LOCUS       NM_015460               5073 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens myosin VIIA and Rab interacting protein (MYRIP),
            transcript variant 1, mRNA.
ACCESSION   NM_015460 XM_942036 XM_945644
VERSION     NM_015460.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5073)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5073)
  AUTHORS   Conte,I.L., Hellen,N., Bierings,R., Mashanov,G.I., Manneville,J.B.,
            Kiskin,N.I., Hannah,M.J., Molloy,J.E. and Carter,T.
  TITLE     Interaction between MyRIP and the actin cytoskeleton regulates
            Weibel-Palade body trafficking and exocytosis
  JOURNAL   J Cell Sci 129 (3), 592-603 (2016)
   PUBMED   26675235
  REMARK    GeneRIF: The role of MyRIP in Ca(2+)-driven exocytosis requires
            both MyoVa- and actin-binding potential.
REFERENCE   3  (bases 1 to 5073)
  AUTHORS   Huet,S., Fanget,I., Jouannot,O., Meireles,P., Zeiske,T.,
            Larochette,N., Darchen,F. and Desnos,C.
  TITLE     Myrip couples the capture of secretory granules by the actin-rich
            cell cortex and their attachment to the plasma membrane
  JOURNAL   J Neurosci 32 (7), 2564-2577 (2012)
   PUBMED   22396429
  REMARK    GeneRIF: Myrip couples the retention of secretory granules in the
            cell cortex, their transport to the plasma membrane, and their
            attachment to the plasma membrane, thus promoting secretion.
REFERENCE   4  (bases 1 to 5073)
  AUTHORS   Rojo Pulido,I., Nightingale,T.D., Darchen,F., Seabra,M.C.,
            Cutler,D.F. and Gerke,V.
  TITLE     Myosin Va acts in concert with Rab27a and MyRIP to regulate acute
            von-Willebrand factor release from endothelial cells
  JOURNAL   Traffic 12 (10), 1371-1382 (2011)
   PUBMED   21740491
  REMARK    GeneRIF: A Rab27a/MyRIP/myosin Va complex is involved in linking
            von-Willebrand factor (Vwf) to the peripheral actin cytoskeleton of
            endothelial cells to allow full maturation and prevent premature
            secretion of vWF.
REFERENCE   5  (bases 1 to 5073)
  AUTHORS   Kopplin,L.J., Igo,R.P. Jr., Wang,Y., Sivakumaran,T.A.,
            Hagstrom,S.A., Peachey,N.S., Francis,P.J., Klein,M.L.,
            SanGiovanni,J.P., Chew,E.Y., Pauer,G.J., Sturgill,G.M., Joshi,T.,
            Tian,L., Xi,Q., Henning,A.K., Lee,K.E., Klein,R., Klein,B.E. and
            Iyengar,S.K.
  TITLE     Genome-wide association identifies SKIV2L and MYRIP as protective
            factors for age-related macular degeneration
  JOURNAL   Genes Immun 11 (8), 609-621 (2010)
   PUBMED   20861866
  REMARK    GeneRIF: A new potentially protective effect was identified at
            rs2679798 in MYRIP.
            GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   6  (bases 1 to 5073)
  AUTHORS   Goehring,A.S., Pedroja,B.S., Hinke,S.A., Langeberg,L.K. and
            Scott,J.D.
  TITLE     MyRIP anchors protein kinase A to the exocyst complex
  JOURNAL   J Biol Chem 282 (45), 33155-33167 (2007)
   PUBMED   17827149
REFERENCE   7  (bases 1 to 5073)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   8  (bases 1 to 5073)
  AUTHORS   Waselle,L., Coppola,T., Fukuda,M., Iezzi,M., El-Amraoui,A.,
            Petit,C. and Regazzi,R.
  TITLE     Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin
            exocytosis
  JOURNAL   Mol Biol Cell 14 (10), 4103-4113 (2003)
   PUBMED   14517322
  REMARK    GeneRIF: Slac2c/MyRIP is part of a complex mediating the
            interaction of secretory granules with cortical actin cytoskeleton
REFERENCE   9  (bases 1 to 5073)
  AUTHORS   Fukuda,M. and Kuroda,T.S.
  TITLE     Slac2-c (synaptotagmin-like protein homologue lacking C2
            domains-c), a novel linker protein that interacts with Rab27,
            myosin Va/VIIa, and actin
  JOURNAL   J Biol Chem 277 (45), 43096-43103 (2002)
   PUBMED   12221080
  REMARK    GeneRIF: Slac2-c/MyRIP contains an N-terminal Slp homology domain
            (SHD) and functions as a linker protein that interacts with myosin
            Rab27A/B, VIIa/Va, and actin.
REFERENCE   10 (bases 1 to 5073)
  AUTHORS   El-Amraoui,A., Schonn,J.S., Kussel-Andermann,P., Blanchard,S.,
            Desnos,C., Henry,J.P., Wolfrum,U., Darchen,F. and Petit,C.
  TITLE     MyRIP, a novel Rab effector, enables myosin VIIa recruitment to
            retinal melanosomes
  JOURNAL   EMBO Rep 3 (5), 463-470 (2002)
   PUBMED   11964381
  REMARK    GeneRIF: a molecular complex composed of Rab27A, MyRIP and myosin
            VIIa bridges retinal melanosomes to the actin cytoskeleton and
            thereby mediates the local trafficking of these organelles
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104163.2, CF138044.1, BC092512.1, AB083783.1 and AK125334.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015460.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Both variants 1 and
            2 encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092512.1, SRR1660805.196895.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302541.11/ ENSP00000301972.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC104163.2         10313-10363         c
            52-52               CF138044.1         7-7
            53-1271             BC092512.1         1-1219
            1272-2518           AB083783.1         934-2180
            2519-3545           AK125334.1         1955-2981
            3546-5073           BC092512.1         3494-5021
FEATURES             Location/Qualifiers
     source          1..5073
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..5073
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /note="myosin VIIA and Rab interacting protein"
                     /db_xref="GeneID:25924"
                     /db_xref="HGNC:HGNC:19156"
                     /db_xref="MIM:611790"
     exon            1..308
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            309..448
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..2918
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /note="isoform a is encoded by transcript variant 1;
                     synaptotagmin-like protein homologue lacking C2 domains-c;
                     rab effector MYRIP; exophilin-8; Slp homologue lacking C2
                     domains; slp homolog lacking C2 domains c; myosin-VIIa-
                     and Rab-interacting protein; synaptotagmin-like protein
                     lacking C2 domains C"
                     /codon_start=1
                     /product="rab effector MyRIP isoform a"
                     /protein_id="NP_056275.2"
                     /db_xref="CCDS:CCDS2689.1"
                     /db_xref="GeneID:25924"
                     /db_xref="HGNC:HGNC:19156"
                     /db_xref="MIM:611790"
                     /translation="MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLD
                     EEGSKCSILSKHQQFVEHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAW
                     VCCVCQQARLLRAQSLEWFYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSL
                     FESNLENEGSISGSDSTFYRQSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDK
                     QNEASYLRDHKEELTEELATTILQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEG
                     TSASPGGYRAPAALWRSQSAFSITGEEALKTPPVEAPSRQPRDQGQHPRAESALPSWK
                     SVDRLDETNLAPVLQSPDGNWVALKDGAPPPTRLLAKPKSGTFQALEVASSVASAYDE
                     MGSDSEEDFDWSEALSKLCPRSRALPRNPQPQPTQAQSSDQGPIAASPSSALSPNPEA
                     MCSDSETSSAGSSREVGHQARLSWLQRKAPRNPAAEKMRLHGELDVNFNPQLASRETS
                     DSSEPEEAPHTTDRRARRWRRARLGSEEPSKEPSSPSAQLRDLDTHQVSDDLSETDIS
                     NEARDPQTLTDTTEEKRRNRLYELAMKMSEKETSSGEDQESEPKTESENQKESLSSED
                     NSQSVQEELKKKFSAVSLCNISTEVLKVINATEELIAGSTGPWESPQVPPDRQKGMFP
                     RGTDQVRLDEQLTSLEENVYLAAGTVYGLETQLTELEDAARCIHSGTDETHLADLEDQ
                     VATAAAQVHHAELQISDIESRISALTIAGLNIAPCVRFTRRRDQKQRTQVQTIDTSRQ
                     QRRKLPAPPVKAEKIETSSVTTIKTFNHNFILQGSSTNRTKERKGTTKDLMEPALESA
                     VMY"
     exon            449..670
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            671..807
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            808..888
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            889..986
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1067
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1211
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1365
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..2003
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2243
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2244..2438
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2600
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2705
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2766
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2767..2885
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..5073
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5049..5054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /note="hexamer: AGTAAA"
     polyA_site      5073
                     /gene="MYRIP"
                     /gene_synonym="SLAC2-C; SLAC2C"
                     /note="major polyA site"
ORIGIN      
        1 aggctggccc tggctgcctg cggcgcgggc gcctccctcg cagccgctgc tgccgacgcc
       61 gctgcgctcc cgcctcctgt cggttcccgg gttcccgctg cggctgcggt tctggcagcc
      121 gagcccccgc ggtgctgcag cccagcttta gcgcgcagac cgacccgcgc cccttcttcg
      181 ccgccggcag cctctaatcc acgcggcgcg ttgcggcagg tgccctgggc gtactgaggc
      241 gcggtggcct gagcccggcc gccatcgatg accccggtcg cggacttgct tcaggctggc
      301 caccccccgt cttgtttcat catctgtgtt gagtaaccat ggggaggaag ctggacctgt
      361 ctggtttgac tgatgatgaa acagagcatg ttcttcaggt ggttcaaaga gacttcaatc
      421 ttcgcaaaaa agaagaagaa cgactaagtg agctgaagca gaagctggat gaggaaggca
      481 gcaagtgcag catcctctcg aagcaccagc agtttgtgga gcactgctgc atgcgctgct
      541 gctcgccctt caccttcctc gtcaacacca agcgccagtg tggagattgc aaattcaatg
      601 tctgcaagag ctgctgctcc taccagaagc acgaaaaggc ctgggtctgc tgcgtctgcc
      661 agcaagcgag gcttctgagg gcccaatctc tggaatggtt ctacaataat gtgaagagcc
      721 gcttcaagcg ctttggcagt gccaaggttc tgaagaacct gtacaggaag caccggctgg
      781 agagtggcgc gtgcttcgac attctaggag gaagcctttt tgagtcaaac ctggagaatg
      841 aaggaagcat ttctggcagt gattcaacat tttataggca gtcagaagga catagtgtga
      901 tggacacctt ggctgtggcc ctacgggtgg ctgaagaggc cattgaggaa gcaatttcca
      961 aagcagaggc atatggggac agcctggaca agcaaaatga ggccagttac ctgcgggacc
     1021 acaaggagga gctaactgag gaactggcca cgacaatcct gcagaagatt atacgaaaac
     1081 agaagagcaa aagtgagcag caagtggaag aagagccagg atggccacat ccccagagtt
     1141 gcagcacaaa ggtggcagat gaggggacct cagcatcccc tggaggctac cgtgctcccg
     1201 ctgccctctg gaggtcccag tctgccttct caatcactgg agaagaagcc ctgaagaccc
     1261 ctccagtgga ggctccatcg aggcagccaa gggaccaagg ccaacacccg agagcagagt
     1321 ctgctctgcc cagctggaag agtgtggaca ggctggatga aacaaacctg gccccagttt
     1381 tgcagagccc cgacgggaac tgggtggccc tgaaggatgg cgctccaccc cccacccgac
     1441 tactggccaa acctaagagc gggacgtttc aggccctgga ggtggcctcc agtgtggcat
     1501 ctgcctacga tgagatgggc tccgatagcg aggaagactt tgactggagt gaggccttga
     1561 gcaagctgtg tcccaggtcc cgggccctgc ccaggaaccc ccagcctcag cccacacagg
     1621 cccagagctc tgaccaaggc cccatagctg cctccccatc ctctgcactc tcccccaacc
     1681 ctgaggccat gtgctctgac tcggagacct cctccgcagg ctcttcccga gaagttgggc
     1741 accaggccag actgtcctgg ttgcagagga aggcccccag gaaccctgca gctgagaaga
     1801 tgcgcttgca tggagagctg gacgtgaact tcaaccccca gttggccagc agggagacct
     1861 cggacagcag cgagccggag gaggcccccc acaccacaga ccggcgggcc aggaggtgga
     1921 gaagagcccg actgggctca gaagagccaa gcaaagaacc atcttccccc agcgcccagc
     1981 tccgggatct agacacacat caggtgtcgg atgatttatc agagacagac atcagcaatg
     2041 aggctcggga tccccagact ctcacagaca ccacagagga gaaacggaga aacaggctgt
     2101 acgagttagc aatgaaaatg agtgaaaagg agacttcttc aggggaggat caggagtctg
     2161 agcccaagac agaatctgag aaccagaagg aaagtctgtc ctctgaagac aacagccaga
     2221 gtgtccagga agagctgaag aagaagtttt ctgctgtttc tctctgcaac atctccacag
     2281 aagtcctgaa agtcatcaat gccacagagg agttgatagc aggatctaca gggccctggg
     2341 agtccccaca agtccctcct gacagacaga aggggatgtt tcctcgtggg acagaccaag
     2401 tgagactgga tgagcagctg acttccctgg aagaaaatgt atacctggca gcaggcactg
     2461 tgtatggact ggagacccag ctgactgagc tagaagatgc cgcccgctgc atccacagtg
     2521 gcactgatga gacccatctg gcggatctgg aggaccaggt ggccacggct gcagcccaag
     2581 tccaccatgc tgaactccag atttcagata ttgagagccg gatttcagcc ctgaccattg
     2641 caggattaaa catagcacca tgtgtgcgct tcacaagaag acgggatcag aagcaaagga
     2701 cccaggtaca aaccatagat acatcaaggc agcaaaggag gaaactgcct gctccaccgg
     2761 tgaaagctga aaaaattgag acatcttcag tgactaccat taaaacattt aaccacaact
     2821 tcattctcca aggctcctca acaaacagga ctaaggaaag gaaaggcacc accaaggatt
     2881 tgatggagcc tgctctggag tcagctgtga tgtactgaca ccatggaatt ccactgccag
     2941 tgacccactg cctccggccg tacacgacag tgccttgacc caacagccat cgagtactgt
     3001 atgtatttcc acctgaggag aaggcctggg gaggccacag tgcaccattg cacagggctg
     3061 tcctgatacc tcatccagaa agccgtctca gacttcagca ctgcggtctt gcccactctc
     3121 tgccttaggc tcccagggga atccaagaca gaaaatgaag acactggctt ccaacagcag
     3181 cgctccatgt ttaagataca tattttccct gtttgctttg ctactgtatg ttgactttaa
     3241 gatctttttt taaatacatt tgattcagct agtattccat gtcaacaatt tgtccaaagg
     3301 aaaactgctg gagggaggtg gagggaggaa ggtgggaatt attatttaat acatcattaa
     3361 tgcttattaa tctctcacaa gcatctttgt cttgcaaatc ctaagggaaa agcaagtccc
     3421 tgcagtgagc actagggaca gtctaatttg gggattgctc aaccatcaag actgcaggtc
     3481 tcccttcagc cacctccttc ctgctaaaag cttagcctac cacactacca gtcattccca
     3541 tcgctttgca atcacaagcc acaggatgag aagttctgac tcactcatgc catgcccagg
     3601 gctatctgaa acaatgtctc attaagaatt tagggttctt ccatgggctt actgacagtt
     3661 gcccagatct gaaggggaaa gggtcttgag aaagaccatc actggctcaa ctttagggca
     3721 ctgtccagag tcaacatgat gtggtttagc agtgatcaca tctaaacaaa gtttaggtaa
     3781 atgaattatc gcagagaaaa accacatgag aaaatttttg tactccaaat ttacttccca
     3841 ataaatattc agcaaagtag taaaatgacc ttaaagataa aaatgattag ggaatagcct
     3901 tagaaaattt ataggtataa aaaattcaag gacaaactgt gcatttaatg gacacaagaa
     3961 ttgactctaa ctccatgtct gtggtttctt tgaacccata tcaaatgtat gactatttag
     4021 agtgtttata agagataatg gaactgaact ttcactcaat taattgggca ttaacaacct
     4081 tcttttatgt ttgttcctga tatagtctga atcttaggaa gaaggtaaaa gaaaggaggc
     4141 aagagaatag ttatgatgaa tatgtgttaa gtgcctgctc tgaaggaggc aatgttcttc
     4201 tcatttgaat ccttatggca accttattca ataggttttc ccatatttca gatttaataa
     4261 ctgaaggcca gagagattaa tttgccaaag ccacaccttt atgctaatta tgattggaat
     4321 gcatcacaaa agcctaactc tgttgttttc aacctctacg ttattttgct gctatgtgca
     4381 tttccagatc tgattttctg ctaacttgtg tgctatgatc cactcctgat gggggtctac
     4441 attaatcttc cagtactcct tgctgatgct gtgttatgtg tcatctaaca gaaatgactc
     4501 ctttgaaata agtaaatctt tggctttttg ttctgttggt gtgattcaaa gcaaaacaaa
     4561 caaacaaaaa caaattttaa gaacacaaca aaaaagattt gacttccgaa tagaatgttt
     4621 tctttaagag gcatgaaaag caactattgt tgtgttacag tgttaaaaat attcagtttt
     4681 ctttgacaaa aatgtgtact gtgtaagcct tgcaaacaaa aaacaacaaa aaagaagcag
     4741 cagcagcagc ctgctgtgtg gcatctgaac ttttataaag gtttccttgt gccaaataag
     4801 tgcaaagatt taatttacta ttaaaaacca taagcatatg ttatagttcc agaagaatta
     4861 ttttgtcatc aagtgatttt gatctttagt gtcaatattt atatttagat taatttttat
     4921 aaatgaaaat attttaatgg tttaagaaaa tgaggacaac aggataatat ctttgatgac
     4981 ttctgaaagt tatgcttccc ttcatgttat atgcacattg ccaagaatta ctgtcaagag
     5041 aaatgataag taaaagtcat ttatgaaaat aaa
//
