LOCUS       NM_020702               6447 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens myogenesis regulating glycosidase (MYORG), mRNA.
ACCESSION   NM_020702 XM_372083
VERSION     NM_020702.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6447)
  AUTHORS   Hobara,T., Higuchi,Y., Yoshida,M., Suehara,M., Ando,M., Yuan,J.H.,
            Yoshimura,A., Kojima,F., Matsuura,E., Okamoto,Y., Mitsui,J.,
            Tsuji,S. and Takashima,H.
  TITLE     Genetic and pathophysiological insights from autopsied patient with
            primary familial brain calcification: novel MYORG variants and
            astrocytic implications
  JOURNAL   Acta Neuropathol Commun 12 (1), 136 (2024)
   PUBMED   39180105
  REMARK    GeneRIF: Genetic and pathophysiological insights from autopsied
            patient with primary familial brain calcification: novel MYORG
            variants and astrocytic implications.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6447)
  AUTHORS   Zhao,T., Xu,S., Liu,S., Xu,J., Zhang,X. and Zhan,Y.
  TITLE     Fahr's disease linked to a novel mutation in MYORG variants
            manifesting as paroxysmal limb stiffness and dysarthria: Case
            report and literature review
  JOURNAL   Mol Genet Genomic Med 11 (12), e2276 (2023)
   PUBMED   37680026
  REMARK    GeneRIF: Fahr's disease linked to a novel mutation in MYORG
            variants manifesting as paroxysmal limb stiffness and dysarthria:
            Case report and literature review.
            Review article
REFERENCE   3  (bases 1 to 6447)
  AUTHORS   Meek,R.W., Brockerman,J., Fordwour,O.B., Zandberg,W.F., Davies,G.J.
            and Vocadlo,D.J.
  TITLE     The primary familial brain calcification-associated protein MYORG
            is an alpha-galactosidase with restricted substrate specificity
  JOURNAL   PLoS Biol 20 (9), e3001764 (2022)
   PUBMED   36129849
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6447)
  AUTHORS   Du,J., Zhu,X., Liu,J. and Tan,Y.
  TITLE     Paroxysmal Kinesigenic Dyskinesia Secondary to Brain Calcification
            with a Homozygous MYORG Mutation
  JOURNAL   Mov Disord 36 (11), 2699-2701 (2021)
   PUBMED   34346093
  REMARK    GeneRIF: Paroxysmal Kinesigenic Dyskinesia Secondary to Brain
            Calcification with a Homozygous MYORG Mutation.
REFERENCE   5  (bases 1 to 6447)
  AUTHORS   Malaquias,M.J., Martins,R.C., Oliveira,J., Freixo,J.P. and
            Magalhaes,M.
  TITLE     MYORG gene disease-causing variants in a family with primary
            familial brain calcification presenting with stroke-like episodes
  JOURNAL   Clin Genet 98 (5), 517-519 (2020)
   PUBMED   32896900
  REMARK    GeneRIF: MYORG gene disease-causing variants in a family with
            primary familial brain calcification presenting with stroke-like
            episodes.
REFERENCE   6  (bases 1 to 6447)
  AUTHORS   Forouhideh,Y., Muller,K., Ruf,W., Assi,M., Seker,T., Tunca,C.,
            Knehr,A., Strom,T.M., Gorges,M., Schradt,F., Meitinger,T.,
            Ludolph,A.C., Pinkhardt,E.H., Basak,A.N., Kassubek,J., Uttner,I.
            and Weishaupt,J.H.
  TITLE     A biallelic mutation links MYORG to autosomal-recessive primary
            familial brain calcification
  JOURNAL   Brain 142 (2), e4 (2019)
   PUBMED   30649222
  REMARK    GeneRIF: A point mutation in MYORG is associated with primary
            familial brain calcification in a Turkish family.
REFERENCE   7  (bases 1 to 6447)
  AUTHORS   Chen,Y., Fu,F., Chen,S., Cen,Z., Tang,H., Huang,J., Xie,F.,
            Zheng,X., Yang,D., Wang,H., Huang,X., Zhang,Y., Zhou,Y., Liu,J.Y.
            and Luo,W.
  TITLE     Evaluation of MYORG mutations as a novel cause of primary familial
            brain calcification
  JOURNAL   Mov Disord 34 (2), 291-297 (2019)
   PUBMED   30589467
  REMARK    GeneRIF: MYORG as a novel causative gene for primary familial brain
            calcification
REFERENCE   8  (bases 1 to 6447)
  AUTHORS   Yao,X.P., Cheng,X., Wang,C., Zhao,M., Guo,X.X., Su,H.Z., Lai,L.L.,
            Zou,X.H., Chen,X.J., Zhao,Y., Dong,E.L., Lu,Y.Q., Wu,S., Li,X.,
            Fan,G., Yu,H., Xu,J., Wang,N., Xiong,Z.Q. and Chen,W.J.
  TITLE     Biallelic Mutations in MYORG Cause Autosomal Recessive Primary
            Familial Brain Calcification
  JOURNAL   Neuron 98 (6), 1116-1123 (2018)
   PUBMED   29910000
  REMARK    GeneRIF: Findings provide strong evidence that loss-of-function
            mutations of MYORG cause brain calcification in humans. Compound
            heterozygous or homozygous mutations of MYORG co-segregated
            completely with primary familial brain calcification in six
            families.
REFERENCE   9  (bases 1 to 6447)
  AUTHORS   Chapuis,J., Hot,D., Hansmannel,F., Kerdraon,O., Ferreira,S.,
            Hubans,C., Maurage,C.A., Huot,L., Bensemain,F., Laumet,G.,
            Ayral,A.M., Fievet,N., Hauw,J.J., DeKosky,S.T., Lemoine,Y.,
            Iwatsubo,T., Wavrant-Devrieze,F., Dartigues,J.F., Tzourio,C.,
            Buee,L., Pasquier,F., Berr,C., Mann,D., Lendon,C., Alperovitch,A.,
            Kamboh,M.I., Amouyel,P. and Lambert,J.C.
  TITLE     Transcriptomic and genetic studies identify IL-33 as a candidate
            gene for Alzheimer's disease
  JOURNAL   Mol Psychiatry 14 (11), 1004-1016 (2009)
   PUBMED   19204726
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 6447)
  AUTHORS   Datta,K., Guan,T. and Gerace,L.
  TITLE     NET37, a nuclear envelope transmembrane protein with glycosidase
            homology, is involved in myoblast differentiation
  JOURNAL   J Biol Chem 284 (43), 29666-29676 (2009)
   PUBMED   19706595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356494.13, CB988183.1, BC110493.2, AB032987.2, AW008982.1 and
            AI066728.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020702.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.186998.1,
                                           SRR1803614.1556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297625.8/ ENSP00000297625.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL356494.13        43300-43301         c
            3-327               CB988183.1         30-354
            328-2604            BC110493.2         57-2333
            2605-3090           AB032987.2         2333-2818
            3091-3091           AL356494.13        36425-36425         c
            3092-5594           AB032987.2         2820-5322
            5595-5595           AL356494.13        33921-33921         c
            5596-6111           AB032987.2         5324-5839
            6112-6446           AW008982.1         1-335               c
            6447-6447           AI066728.1         8-8                 c
FEATURES             Location/Qualifiers
     source          1..6447
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..6447
                     /gene="MYORG"
                     /gene_synonym="IBGC7; KIAA1161; NET37"
                     /note="myogenesis regulating glycosidase"
                     /db_xref="GeneID:57462"
                     /db_xref="HGNC:HGNC:19918"
                     /db_xref="MIM:618255"
     exon            1..106
                     /gene="MYORG"
                     /gene_synonym="IBGC7; KIAA1161; NET37"
                     /inference="alignment:Splign:2.1.0"
     exon            107..6447
                     /gene="MYORG"
                     /gene_synonym="IBGC7; KIAA1161; NET37"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2314
                     /gene="MYORG"
                     /gene_synonym="IBGC7; KIAA1161; NET37"
                     /EC_number="3.2.1.-"
                     /note="myogenesis regulating glycosidase (putative)"
                     /codon_start=1
                     /product="myogenesis-regulating glycosidase"
                     /protein_id="NP_065753.2"
                     /db_xref="CCDS:CCDS78391.1"
                     /db_xref="GeneID:57462"
                     /db_xref="HGNC:HGNC:19918"
                     /db_xref="MIM:618255"
                     /translation="MLQNPQEKSQAYPRRRRPGCYAYRQNPEAIAAAAMYTFLPDNFS
                     PAKPKPSKDLKPLLGSAVLGLLLVLAAVVAWCYYSVSLRKAERLRAELLDLKAGGFSI
                     RNQKGEQVFRLAFRSGALDLDSCSRDGALLGCSLTADGLPLHFFIQTVRPKDTVMCYR
                     VRWEEAAPGRAVEHAMFLGDAAAHWYGGAEMRTQHWPIRLDGQQEPQPFVTSDVYSSD
                     AAFGGILERYWLSSRAAAIKVNDSVPFHLGWNSTERSLRLQARYHDTPYKPPAGRAAA
                     PELSYRVCVGSDVTSIHKYMVRRYFNKPSRVPAPEAFRDPIWSTWALYGRAVDQDKVL
                     RFAQQIRLHHFNSSHLEIDDMYTPAYGDFDFDEVKFPNASDMFRRLRDAGFRVTLWVH
                     PFVNYNSSRFGEGVERELFVREPTGRLPALVRWWNGIGAVLDFTHPKARDWFQGHLRR
                     LRSRYSVASFKFDAGEVSYLPRDFSTYRPLPDPSVWSRRYTEMALPFFSLAEVRVGYQ
                     SQNISCFFRLVDRDSVWGYDLGLRSLIPAVLTVSMLGYPFILPDMVGGNAVPQRTAGG
                     DVPERELYIRWLEVAAFMPAMQFSIPPWRYDAEVVAIAQKFAALRASLVAPLLLELAG
                     EVTDTGDPIVRPLWWIAPGDETAHRIDSQFLIGDTLLVAPVLEPGKQERDVYLPAGKW
                     RSYKGELFDKTPVLLTDYPVDLDEIAYFTWAS"
     regulatory      4178..4183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYORG"
                     /gene_synonym="IBGC7; KIAA1161; NET37"
                     /note="hexamer: ATTAAA"
     polyA_site      4204
                     /gene="MYORG"
                     /gene_synonym="IBGC7; KIAA1161; NET37"
                     /note="major polyA site"
     regulatory      6091..6096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYORG"
                     /gene_synonym="IBGC7; KIAA1161; NET37"
                     /note="hexamer: ATTAAA"
     polyA_site      6114
                     /gene="MYORG"
                     /gene_synonym="IBGC7; KIAA1161; NET37"
     regulatory      6422..6427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYORG"
                     /gene_synonym="IBGC7; KIAA1161; NET37"
                     /note="hexamer: AATAAA"
     polyA_site      6447
                     /gene="MYORG"
                     /gene_synonym="IBGC7; KIAA1161; NET37"
                     /note="major polyA site"
ORIGIN      
        1 agacagagcc ccgcgcggcg cggcggcagc ttcactctgg ttcaagcgca ggggatcggc
       61 gggaagctct ttcacccccg cttctgccgg gctgtaactg caatggagca ggttgagatg
      121 aactcagtca gatggcccca cggcccgctc ctttcttagc agcccactaa tgctccagaa
      181 ccctcaggag aagagccagg cctacccccg ccgccgccgg cctggctgct acgcataccg
      241 tcagaacccc gaggccatcg cagccgcagc tatgtacacc ttcctgcccg acaacttctc
      301 acctgccaag cccaagcctt ccaaagacct gaagccgctg ctgggctccg cggttctggg
      361 gctgctgctt gtgctggccg cggtggtggc ctggtgctac tacagcgtct ccctacgcaa
      421 ggcggagcga cttcgcgcgg agctgctgga cctgaaagct ggcggcttct ccatccgcaa
      481 tcagaaggga gagcaggtct tccgcctggc cttccgctcc ggcgcgctgg accttgactc
      541 ctgcagccgc gatggcgccc tgctgggctg ctcgctcacg gccgacgggc tgccgctgca
      601 cttcttcatc cagactgtgc ggcccaagga cacggtcatg tgctaccgcg tgcgctggga
      661 ggaggcagcg ccgggccggg ccgtggagca cgccatgttc ttgggcgacg cggcggccca
      721 ctggtatggt ggcgccgaga tgaggacgca acactggccc atccgcctgg atggccagca
      781 ggagccccag ccgttcgtca ccagcgatgt ctactcctcc gacgccgcgt ttgggggcat
      841 cctcgagcgc tactggctat cttcgcgcgc ggccgccatc aaagtcaatg actcagtgcc
      901 cttccacctg ggctggaaca gcacggagcg ctcgctgcgg cttcaggcgc gctaccacga
      961 cacgccctac aagccacccg ccggccgcgc cgcagcgcca gagctgagct accgagtgtg
     1021 cgtgggctca gacgtcacct ccatccacaa gtacatggtg cgtcgctact tcaacaagcc
     1081 gtcaagggtg ccagcacccg aggccttccg agaccccatt tggtccacat gggcgctgta
     1141 cgggcgcgcc gtggaccagg acaaggtgct gcgttttgcc caacagatcc gcctgcacca
     1201 cttcaacagc agccacctgg aaatcgacga catgtacaca cctgcttatg gcgacttcga
     1261 cttcgatgag gtcaaattcc ccaacgccag cgacatgttc cgccgcctgc gcgacgccgg
     1321 cttccgcgtc acgctctggg tgcacccttt tgtcaactac aactcgtcgc gcttcggcga
     1381 gggcgtggag cgcgagctgt tcgtgcgcga acccacgggc cggttacctg cgctggtgcg
     1441 ctggtggaac ggcatcggcg cggtgctaga cttcacgcac ccaaaggccc gcgactggtt
     1501 ccagggacac ctgcggcggc tgcgctctcg ctactccgtg gcttccttca agttcgacgc
     1561 gggcgaggtc agctacctgc cgcgggactt cagcacctac cggccgctgc cggaccccag
     1621 cgtctggagc cggcgctaca ctgagatggc gctgcccttc ttctcgctgg cggaggtgcg
     1681 cgtaggctac cagtcacaga acatctcctg cttcttccgc ctggtggatc gcgactctgt
     1741 gtggggctac gacctggggt tgcgctcact catccccgcg gtgctcaccg tcagcatgct
     1801 gggctaccca ttcatcctac ccgatatggt gggcggcaac gccgtgcccc agcggacagc
     1861 cggcggcgat gtgcccgagc gcgagctcta cattcgctgg ctggaagtgg ccgcctttat
     1921 gccggccatg cagttctcta tcccgccctg gcgctacgac gcggaagtgg tggccatcgc
     1981 gcagaagttc gccgccctgc gggcctcgct tgtggcaccg ctgttgcttg agctggcggg
     2041 cgaggtcacc gacacgggtg accctatcgt gcgccccctt tggtggattg cgcccggcga
     2101 cgagacagct caccgtatcg actcgcagtt ccttattggg gacacgctgc ttgtggcccc
     2161 ggtgctggag ccaggcaagc aggagcgcga cgtctatttg cccgccggca agtggcgcag
     2221 ctacaagggt gagcttttcg acaagacgcc ggtgctgctc accgattacc cggtcgacct
     2281 ggatgagatc gcctacttta cctgggcgtc ctgacccagc ccagggcccg gtaaccgcaa
     2341 agcccccagt cttcatgcag accttgaacc ctccgtcaca cccgcaccat gtactcccag
     2401 gaacctccca cctctatacc acccattaag tggctgctga cttaaatgtg ctggaaccag
     2461 ctgctgaagg tggggcctag ggagggggca ctgaagcaat ctcctgctcc aacgcacaat
     2521 ccttactgtg ccctttccac ccccacactc acaccaatct gcagaaacct cttccctggg
     2581 gtggaagcca gagagcttag aggaaaaagg tcagctctct tcctgttata catggttata
     2641 catggttggg gtttaaaagc acaaagagaa acctccccct cctggctttc gtggccatct
     2701 ttgtccatct taggtgggga cttgatctta tttaaggtct ccaaatagcc cccaccacac
     2761 ttagaacgtg tgttttctta gtgttagaag ccaggccctg agtccccagc actcacctga
     2821 actgtggctg atttggtccc agtccagctg gggaggtgtt tggctgacaa ggaggcaaga
     2881 gatcccctcc cagggaacag gaggactggg cttagcacag agccatcatc atgttcccaa
     2941 tttgtgaaga gactcctaac actgcactaa cccatttgtg tacatacatg ggctcagccc
     3001 tgggccaaat gtgcctgatg ggaacagact tgcagggcca tgcaggccag acttcgtgcc
     3061 ttaactgaag agtgtgcgtg tgtgtgtgtg agagagagag agagagagaa acacgcatca
     3121 tgggtccctg atctatgaaa tgaacacaac ctctctgagg ctggatgatc tggaggaagg
     3181 gggcatggag caaatttgag gctctgattg ctgagccagc ctcctcccag gcggtttccc
     3241 caggactctc gtaggaaata aatagccctt tcaagattcc tcagctgcct caccccctgc
     3301 acatgtgcct ggggtgtggc ctagaaggga gtgatgttct tactctggtg gtctgtgctt
     3361 ctgaacacag gctacatgca cacactgaca actaccaata aacagacagg ggaaggtctt
     3421 tcatctcagc cattttctct tccccccgcc cccccttaga tggagtcttg ctctgtcacc
     3481 caggttggag tgcagtggca caatcagctc actgcaaccc ctcctcctag gttcaagcga
     3541 ttgagtagct gagattacag gcatgcatca ctatgcctgg ctttttgtat tttttagtag
     3601 agatggggtt taccatgttg gccaggctag tctcaaactc ctgacctagt gatgcaccca
     3661 ccttggcctc ccaaagtgtt gggattacag gcatgagcca ccacgccagc cattttctct
     3721 ttctaagaag agcaacctca gccggagtga gttttttctg actttgcagc tgagtctgga
     3781 gaaaagtggc atgccagagc gggtcggtgg gaaacagggt gaactttagc ttccatcaac
     3841 agctctggta gcaaaaccag tcccctaccc cctagagaat gcatccgttt ccccacctga
     3901 tatggtttgg ctgtgtcccc acctaaaact catcttgaat tgtagctccc ataattgcca
     3961 tgtgttgtgg gaaggaccca gtgggagata attgaaatat gggggcagtt tccgccatac
     4021 tgttctggtg atagtgaata gatctcatga gagctgatga ttttataaga ggtttcccct
     4081 tttgcttagt tctcattctc tcttgcctgc cgccatgtaa gacgtgcctt tctgtcatgc
     4141 ttgtgaggcc tccccagcca cgtggagctg tgagttcatt aaacctcttt ttctttataa
     4201 attacccagt cttggttatg tctttatcag cactgtgaaa atgaacctat acagtaaatt
     4261 ggtaccagta gagtggggcg ctgctgtaaa tacccaaaaa tgtggaagca actttggaac
     4321 tgggtaacag gcagaggttg gaacagtttg gagggatcag aagacaggaa aatgtgggaa
     4381 agtttgggac ttcctagaga cttgttaaat ggctttgacc aaaatgctga taatgattgg
     4441 gacatgaaat ccaggctgag ttggtctcag atagcgatga ggaacttgtt tggtactgga
     4501 gtaaaggtga ctcttgctat attttagcaa agagactggc tgcattttgc ccctgcccta
     4561 gagatttgtg gaactttgaa ctcgagggag atgatttagg gtatctggca gaagaaattt
     4621 ctaagcagca aagcattcat gaggtgactt gggtgctgtt aaaagcattc agttttaaaa
     4681 gggaaacaga ctataaaagt ttggaaaatt tgcagcctga tgatgagata gaaaagaaaa
     4741 acccattttc tgaggataaa ttcaagcccc ctgcagaaat ttgcataagt aacaaggagc
     4801 caaatgttaa tcactaagac atggggaaaa tgtctgcagg gcatgtcaga gacctttgca
     4861 gcagtgcctc ccatcacagg cctggaggcc taggagggaa aaaatggttt tgtgggccag
     4921 gcccaaggtc cccttgctgt gtgcagccca gggacttggt accatgcatc ccagctgctc
     4981 tagtcatggc taaaaggggc caagatacag ctcaggcctt ggcttcagag ggtgcaagcc
     5041 ccaagtcttg gcatcttcca cgtagtgttg agcctgcagg tgcacagaag tcaagaactg
     5101 aggtttggga acctctgcct agatttcaga gaatgtatgg aaatgcatgt atgtccaggc
     5161 agaagtttgc tacaggagtg aggccctcat ggagaacctc tgttaaggca atgtggaagg
     5221 ggaagccccc acacagagac cccactggga cactgcctag tagagctgtc agaagaaggc
     5281 caccgtcctc cagacatcag aatggtatat ccactgacag cttgcaccat gcacctggaa
     5341 aagccacaga cactcaacgc cagcctgtaa aagcaaccga gaagtaggct gtaccctgca
     5401 atgccatagg ggtggagctg cccaagacca tgggaaccca cctcctgcat cagtgtgacc
     5461 tggatgtgag acatggagtc aaaggagacc attttggagc tttaagattt aactgccctg
     5521 ctggatttca gacttgcatg gggcctttag ccacttcgtt ttggccaact tctcccactt
     5581 gaaatgggtg tatttagcca atgcctgtac ctccgttgta tctaggaagt aactaactag
     5641 cctttgattt tacaggctca taggtggaag ggacttgcct tgtttcagat gagactttgg
     5701 agtatggact tttgagttaa tgctgaaatg agttaagact ttgggggact gttgggaagg
     5761 catgattgat ttttaaatga gaggacatga gatttgggag gggccaggga gagaatgata
     5821 tggtttggct gtgtccccat ccaaatatca ccttaaattg tagctcccat aattgtggga
     5881 gggacctggt gggagataat tgaatcatag gggcagtttc tcccatactg ttctggtggt
     5941 agtgaataag tctcacgaga tctgatggtt taataagggg tttccccttt tgcttggctc
     6001 tcattctctc ttgtctgctg ccatgtaaga tgtgcctttt gccttccacc atgattgtga
     6061 ggcctcccag ccacatggaa ctgtgagttc attaaacctc tttttcttca taaattaccc
     6121 agtctcgggt atgtctttat cagcagtgtg aaaacagact aatacaccac tcctctacct
     6181 tctttatttt ctcagtgtgg aaaatgcctg atgaaagctt tggggccctc acagatgcac
     6241 aactcaagtg ctgattctat cacttatcta ccagctctgt gaccttgaac aagccgctta
     6301 accttgctaa gcctctgttt tctcatatgt caaatggtga taataatgcc tacctcccga
     6361 ggttgttgta agaattataa gcacaaatgt atgtaaagtg cctggcacaa agtaggtgct
     6421 caataaatgg tagctattat aatacta
//
