcctggaaaa aattaaaaag tagttagttt aattattctg taaattattt
     4861 aattttgtca agatgtaagt atttatattc acagcctctt atgttaacgt ttgctattta
     4921 tttaacattt ttatttatta attttatact atttcaacta gaccccacac cagggcaccc
     4981 taagagggga aaaaagtgaa ttcaaagcaa aaataactat ttgactataa tataggccac
     5041 aaaaaatctt gatataactc ctagttataa ttttgatgca accaagttat tttttatata
     5101 ttttgttatt tattctttta ataatggaat ttttttaaaa agtattttgt aactgaggaa
     5161 ttttgataat ttggggattt tgttttccct tggtctaatg gagagaaaga cattttggtt
     5221 ttctttttcc attttgggtt ccttttgttt caggcacgga taacagcaaa tggaattctg
     5281 tatttattat tatttaagtg tagcgcagat gtgtgtgctt gggcgtgttt ctcgtgtcgc
     5341 gtttgcgtgt cggctcttgc ggtggagtcc tgttgctgtg agggagtgct ggccgcaggc
     5401 agcctcgagt caccgccagg ctcacaggct gtgccacccg tccctccgac agctccaata
     5461 ctgtgaccct ccttcctcag gaagcgcgtt gaacccacag cactccgtgg tgtgtttgca
     5521 gggtgatttc ctaataaaag tccactctga ctgtgaa
//
