LOCUS       NM_152372               5760 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens myomesin 3 (MYOM3), mRNA.
ACCESSION   NM_152372
VERSION     NM_152372.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5760)
  AUTHORS   Lee,M., Shin,J., Kato,T., Kanda,K., Oikawa,S., Sakuma,J.,
            Sugama,K., Kawakami,Y., Suzuki,K. and Akimoto,T.
  TITLE     An acute eccentric exercise increases circulating myomesin 3
            fragments
  JOURNAL   J Physiol Sci 71 (1), 4 (2021)
   PUBMED   33468054
  REMARK    GeneRIF: An acute eccentric exercise increases circulating myomesin
            3 fragments.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5760)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5760)
  AUTHORS   Shakeel,M., Irfan,M. and Khan,I.A.
  TITLE     Rare genetic mutations in Pakistani patients with dilated
            cardiomyopathy
  JOURNAL   Gene 673, 134-139 (2018)
   PUBMED   29886034
  REMARK    GeneRIF: mutations in Pakistani patients with dilated
            cardiomyopathy rs375563861 (C2orf40), rs143187236 (MYOM3), and
            rs564181443 (RTKN2) have 3 fold or higher allele frequency in South
            Asians than in the global populations
REFERENCE   4  (bases 1 to 5760)
  AUTHORS   Rouillon,J., Poupiot,J., Zocevic,A., Amor,F., Leger,T., Garcia,C.,
            Camadro,J.M., Wong,B., Pinilla,R., Cosette,J., Coenen-Stass,A.M.,
            Mcclorey,G., Roberts,T.C., Wood,M.J., Servais,L., Udd,B., Voit,T.,
            Richard,I. and Svinartchouk,F.
  TITLE     Serum proteomic profiling reveals fragments of MYOM3 as potential
            biomarkers for monitoring the outcome of therapeutic interventions
            in muscular dystrophies
  JOURNAL   Hum Mol Genet 24 (17), 4916-4932 (2015)
   PUBMED   26060189
  REMARK    GeneRIF: MYOM3 fragments hold promise for minimally invasive
            assessment of experimental therapies for DMD and other
            neuromuscular disorders.
REFERENCE   5  (bases 1 to 5760)
  AUTHORS   Goes,F.S., Hamshere,M.L., Seifuddin,F., Pirooznia,M.,
            Belmonte-Mahon,P., Breuer,R., Schulze,T., Nothen,M., Cichon,S.,
            Rietschel,M., Holmans,P., Zandi,P.P., Craddock,N. and Potash,J.B.
  CONSRTM   Bipolar Genome Study (BiGS)
  TITLE     Genome-wide association of mood-incongruent psychotic bipolar
            disorder
  JOURNAL   Transl Psychiatry 2 (10), e180 (2012)
   PUBMED   23092984
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5760)
  AUTHORS   Luke,M.M., O'Meara,E.S., Rowland,C.M., Shiffman,D., Bare,L.A.,
            Arellano,A.R., Longstreth,W.T. Jr., Lumley,T., Rice,K., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Gene variants associated with ischemic stroke: the cardiovascular
            health study
  JOURNAL   Stroke 40 (2), 363-368 (2009)
   PUBMED   19023099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5760)
  AUTHORS   Schoenauer,R., Lange,S., Hirschy,A., Ehler,E., Perriard,J.C. and
            Agarkova,I.
  TITLE     Myomesin 3, a novel structural component of the M-band in striated
            muscle
  JOURNAL   J Mol Biol 376 (2), 338-351 (2008)
   PUBMED   18177667
REFERENCE   8  (bases 1 to 5760)
  AUTHORS   Shiffman,D., O'Meara,E.S., Bare,L.A., Rowland,C.M., Louie,J.Z.,
            Arellano,A.R., Lumley,T., Rice,K., Iakoubova,O., Luke,M.M.,
            Young,B.A., Malloy,M.J., Kane,J.P., Ellis,S.G., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Association of gene variants with incident myocardial infarction in
            the Cardiovascular Health Study
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (1), 173-179 (2008)
   PUBMED   17975119
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX647453.1 and AL591178.12.
            
            On Nov 22, 2018 this sequence version replaced NM_152372.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647453.1, BX647455.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374434.4/ ENSP00000363557.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1705              BX647453.1         2-1706
            1706-1737           AL591178.12        52253-52284         c
            1738-2679           BX647453.1         1739-2680
            2680-2709           AL591178.12        42731-42760         c
            2710-4327           BX647453.1         2711-4328
            4328-5760           AL591178.12        18756-20188         c
FEATURES             Location/Qualifiers
     source          1..5760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..5760
                     /gene="MYOM3"
                     /note="myomesin 3"
                     /db_xref="GeneID:127294"
                     /db_xref="HGNC:HGNC:26679"
                     /db_xref="MIM:616832"
     exon            1..105
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            106..284
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..4437
                     /gene="MYOM3"
                     /note="myomesin family, member 3"
                     /codon_start=1
                     /product="myomesin-3"
                     /protein_id="NP_689585.3"
                     /db_xref="CCDS:CCDS41281.1"
                     /db_xref="GeneID:127294"
                     /db_xref="HGNC:HGNC:26679"
                     /db_xref="MIM:616832"
                     /translation="MTLPHSLGGAGDPRPPQAMEVHRLEHRQEEEQKEERQHSLRMGS
                     SVRRRTFRSSEEEHEFSAADYALAAALALTASSELSWEAQLRRQTSAVELEERGQKRV
                     GFGNDWERTEIAFLQTHRLLRQRRDWKTLRRRTEEKVQEAKELRELCYGRGPWFWIPL
                     RSHAVWEHTTVLLTCTVQASPPPQVTWYKNDTRIDPRLFRAGKYRITNNYGLLSLEIR
                     RCAIEDSATYTVRVKNAHGQASSFAKVLVRTYLGKDAGFDSEIFKRSTFGPSVEFTSV
                     LKPVFAREKEPFSLSCLFSEDVLDAESIQWFRDGSLLRSSRRRKILYTDRQASLKVSC
                     TYKEDEGLYMVRVPSPFGPREQSTYVLVRDAEAENPGAPGSPLNVRCLDVNRDCLILT
                     WAPPSDTRGNPITAYTIERCQGESGEWIACHEAPGGTCRCPIQGLVEGQSYRFRVRAI
                     SRVGSSVPSKASELVVMGDHDAARRKTEIPFDLGNKITISTDAFEDTVTIPSPPTNVH
                     ASEIREAYVVLAWEEPSPRDRAPLTYSLEKSVIGSGTWEAISSESPVRSPRFAVLDLE
                     KKKSYVFRVRAMNQYGLSDPSEPSEPIALRGPPATLPPPAQVQAFRDTQTSVSLTWDP
                     VKDPELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPGLRTGKEYEFCVRSVSEAGVG
                     ESSAATEPIRVKQALATPSAPYGFALLNCGKNEMVIGWKPPKRRGGGKILGYFLDQHD
                     SEELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFECKEWT
                     MPQPGPPYDVRASEVRATSLVLQWEPPLYMGAGPVTGYHVSFQEEGSEQWKPVTPGPI
                     SGTHLRVSDLQPGKSYVFQVQAMNSAGLGQPSMPTDPVLLEDKPGAHEIEVGVDEEGF
                     IYLAFEAPEAPDSSEFQWSKDYKGPLDPQRVKIEDKVNKSKVILKEPGLEDLGTYSVI
                     VTDADEDISASHTLTEEELEKLKKLSHEIRNPVIKLISGWNIDILERGEVRLWLEVEK
                     LSPAAELHLIFNNKEIFSSPNRKINFDREKGLVEVIIQNLSEEDKGSYTAQLQDGKAK
                     NQITLTLVDDDFDKLLRKADAKRRDWKRKQGPYFERPLQWKVTEDCQVQLTCKVTNTK
                     KETRFQWFFQRAEMPDGQYDPETGTGLLCIEELSKKDKGIYRAMVSDDRGEDDTILDL
                     TGDALDAIFTELGRIGALSATPLKIQGTEEGIRIFSKVKYYNVEYMKTTWFHKDKRLE
                     SGDRIRTGTTLDEIWLHILDPKDSDKGKYTLEIAAGKEVRQLSTDLSGQAFEDAMAEH
                     QRLKTLAIIEKNRAKVVRGLPDVATIMEDKTLCLTCIVSGDPTPEISWLKNDQPVTFL
                     DRYRMEVRGTEVTITIEKVNSEDSGRYGVFVKNKYGSETGQVTISVFKHGDEPKELKS
                     M"
     exon            285..365
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            366..525
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            526..683
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            684..779
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            780..868
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            869..913
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1051
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1213
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1355
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1555
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1609
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1737
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1921
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2093
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2215
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            2216..2403
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2530
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2709
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2824
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..2981
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3091
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3092..3136
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3273
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..3418
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3419..3478
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3546
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3657
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..3745
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3746..3784
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3785..3893
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            3894..4057
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4094
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4117
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            4118..4173
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     exon            4174..5760
                     /gene="MYOM3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5732..5737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYOM3"
                     /note="hexamer: AATAAA"
     polyA_site      5760
                     /gene="MYOM3"
                     /note="major polyA site"
ORIGIN      
        1 attcttctcc cggtgcccgc tgagccgagg gcaagaagag aacaaggacc ctctcggcct
       61 caggaatctt ctccccagag actcctaagt gggcacactg cttctgttgt tgctctcgta
      121 accatgactc tgccgcacag cttgggaggt gcgggggacc cccggccccc ccaggccatg
      181 gaggttcaca ggctggagca ccggcaggag gaggagcaga aggaggagcg gcagcacagc
      241 ctgcgcatgg gctcctctgt gcggaggcgg accttccgca gcagcgaaga agagcatgag
      301 ttcagcgccg cggactacgc cctggcagca gccctggctc tgacggcctc ctccgagctg
      361 tcttgggaag cccagctgag acgccagacc tctgccgtgg agctggagga gcgagggcag
      421 aagcgggtgg gcttcggcaa tgactgggag aggactgaga tcgccttcct gcagacccac
      481 cggctgctgc gccagaggcg ggactggaag acgctgaggc ggcggacaga ggagaaggtc
      541 caggaggcca aggagctgag ggagctgtgc tacggccgcg ggccctggtt ctggatccct
      601 cttcgctccc acgccgtctg ggagcacacc acggtcctgc tgacctgcac tgtccaggcc
      661 tcaccaccac cccaggtcac ctggtacaaa aatgacacac ggattgatcc ccgcctcttt
      721 cgtgccggaa aataccgaat caccaacaac tacgggctgc tgtccctgga gattaggaga
      781 tgcgccattg aggactcagc aacttacact gtgcgagtga agaacgccca cggccaggcc
      841 tcctccttcg ccaaagtcct cgtccgcact tacctgggga aggatgctgg cttcgattca
      901 gagatcttca aaagatcgac gtttggcccc agcgtggaat tcacctcggt gctgaagcca
      961 gtctttgctc gtgagaagga acccttctcc ctgtcatgct tgttttcgga agatgtgtta
     1021 gatgctgaga gcatccagtg gttccgagat gggagcctac tgaggtcctc gagacgtcgg
     1081 aagatcctct acacagaccg ccaggcatcc ctgaaggtgt cctgcaccta caaggaggac
     1141 gaggggctct acatggtccg ggtgccctcg cccttcggac cccgggaaca gagcacctac
     1201 gtgcttgtga gagatgccga ggccgagaac cccggggccc caggctcccc actgaacgtc
     1261 cgatgcctgg atgtgaacag agactgcctc atcctgactt gggccccgcc cagtgacacc
     1321 cggggcaacc ccatcactgc ctacaccatt gagcggtgcc agggcgagtc tggggaatgg
     1381 atcgcctgcc atgaggcccc cggagggact tgtcggtgcc caatccaagg cctcgtcgaa
     1441 ggtcagagct atcggttccg ggtgagagcc atcagcaggg taggcagcag cgtcccctcc
     1501 aaggcctcag agttggttgt catgggtgac catgatgcag cccggaggaa gacagagatc
     1561 ccctttgatc tgggaaacaa gatcaccatc agcacagacg cttttgaaga tactgtgacc
     1621 atcccctcac cgccaaccaa tgtccatgcc agcgagatcc gagaggccta tgtggttctg
     1681 gcctgggagg agcccagccc ccgggacaga gcaccactga cgtactccct ggagaagtca
     1741 gtcataggta gtggcacctg ggaggccatc agctcggaaa gccctgtgag atccccgaga
     1801 ttcgccgttc tggacctgga gaaaaagaag tcgtatgtct tcagagtgcg agcaatgaac
     1861 cagtatggcc tgagcgatcc ctcggagccc agcgaaccca tcgccttgcg gggcccgcca
     1921 gctaccctcc ctcctccagc tcaagttcaa gctttcagag acacacagac ctctgtctcc
     1981 ctgacatggg atcctgtgaa agacccagag ctcctgggtt attacatcta ctcccggaag
     2041 gtggggacat ctgagtggca aacagttaac aacaaaccca tccaaggcac caggtttaca
     2101 gttcccgggc tgaggacggg gaaggagtac gagttttgtg tcaggtcagt cagcgaggct
     2161 ggggtaggcg agagctcagc cgccaccgag cccatcaggg tcaagcaggc tctggctacc
     2221 ccgtctgccc catatggctt tgccctcctg aactgcggga agaatgaaat ggtcattggg
     2281 tggaaacccc ccaagcgtcg tggaggtggc aagatcctgg gctacttcct ggaccagcat
     2341 gactcggaag agctggactg gcatgcggtc aatcagcagc ccatccccac ccgggtctgc
     2401 aaggtcagtg accttcatga aggccacttc tatgagttcc gtgcccgggc tgccaactgg
     2461 gcaggtgttg gcgagctgtc ggcacccagc agcctgtttg agtgcaaaga gtggacaatg
     2521 ccccagccag gccccccgta cgatgtacgg gcatccgagg tgcgggccac atccctggtg
     2581 ctgcagtggg aacccccact gtatatgggg gctgggcctg tcacaggcta tcacgtcagt
     2641 ttccaggagg aaggctctga gcagtggaag ccggtcaccc caggccccat ctctggcacc
     2701 cacctgaggg tttccgactt gcagccagga aagagttacg tgttccaggt acaggccatg
     2761 aattcagctg gtctggggca accgtccatg cccactgatc ccgtgctcct ggaggacaag
     2821 ccaggtgccc atgagatcga ggttggtgtg gatgaagagg gctttatcta tttggctttt
     2881 gaagcccctg aagcccccga ctcctcagag tttcagtggt ccaaagacta caagggccca
     2941 ctggaccccc agagggtcaa gatcgaggat aaagttaaca agtccaaggt catcctgaaa
     3001 gaacccggcc tcgaggattt gggcacctac tcagtcatag tcactgatgc cgatgaagac
     3061 atctccgcaa gccacacgct aaccgaggaa gagctggaga agctgaagaa gctgagtcat
     3121 gagatcagaa acccagtgat caaactgatc tccggctgga acattgacat cctggagcga
     3181 ggggaggtgc ggctttggct ggaagtagaa aagttatctc cagccgctga gctacatcta
     3241 atcttcaaca acaaggagat cttcagctcg ccgaaccgca aaatcaattt tgaccgagag
     3301 aagggcctgg tggaagtgat catccagaac ttgtctgagg aggacaaagg gtcgtacacc
     3361 gctcaactcc aagatggaaa agccaaaaac cagattacct tgacactggt ggatgacgat
     3421 tttgacaagc ttctgaggaa ggcagatgct aagagaaggg actggaagag aaaacagggt
     3481 ccctattttg agcggccgtt gcagtggaag gtcacggagg actgccaagt gcagctgacg
     3541 tgcaaggtga ccaacaccaa gaaggagact cgctttcagt ggttcttcca gagggcagag
     3601 atgccagatg gtcagtatga cccagagacg ggaacgggac ttctctgcat tgaagagttg
     3661 tccaaaaagg acaagggaat ttacagagcg atggtttctg acgatcgagg ggaggacgac
     3721 accatattgg acctcacggg tgacgccctg gatgccatct tcaccgagtt gggcaggatt
     3781 ggtgccctct ctgcaactcc actgaaaatc caggggaccg aggaagggat ccggatcttc
     3841 agcaaggtca agtactacaa cgtggagtac atgaaaacca cctggttcca caaagacaaa
     3901 cgtctggaga gtggtgatcg gataaggacg ggcaccaccc tggatgagat ctggcttcac
     3961 atcctggacc ccaaagactc agacaagggc aaatacactc tggaaatagc tgcagggaag
     4021 gaagtccggc agctctcaac agatctctca gggcaagctt ttgaggatgc aatggctgaa
     4081 caccagagac tgaaaacctt ggccatcatc gagaagaatc gtgccaaagt ggtgagaggt
     4141 ctgccggatg tggccactat catggaagat aagaccctgt gcttgacttg catcgtctca
     4201 ggagacccca cccctgaaat ctcttggctg aagaatgacc agcctgtcac cttccttgac
     4261 cgataccgca tggaagtgag ggggacagag gtcaccatca ccattgagaa ggtcaacagt
     4321 gaagacagcg gccgctacgg cgtcttcgtc aagaacaagt atggctccga gacgggccag
     4381 gtcaccatca gtgtgttcaa gcacggggac gagcccaagg agctgaagag catgtgacag
     4441 cgtgtgtcca ggcacagtct gagtctagtc tacatggacc agtagggaca acctgtacca
     4501 gggtcacagc ctggcacagg ctacaggggt ggggcagaag gaaaggggac aagatagaac
     4561 ccaggatgtg agggtggggg tggagcggat gcaccaaagt ggagaagcaa agatctttct
     4621 ggggtcctga gtggcttcca ggagagcggg atgaaccctg gacctggagt aggagacccg
     4681 gatgcactgg ggctatctaa cagtactggc atctgatagg tagaggtcag gtacgctgct
     4741 aaacactgca gctcccacca catagaatta tccgacccca gatgtcaaaa gtgccaaggg
     4801 ccatgagccc tgccataaac tgatacatcg cacccctctt ttaggatccc atagtttcaa
     4861 ttcatgtaag ttcaacagac acctgaagtc tagcatgtgg gaggctgagg atggagctgg
     4921 gaacacaaag gcagctgata agcaggttct gcttgcaaag aggcctcagt ccagtgggag
     4981 aaacagacct gggcgcaaac aactccagga caaggcagga catgataaag attataaagc
     5041 aggtccaagg aaagtgccgc cagtggtcca aggagggaga cagagggtcg tcccaacagg
     5101 gggaggtagg gctttgaaaa caccttcatc caggctgggc gaggtggctc acgcctgtaa
     5161 tcccagtagt ttgggaggcc aaggcgggca gatcacctga ggtcaggagt tttagaccag
     5221 cctggccaac atgacgaaac ccggtctcta ctaaaaatac aaaaattagc caggcatggt
     5281 ggcaggtgcc tgtaatcccg gctattcaga aggccgaggt gggagaatcc gttgaacctg
     5341 ggaggcggag gttgtgatga gccaagattg agccaaaaaa aaattagcag aattggtgtt
     5401 gggccctgaa aaattagtcc gattttgtgg tggtaatggg agaaggacat cccaggagca
     5461 gggtctggtg ggaggaaagg gaaggaggag gctaaggctg cccaggaggc cttggatacc
     5521 aggcttggag ctggtaacct ccagggcttc cagcacgggg cctctgcctg gtgtgacaga
     5581 taccggctgg cctcacttga tggatctcag tactgagctg ggcatttctc tgccccccaa
     5641 cttttttctt tttaaaaata agatggggag tgttcataaa attatagatg tttgttgtaa
     5701 aattttggaa aaccctggaa attatagaga aaataaacat aatctatact cccaacacca
//
