LOCUS       NM_001085487            7751 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens Myb like, SWIRM and MPN domains 1 (MYSM1), mRNA.
ACCESSION   NM_001085487 XM_055481
VERSION     NM_001085487.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7751)
  AUTHORS   Mathias,B., O'Leary,D., Saucier,N., Ahmad,F., White,L.S.,
            Russell,L., Shinawi,M., Smith,M.J., Abraham,R.S., Cooper,M.A.,
            Kitcharoensakkul,M., Green,A.M. and Bednarski,J.J.
  TITLE     MYSM1 attenuates DNA damage signals triggered by physiologic and
            genotoxic DNA breaks
  JOURNAL   J Allergy Clin Immunol 153 (4), 1113-1124 (2024)
   PUBMED   38065233
  REMARK    GeneRIF: MYSM1 attenuates DNA damage signals triggered by
            physiologic and genotoxic DNA breaks.
REFERENCE   2  (bases 1 to 7751)
  AUTHORS   Liang,Y., Bhatt,G., Tung,L.T., Wang,H., Kim,J.E., Mousa,M.,
            Plackoska,V., Illes,K., Georges,A.A., Gros,P., Henneman,L.,
            Huijbers,I.J., Nagar,B. and Nijnik,A.
  TITLE     Deubiquitinase catalytic activity of MYSM1 is essential in vivo for
            hematopoiesis and immune cell development
  JOURNAL   Sci Rep 13 (1), 338 (2023)
   PUBMED   36611064
  REMARK    GeneRIF: Deubiquitinase catalytic activity of MYSM1 is essential in
            vivo for hematopoiesis and immune cell development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7751)
  AUTHORS   Chen,X., Wang,W., Li,Y., Huo,Y., Zhang,H., Feng,F., Xi,W.,
            Zhang,T., Gao,J., Yang,F., Chen,S., Yang,A. and Wang,T.
  TITLE     MYSM1 inhibits human colorectal cancer tumorigenesis by activating
            miR-200 family members/CDH1 and blocking PI3K/AKT signaling
  JOURNAL   J Exp Clin Cancer Res 40 (1), 341 (2021)
   PUBMED   34706761
  REMARK    GeneRIF: MYSM1 inhibits human colorectal cancer tumorigenesis by
            activating miR-200 family members/CDH1 and blocking PI3K/AKT
            signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7751)
  AUTHORS   Tian,M., Liu,W., Zhang,Q., Huang,Y., Li,W., Wang,W., Zhao,P.,
            Huang,S., Song,Y., Shereen,M.A., Qin,M., Liu,Y., Wu,K. and Wu,J.
  TITLE     MYSM1 Represses Innate Immunity and Autoimmunity through
            Suppressing the cGAS-STING Pathway
  JOURNAL   Cell Rep 33 (3), 108297 (2020)
   PUBMED   33086059
  REMARK    GeneRIF: MYSM1 Represses Innate Immunity and Autoimmunity through
            Suppressing the cGAS-STING Pathway.
REFERENCE   5  (bases 1 to 7751)
  AUTHORS   Kroeger,C., Roesler,R., Wiese,S., Hainzl,A. and Gatzka,M.V.
  TITLE     Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and
            Replication Factors
  JOURNAL   Int J Mol Sci 21 (11), 3762 (2020)
   PUBMED   32466590
  REMARK    GeneRIF: Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair
            and Replication Factors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7751)
  AUTHORS   Huang,Y.C., Lin,J.M., Lin,H.J., Chen,C.C., Chen,S.Y., Tsai,C.H. and
            Tsai,F.J.
  TITLE     Genome-wide association study of diabetic retinopathy in a
            Taiwanese population
  JOURNAL   Ophthalmology 118 (4), 642-648 (2011)
   PUBMED   21310492
REFERENCE   7  (bases 1 to 7751)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 7751)
  AUTHORS   Dephoure,N., Zhou,C., Villen,J., Beausoleil,S.A., Bakalarski,C.E.,
            Elledge,S.J. and Gygi,S.P.
  TITLE     A quantitative atlas of mitotic phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 105 (31), 10762-10767 (2008)
   PUBMED   18669648
REFERENCE   9  (bases 1 to 7751)
  AUTHORS   Zhu,P., Zhou,W., Wang,J., Puc,J., Ohgi,K.A., Erdjument-Bromage,H.,
            Tempst,P., Glass,C.K. and Rosenfeld,M.G.
  TITLE     A histone H2A deubiquitinase complex coordinating histone
            acetylation and H1 dissociation in transcriptional regulation
  JOURNAL   Mol Cell 27 (4), 609-621 (2007)
   PUBMED   17707232
  REMARK    GeneRIF: The identification of histone H2A deubiquitinase (2A-DUB,
            or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that
            helps in delineating a strategy for specific regulatory pathways of
            gene activation, is reported.
REFERENCE   10 (bases 1 to 7751)
  AUTHORS   Yoneyama,M., Tochio,N., Umehara,T., Koshiba,S., Inoue,M.,
            Yabuki,T., Aoki,M., Seki,E., Matsuda,T., Watanabe,S., Tomo,Y.,
            Nishimura,Y., Harada,T., Terada,T., Shirouzu,M., Hayashizaki,Y.,
            Ohara,O., Tanaka,A., Kigawa,T. and Yokoyama,S.
  TITLE     Structural and functional differences of SWIRM domain subtypes
  JOURNAL   J Mol Biol 369 (1), 222-238 (2007)
   PUBMED   17428495
  REMARK    GeneRIF: The SWIRM structure of human MYb-like, Swirm and Mpn
            domain-containing protein-1 (MYSM1), is reported.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL450024.17 and AL035411.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001085487.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.43001.1,
                                           SRR1660809.125123.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000472487.6/ ENSP00000418734.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AL450024.17        5120-5197           c
            79-157              AL450024.17        264-342             c
            158-228             AL035411.28        142112-142182       c
            229-306             AL035411.28        139591-139668       c
            307-330             AL035411.28        139477-139500       c
            331-409             AL035411.28        138289-138367       c
            410-508             AL035411.28        134404-134502       c
            509-1269            AL035411.28        131036-131796       c
            1270-1400           AL035411.28        126177-126307       c
            1401-1504           AL035411.28        124728-124831       c
            1505-1582           AL035411.28        122824-122901       c
            1583-1671           AL035411.28        121121-121209       c
            1672-1726           AL035411.28        118235-118289       c
            1727-1777           AL035411.28        117883-117933       c
            1778-1852           AL035411.28        117098-117172       c
            1853-2041           AL035411.28        116289-116477       c
            2042-2174           AL035411.28        114750-114882       c
            2175-2280           AL035411.28        110657-110762       c
            2281-2338           AL035411.28        110421-110478       c
            2339-7751           AL035411.28        103994-109406       c
FEATURES             Location/Qualifiers
     source          1..7751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.1"
     gene            1..7751
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /note="Myb like, SWIRM and MPN domains 1"
                     /db_xref="GeneID:114803"
                     /db_xref="HGNC:HGNC:29401"
                     /db_xref="MIM:612176"
     exon            1..78
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2497
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /EC_number="3.1.2.15"
                     /note="histone H2A deubiquitinase MYSM1; myb-like, SWIRM
                     and MPN domain-containing protein 1"
                     /codon_start=1
                     /product="deubiquitinase MYSM1"
                     /protein_id="NP_001078956.1"
                     /db_xref="CCDS:CCDS41343.1"
                     /db_xref="GeneID:114803"
                     /db_xref="HGNC:HGNC:29401"
                     /db_xref="MIM:612176"
                     /translation="MAAEEADVDIEGDVVAAAGAQPGSGENTASVLQKDHYLDSSWRT
                     ENGLIPWTLDNTISEENRAVIEKMLLEEEYYLSKKSQPEKVWLDQKEDDKKYMKSLQK
                     TAKIMVHSPTKPASYSVKWTIEEKELFEQGLAKFGRRWTKISKLIGSRTVLQVKSYAR
                     QYFKNKVKCGLDKETPNQKTGHNLQVKNEDKGTKAWTPSCLRGRADPNLNAVKIEKLS
                     DDEEVDITDEVDELSSQTPQKNSSSDLLLDFPNSKMHETNQGEFITSDSQEALFSKSS
                     RGCLQNEKQDETLSSSEITLWTEKQSNGDKKSIELNDQKFNELIKNCNKHDGRGIIVD
                     ARQLPSPEPCEIQKNLNDNEMLFHSCQMVEESHEEEELKPPEQEIEIDRNIIQEEEKQ
                     AIPEFFEGRQAKTPERYLKIRNYILDQWEICKPKYLNKTSVRPGLKNCGDVNCIGRIH
                     TYLELIGAINFGCEQAVYNRPQTVDKVRIRDRKDAVEAYQLAQRLQSMRTRRRRVRDP
                     WGNWCDAKDLEGQTFEHLSAEELAKRREEEKGRPVKSLKVPRPTKSSFDPFQLIPCNF
                     FSEEKQEPFQVKVASEALLIMDLHAHVSMAEVIGLLGGRYSEVDKVVEVCAAEPCNSL
                     STGLQCEMDPVSQTQASETLAVRGFSVIGWYHSHPAFDPNPSLRDIDTQAKYQSYFSR
                     GGAKFIGMIVSPYNRNNPLPYSQITCLVISEEISPDGSYRLPYKFEVQQMLEEPQWGL
                     VFEKTRWIIEKYRLSHSSVPMDKIFRRDSDLTCLQKLLECMRKTLSKVTNCFMAEEFL
                     TEIENLFLSNYKSNQENGVTEENCTKELLM"
     exon            79..157
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            158..228
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            229..306
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            307..330
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            331..409
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..508
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            509..1269
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1400
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1504
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1582
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1671
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1726
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1777
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1852
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..2041
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2174
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2280
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2338
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..7751
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7726..7731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /note="hexamer: CATAAA"
     regulatory      7732..7737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /note="hexamer: AATAAA"
     polyA_site      7747
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /note="major polyA site"
     polyA_site      7751
                     /gene="MYSM1"
                     /gene_synonym="2A-DUB; 2ADUB; BMFS4"
                     /note="major polyA site"
ORIGIN      
        1 aggtcccatc atggcggctg aagaggcgga tgtggatatc gaaggggacg tggtagcggc
       61 ggcgggggca cagccaggaa gtggtgaaaa tacagcatca gttttacaaa aagatcacta
      121 tcttgattca tcttggagaa cagagaatgg ccttattcct tggaccttgg ataacaccat
      181 cagtgaagag aacagagctg ttattgagaa aatgttgttg gaagaagaat attatttatc
      241 taaaaaatca caaccggaaa aagtctggct tgatcaaaag gaagatgata aaaaatacat
      301 gaagagtctg cagaaaacag caaaaatcat ggtacactct cctacaaaac cagccagtta
      361 ctcagtaaag tggacgatag aagaaaaaga gctgtttgaa caagggctgg ctaaatttgg
      421 ccgaagatgg accaaaattt caaagctaat tggaagccgc actgttttac aagtgaagag
      481 ttatgcaaga cagtatttta aaaataaggt caaatgcggt ctggataaag aaacaccaaa
      541 tcagaagacc ggccataatc ttcaagttaa aaatgaagat aaagggacaa aggcatggac
      601 accatcatgt ttaaggggac gtgctgatcc caacttgaat gctgtaaaaa ttgaaaagtt
      661 atctgatgat gaagaagtag acatcacaga tgaggtggac gagttgtctt ctcaaacacc
      721 ccagaagaat tctagcagtg atctcttgtt agactttcct aatagtaaaa tgcatgaaac
      781 caatcaagga gaattcatta cttctgacag ccaggaagct ctcttttcta agtcttccag
      841 gggctgtctt caaaatgaaa agcaagatga aacactttca agctcagaaa ttacactgtg
      901 gactgagaaa cagagcaatg gtgacaaaaa atcaattgaa ttaaatgacc agaaatttaa
      961 tgaattgatt aaaaactgca acaagcatga tggaagggga ataatagttg atgccaggca
     1021 gttgccttct ccagagcctt gtgaaattca gaaaaatttg aatgataatg aaatgctttt
     1081 tcattcttgc caaatggtag aggaaagcca tgaggaagaa gagcttaagc caccagaaca
     1141 ggaaatagaa atagatagaa atatcattca agaagaagaa aaacaagcaa ttcctgagtt
     1201 ttttgagggg cgccaagcta aaacaccaga acgctatttg aaaattagaa attatatttt
     1261 ggatcaatgg gagatatgca aaccaaaata cttaaataag acctcagtac gtcctggcct
     1321 gaagaactgt ggagatgtta attgtattgg acggattcat acatacctcg aattgatagg
     1381 agcaatcaat tttggatgtg aacaggctgt gtataatagg ccacaaacag ttgacaaagt
     1441 acgaatcaga gacagaaaag atgcagtaga agcataccaa cttgcccagc gtctgcagtc
     1501 tatgcgtaca aggagacgta gggtccgaga cccatgggga aactggtgtg atgcaaagga
     1561 cttagaagga caaacgtttg agcatctctc tgctgaggag ttggcaaaaa gaagagaaga
     1621 ggaaaaaggc agacctgtta aatctttaaa agtgccaaga ccaacaaaaa gctcgtttga
     1681 tcccttccaa ctgatacctt gtaatttttt tagtgaagaa aagcaggagc catttcaggt
     1741 gaaagtggct tcagaagcac ttttaataat ggatttgcat gctcatgttt ctatggcaga
     1801 agtgattggt ctgttaggag gaagatactc agaagttgat aaagtagttg aagtctgtgc
     1861 agcagaacca tgtaacagtc tgagtacagg actacagtgt gagatggatc ctgtatcaca
     1921 aacacaggcc tcagaaacct tggctgttag aggcttcagt gttattggat ggtatcattc
     1981 tcatcctgct tttgatccta atccttcctt acgagatatt gacacacaag ctaaatacca
     2041 gagttacttc tccagaggag gtgcaaagtt cattgggatg attgttagtc cctataatcg
     2101 aaataatccc ttaccatatt ctcagattac ctgcctggtt ataagtgagg aaattagccc
     2161 agatggctct tatcgcttac cttacaaatt tgaagtacag cagatgttag aagaacctca
     2221 gtggggatta gtatttgaaa agacaagatg gataatagaa aaatacaggc tctcccatag
     2281 cagcgtcccc atggataaaa tctttcgccg ggattctgac ctgacttgtt tgcagaaact
     2341 tttggagtgt atgaggaaga ctctgagcaa agtgaccaat tgctttatgg ctgaagaatt
     2401 cttgactgaa atagaaaatt tgttcctttc caattataaa agcaaccaag agaatggagt
     2461 aaccgaagag aactgtacaa aggaattgtt aatgtgatta ttttaaagtt aagacatttt
     2521 aatcttgaca cagtagatct tactttcaaa gttataaact tgaagtgatt gtagttaaca
     2581 ttggcacagc tttggtattt tttctctatt tcacaaaatc caaactttgc cacataaatc
     2641 atgtgaaaag gaagagatac aaatttgttt tcatatagtg attatcagag tgttctgcaa
     2701 accagggtcc accacggtgt tctagtcctt tactgagcaa tgctgtaggc tgtgaaacta
     2761 agcaacctgg tcggctttac tgttgtgttc agcttgggat ttggactatg tctctaagtc
     2821 atttcttccc tgaactagtc atttatgttc cattgtggta tctcctattt catttaaaag
     2881 cacttccatt ctttccatat attctgctga gatttgttta tggctataaa tgagatatgg
     2941 atgggtggtc actgagataa ttaatatggt ttagaactac tgattaataa atctaacagg
     3001 agaccaggag aggcatgaca agaaaatctt aaaaacagga aaaacccaaa ggagagaact
     3061 aaattaccag tttctaatca tagatactat cttccatttc attgtatagc agtagtatca
     3121 taagatatgc cattttctca gctatctgaa aatttttaac caattttaca cacataaaat
     3181 aattagcttc aattgtgagt ccacttacat tagtaggtgt gataaaacct catttaactg
     3241 gaacataggt aatcataact caaacttttt ttctactgcc tactactagg agaaagaggc
     3301 aaatgataat aaagctggaa taaatcagag atttaatttt taaaacaagc ctttcaggac
     3361 atgttacata ttcagcccag tttcatatgc tttctgaatc tataatggag gtcagtgaac
     3421 ttttttaatg taaagggcca gtttgtaaat aattttggct tttcaggcca catatgatgt
     3481 ctatgagaca ttcttctttg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttttac
     3541 agccctttaa aatgataaaa accattgtta actcacaggc ctcataaaac ataggctgtt
     3601 ggctattatt ctccaaccct tgatctagag aattttaaac attagaattt tgttttacat
     3661 ttgttaagct ttacgtcatc ttcaaatgac accaaaactc agaattatga tctgcattta
     3721 agccaatttt aaaataaaat aagcagtcaa tgctgcctca tttattgaaa ttcagtagat
     3781 tttagtttat ttcttagtag tcagagaatt gatttatagc tattcaccaa acattcttac
     3841 taacgtttcc ttatatctaa atcagattga ttctatattt tgctttgttt gtaatcaata
     3901 gccaatgaag aataaggagt attggaagaa gcagtgagtc agctttaggt gacctggttc
     3961 ttgtctcaac tttgtgattt ggggagatac agtttacttt ccctgagcct taattcttgt
     4021 gtaactgaag tctaacttaa cttcttaatg tccttccaga actaaaattt tattgttcat
     4081 tctaatcgtt ggactactct tgtgaagttt atattttgag ttaatacagt ttccaaatta
     4141 acatacattt aaaaaaaaaa gggtagtatt tttccatttc tctgtgtgca cttaggataa
     4201 acagtgaagt atagcttata aaacaattag tttgagggct gagagtgtaa gaggaactat
     4261 accaaaagtc aggaaacctg agctcttacc ctaactctgt taccaacttt gctgtgtgac
     4321 cttaatcaaa acacataacc tggaccccat gctcctcacc agtaaatcaa gggcctgaat
     4381 tttatggctt agtattccct tccaagctcc gaagttgcgt gattctgtga aaggcagtga
     4441 ttgattcctt tgtactcatc ttccttttga cctgtttcct catgatatat tggggaacaa
     4501 atactaaaaa gtgttttata ctagctttct tgattgacat ttccctataa tactgatgaa
     4561 tttgggtgat ggaaagtaat ggaaattgtt aaaagttctg ctctcaaatc tgagtctcct
     4621 tgccctgtgt gccaatgttt aaccatattt gctaatctaa gccatattgc gaggatctca
     4681 aggatgatac ttgtcaagag tttggggcct tgagagcaca gttttcaaaa taatacttag
     4741 tattttctga ctatagagta catttgtctt gtaaagtata ttttaaaata cagagaagtg
     4801 tgaagtacaa atatctcagt gctactattt aaaaaaacac aattagtata taaatccttc
     4861 cccatttttt tgacagtata attttagtat gttaaacttg gttacttctt tctctcttcc
     4921 tccatcattt tccctgcttc ctttttcttt tgtcatattc ttaaaacaat tttgcaacca
     4981 caggtaccca cattgctggc actaccagcc ttgggctact accgaggata atggagccag
     5041 ggccttgtag aagcacagag gaagtctaga actgaggggg cctatgatac aggaagttca
     5101 ggaggcagag tctcaaagga acacctgcct ttaataatgt ttacagaagt ggagaaagga
     5161 ctaaaggact taaagacatg caggtgtctt catcctgatt ctgtctttgt tattgcacaa
     5221 tgactataaa ataatgacct aatttttttt tttttctggc ttggctaatg gaaatcgaca
     5281 ctagcgcttc cccagtatta gacttaatct aattccaaag taacattcaa gaaaagaaaa
     5341 accagtggaa caggatcagt aagctcagac tctccatctc cattatttta gccttgacca
     5401 ttcttctcta atccttttaa attatcttca gtttccagtt caagttacat tgcttcagtt
     5461 acagtttgtt tgaccctgta ttcagagctg cattatgatt cttgtgggcc ctagatagtt
     5521 ttgccatctt agaccccttc ttccatacaa aattaaaagt gatattttac aattgtatct
     5581 gtatgaaatg aatgtattaa tattttagat taaaacattt tgtttagaag ttcagttttt
     5641 tcttatgagg ctaaaaaaaa ttaaaacatt tttgtgggct tctaaaaaac tgtgggcctt
     5701 aggtactgtg cctaatggat aagttggcat tgcctgtatt ctgaagggca tcattggaaa
     5761 aatagcagtc attattctgt ccccttctcc caccaccaca gtccttggag aagcctttgc
     5821 cactccatcc aggagcactg cagtttccac ggttatagat ctatagactt gaacttactt
     5881 ccttcccaac ctaacgaaaa ctcacaagga ttacttggga ccattcatcc tcaaaaaaga
     5941 taggaggcag tggtttgttt tagtcttcag atatttttgt tttggtcagt ccctaatctg
     6001 tagttttgaa actcgtgcca cacttgaaag ggaaacatcc tactaccttt ctttcctctc
     6061 catttcccac aaaccctttc cttcatcatc actccctgca ttcttacttc tcagcatata
     6121 aatacaagac ccttctttct attatttgtt gaaagctagg cctgtaaaat agagatggac
     6181 agaccatgca tgtttccatg aagctattta atgctgctcc cagtcttctg tccataccat
     6241 tccttccctg cccctaggag tggggttgag gtctgtgaca tgcagactgt aagcacagtc
     6301 agaacctctg cagctctcaa cccaacagag gagactgtgg cttcaacatg ccaacctgag
     6361 caggtctcct ctgcattacc ttcctcccat ttctcttcct gggtcctgat gaggtgagct
     6421 ggaggaacca atagtcagga tgccctggaa ttgatgttgc tctgttttgt gctcacaaaa
     6481 cagccatgta acacatgagc acctgagttg aagccatcca gtcgcaagtc agcagacagc
     6541 agttgatgga attctcagta gaaattcagt aagggtgccc aaattttatt ttttttttca
     6601 cctatactct accaatatat ggtatttagg aaaacttctt ttatccaagc acaaagaaaa
     6661 gcacacacat ttttataatc atctgcttca tcagggtaaa taaataattt aacaaatttg
     6721 atcagcatct ctagtttacc agtactttaa tattagtttt cttacaaatt aatgtatttt
     6781 gcaatatttc cagaaaatca ctgtgggaga ataatgtaat atactttagg atatatttcc
     6841 tgaccttttc ttaaatggct tcatgtgcta ttcccccaaa ttctgctttc tctattttct
     6901 tttttattta acctataatt atactttcta gtatattctg agtctatctt ctaagccacc
     6961 ttacattttt cctggaacaa gggagggaat aaatagttgc ctccactaaa tcaggaaaaa
     7021 ataaaaatat cccaggggag ctgtgattat gccaagagct ctaaacagaa gtttgagaag
     7081 gtaaaaatta agttgtagta tctgagttgt ttttattttc ttcctttggt gtttatgaag
     7141 gtattcataa gaactttaat ttcaggggaa aaaaatgcct gatttgctat ttttgacatt
     7201 tcctcgtctc ttaagaagtc agttaaatat gttttcatag tttatattcc tgtttcatag
     7261 attactgtga aacatgtatt taaacctatg aattataaaa tagtatttag attctagcgt
     7321 gagttaaata gattagtcat atatctttta gatttgtgga tttgacatgt aaattatgtg
     7381 ttgtgtataa gtaagttagt tactaaacat atggcatggt tattgataaa cttgttgcta
     7441 tttttttcca aatgctatca gtgtttgtgg acttttaaaa attagtttga attttggaat
     7501 gttctgtgat aaaatgtaat ttcaactatt ttgtacattt aaatatgcca tgttgtatat
     7561 gtctgtattt aaaaatgttg taaatacctg cattttaaga attatgaaag attttcctca
     7621 aaaatgacag aactctccat acttaattgt gacacattat aagatatctg attttaagct
     7681 tttggatttt gttctaaaaa ttaagtttaa acatgctgaa aattccataa aaataaaatt
     7741 ttgaaaataa a
//
