LOCUS       NM_002479               1507 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens myogenin (MYOG), mRNA.
ACCESSION   NM_002479
VERSION     NM_002479.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1507)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1507)
  AUTHORS   Gao,Q., Wang,P., Qiu,H., Qiu,B., Yi,W., Tu,W., Lin,B., Sun,D.,
            Zeng,R., Huang,M., Chen,J., Cen,J. and Zhuang,J.
  TITLE     Myogenin suppresses apoptosis induced by angiotensin II in human
            induced pluripotent stem cell-derived cardiomyocytes
  JOURNAL   Biochem Biophys Res Commun 552, 84-90 (2021)
   PUBMED   33743352
  REMARK    GeneRIF: Myogenin suppresses apoptosis induced by angiotensin II in
            human induced pluripotent stem cell-derived cardiomyocytes.
REFERENCE   3  (bases 1 to 1507)
  AUTHORS   Cooper,L.M., West,R.C., Hayes,C.S. and Waddell,D.S.
  TITLE     Dual-specificity phosphatase 29 is induced during neurogenic
            skeletal muscle atrophy and attenuates glucocorticoid receptor
            activity in muscle cell culture
  JOURNAL   Am J Physiol Cell Physiol 319 (2), C441-C454 (2020)
   PUBMED   32639872
  REMARK    GeneRIF: Dual-specificity phosphatase 29 is induced during
            neurogenic skeletal muscle atrophy and attenuates glucocorticoid
            receptor activity in muscle cell culture.
REFERENCE   4  (bases 1 to 1507)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1507)
  AUTHORS   Liu,Z., Zhang,X., Lei,H., Lam,N., Carter,S., Yockey,O., Xu,M.,
            Mendoza,A., Hernandez,E.R., Wei,J.S., Khan,J., Yohe,M.E.,
            Shern,J.F. and Thiele,C.J.
  TITLE     CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation
            through a feed-forward loop with MYOD and MYOG
  JOURNAL   Nat Commun 11 (1), 911 (2020)
   PUBMED   32060262
  REMARK    GeneRIF: CASZ1 plays a critical role in inducing skeletal
            myogenesis and co-operating to form a feed-forward loop with MYOD
            and MYOG that is critical for Embryonal rhabdomyosarcoma
            differentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1507)
  AUTHORS   Funk,W.D. and Wright,W.E.
  TITLE     Cyclic amplification and selection of targets for multicomponent
            complexes: myogenin interacts with factors recognizing binding
            sites for basic helix-loop-helix, nuclear factor 1,
            myocyte-specific enhancer-binding factor 2, and COMP1 factor
  JOURNAL   Proc Natl Acad Sci U S A 89 (20), 9484-9488 (1992)
   PUBMED   1329097
REFERENCE   7  (bases 1 to 1507)
  AUTHORS   Chakraborty,T., Martin,J.F. and Olson,E.N.
  TITLE     Analysis of the oligomerization of myogenin and E2A products in
            vivo using a two-hybrid assay system
  JOURNAL   J Biol Chem 267 (25), 17498-17501 (1992)
   PUBMED   1325437
REFERENCE   8  (bases 1 to 1507)
  AUTHORS   Salminen,A., Braun,T., Buchberger,A., Jurs,S., Winter,B. and
            Arnold,H.H.
  TITLE     Transcription of the muscle regulatory gene Myf4 is regulated by
            serum components, peptide growth factors and signaling pathways
            involving G proteins
  JOURNAL   J Cell Biol 115 (4), 905-917 (1991)
   PUBMED   1659574
REFERENCE   9  (bases 1 to 1507)
  AUTHORS   Lassar,A.B., Davis,R.L., Wright,W.E., Kadesch,T., Murre,C.,
            Voronova,A., Baltimore,D. and Weintraub,H.
  TITLE     Functional activity of myogenic HLH proteins requires
            hetero-oligomerization with E12/E47-like proteins in vivo
  JOURNAL   Cell 66 (2), 305-315 (1991)
   PUBMED   1649701
REFERENCE   10 (bases 1 to 1507)
  AUTHORS   Weintraub,H., Davis,R., Tapscott,S., Thayer,M., Krause,M.,
            Benezra,R., Blackwell,T.K., Turner,D., Rupp,R., Hollenberg,S. et
            al.
  TITLE     The myoD gene family: nodal point during specification of the
            muscle cell lineage
  JOURNAL   Science 251 (4995), 761-766 (1991)
   PUBMED   1846704
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC053899.1 and AC105940.2.
            
            On Nov 24, 2018 this sequence version replaced NM_002479.5.
            
            Summary: Myogenin is a muscle-specific transcription factor that
            can induce myogenesis in a variety of cell types in tissue culture.
            It is a member of a large family of proteins related by sequence
            homology, the helix-loop-helix (HLH) proteins. It is essential for
            the development of functional skeletal muscle. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053899.1, X17651.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241651.5/ ENSP00000241651.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BC053899.1         27-65
            40-40               AC105940.2         27334-27334         c
            41-1403             BC053899.1         67-1429
            1404-1453           AC105940.2         24544-24593         c
            1454-1507           BC053899.1         1477-1530
FEATURES             Location/Qualifiers
     source          1..1507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1507
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /note="myogenin"
                     /db_xref="GeneID:4656"
                     /db_xref="HGNC:HGNC:7612"
                     /db_xref="MIM:159980"
     exon            1..522
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..726
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /note="myogenic factor 4; class C basic helix-loop-helix
                     protein 3"
                     /codon_start=1
                     /product="myogenin"
                     /protein_id="NP_002470.2"
                     /db_xref="CCDS:CCDS1433.1"
                     /db_xref="GeneID:4656"
                     /db_xref="HGNC:HGNC:7612"
                     /db_xref="MIM:159980"
                     /translation="MELYETSPYFYQEPRFYDGENYLPVHLQGFEPPGYERTELTLSP
                     EAPGPLEDKGLGTPEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFE
                     ALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPGVPS
                     ECSSHSASCSPEWGSALEFSANPGDHLLTADPTDAHNLHSLTSIVDSITVEDVSVAFP
                     DETMPN"
     exon            523..604
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /inference="alignment:Splign:2.1.0"
     exon            605..1507
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1487..1492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /note="hexamer: AATAAA"
     polyA_site      1507
                     /gene="MYOG"
                     /gene_synonym="bHLHc3; myf-4; MYF4"
                     /note="major polyA site"
ORIGIN      
        1 gggctgctgg agcttggggg ctggtggcag gaacaagcct tttccgaccc catggagctg
       61 tatgagacat ccccctactt ctaccaggaa ccccgcttct atgatgggga aaactacctg
      121 cctgtccacc tccagggctt cgaaccacca ggctacgagc ggacggagct caccctgagc
      181 cccgaggccc cagggcccct tgaggacaag gggctgggga cccccgagca ctgtccaggc
      241 cagtgcctgc cgtgggcgtg taaggtgtgt aagaggaagt cggtgtccgt ggaccggcgg
      301 cgggcggcca cactgaggga gaagcgcagg ctcaagaagg tgaatgaggc cttcgaggcc
      361 ctgaagagaa gcaccctgct caaccccaac cagcggctgc ccaaggtgga gatcctgcgc
      421 agtgccatcc agtacatcga gcgcctccag gccctgctca gctccctcaa ccaggaggag
      481 cgtgacctcc gctaccgggg cgggggcggg ccccagccag gggtgcccag cgaatgcagc
      541 tctcacagcg cctcctgcag tccagagtgg ggcagtgcac tggagttcag cgccaaccca
      601 ggggatcatc tgctcacggc tgaccctaca gatgcccaca acctgcactc cctcacctcc
      661 atcgtggaca gcatcacagt ggaagatgtg tctgtggcct tcccagatga aaccatgccc
      721 aactgagatt gtcttccaag ccgggcatcc ttgcgagccc cccaagctgg ccacagatgc
      781 cactacttct gtagcagggg cctcctaagc caggctgccc tgatgctagg aagccagctc
      841 tggggtgcca taggccagac tatccccttc ctcatccatg taaggttaac ccacccccca
      901 gcaagggact ggacgccctc attcagctgc ctccttagag gagagggcat cccctttcca
      961 gggaggtaaa gcaggggacc agagcgcccc ctcgtgtatg ccccagctca gggggcaaac
     1021 tcaggagctt cctttttatc ataacgcggc ctctaattcc accccccaag tgaaacggtt
     1081 tgagagacgc agtgccctga cctggacaag ctgtgcacgt ctcctgttct ggtctcttcc
     1141 cgatgccagt ggctgggctg ggcctgccct gaattgagag agaagaaggg gagaggaaca
     1201 gccctctgtt cccaagtccc tggggggcca aacttttgca gtgaatattg ggaaccttcc
     1261 agtggtttta tgttttgttt tgtttcgtgt gttgtttgta aagctgccat ccgaccaagg
     1321 tctcctgtgc tgaagttgcc ggggacaggc agggaaaagg ggttggggcc tcttgggggt
     1381 gatttctttt gttaacaaag cattgtgtgg ttttgccatt gttttgtatt tttttttttt
     1441 tttttttttt ttgctaactt atttggattt ccttttttaa aaaatgaata aagactggtt
     1501 gccagaa
//
