LOCUS       NM_001127392            5940 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens myelin regulatory factor (MYRF), transcript variant 2,
            mRNA.
ACCESSION   NM_001127392
VERSION     NM_001127392.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5940)
  AUTHORS   Slaba,K., Jezova,M., Pokorna,P., Palova,H., Tuckova,J., Papez,J.,
            Prochazkova,D., Jabandziev,P. and Slaby,O.
  TITLE     Two sisters with cardiac-urogenital syndrome secondary to
            pathogenic splicing variant in the MYRF gene with unaffected
            parents: A case of gonadal mosaicism?
  JOURNAL   Mol Genet Genomic Med 11 (5), e2139 (2023)
   PUBMED   36695166
  REMARK    GeneRIF: Two sisters with cardiac-urogenital syndrome secondary to
            pathogenic splicing variant in the MYRF gene with unaffected
            parents: A case of gonadal mosaicism?
REFERENCE   2  (bases 1 to 5940)
  AUTHORS   Ouyang,J., Sun,W., Shen,H., Liu,X., Wu,Y., Jiang,H., Li,X.,
            Wang,Y., Jiang,Y., Li,S., Xiao,X., Hejtmancik,J.F., Tan,Z. and
            Zhang,Q.
  TITLE     Truncation mutations in MYRF underlie primary angle closure
            glaucoma
  JOURNAL   Hum Genet 142 (1), 103-123 (2023)
   PUBMED   36129575
  REMARK    GeneRIF: Truncation mutations in MYRF underlie primary angle
            closure glaucoma.
REFERENCE   3  (bases 1 to 5940)
  AUTHORS   Yu,X., Sun,N., Guo,C., Zhao,Z., Ye,M., Zhang,J., Ge,J. and Fan,Z.
  TITLE     Evaluation of MYRF as a candidate gene for primary angle closure
            glaucoma
  JOURNAL   Mol Vis 27, 734-740 (2021)
   PUBMED   35136345
  REMARK    GeneRIF: Evaluation of MYRF as a candidate gene for primary angle
            closure glaucoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5940)
  AUTHORS   Huang,H., Zhou,F., Zhou,S. and Qiu,M.
  TITLE     MYRF: A Mysterious Membrane-Bound Transcription Factor Involved in
            Myelin Development and Human Diseases
  JOURNAL   Neurosci Bull 37 (6), 881-884 (2021)
   PUBMED   33864620
  REMARK    GeneRIF: MYRF: A Mysterious Membrane-Bound Transcription Factor
            Involved in Myelin Development and Human Diseases.
REFERENCE   5  (bases 1 to 5940)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 5940)
  AUTHORS   Montano,S.P., Cote,M.L., Fingerman,I., Pierce,M., Vershon,A.K. and
            Georgiadis,M.M.
  TITLE     Crystal structure of the DNA-binding domain from Ndt80, a
            transcriptional activator required for meiosis in yeast
  JOURNAL   Proc Natl Acad Sci U S A 99 (22), 14041-14046 (2002)
   PUBMED   12384578
REFERENCE   7  (bases 1 to 5940)
  AUTHORS   Stohr,H., Marquardt,A., White,K. and Weber,B.H.
  TITLE     cDNA cloning and genomic structure of a novel gene (C11orf9)
            localized to chromosome 11q12-->q13.1 which encodes a highly
            conserved, potential membrane-associated protein
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 211-216 (2000)
   PUBMED   10828591
REFERENCE   8  (bases 1 to 5940)
  AUTHORS   Cooper,P.R., Nowak,N.J., Higgins,M.J., Church,D.M. and Shows,T.B.
  TITLE     Transcript mapping of the human chromosome 11q12-q13.1 gene-rich
            region identifies several newly described conserved genes
  JOURNAL   Genomics 49 (3), 419-429 (1998)
   PUBMED   9615227
REFERENCE   9  (bases 1 to 5940)
  AUTHORS   Kaplan,J.D., Stewart,B., Prasov,L. and Pyle,L.C.
  TITLE     MYRF-Related Cardiac Urogenital Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   36375006
REFERENCE   10 (bases 1 to 5940)
  AUTHORS   Longoni,M., Pober,B.R. and High,F.A.
  TITLE     Congenital Diaphragmatic Hernia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301533
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002380.3, HY145048.1,
            HY148147.1, AB023171.2 and AI366703.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001127392.2.
            
            Summary: This gene encodes a transcription factor that is required
            for central nervous system myelination and may regulate
            oligodendrocyte differentiation. It is thought to act by increasing
            the expression of genes that effect myelin production but may also
            directly promote myelin gene expression. Loss of a similar gene in
            mouse models results in severe demyelination. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Nov
            2014].
            
            Transcript Variant: This variant (2) lacks a 5' exon and uses an
            alternate 5' terminal exon, compared to variant 1. It encodes
            isoform 2 which is longer and has a distinct N-terminus compared to
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023171.2, SRR14038196.1394986.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278836.10/ ENSP00000278836.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AP002380.3         73640-73640
            2-2                 HY145048.1         3-3
            3-13                HY148147.1         2-12
            14-5939             AB023171.2         1-5926
            5940-5940           AI366703.1         11-11               c
FEATURES             Location/Qualifiers
     source          1..5940
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.2"
     gene            1..5940
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /note="myelin regulatory factor"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
     exon            1..155
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..3565
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; myelin gene regulatory factor"
                     /codon_start=1
                     /product="myelin regulatory factor isoform 2 precursor"
                     /protein_id="NP_001120864.1"
                     /db_xref="CCDS:CCDS44622.1"
                     /db_xref="GeneID:745"
                     /db_xref="HGNC:HGNC:1181"
                     /db_xref="MIM:608329"
                     /translation="MEVVDETEALQRFFEGHDINGALEPSNIDTSILEEYISKEDASD
                     LCFPDISAPASSASYSHGQPAMPGSSGVHHLSPPGGGPSPGRHGPLPPPGYGTPLNCN
                     NNNGMGAAPKPFPGGTGPPIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNEPHLLRT
                     ITPETLCHVGVPSRLEHPPPPPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPIPHYAA
                     MGQGLVPTDLHHTQQSQMLHQLLQQHGAELPTHPSKKRKHSESPPSTLNAQMLNGMIK
                     QEPGTVTALPLHPTRAPSPPWPPQGPLSPGPGSLPLSIARVQTPPWHPPGAPSPGLLQ
                     DSDSLSGSYLDPNYQSIKWQPHQQNKWATLYDANYKELPMLTYRVDADKGFNFSVGDD
                     AFVCQKKNHFQVTVYIGMLGEPKYVKTPEGLKPLDCFYLKLHGVKLEALNQSINIEQS
                     QSDRSKRPFNPVTVNLPPEQVTKVTVGRLHFSETTANNMRKKGKPNPDQRYFMLVVAL
                     QAHAQNQNYTLAAQISERIIVRASNPGQFESDSDVLWQRAQVPDTVFHHGRVGINTDR
                     PDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDTTEQLKRISRMRLVHYRYKPEFAAS
                     AGIEATAPETGVIAQEVKEILPEAVKDTGDMVFANGKTIENFLVVNKERIFMENVGAV
                     KELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGSSGAFSHAGSQFSRAGSVPHK
                     KRPPKVASKSSSVVPDQACISQRFLQGTIIALVVVMAFSVVSMSTLYVLSLRTEEDLV
                     DTDGSFAVSTSCLLALLRPQPPGGSEALCPWSSQSFGTTQLRQSPLTTGLPGIQPSLL
                     LVTTSLTSSAPGSAVRTLDMCSSHPCPVICCSSPTTNPTTGPSLGPSFNPGHVLSPSP
                     SPSTNRSGPSQMALLPVTNIRAKSWGLSVNGIGHSKHHKSLEPLASPAVPFPGGQGKA
                     KNSPSLGFHGRARRGALQSSVGPAEPTWAQGQSASLLAEPVPSLTSIQVLENSMSITS
                     QYCAPGDACRPGNFTYHIPVSSGTPLHLSLTLQMNSSSPVSVVLCSLRSKEEPCEEGS
                     LPQSLHTHQDTQGTSHRWPITILSFREFTYHFRVALLGQANCSSEALAQPATDYHFHF
                     YRLCD"
     exon            156..243
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            244..507
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            508..569
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            570..849
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1100
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1224
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1420
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1497
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1608
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1699
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1900
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2012
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2122
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2283
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2356
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2445
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2514
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2595
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2681
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2873
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..3125
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            3126..3228
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..3303
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..3409
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3484
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..5940
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5910..5915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /note="hexamer: AATAAA"
     polyA_site      5940
                     /gene="MYRF"
                     /gene_synonym="11orf9; C11orf9; CUGS; MMERV; MRF; Ndt80;
                     pqn-47"
                     /note="major polyA site"
ORIGIN      
        1 gtagccggag cccagccggg actgtcgcgc gggccgcgcc ggcgatgccg cgcccccggg
       61 ccgggctgta gcggggccgc ggctggagtg tgcgccgggc aggcgggaca tggaggtggt
      121 ggacgagacg gaggcgctgc agcgcttctt cgaaggccac gacatcaacg gtgccctgga
      181 gccctccaac atagacacca gcatcctgga ggagtacatc agcaaggagg atgcctccga
      241 cctctgcttc cctgacatct ctgctccagc cagctcggcc tcctactccc acgggcagcc
      301 tgcgatgcct ggctccagcg gggtccacca cctgagcccc cctgggggtg gaccctcccc
      361 ggggcgccat ggtcccctcc cacccccggg ctacggcacc ccgctgaact gcaacaacaa
      421 caacggcatg ggcgctgccc ccaagccctt cccggggggc accgggcccc ccatcaaggc
      481 tgagcccaag gctccctatg ccccaggcac actgccggac tctcccccag actcgggctc
      541 cgaggcctac tccccccagc aggtgaatga gccccacctc ctgcgcacga taacccctga
      601 gacactgtgc cacgtgggag tgccctcccg cctggagcat ccgcccccac ctccagccca
      661 cttgccaggc cccccgccac ccccaccacc cccacctcac taccctgtcc tgcagcggga
      721 tctgtacatg aaggccgagc ccccgatccc ccactacgct gccatggggc aggggctggt
      781 gcccactgat cttcaccaca cccagcagtc ccagatgctg caccagctcc tgcagcagca
      841 cggagctgag ctccctacac acccctccaa gaagaggaag cactctgaat ccccccccag
      901 caccctcaat gcccagatgc tgaatggaat gatcaaacag gagcctggga ccgtgacagc
      961 cctgcctctg caccccactc gagccccatc gccaccctgg cctccccagg gtccgctctc
     1021 cccgggccct ggttccttgc ctctcagcat tgcccgtgtc cagacaccgc cttggcaccc
     1081 gccaggtgcc ccctccccag gcctcctgca ggacagtgac agcctcagtg gctcctacct
     1141 ggaccccaac taccagtcca tcaagtggca gcctcatcag cagaacaagt gggcgaccct
     1201 gtacgatgct aactacaagg agctgcccat gctcacctac cgcgtggatg cggacaaggg
     1261 cttcaacttt tcggtgggcg acgacgcctt tgtgtgccag aagaagaacc acttccaggt
     1321 gacagtgtac atcggcatgc tgggcgagcc caagtacgtc aagacgcccg agggcctcaa
     1381 gcccctcgac tgcttctatc tgaagctgca cggagtgaag ctggaggccc tgaaccagtc
     1441 cattaacatc gagcagtccc agtcagaccg gagcaagcgg cccttcaacc cggtcacggt
     1501 caatctgccc cctgagcagg tcacgaaggt gactgtgggg cggctgcact tcagcgagac
     1561 caccgctaac aacatgcgta agaagggcaa gcccaacccg gaccagaggt acttcatgct
     1621 ggtggtggcc ctccaggctc atgcacagaa ccagaactac acgctggccg cccagatctc
     1681 agagcgcatc attgtgcggg cctccaaccc aggccagttc gagagcgaca gcgatgtgtt
     1741 gtggcagcgg gcacaggtgc ccgacaccgt cttccaccac ggccgcgtgg gcatcaacac
     1801 agaccggccg gatgaggcgc tggttgtgca cgggaatgtc aaggtcatgg gctcgcttat
     1861 gcacccctcc gacctgcgcg ccaaggaaca cgtgcaggag gtggacacca ccgagcaatt
     1921 gaagaggatc tcgcgcatgc ggctggtgca ctacagatac aagcccgagt tcgccgccag
     1981 cgcgggcatc gaggccaccg cgccagagac aggtgtcatc gctcaggagg tgaaggagat
     2041 cttgcctgag gctgtgaaag acaccggaga catggtcttt gccaatggga aaaccataga
     2101 gaacttcctg gtggtgaaca aggagcgcat cttcatggag aacgtagggg ccgtgaagga
     2161 gctgtgcaag ctgacagaca acctggagac gcgcattgat gagctggagc gctggagcca
     2221 caagctggcc aagctgcggc ggctcgacag cctcaagtcc accggcagct cgggcgcctt
     2281 cagccatgca gggagccagt tcagtcgggc gggcagcgtc ccccacaaga agaggccccc
     2341 caaggtggcc agcaagtcat cgtccgtggt tccggaccag gcctgcatca gccagcgctt
     2401 cctgcaggga accatcattg ccctggtggt ggtcatggcc ttcagcgtgg tgtccatgtc
     2461 cacactgtac gtgctgagcc tgcgcacaga ggaggacctg gtagacactg atggctcttt
     2521 tgccgtgtcc acttcctgtc tcctggccct gctccggccc cagccccctg gggggagtga
     2581 ggccttgtgc ccatggtcca gccagagctt tgggaccacg cagctccgac agtccccctt
     2641 gaccacgggg ctaccaggca tacagccctc tttgctgctg gtgaccacca gcctcaccag
     2701 ctcggcccca ggttctgctg tccgcacctt ggacatgtgt tccagccacc cctgccctgt
     2761 catctgctgt tcctcaccca ctaccaaccc taccactggt cctagtcttg gccccagctt
     2821 taaccctggc catgttctca gcccaagtcc cagccccagc accaaccgct caggccccag
     2881 ccagatggcc cttctgccag tcaccaacat cagagccaag tcctggggtc tttcagtcaa
     2941 tggcattggc cactccaagc atcacaagag tctggagcct ctggccagcc ctgcagtccc
     3001 cttccctggg gggcagggca aagccaagaa cagtcccagc cttggtttcc atggccgggc
     3061 ccgccgaggg gccctccagt ccagcgtggg ccctgctgag cccacctggg cccagggcca
     3121 gtcagcctct ctccttgcag agccagtgcc ctccctgacc tccatccagg tgctggagaa
     3181 ttcgatgtcc atcacctccc agtactgtgc tccaggggat gcctgcaggc ctgggaactt
     3241 cacctaccac atccctgtca gtagtggcac cccactgcac ctcagcctga ctctgcagat
     3301 gaactcctcc tcccccgtgt ctgtggtgct gtgcagcctg aggtcaaagg aggaaccatg
     3361 tgaggagggg agccttccac agagtctcca cacccaccag gacacccagg gcacctctca
     3421 ccggtggcca ataaccatcc tgtccttccg tgaattcacc taccacttcc gggtggcact
     3481 gctgggtcag gccaactgca gttcagaggc tctcgcccag ccagccacag actaccactt
     3541 ccacttctac cgcctgtgtg actgagctgc cctcctgagg cagcaccaca ccagggacca
     3601 ggggtgccca ggcacccccc aacactggat gcaatggtgt tacactggag cccgctgcag
     3661 gccagctctg ctgttcactg gccctacccg agactggtga aactggaagt cttcacactg
     3721 gagttgctgt tccagctggt cgcccctcac ggcacagagg gaacctgaga gccagagact
     3781 tcttgggcct tcctgcctgc caccccctag gggccaggac aggaccagtt tacctctttc
     3841 cagatatggt ggttggaggg ctggttcagg tgccctggag ggaaggggaa gcctgtggcc
     3901 ctgatttgtt cagagcccat tctcccttgc ctcccctttt gagactggag ccaacccttt
     3961 tggagagagg acctgcccac ctttgagatc agcagggggc tcggatccag ccctaagaga
     4021 cttgggtgga cccccatgag tcaatggagg gcagacggct ctccccctta aagctgttcc
     4081 ctgggggatg gcttggtagt ggactttctg gggtttgcct gttacgccag actcggactt
     4141 ctaagcttta agtgtggccc aggaggtttc ttctccctgg gagggcttgg ctcccaagaa
     4201 gtcccagggc agccgaggcc agccctgcct gggttggaga aactgacttt gtgccttaag
     4261 tctactcagt gcctggtgaa gccaccctca gcccttcaca ggcctgaacc agtaggggcc
     4321 agtgggccag gtaagcccta gagccttgaa ccaggaatat ccaggaagag gaaattccct
     4381 ttgagccccc agatggtatt gcagcttcac tgcctgcgtt cctgggagcg tctggagctc
     4441 acagtgatca gtgaccacat cattctctct gagcagagga gcaggaatcc ctcaagcagc
     4501 agcctggtct tggctggtgg gcagatgcaa atagcttttg ctgttattaa tgaagtaatt
     4561 actaaatgca cttaaaccag ggcaggaagg aatggaagga tggagctaga aagctcagag
     4621 tgggccagag caggggtgtg acacttgcaa agacagggct ctgactctga tccctcccag
     4681 ggagcctccg acacccatcc cactcccaac caccaagacc ctgggttagg gaagaagttg
     4741 tatcttaagt gccaccttca agtttcttag tggtgcctgg tgcattccga ggctacatcc
     4801 aggctcatgg aaggagtgta gtattcattt agccatgtct gccatgggtc cagaaatggg
     4861 aaagggaatt gctgtccttg ccctgtggta tgctgccacc tctttgggaa gcaggccttg
     4921 cccctgtccc accactcatt ctcagctttg aatgggaggc ctttctatag tggaggcctt
     4981 tccttgaagc ctatgaactg caggccccct tttgccattg atctcaaagc acttgtcctc
     5041 aggataggga agagcagggg gatgcaggaa tagcagggat agcttgctcc cagccccctc
     5101 cccaatttgg ttccgttgac ataggaattt tacgattccc aaaccatgca ggggctgagc
     5161 cttccttatg atgactttgt tctccctccc actgggggaa tcctccctat gccttaaaac
     5221 tgccgagccc cactccatgt aataggattc ctgggcttcc tcaatggggg ttcatgttct
     5281 tggactgcgg gccctcagtc cttaactgga aagtgaccgt ccactgcccc atggagccca
     5341 tctggacaca gcacagcccc aaaaccgtta gcagctggct ctgtttccaa gcctggggag
     5401 gggttcctca gtgcaggagt tggggacagg ctggggatcc aagctgcttg agggggtcaa
     5461 ccttggacca aagttgcctt aagcctgtgg taaaagggct tcagggaagg taagtgggcc
     5521 acctgctgga agctgccagc tgcccggctg gcaatggtgt gagtgtcttg gccctgtccc
     5581 tgccctgggg tccagcaggt catccctccc ttcttctctc tcctttggcg tttgttcctg
     5641 tagtcactgg gctaatctcc ccctagcttc aagctgtaca tagggcctcc cagtgcaaat
     5701 cctcctgccc ataccgtgca cccttagaag cctgcgtgtg catagagcgc cccctacttc
     5761 ccagttaact cccagttctt ctccctgagc ttggtatttg tcatgtgcca actctgactc
     5821 tgaggtgggc agtgagggaa gcagccccgg gcctgcttgc ttcctgtccc cgaaatgttc
     5881 gtttcttctg aagtaaatat acatatataa ataaatgtat aaatactgct ttgtatctga
//
