LOCUS       NM_182530               3590 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens myelin regulatory factor like (MYRFL), mRNA.
ACCESSION   NM_182530 XM_011508357 XM_011539050
VERSION     NM_182530.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3590)
  AUTHORS   Aprato,J., Sock,E., Weider,M., Elsesser,O., Frob,F. and Wegner,M.
  TITLE     Myrf guides target gene selection of transcription factor Sox10
            during oligodendroglial development
  JOURNAL   Nucleic Acids Res 48 (3), 1254-1270 (2020)
   PUBMED   31828317
  REMARK    GeneRIF: By characterization of the exact DNA-binding requirements
            of Myrf, we furthermore show that cooperative activation is a
            consequence of joint binding of Sox10 and Myrf to the same
            regulatory regions.
REFERENCE   2  (bases 1 to 3590)
  AUTHORS   Anney,R.J., Lasky-Su,J., O'Dushlaine,C., Kenny,E., Neale,B.M.,
            Mulligan,A., Franke,B., Zhou,K., Chen,W., Christiansen,H.,
            Arias-Vasquez,A., Banaschewski,T., Buitelaar,J., Ebstein,R.,
            Miranda,A., Mulas,F., Oades,R.D., Roeyers,H., Rothenberger,A.,
            Sergeant,J., Sonuga-Barke,E., Steinhausen,H., Asherson,P.,
            Faraone,S.V. and Gill,M.
  TITLE     Conduct disorder and ADHD: evaluation of conduct problems as a
            categorical and quantitative trait in the international multicentre
            ADHD genetics study
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (8), 1369-1378 (2008)
   PUBMED   18951430
REFERENCE   3  (bases 1 to 3590)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025263.22, AC078922.14, EG328354.1, AK057785.1, BC101820.1 and
            BG187742.1.
            
            On May 17, 2019 this sequence version replaced NM_182530.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was availabe for
            the full length of the gene. The genomic coordinates used for the
            transcript record were based on partial transcript and RNA-seq
            alignments.
            
            CCDS Note: This gene lacks full-length transcript support, and
            therefore this CCDS representation is inferred based on partial
            transcript alignments, orthologous alignments and RNA-seq data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2144835,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000552032.7/ ENSP00000448753.2
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AC025263.22        7437-7773           c
            338-428             AC078922.14        156761-156851       c
            429-496             AC078922.14        133036-133103       c
            497-755             AC078922.14        132678-132936       c
            756-847             AC078922.14        131839-131930       c
            848-998             AC078922.14        125161-125311       c
            999-1194            AC078922.14        120965-121160       c
            1195-1271           AC078922.14        118291-118367       c
            1272-1382           AC078922.14        116650-116760       c
            1383-1473           AC078922.14        114885-114975       c
            1474-1651           AC078922.14        108310-108487       c
            1652-1983           EG328354.1         28-359              c
            1984-2306           AK057785.1         5-327
            2307-2307           AC078922.14        75824-75824         c
            2308-2823           BC101820.1         164-679
            2824-2824           AC078922.14        54227-54227         c
            2825-3091           BC101820.1         681-947
            3092-3219           BG187742.1         170-297
            3220-3590           AC078922.14        53034-53404         c
FEATURES             Location/Qualifiers
     source          1..3590
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..3590
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /note="myelin regulatory factor like"
                     /db_xref="GeneID:196446"
                     /db_xref="HGNC:HGNC:26316"
     exon            1..337
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..3024
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /codon_start=1
                     /product="myelin regulatory factor-like protein"
                     /protein_id="NP_872336.2"
                     /db_xref="CCDS:CCDS76577.1"
                     /db_xref="GeneID:196446"
                     /db_xref="HGNC:HGNC:26316"
                     /translation="MDVVGENEALQQFFEAQGANGTLENPALDTSLLEEFLGNDFDLG
                     ALQRQLPDTPPYSASDSCSPPQVKGACYPTLRPTAGRTPAPFLHPTAAPAMPPMHPLQ
                     STSGMGDSCQIHGGFHSCHSNASHLATPLDQSVSSHLGIGCSYPQQPLCHSPGASLPP
                     TKKRKCTQALEDSGECRVWACHCRPMTSRSRSSEVQDPDSEGQNRMPTDQCSPALKWQ
                     PCHSVPWHSLLNSHYEKLPDVGYRVVTDKGFNFSPADEAFVCQKKNHFQITIHIQVWG
                     SPKFVETEMGLKPIEMFYLKVFGTKVEATNQIIAIEQSQADRSKKIFNPVKIDLLADQ
                     VTKVTLGRLHFSETTANNMRKKGKPNPDQRYFMLVVGLYAANQDQFYLLSAHISERII
                     VRASNPGQFENDSDALWQRGQVPESIVCHGRVGINTDAPDEALVVCGNMKVMGTIMHP
                     SDSRAKQNIQEVDTNEQLKRIAQMRIVEYDYKPEFASAMGINTAHQTGMIAQEVQEIL
                     PRAVREVGDVTCGNGETLENFLMVDKDQIFMENVGAVKQLCKLTNNLEERIEELEIWN
                     RKLARLKRLSSWKSSASEASTISKSSRAVSASSPRRAVHKKNNKVYFSGKRQACPNWV
                     FQTLVITLIAVMAFCALTIVALYILSLKDQDRRVPNLPPSNITSSQEPALLPTASSSA
                     PNTSLVTTPASLQVPEITFCEILPCQETYCCPIRGMKEVSSSPVQRQSEEKEFHQRRW
                     SEDKSKSVLARNALSGPDWESDWIDTTISSIQIMEIQQIIDHQYCIQSLQCGSGNYNY
                     NIPVNKHTPTNVKFSLEINTTEPLIVFQCKFTLGNICFHSKRGTKGLESHREISQEMT
                     QGYQHIWSLPVAPFSDSMFHFRVAAPDLADCSTDPYFAGIFFTDYFFYFYRRCA"
     exon            338..428
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            429..496
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            497..755
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            756..847
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            848..998
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1194
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1271
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1382
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1473
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1674
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1783
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1893
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2057
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2121
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2207
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2282
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2335
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            2336..2515
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2578
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            2579..2666
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2741
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2862
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..2937
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     exon            2938..3590
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3194..3199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /note="hexamer: AATAAA"
     polyA_site      3219
                     /gene="MYRFL"
                     /gene_synonym="bcm1377; C12orf15; C12orf28"
                     /note="major polyA site"
ORIGIN      
        1 agagtagaaa cagttcctta tattaagaca gatgaatttg ctacctcttc cctcttcatg
       61 aatttttttt aaatgtatgg ttgtatatcc ttccagtttt ataatcacat ttgaaaactc
      121 aaccatcttt ctgggcacaa tttgatggct gaagatatgc ttcactccaa taaaaagaaa
      181 atgaagattt ttcaagagca ttcgtaggct tcgaatcaaa aggacagtac ttatttcctg
      241 aggtctgata accgttgttt tatgaggaaa tagtactagg atcacagtac catggatgtg
      301 gtaggcgaaa atgaggccct gcagcagttc tttgaagctc agggagccaa tggtactctg
      361 gagaacccag ccctggacac aagtctgttg gaggaatttc tgggcaatga ctttgatttg
      421 ggggccttgc aacgccagct cccagacacc ccgccctatt ctgcatccga ctcatgctct
      481 cctccgcagg tcaaaggtgc atgctaccca accctgaggc ccacagctgg gaggactcca
      541 gctccttttc tccaccccac agctgctcct gcgatgccgc ccatgcaccc gctgcagagc
      601 acctctggaa tgggcgactc ctgccaaatc cacggaggct ttcacagctg ccactcaaac
      661 gccagtcatc ttgccacccc cctggaccaa tccgtgtcct cccatctggg gataggttgt
      721 tcttaccctc agcagcctct gtgtcacagc cctggagcct cattgcctcc aaccaagaag
      781 agaaagtgca cgcaggcact ggaggactcc ggggaatgcc gagtgtgggc ctgccactgc
      841 agaccgatga caagtaggag tcgcagcagt gaagtccagg accctgacag tgagggacag
      901 aacagaatgc ctacagacca gtgctctcct gctctgaagt ggcaaccatg ccatagtgtt
      961 ccttggcaca gcttattaaa cagtcattat gaaaaactac ctgatgtggg ctatcgagtt
     1021 gtaacagaca aaggatttaa tttttcacca gcagatgaag cttttgtttg ccaaaagaag
     1081 aatcatttcc agataaccat tcacatccaa gtttggggaa gtccaaaatt tgttgaaacc
     1141 gagatgggcc taaagccaat agaaatgttt tacttgaaag tttttggcac taaggtggaa
     1201 gctaccaatc aaataattgc tattgaacag tcccaagcag ataggagcaa aaagattttc
     1261 aatcctgtta aaattgacct actggctgac caggtcacca aagtaacact gggacgatta
     1321 cacttcagcg aaaccacagc aaataatatg agaaaaaagg gaaaaccaaa tccagaccag
     1381 agatacttca tgttggtggt tggactgtat gctgctaacc aagaccagtt ctatctgttg
     1441 tctgcccaca tctctgaaag gatcattgta agggcctcta accctgggca gtttgaaaat
     1501 gacagtgatg cattgtggca gcgaggacaa gttccagaat ctattgtctg tcacggtcga
     1561 gtaggaatca acacagatgc gccggacgaa gccctggttg tctgtggcaa catgaaagtg
     1621 atggggacca tcatgcatcc ctctgacagc cgggcaaagc agaatatcca ggaggttgac
     1681 acgaatgaac agctgaaaag aatagcccaa atgagaattg ttgaatatga ctacaaacct
     1741 gaatttgcat ctgcaatggg aataaacact gcccatcaaa caggaatgat tgcccaggag
     1801 gtgcaagaaa tcctgcccag agcagtaaga gaggttggtg atgtcacctg cggaaacgga
     1861 gagaccttgg agaacttcct catggtggat aaggaccaga tctttatgga aaatgtaggt
     1921 gcagtgaagc aactgtgcaa actaactaac aaccttgagg aaagaataga agagttagaa
     1981 atatggaaca gaaagctggc ccggctaaag cggctcagta gttggaagtc atcagccagt
     2041 gaagcaagca caatcagcaa atctagcaga gccgttagtg catcttctcc aagaagggcc
     2101 gttcataaaa aaaacaacaa ggtttatttt tcaggaaaaa gacaggcgtg tcctaattgg
     2161 gttttccaga ccttggttat aactctgatt gctgtgatgg cattttgtgc tttgacgata
     2221 gttgccctct atatacttag cttaaaagat caagaccgac gtgtcccaaa tctccctcca
     2281 agcaatatca caagctcaca ggagccagct ctgctgccca cagcctcctc ctcagcacct
     2341 aatacatccc tggtaaccac accggcctcc ttacaagtac ctgaaattac tttctgtgaa
     2401 atcctgccgt gtcaggagac ttattgctgc cccatccggg gaatgaaaga agtctcttca
     2461 agtcctgtgc aaagacaatc tgaggagaag gaattccatc agaggcgatg gtcagaagac
     2521 aaaagcaaat cagttttggc aagaaatgca ctcagcggcc ctgactggga gagtgactgg
     2581 attgatacaa ccatcagttc tattcagatt atggaaatcc agcaaataat agatcatcag
     2641 tattgcattc aaagcctcca gtgcggatct ggaaattata attacaatat tcctgttaat
     2701 aaacacacac ccaccaatgt caagttctct ctggaaataa acacaacaga gccattgata
     2761 gtcttccagt gcaaattcac ccttggaaat atatgtttcc atagtaaaag gggaaccaaa
     2821 gggctggaaa gccacagaga aatctcccag gagatgacac agggatatca gcacatttgg
     2881 agcctccctg tagccccatt ttctgacagc atgttccatt tccgtgtagc tgcaccggat
     2941 ttagctgact gttcaactga tccttatttt gctgggatat tcttcaccga ttacttcttt
     3001 tacttctatc gacgctgtgc ctaatttgtt caagtttggg gactttacca aagaaaaata
     3061 ctcaggaata catttaacag aaacgaacat cctcttgcaa cttctttttt cttctttgta
     3121 aaacatttac gtttattgct gaaggacttt ttcaggcttt agcttccaac agttttgaga
     3181 cattaatgag gagaataaaa tgtttgctga aacttgaaat aatgtgatgt ttgattttgc
     3241 catgactatg aagaaaacat ttcctggagc aaacagttct gttgaattta aaaatactat
     3301 tatttctggt attaaggaag ttgtgagctc aaaataagga gatctagcct ctattttgtt
     3361 ttaatgtatt ttaaagcttt tgaaaaaacc aaaagggcca tgtcgacttc ggcccactaa
     3421 acatagactc ttgagaatgt gtgatatggt atgtggagga gatgtggggg gtggtatctg
     3481 atactgagct cacatttagg caaattgtcc tatgtgtgtg tgtattgtat aaacacatac
     3541 actagagtac agaatgtagt ttgttaatca aatggattta agagaaataa
//
