LOCUS       NM_001378306            8609 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens myocardin (MYOCD), transcript variant 3, mRNA.
ACCESSION   NM_001378306 XM_005256864
VERSION     NM_001378306.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8609)
  AUTHORS   Bankell,E., Liu,L., van der Horst,J., Rippe,C., Jepps,T.A.,
            Nilsson,B.O. and Sward,K.
  TITLE     Suppression of smooth muscle cell inflammation by myocardin-related
            transcription factors involves inactivation of TANK-binding kinase
            1
  JOURNAL   Sci Rep 14 (1), 13321 (2024)
   PUBMED   38858497
  REMARK    GeneRIF: Suppression of smooth muscle cell inflammation by
            myocardin-related transcription factors involves inactivation of
            TANK-binding kinase 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8609)
  AUTHORS   Javanshir,E., Ebrahimi,Z.J., Mirzohreh,S.T., Ghaffari,S.,
            Banisefid,E., Alamdari,N.M. and Roshanravan,N.
  TITLE     Disparity of gene expression in coronary artery disease: insights
            from MEIS1, HIRA, and Myocardin
  JOURNAL   Mol Biol Rep 51 (1), 712 (2024)
   PUBMED   38824221
  REMARK    GeneRIF: Disparity of gene expression in coronary artery disease:
            insights from MEIS1, HIRA, and Myocardin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8609)
  AUTHORS   Sakai,T., Choo,Y.Y., Mitsuhashi,S., Ikebe,R., Jeffers,A., Idell,S.,
            Tucker,T.A. and Ikebe,M.
  TITLE     Myocardin regulates fibronectin expression and secretion from human
            pleural mesothelial cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (4), L419-L430 (2024)
   PUBMED   38349126
  REMARK    GeneRIF: Myocardin regulates fibronectin expression and secretion
            from human pleural mesothelial cells.
REFERENCE   4  (bases 1 to 8609)
  AUTHORS   Liu,L., Kryvokhyzha,D., Rippe,C., Jacob,A., Borreguero-Munoz,A.,
            Stenkula,K.G., Hansson,O., Smith,C.W.J., Fisher,S.A. and Sward,K.
  TITLE     Myocardin regulates exon usage in smooth muscle cells through
            induction of splicing regulatory factors
  JOURNAL   Cell Mol Life Sci 79 (8), 459 (2022)
   PUBMED   35913515
  REMARK    GeneRIF: Myocardin regulates exon usage in smooth muscle cells
            through induction of splicing regulatory factors.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8609)
  AUTHORS   Mikhailov,A.T. and Torrado,M.
  TITLE     In search of novel targets for heart disease: myocardin and
            myocardin-related transcriptional cofactors
  JOURNAL   Biochem Res Int 2012, 973723 (2012)
   PUBMED   22666593
REFERENCE   6  (bases 1 to 8609)
  AUTHORS   Du,K.L., Chen,M., Li,J., Lepore,J.J., Mericko,P. and Parmacek,M.S.
  TITLE     Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals
            and induces smooth muscle cell differentiation from
            undifferentiated embryonic stem cells
  JOURNAL   J Biol Chem 279 (17), 17578-17586 (2004)
   PUBMED   14970199
REFERENCE   7  (bases 1 to 8609)
  AUTHORS   Wang,Z., Wang,D.Z., Pipes,G.C. and Olson,E.N.
  TITLE     Myocardin is a master regulator of smooth muscle gene expression
  JOURNAL   Proc Natl Acad Sci U S A 100 (12), 7129-7134 (2003)
   PUBMED   12756293
REFERENCE   8  (bases 1 to 8609)
  AUTHORS   Du,K.L., Ip,H.S., Li,J., Chen,M., Dandre,F., Yu,W., Lu,M.M.,
            Owens,G.K. and Parmacek,M.S.
  TITLE     Myocardin is a critical serum response factor cofactor in the
            transcriptional program regulating smooth muscle cell
            differentiation
  JOURNAL   Mol Cell Biol 23 (7), 2425-2437 (2003)
   PUBMED   12640126
  REMARK    GeneRIF: Myocardin is a critical serum response factor cofactor
            regulating smooth muscle cell differentiation; forced expression of
            myocardin activated expression of SM22 alpha, smooth muscle
            alpha-actin, and calponin-h1 genes in mouse ES cells
REFERENCE   9  (bases 1 to 8609)
  AUTHORS   Wang,D.Z., Li,S., Hockemeyer,D., Sutherland,L., Wang,Z.,
            Schratt,G., Richardson,J.A., Nordheim,A. and Olson,E.N.
  TITLE     Potentiation of serum response factor activity by a family of
            myocardin-related transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14855-14860 (2002)
   PUBMED   12397177
REFERENCE   10 (bases 1 to 8609)
  AUTHORS   Wang,D., Chang,P.S., Wang,Z., Sutherland,L., Richardson,J.A.,
            Small,E., Krieg,P.A. and Olson,E.N.
  TITLE     Activation of cardiac gene expression by myocardin, a
            transcriptional cofactor for serum response factor
  JOURNAL   Cell 105 (7), 851-862 (2001)
   PUBMED   11439182
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005358.1.
            
            On Feb 7, 2020 this sequence version replaced XM_005256864.1.
            
            Summary: This gene encodes a nuclear protein, which is expressed in
            heart, aorta, and in smooth muscle cell-containing tissues. It
            functions as a transcriptional co-activator of serum response
            factor (SRF) and modulates expression of cardiac and smooth
            muscle-specific SRF-target genes, and thus may play a crucial role
            in cardiogenesis and differentiation of the smooth muscle cell
            lineage. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene.[provided by
            RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.175410.1,
                                           SRR1803612.280141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-354               AC005358.1         74204-74557
            355-420             AC005358.1         113442-113507
            421-464             AC005358.1         118809-118852
            465-520             AC005358.1         123833-123888
            521-596             AC005358.1         125660-125735
            597-758             AC005358.1         131161-131322
            759-934             AC005358.1         144475-144650
            935-1060            AC005358.1         147517-147642
            1061-1314           AC005358.1         152497-152750
            1315-1468           AC005358.1         154233-154386
            1469-2401           AC005358.1         160728-161660
            2402-2545           AC005358.1         164728-164871
            2546-2674           AC005358.1         166399-166527
            2675-2732           AC005358.1         168964-169021
            2733-8609           AC005358.1         171387-177263
FEATURES             Location/Qualifiers
     source          1..8609
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..8609
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /note="myocardin"
                     /db_xref="GeneID:93649"
                     /db_xref="HGNC:HGNC:16067"
                     /db_xref="MIM:606127"
     exon            1..354
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            355..420
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            421..464
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            465..520
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            521..596
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     CDS             581..3304
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="myocardin isoform 3"
                     /protein_id="NP_001365235.1"
                     /db_xref="GeneID:93649"
                     /db_xref="HGNC:HGNC:16067"
                     /db_xref="MIM:606127"
                     /translation="MHILQASTAERSIPTAQMKLKRARLADDLNEKIALRPGPLELVE
                     KNILPVDSAVKEAIKGNQVSFSKSTDAFAFEEDSSSDGLSPDQTRSEDPQNSAGSPPD
                     AKASDTPSTGSLGTNQDLASGSENDRNDSASQPSHQSDAGKQGLGPPSTPIAVHAAVK
                     SKSLGDSKNRHKKPKDPKPKVKKLKYHQYIPPDQKAEKSPPPMDSAYARLLQQQQLFL
                     QLQILSQQQQQQQHRFSYLGMHQAQLKEPNEQMVRNPNSSSTPLSNTPLSPVKNSFSG
                     QTGVSSFKPGPLPPNLDDLKVSELRQQLRIRGLPVSGTKTALMDRLRPFQDCSGNPVP
                     NFGDITTVTFPVTPNTLPNYQSSSSTSALSNGFYHFGSTSSSPPISPASSDLSVAGSL
                     PDTFNDASPSFGLHPSPVHVCTEESLMSSLNGGSVPSELDGLDSEKDKMLVEKQKVIN
                     ELTWKLQQEQRQVEELRMQLQKQKRNNCSEKKPLPFLAASIKQEEAVSSCPFASQVPV
                     KRQSSSSECHPPACEAAQLQPLGNAHCVESSDQTNVLSSTFLSPQCSPQHSPLGAVKS
                     PQHISLPPSPNNPHFLPSSSGAQGEGHRVSSPISSQVCTAQNSGAHDGHPPSFSPHSS
                     SLHPPFSGAQADSSHGAGGNPCPKSPCVQQKMAGLHSSDKVGPKFSIPSPTFSKSSSA
                     ISEVTQPPSYEDAVKQQMTRSQQMDELLDVLIESGEMPADAREDHSCLQKVPKIPRSS
                     RSPTAVLTKPSASFEQASSGSQIPFDPYATDSDEHLEVLLNSQSPLGKMSDVTLLKIG
                     SEEPHFDGIMDGFSGKAAEDLFNAHEILPGPLSPMQTQFSPSSVDSNGLQLSFTESPW
                     ETMEWLDLTPPNSTPGFSALTTSSPSIFNIDFLDVTDLNLNSSMDLHLQQW"
     exon            597..758
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            759..934
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1060
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1314
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1468
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..2401
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2545
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2674
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2732
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..8609
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6972..6977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /note="hexamer: AATAAA"
     polyA_site      6998
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
     regulatory      8584..8589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /note="hexamer: AATAAA"
     polyA_site      8609
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /note="major polyA site"
ORIGIN      
        1 aatcgccggc agcctatgac atcagacagg aacgcctggg atgccgcgct gctcctggcc
       61 aacctccgag gaggaggagg gtcccgccgg ctaagagtta attagccccg cacggcgagg
      121 ggggaggcgc cagttttctg gggacactgg ctgccactgt actcctaccc aggggagctc
      181 acggagagtt ggatgaattc tgggttgtta gctgcggtca gctgggctcc cgggagcctg
      241 ttgctggtgg agaacagggg gcgcctggcc aagggaccag cggcttgctg agactcaaca
      301 tgacactcct ggggtctgag cattccttgc tgattaggag caagttcaga tcagttttac
      361 agttaagact tcaacaaaga aggacccagg aacaactggc taaccaaggc ataataccac
      421 actaatccaa gctacagcag ccacatactt actgcaaaac cttgcactga aacgtccagc
      481 tgaattccat gagcaaagaa aacatttgga tagtgacaag gctaaaaatt ccctgaagcg
      541 caaagccaga aacaggtgca acagtgccga cttggttaat atgcacatac tccaagcttc
      601 cactgcagag aggtccattc caactgctca gatgaagctg aaaagagccc gactcgccga
      661 tgatctcaat gaaaaaattg ctctacgacc agggccactg gagctggtgg aaaaaaacat
      721 tcttcctgtg gattctgctg tgaaagaggc cataaaaggt aaccaggtga gtttctccaa
      781 atccacggat gcttttgcct ttgaagagga cagcagcagc gatgggcttt ctccggatca
      841 gactcgaagt gaagaccccc aaaactcagc gggatccccg ccagacgcta aagcctcaga
      901 taccccttcg acaggttctc tggggacaaa ccaggatctt gcttctggct cagaaaatga
      961 cagaaatgac tcagcctcac agcccagcca ccagtcagat gcggggaagc aggggcttgg
     1021 cccccccagc acccccatag ccgtgcatgc tgctgtaaag tccaaatcct tgggtgacag
     1081 taagaaccgc cacaaaaagc ccaaggaccc caagccaaag gtgaagaagc ttaaatatca
     1141 ccagtacatt cccccagacc agaaggcaga gaagtcccct ccacctatgg actcagccta
     1201 cgctcggctg ctccagcaac agcagctgtt cctgcagctc caaatcctca gccagcagca
     1261 gcagcagcag caacaccgat tcagctacct agggatgcac caagctcagc ttaaggaacc
     1321 aaatgaacag atggtcagaa atccaaactc ttcttcaacg ccactgagca ataccccctt
     1381 gtctcctgtc aaaaacagtt tttctggaca aactggtgtc tcttctttca aaccaggccc
     1441 actcccacct aacctggatg atctgaaggt ctctgaatta agacaacagc ttcgaattcg
     1501 gggcttgcct gtgtcaggca ccaaaacggc tctcatggac cggcttcgac ccttccagga
     1561 ctgctctggc aacccagtgc cgaactttgg ggatataacg actgtcactt ttcctgtcac
     1621 acccaacacg ctgcccaatt accagtcttc ctcttctacc agtgccctgt ccaacggctt
     1681 ctaccacttt ggcagcacca gctccagccc cccgatctcc ccagcctcct ctgacctgtc
     1741 agtcgctggg tccctgccgg acaccttcaa tgatgcctcc ccctccttcg gcctgcaccc
     1801 gtccccagtc cacgtgtgca cggaggaaag tctcatgagc agcctgaatg ggggctctgt
     1861 tccttctgag ctggatgggc tggactccga gaaggacaag atgctggtgg agaagcagaa
     1921 ggtgatcaat gaactcacct ggaaactcca gcaagagcag aggcaggtgg aggagctgag
     1981 gatgcagctt cagaagcaga aaaggaataa ctgttcagag aagaagccgc tgcctttcct
     2041 ggctgcctcc atcaagcagg aagaggctgt ctccagctgt ccttttgcat cccaagtacc
     2101 tgtgaaaaga caaagcagca gctcagagtg tcacccaccg gcttgtgaag ctgctcaact
     2161 ccagcctctt ggaaatgctc attgtgtgga gtcctcagat caaaccaatg tactttcttc
     2221 cacatttctc agcccccagt gttcccctca gcattcaccg ctgggggctg tgaaaagccc
     2281 acagcacatc agtttgcccc catcacccaa caaccctcac tttctgccct catcctccgg
     2341 ggcccaggga gaagggcaca gggtctcctc gcccatcagc agccaggtgt gcactgcaca
     2401 gaactcagga gcacacgatg gccatcctcc aagcttctct ccccattctt ccagcctcca
     2461 cccgcccttc tctggagccc aagcagacag cagtcatggt gccgggggaa acccttgtcc
     2521 caaaagccca tgtgtacagc aaaagatggc tggtttacac tcttctgata aggtggggcc
     2581 aaagttttca attccatccc caactttttc taagtcaagt tcagcaattt cagaggtaac
     2641 acagcctcca tcctatgaag atgccgtaaa gcagcaaatg acccggagtc agcagatgga
     2701 tgaactcctg gacgtgctta ttgaaagcgg agaaatgcca gcagacgcta gagaggatca
     2761 ctcatgtctt caaaaagtcc caaagatacc cagatcttcc cgaagtccaa ctgctgtcct
     2821 caccaagccc tcggcttcct ttgaacaagc ctcttcaggc agccagatcc cctttgatcc
     2881 ctatgccacc gacagtgatg agcatcttga agtcttatta aattcccaga gccccctagg
     2941 aaagatgagt gatgtcaccc ttctaaaaat tgggagcgaa gagcctcact ttgatgggat
     3001 aatggatgga ttctctggga aggctgcaga agacctcttc aatgcacatg agatcttgcc
     3061 aggccccctc tctccaatgc agacacagtt ttcaccctct tctgtggaca gcaatgggct
     3121 gcagttaagc ttcactgaat ctccctggga aaccatggag tggctggacc tcactccgcc
     3181 aaattccaca ccaggcttta gcgccctcac caccagcagc cccagcatct tcaacatcga
     3241 tttcctggat gtcactgatc tcaatttgaa ttcttccatg gaccttcact tgcagcagtg
     3301 gtagaatgcc caatgcacca gtgctatgga agaccaatgg agttccatgg gggaaagcac
     3361 acagccatac atactttact gtccaaaaac agaagaagaa gaagagaatt aaaaagaagc
     3421 aatgatttct gtgccaatga acaagaacaa aagtcatttt tagaaataca tatactgtaa
     3481 tatttaccaa cagtcagtaa ctgttaatga tttcaacaat gcattaaaag aatgtgcttt
     3541 ctcagattaa ggatgccaaa aaagatattt cactgccttt tcaaagacca gtatattttc
     3601 tagcccataa tttttctcag gcattgttgg ggcataagct cacactgtaa gcttttctca
     3661 tgaattcact agacataacg tggaaggaaa acgtagtctt ttgggagtac agggaagcca
     3721 gcccctcaaa gcttatggaa gacatacctg caatggaagc tgttgcccaa tgtctccatt
     3781 actatctttc aaaagagaag ccagacccag cttcagatca aaagttcttg agacagagga
     3841 acaaaaccaa tcgatttcca gggaagctaa tcaactctct tttccctcta ccacaaaact
     3901 gccctgctgg agtggttctg aacctgtacc caggactcga tgtggtcact aataacaatt
     3961 aacctgaact gagtccacag aactccactc ggaactttct tcttttttaa ctagtggccc
     4021 aatcattccc accatctctg tgctgataag tacgtgtcct agatgagaac cctgaagaat
     4081 gcagaccttc ttcccccgaa ggagatgcca caagctctcc aacacagccc cctttagttc
     4141 caaagactag agatgaccac attggtagaa gtatatctcg aggcacagga agggagcccc
     4201 accagggata attcagacag gactagagaa taacatcatt tcacataccc tgggataaac
     4261 accctgggtt cctatagaag gactattact tatgggagtc caacttctcc ttttgttttg
     4321 ttattatcag tttatctttc tcccactcca cttttccttc aaggtaccaa tcctttcctg
     4381 ttcctcgttt ggccatcttt ctttttctgc ctccacattg ggaggggagg acttctcagt
     4441 tctaacaagc tgccatactc ctaagaaagc catttttgaa aaatttaaca atccaggttc
     4501 ttctggagaa ctcattctcc acacgcacag tttgctgcaa aaggaagttg caagaatttc
     4561 ttgaggaaga aactggtgac ttggtccatc agtcacgaag ttctttctat tctcgtttag
     4621 ttttcaagaa attattggtt tgtgttgctc tggggaaatt ggaaatcatt acattgtaaa
     4681 gacaaatatg gatgatattt acaagagaga atttcagatc tgggtttttg aaagaaaaca
     4741 gaattgcgca ttgaaaacga tggaaggaaa aagacaatgg tctaatgtgc attcctcatt
     4801 acctctcgtg gctttggctg ggagttggaa aaagctaaaa tttcagaaca gtctctgtaa
     4861 ggctctctgt ggctccagtt caccatttta tattgttgca tgctgtagaa aggagctatt
     4921 gctgttgttt tgttttttta tttaaatcac taaggcactg tttttatctt ttgtaaaaaa
     4981 aaaaaaaaag ttgttcactg tgcacttata gaaaaaataa tcaaaaatgt tgggatttta
     5041 gaagctctct ttttgataaa ccaaagattt agaagtcatt ccattgttaa cttgtaaaaa
     5101 tgtgtgaaca cagagagttt ttggtgattg ctactctgaa agctgccaga tcttattctg
     5161 ggggtgggat gtggaggaat acacatacac acacaaacat acatgtatgt ataatagata
     5221 tatacatatg tgtatattat atctgtgtgt gcatgtatct ccaaaagcgg cgttacagag
     5281 ttctacacca aaagccttta acccttaatc tgctgtgaat gatacctggc ctttctcact
     5341 atgaatttct gattaaccaa ccagactaca cgttgcctct ctgtgtatga ctaacggctc
     5401 caacccgatg actcacagct acttgcttat cgtgaacaag ctcatcttgg caatgaatat
     5461 ggatgtgaaa agacagaaca gcttcaccat tagtagctgg aaatggtatc acagtctctt
     5521 atagaggaat atgaaaggaa caagaaaatc attttacatt ccttttatct gtattgtgct
     5581 ttaaaagatc cacatggtaa attttttatt ttgcttttat gtcagtcatc agaaccaaaa
     5641 aaatccagaa gaaaaaattg ccagtgtttc ctttgaagat gaagctactg gggaagaaaa
     5701 ccttattaat acactccaca catttgttca ttcctcagct gttggtgttt tcttggggtc
     5761 ttgacaaagc ttgctggtca gtgcactttt caggtgtcac gttttgctgt ttgtatgttt
     5821 tttcttcccc ttacttcctt tggaaaacaa actcacacag tgcccctact ctgagacctg
     5881 ggactgagtg ttaattattt tttccttggg tatttctatc tgagagacta gacctagtta
     5941 ggaggcctct gtacttctcc agattgtacc tttttatggg gatctttgag gctatgaccc
     6001 aggactgata gatatgcctt acggaagaca aaagataaaa tggttcctat atcctaatgc
     6061 aaaccaacac agttaaaaga gcagatctct ggataactgc tctcaacctg cttctacagt
     6121 ctccacaaac cgcattcacc ctctctcttc atagctcaga catgaaattt gagggagaaa
     6181 actggagata attgggagaa aattgatgaa gttggctgct tccagtagat cagataatcc
     6241 atgaatttgt ctcccattga gaattttatt ttaaattctt ttaaactctt cgttgtgtct
     6301 tttgtgatga caaatcaggc atgactaaaa gatgtacaga gacttacgaa gatggtcaca
     6361 ttcaagttcc ctaatgctct tagaacctga agatgaccat gtgtagtttt cttaagacct
     6421 ctgaaccccc atggtgatga agacttgaag acatttgcag ctatctgctg cagtctggta
     6481 gattcatact tatctaaaga agtcaaaaaa tttattcgtg caagtgcttg caggaagcca
     6541 gtgcttatta gtagtgaccc tgcttctatc aacgttattg agacaacaca tattctattc
     6601 taagggagaa agagggagga agagagggag ggagggagga agaagaggga gggagcgagg
     6661 aaggaagata ggagatgggt aggggggtaa agagaaaagg agggagaagg gaaggaagga
     6721 aagaagagag gaaagaaagg agggaaggaa aaaagggcca aactttctga tctatgaact
     6781 tctcagttca gctgtcacat tatgagaagt aaatcagaat ttttttaagg agaagtcatt
     6841 cttagcacta caataattgt accagtaatt gaggaaacca agacaatctt cacctgaata
     6901 atagagggtc tgagaactgt cagccttttg ccattcaaaa acatttatgt ccaacctgaa
     6961 aaaaaagcat caataaaacc tatcccaagc attcaaaata gtcctttcca aatgttattt
     7021 attttaaagt caatcagctc ttttagaaac agattctggt ctggctgaaa actcccacaa
     7081 caaatttact catccagtgg ctaatattta atgcccacca tgggcagagc acacaaatct
     7141 tcagataaac aatactgaat tgattcagca cagattgttc agatttgaat gaccagggag
     7201 ttgtatttgc acatgcaaga acactaagaa tctcccagtc ctcaaactag aaacctttca
     7261 gctacgatga aaaaaaaaaa ggggtcttca tttttccaag agggggtgga ggtggggatc
     7321 actttttagc taaaagctat ctctcacttc aaaattcttg tctttttctt tgtggacaaa
     7381 caccagtagt ctatcacttg gagatctttt aatatctccc atcatttaaa acatccacga
     7441 gagtttgaag atttgtgttg attgccagat acagaagccc cttgaaaata aggaaagggt
     7501 ggaggaagca tttttgtgtc ctatccctac ttatcgtagc agctctatag acaaaaggga
     7561 cacttactgg tgagcctctg gcccttaaaa gaaaatcatc taagaatatg aaggcaattt
     7621 gatttccccc cacagccctc agctgccttc ctcacagaag gaagttccca aaattgctgg
     7681 tacacagttt gcaatcaaat atcagatatg agaaaacctg tagtgaagag tctgggttct
     7741 tggttttctc ataaatccaa tataaatttg taggttggtt cagggtcaaa attgccagtg
     7801 ctttattaga cagatgatac tgatagacac acagagccca ggtcctggaa caagacaatc
     7861 ctgtagtgcc aagatctggt cagttgcgtt aaggagctgg gtttgattct agagtccagg
     7921 tttatagaga aaccctggct agattgagcc tacccatggg gagacgattt caagacagga
     7981 tgagatctgg gaagaatttt gttgtcatct gccagggaaa ttatcacagg actcattgaa
     8041 tgcaataaca tgtgagtaag ttcccttttg attctgggaa tcagcgattt tccctgtgga
     8101 ttaagacaaa ccaacgccag aaggtctcct gtgcttattt taaccatctg ctcccatcgt
     8161 gaaccctgga gcatgcattt cctagaagtg gtttcatagc tcctgtgtgt tcatggaaaa
     8221 ggggagtata atgatgggga tgctggaagc ttttttaatg ttttccaaag gaaaggaacc
     8281 cacactgctc cccagagttc ctttccaatg gccctgcagt aagaacggag gacaatgtat
     8341 tgctgggtgc ttaaaatcct ccctcagtga agcacaaaga gacactttgt aaagaaaaaa
     8401 agagcaagca taggttctct gtgggacctt gtggagtggt gttttcacgt tggtctcttt
     8461 ggctcaattg agcataatca gaaagaaatg tgggttattg ggaagagaca aaaagcagtg
     8521 gctaaaatac caaagttggc atgtgttctt ttttaaaaaa aaaaaaaaat gcatatattt
     8581 ttaaataaaa tgtttatttt aaaaagaaa
//
