LOCUS       NM_003970               5008 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens myomesin 2 (MYOM2), mRNA.
ACCESSION   NM_003970
VERSION     NM_003970.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5008)
  AUTHORS   Auxerre-Plantie,E., Nielsen,T., Grunert,M., Olejniczak,O.,
            Perrot,A., Ozcelik,C., Harries,D., Matinmehr,F., Dos Remedios,C.,
            Muhlfeld,C., Kraft,T., Bodmer,R., Vogler,G. and Sperling,S.R.
  TITLE     Identification of MYOM2 as a candidate gene in hypertrophic
            cardiomyopathy and Tetralogy of Fallot, and its functional
            evaluation in the Drosophila heart
  JOURNAL   Dis Model Mech 13 (12) (2020)
   PUBMED   33033063
  REMARK    GeneRIF: Identification of MYOM2 as a candidate gene in
            hypertrophic cardiomyopathy and Tetralogy of Fallot, and its
            functional evaluation in the Drosophila heart.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5008)
  AUTHORS   Cornelis,M.C., Fornage,M., Foy,M., Xun,P., Gladyshev,V.N.,
            Morris,S., Chasman,D.I., Hu,F.B., Rimm,E.B., Kraft,P., Jordan,J.M.,
            Mozaffarian,D. and He,K.
  TITLE     Genome-wide association study of selenium concentrations
  JOURNAL   Hum Mol Genet 24 (5), 1469-1477 (2015)
   PUBMED   25343990
REFERENCE   3  (bases 1 to 5008)
  AUTHORS   Cai,D.C., Fonteijn,H., Guadalupe,T., Zwiers,M., Wittfeld,K.,
            Teumer,A., Hoogman,M., Arias-Vasquez,A., Yang,Y., Buitelaar,J.,
            Fernandez,G., Brunner,H.G., van Bokhoven,H., Franke,B.,
            Hegenscheid,K., Homuth,G., Fisher,S.E., Grabe,H.J., Francks,C. and
            Hagoort,P.
  TITLE     A genome-wide search for quantitative trait loci affecting the
            cortical surface area and thickness of Heschl's gyrus
  JOURNAL   Genes Brain Behav 13 (7), 675-685 (2014)
   PUBMED   25130324
REFERENCE   4  (bases 1 to 5008)
  AUTHORS   Flix,B., de la Torre,C., Castillo,J., Casal,C., Illa,I. and
            Gallardo,E.
  TITLE     Dysferlin interacts with calsequestrin-1, myomesin-2 and dynein in
            human skeletal muscle
  JOURNAL   Int J Biochem Cell Biol 45 (8), 1927-1938 (2013)
   PUBMED   23792176
  REMARK    GeneRIF: a direct interaction of dysferlin with Trim72/MG53, AHNAK,
            cytoplasmic dynein, myomesin-2 and calsequestrin-1, but not with
            caveolin-3 or dystrophin, is reported.
REFERENCE   5  (bases 1 to 5008)
  AUTHORS   Blandin,G., Marchand,S., Charton,K., Daniele,N., Gicquel,E.,
            Boucheteil,J.B., Bentaib,A., Barrault,L., Stockholm,D., Bartoli,M.
            and Richard,I.
  TITLE     A human skeletal muscle interactome centered on proteins involved
            in muscular dystrophies: LGMD interactome
  JOURNAL   Skelet Muscle 3 (1), 3 (2013)
   PUBMED   23414517
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5008)
  AUTHORS   Zhao,X., Leon,I.R., Bak,S., Mogensen,M., Wrzesinski,K., Hojlund,K.
            and Jensen,O.N.
  TITLE     Phosphoproteome analysis of functional mitochondria isolated from
            resting human muscle reveals extensive phosphorylation of inner
            membrane protein complexes and enzymes
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000299 (2011)
   PUBMED   20833797
REFERENCE   7  (bases 1 to 5008)
  AUTHORS   Hornemann,T., Kempa,S., Himmel,M., Hayess,K., Furst,D.O. and
            Wallimann,T.
  TITLE     Muscle-type creatine kinase interacts with central domains of the
            M-band proteins myomesin and M-protein
  JOURNAL   J Mol Biol 332 (4), 877-887 (2003)
   PUBMED   12972258
  REMARK    GeneRIF: Results identify muscle-type creatine kinase as a binding
            partner of a central portion of myomesin and the closely related
            M-protein.
REFERENCE   8  (bases 1 to 5008)
  AUTHORS   van der Ven,P.F., Speel,E.J., Albrechts,J.C., Ramaekers,F.C.,
            Hopman,A.H. and Furst,D.O.
  TITLE     Assignment of the human gene for endosarcomeric cytoskeletal
            M-protein (MYOM2) to 8p23.3
  JOURNAL   Genomics 55 (2), 253-255 (1999)
   PUBMED   9933576
REFERENCE   9  (bases 1 to 5008)
  AUTHORS   Obermann,W.M., van der Ven,P.F., Steiner,F., Weber,K. and
            Furst,D.O.
  TITLE     Mapping of a myosin-binding domain and a regulatory phosphorylation
            site in M-protein, a structural protein of the sarcomeric M band
  JOURNAL   Mol Biol Cell 9 (4), 829-840 (1998)
   PUBMED   9529381
REFERENCE   10 (bases 1 to 5008)
  AUTHORS   Vinkemeier,U., Obermann,W., Weber,K. and Furst,D.O.
  TITLE     The globular head domain of titin extends into the center of the
            sarcomeric M band. cDNA cloning, epitope mapping and immunoelectron
            microscopy of two titin-associated proteins
  JOURNAL   J Cell Sci 106 (Pt 1), 319-330 (1993)
   PUBMED   7505783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596730.1, BC052969.1, AC245164.2, DA233884.1, X69089.1,
            BX501741.1 and BP260135.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003970.3.
            
            Summary: The giant protein titin, together with its associated
            proteins, interconnects the major structure of sarcomeres, the M
            bands and Z discs. The C-terminal end of the titin string extends
            into the M line, where it binds tightly to M-band constituents of
            apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2
            protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique
            N-terminal domain followed by 12 repeat domains with strong
            homology to either fibronectin type III or immunoglobulin C2
            domains. Protein sequence comparisons suggested that the MYOM2
            protein and bovine M protein are identical. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052969.1, SRR1803615.27162.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2151741
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262113.9/ ENSP00000262113.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AL596730.1         30-73
            45-1781             BC052969.1         1-1737
            1782-1782           AC245164.2         133199-133199       c
            1783-2278           DA233884.1         73-568
            2279-2721           X69089.1           2192-2634
            2722-2903           BC052969.1         2678-2859
            2904-3425           BX501741.1         96-617
            3426-3875           BP260135.1         102-551
            3876-4430           BC052969.1         3832-4386
            4431-4809           AC245164.2         77952-78330         c
            4810-5008           BC052969.1         4766-4964
FEATURES             Location/Qualifiers
     source          1..5008
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.3"
     gene            1..5008
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /note="myomesin 2"
                     /db_xref="GeneID:9172"
                     /db_xref="HGNC:HGNC:7614"
                     /db_xref="MIM:603509"
     exon            1..123
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            124..242
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..4533
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /note="titin-associated protein, 165 kD; M-band protein;
                     M-protein; myomesin family member 2; 165 kDa
                     titin-associated protein; 165 kDa connectin-associated
                     protein; myomesin (M-protein) 2, 165kDa"
                     /codon_start=1
                     /product="myomesin-2"
                     /protein_id="NP_003961.3"
                     /db_xref="CCDS:CCDS5957.1"
                     /db_xref="GeneID:9172"
                     /db_xref="HGNC:HGNC:7614"
                     /db_xref="MIM:603509"
                     /translation="MSLVTVPFYQKRHRHFDQSYRNIQTRYLLDEYASKKRASTQASS
                     QKSLSQRSSSQRASSQTSLGGTICRVCAKRVSTQEDEEQENRSRYQSLVAAYGEAKRQ
                     RFLSELAHLEEDVHLARSQARDKLDKYAIQQMMEDKLAWERHTFEERISRAPEILVRL
                     RSHTVWERMSVKLCFTVQGFPTPVVQWYKDGSLICQAAEPGKYRIESNYGVHTLEINR
                     ADFDDTATYSAVATNAHGQVSTNAAVVVRRFRGDEEPFRSVGLPIGLPLSSMIPYTHF
                     DVQFLEKFGVTFRREGETVTLKCTMLVTPDLKRVQPRAEWYRDDVLLKESKWTKMFFG
                     EGQASLSFSHLHKDDEGLYTLRIVSRGGVSDHSAFLFVRDADPLVTGAPGAPMDLQCH
                     DANRDYVIVTWKPPNTTTESPVMGYFVDRCEVGTNNWVQCNDAPVKICKYPVTGLFEG
                     RSYIFRVRAVNSAGISRPSRVSDAVAALDPLDLRRLQAVHLEGEKEIAIYQDDLEGDA
                     QVPGPPTGVHASEISRNYVVLSWEPPTPRGKDPLMYFIEKSVVGSGSWQRVNAQTAVR
                     SPRYAVFDLMEGKSYVFRVLSANRHGLSEPSEITSPIQAQDVTVVPSAPGRVLASRNT
                     KTSVVVQWDRPKHEEDLLGYYVDCCVAGTNLWEPCNHKPIGYNRFVVHGLTTGEQYIF
                     RVKAVNAVGMSENSQESDVIKVQAALTVPSHPYGITLLNCDGHSMTLGWKVPKFSGGS
                     PILGYYLDKREVHHKNWHEVNSSPSKPTILTVDGLTEGSLYEFKIAAVNLAGIGEPSD
                     PSEHFKCEAWTMPEPGPAYDLTFCEVRDTSLVMLWKAPVYSGSSPVSGYFVDFREEDA
                     GEWITVNQTTTASRYLKVSDLQQGKTYVFRVRAVNANGVGKPSDTSEPVLVEARPGTK
                     EISAGVDEQGNIYLGFDCQEMTDASQFTWCKSYEEISDDERFKIETVGDHSKLYLKNP
                     DKEDLGTYSVSVSDTDGVSSSFVLDPEELERLMALSNEIKNPTIPLKSELAYEIFDKG
                     RVRFWLQAEHLSPDASYRFIINDREVSDSEIHRIKCDKATGIIEMVMDRFSIENEGTY
                     TVQIHDGKAKSQSSLVLIGDAFKTVLEEAEFQRKEFLRKQGPHFAEYLHWDVTEECEV
                     RLVCKVANTKKETVFKWLKDDVLYETETLPNLERGICELLIPKLSKKDHGEYKATLKD
                     DRGQDVSILEIAGKVYDDMILAMSRVCGKSASPLKVLCTPEGIRLQCFMKYFTDEMKV
                     NWCHKDAKISSSEHMRIGGSEEMAWLQICEPTEKDKGKYTFEIFDGKDNHQRSLDLSG
                     QAFDEAFAEFQQFKAAAFAEKNRGRLIGGLPDVVTIMEGKTLNLTCTVFGNPDPEVIW
                     FKNDQDIQLSEHFSVKVEQAKYVSMTIKGVTSEDSGKYSINIKNKYGGEKIDVTVSVY
                     KHGEKIPDMAPPQQAKPKLIPASASAAGQ"
     exon            243..398
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            399..537
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            538..695
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            696..788
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            789..877
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            878..928
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1093
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1255
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1397
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1597
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1651
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1779
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1963
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2138
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2260
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2448
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..2575
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2754
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2869
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..3026
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3133
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3178
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3315
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3316..3460
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3520
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3588
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3589..3702
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3790
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3791..3829
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3830..3935
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3936..4099
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4100..4136
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4137..4159
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4160..4215
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4216..5008
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4990..4995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /note="hexamer: AATAAA"
     polyA_site      5008
                     /gene="MYOM2"
                     /gene_synonym="TTNAP"
                     /note="major polyA site"
ORIGIN      
        1 agggaggcac aggcgcttgc tttgcaggag tcagctctgc cttcctcggc tggagtgtgg
       61 gtggcttggt gagccggtgg tcaggaattc tctctcctcc ttgcaatttt cctttctgtc
      121 tgggagcacg ccaagatgtc ccttgtgact gtccccttct accagaagag acataggcac
      181 ttcgaccagt cctaccgtaa tattcaaaca cggtacctgc tggacgaata tgcgtcaaaa
      241 aagcgagctt ccacccaggc atcttcccag aagtccttga gtcagcggtc gtcttcacag
      301 agagcctcca gccagacgtc cctgggagga accatctgca gggtctgtgc gaagcgagtg
      361 agcacgcagg aagatgagga gcaggagaac agaagcaggt accagtccct ggtggccgcc
      421 tatggtgagg ccaagcgaca gcgcttcctc agcgagctgg cccacttgga ggaggatgtc
      481 cacctggcac gctcccaggc ccgcgacaag ctggacaaat acgccattca gcagatgatg
      541 gaggacaagc tggcctggga gagacacaca tttgaagagc ggataagcag ggctcctgag
      601 atcctggtgc ggctgcgatc ccacaccgtc tgggagagga tgtctgtgaa actctgcttc
      661 accgtgcaag gatttcccac gcccgtggtg cagtggtaca aagatggcag tctgatttgc
      721 caggcggctg aaccgggaaa gtacaggatt gagagcaact atggcgtaca cacactggag
      781 atcaacaggg cagactttga cgacactgcg acatactcag cagtggccac caatgcccac
      841 ggacaagtgt ccaccaacgc ggcggtggtg gtgagaaggt tccggggaga cgaggaacca
      901 ttccgttcgg tgggactccc gattggattg cccctgtcat cgatgattcc gtacacgcac
      961 ttcgacgtcc agtttttgga gaagtttggg gtcaccttca ggagggaagg cgagacggtc
     1021 actctcaagt gcaccatgct ggtgacgccg gacctgaagc gggtgcagcc gcgcgccgag
     1081 tggtaccgcg atgacgtgct gttgaaagag tccaagtgga cgaagatgtt ctttggagaa
     1141 ggccaggcct ccctgtcctt cagccacctg cacaaggacg acgagggcct gtacaccctg
     1201 cgcatcgtgt ctcggggcgg cgtcagcgac cacagcgcct tcctgtttgt cagagatgct
     1261 gacccgctgg tcacaggggc ccccggtgca cccatggact tgcagtgcca cgacgccaac
     1321 cgggactacg tcatcgtgac ctggaagccg cccaacacca ccactgagag ccccgtcatg
     1381 ggctattttg tggaccgatg tgaagtagga acgaataatt gggtgcagtg caatgatgca
     1441 ccggtgaaaa tctgcaaata cccggtcaca gggctttttg aaggaaggtc ttacatattc
     1501 cgagtgaggg cagtgaacag tgcgggcatc agccgaccct ccagggtctc tgatgcggtg
     1561 gctgcacttg accccttgga cctcagaagg ttacaagccg ttcatttgga gggagagaag
     1621 gagattgcca tttatcagga tgaccttgaa ggtgacgccc aggttccagg gcctcccacc
     1681 ggtgtgcacg cttccgagat cagcagaaac tatgtcgtcc tcagctggga gccacccact
     1741 ccccgtggca aggacccgct catgtacttc attgagaagt ccgtggtggg gagcggcagc
     1801 tggcagagag tcaacgccca gacggctgtg agatccccga gatatgccgt gtttgacctc
     1861 atggaaggga agtcttatgt gttccgagtg ctgtcagcaa accggcatgg cctgagcgaa
     1921 ccttcggaga taacgtcccc cattcaggcc caggatgtga ccgttgtccc ttctgctccg
     1981 ggtcgggttc ttgcttcccg aaacaccaag acgtcggtgg tggtgcagtg ggaccgacct
     2041 aagcatgagg aggacctgct gggctactac gtggactgct gtgtggccgg aaccaacctc
     2101 tgggagccct gcaaccacaa gcccatcgga tacaacaggt tcgtggtgca cggcttaacc
     2161 acgggagagc agtacatctt ccgagtcaag gcggtcaatg ctgtggggat gagtgaaaat
     2221 tcccaggaat cagacgtcat aaaagtgcag gccgcactca ccgtcccgtc ccatccttat
     2281 gggattacgc tcctcaactg tgacggccac tccatgaccc tcggctggaa ggtcccgaaa
     2341 ttcagtggtg gctcgcccat cctgggctac tacctggaca agcgtgaagt tcaccataaa
     2401 aactggcacg aggtcaattc ctcacccagc aaaccgacaa tcctaacggt ggacggcttg
     2461 acggaaggct cactctacga gttcaaaatc gccgccgtca acctggccgg catcggggag
     2521 ccctcagatc ccagtgagca cttcaagtgt gaggcctgga ccatgccgga gcccggtcct
     2581 gcctacgact tgacgttctg tgaggtcagg gacacgtcct tggtcatgct gtggaaggcc
     2641 cctgtgtact ccggcagcag ccctgtttct ggatatttcg tggacttcag ggaggaggat
     2701 gctggagagt ggatcactgt caatcagacg acaacagcca gccgttattt aaaggtctct
     2761 gacctgcagc aaggtaagac ctatgtcttc agggtccggg cagtcaatgc aaatggcgtg
     2821 gggaagccct cagacacgtc ggagcctgtg ctggtagagg cgagaccagg caccaaggaa
     2881 atcagtgctg gtgtcgatga acaaggcaac atctatctgg gcttcgactg ccaggaaatg
     2941 acagacgcgt ctcagttcac ctggtgtaaa tcctacgagg agatttcaga tgatgagagg
     3001 tttaaaattg aaaccgtggg ggatcactcc aagctgtact taaagaatcc ggataaggag
     3061 gatttaggga cttactccgt gtctgtaagt gatacagacg gagtgtcctc cagttttgtt
     3121 ctggacccag aagagctcga gcgtttgatg gcattgagca atgaaataaa gaaccccaca
     3181 attcctctga aatcggaatt agcttatgag atttttgata aggggcgggt tcgcttctgg
     3241 ctccaggctg agcacttatc accagatgcc agctaccgat ttattattaa cgacagagaa
     3301 gtctctgaca gcgagataca cagaattaaa tgtgacaaag ctactggcat tattgagatg
     3361 gtgatggatc gatttagtat tgaaaatgag gggacctaca ctgtgcagat tcatgatggg
     3421 aaagccaaaa gtcagtcttc tctagttctt attggagatg cattcaagac tgtgctggaa
     3481 gaggctgagt ttcaaaggaa agaatttctc aggaaacaag gccctcattt tgctgagtac
     3541 ttgcactggg atgtcacgga agaatgtgaa gttcgacttg tttgcaaggt tgcaaacacc
     3601 aagaaagaaa ccgttttcaa atggctcaag gatgatgttc tgtatgaaac ggagacactg
     3661 cctaacctgg agaggggaat ctgtgagctc ctcatcccaa agttgtcaaa gaaggaccac
     3721 ggtgaataca aggcaacctt gaaagatgac agaggccaag atgtgtccat ccttgaaata
     3781 gctggcaaag tgtatgatga tatgattttg gcaatgagta gagtctgtgg gaaatctgct
     3841 tcgccactga aggtactctg caccccagaa ggaatacgac ttcagtgttt catgaagtat
     3901 tttacagacg aaatgaaagt gaactggtgt cacaaagatg ctaagatctc atccagtgag
     3961 catatgagaa tcggggggag tgaagagatg gcttggctgc agatatgtga gccgactgag
     4021 aaggataaag gaaaatacac ttttgagatt ttcgatggca aagacaacca tcaacgctcc
     4081 cttgacctgt ccggacaagc ttttgatgaa gcatttgcag aattccagca attcaaagct
     4141 gctgcttttg cagagaagaa tcgtggcagg ttgatcggcg gcttgcctga cgtggtgacc
     4201 atcatggaag ggaagacctt gaatctgacc tgcacggtgt ttggaaaccc tgaccccgaa
     4261 gtgatttggt tcaagaacga ccaggacatc cagctcagcg agcacttctc ggtgaaggtg
     4321 gagcaggcca agtacgtcag catgaccatc aaaggcgtga cctccgagga ctcgggcaag
     4381 tacagcatca acatcaagaa taagtatggc ggggagaaga tcgacgtgac agtgagcgtg
     4441 tacaaacacg gggagaagat cccggacatg gccccgcccc agcaagccaa gcccaagctc
     4501 atccccgcgt ctgcctcagc ggcaggccag tgaaggcgtt ttcctagcct ggagatggga
     4561 aaatatgctt ggcagagaca ggaatgctgt gtgcttgttc caaatgagca gctggcatcc
     4621 gagtggtgtc ctgtgtgggc tgatagttga tcacacattg tgcttttgat ttttgcattt
     4681 ggtgatgaat attttatacc cgtctaaggg agaaagctaa tgttttccac aagactgaac
     4741 aacgtgtatt tacacgaggg tagacggcag atgcctgaca gagagtgggt tggcagacaa
     4801 cacactagaa ttttcacggg tgtgggcaca tgggtgtggc acctggacgt gtgcagcatg
     4861 tggcggtctg tgtgaagcca ccgtgcttct ctttgggggg ccgcgagatc tagcatctct
     4921 gaaatcctgg ctgtcgaggc tttgaagcat gtgttacctg gttaagcttg ttttctcttg
     4981 ctttaggcaa ataaaagttt aaaaatca
//
