LOCUS       NP_001139784             986 aa            linear   PRI 30-APR-2025
DEFINITION  myocardin isoform 1 [Homo sapiens].
ACCESSION   NP_001139784
VERSION     NP_001139784.1
DBSOURCE    REFSEQ: accession NM_001146312.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 986)
  AUTHORS   Bankell,E., Liu,L., van der Horst,J., Rippe,C., Jepps,T.A.,
            Nilsson,B.O. and Sward,K.
  TITLE     Suppression of smooth muscle cell inflammation by myocardin-related
            transcription factors involves inactivation of TANK-binding kinase
            1
  JOURNAL   Sci Rep 14 (1), 13321 (2024)
   PUBMED   38858497
  REMARK    GeneRIF: Suppression of smooth muscle cell inflammation by
            myocardin-related transcription factors involves inactivation of
            TANK-binding kinase 1.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 986)
  AUTHORS   Javanshir,E., Ebrahimi,Z.J., Mirzohreh,S.T., Ghaffari,S.,
            Banisefid,E., Alamdari,N.M. and Roshanravan,N.
  TITLE     Disparity of gene expression in coronary artery disease: insights
            from MEIS1, HIRA, and Myocardin
  JOURNAL   Mol Biol Rep 51 (1), 712 (2024)
   PUBMED   38824221
  REMARK    GeneRIF: Disparity of gene expression in coronary artery disease:
            insights from MEIS1, HIRA, and Myocardin.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 986)
  AUTHORS   Sakai,T., Choo,Y.Y., Mitsuhashi,S., Ikebe,R., Jeffers,A., Idell,S.,
            Tucker,T.A. and Ikebe,M.
  TITLE     Myocardin regulates fibronectin expression and secretion from human
            pleural mesothelial cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (4), L419-L430 (2024)
   PUBMED   38349126
  REMARK    GeneRIF: Myocardin regulates fibronectin expression and secretion
            from human pleural mesothelial cells.
REFERENCE   4  (residues 1 to 986)
  AUTHORS   Liu,L., Kryvokhyzha,D., Rippe,C., Jacob,A., Borreguero-Munoz,A.,
            Stenkula,K.G., Hansson,O., Smith,C.W.J., Fisher,S.A. and Sward,K.
  TITLE     Myocardin regulates exon usage in smooth muscle cells through
            induction of splicing regulatory factors
  JOURNAL   Cell Mol Life Sci 79 (8), 459 (2022)
   PUBMED   35913515
  REMARK    GeneRIF: Myocardin regulates exon usage in smooth muscle cells
            through induction of splicing regulatory factors.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 986)
  AUTHORS   Mikhailov,A.T. and Torrado,M.
  TITLE     In search of novel targets for heart disease: myocardin and
            myocardin-related transcriptional cofactors
  JOURNAL   Biochem Res Int 2012, 973723 (2012)
   PUBMED   22666593
REFERENCE   6  (residues 1 to 986)
  AUTHORS   Du,K.L., Chen,M., Li,J., Lepore,J.J., Mericko,P. and Parmacek,M.S.
  TITLE     Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals
            and induces smooth muscle cell differentiation from
            undifferentiated embryonic stem cells
  JOURNAL   J Biol Chem 279 (17), 17578-17586 (2004)
   PUBMED   14970199
REFERENCE   7  (residues 1 to 986)
  AUTHORS   Wang,Z., Wang,D.Z., Pipes,G.C. and Olson,E.N.
  TITLE     Myocardin is a master regulator of smooth muscle gene expression
  JOURNAL   Proc Natl Acad Sci U S A 100 (12), 7129-7134 (2003)
   PUBMED   12756293
REFERENCE   8  (residues 1 to 986)
  AUTHORS   Du,K.L., Ip,H.S., Li,J., Chen,M., Dandre,F., Yu,W., Lu,M.M.,
            Owens,G.K. and Parmacek,M.S.
  TITLE     Myocardin is a critical serum response factor cofactor in the
            transcriptional program regulating smooth muscle cell
            differentiation
  JOURNAL   Mol Cell Biol 23 (7), 2425-2437 (2003)
   PUBMED   12640126
  REMARK    GeneRIF: Myocardin is a critical serum response factor cofactor
            regulating smooth muscle cell differentiation; forced expression of
            myocardin activated expression of SM22 alpha, smooth muscle
            alpha-actin, and calponin-h1 genes in mouse ES cells
REFERENCE   9  (residues 1 to 986)
  AUTHORS   Wang,D.Z., Li,S., Hockemeyer,D., Sutherland,L., Wang,Z.,
            Schratt,G., Richardson,J.A., Nordheim,A. and Olson,E.N.
  TITLE     Potentiation of serum response factor activity by a family of
            myocardin-related transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14855-14860 (2002)
   PUBMED   12397177
REFERENCE   10 (residues 1 to 986)
  AUTHORS   Wang,D., Chang,P.S., Wang,Z., Sutherland,L., Richardson,J.A.,
            Small,E., Krieg,P.A. and Olson,E.N.
  TITLE     Activation of cardiac gene expression by myocardin, a
            transcriptional cofactor for serum response factor
  JOURNAL   Cell 105 (7), 851-862 (2001)
   PUBMED   11439182
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005358.1 and AK292885.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a nuclear protein, which is expressed in
            heart, aorta, and in smooth muscle cell-containing tissues. It
            functions as a transcriptional co-activator of serum response
            factor (SRF) and modulates expression of cardiac and smooth
            muscle-specific SRF-target genes, and thus may play a crucial role
            in cardiogenesis and differentiation of the smooth muscle cell
            lineage. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene.[provided by
            RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1286588.1,
                                           SRR14372079.1683722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425538.6/ ENSP00000401678.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     Protein         1..986
                     /product="myocardin isoform 1"
                     /calculated_mol_wt=106638
     Region          106..131
                     /region_name="RPEL"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; smart00707"
                     /db_xref="CDD:128947"
     Region          371..404
                     /region_name="SAP"
                     /note="SAP domain; pfam02037"
                     /db_xref="CDD:460424"
     CDS             1..986
                     /gene="MYOCD"
                     /gene_synonym="MGBL; MYCD"
                     /coded_by="NM_001146312.3:300..3260"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS54091.1"
                     /db_xref="GeneID:93649"
                     /db_xref="HGNC:HGNC:16067"
                     /db_xref="MIM:606127"
ORIGIN      
        1 mtllgsehsl lirskfrsvl qlrlqqrrtq eqlanqgiip plkrpaefhe qrkhldsdka
       61 knslkrkarn rcnsadlvnm hilqastaer siptaqmklk rarladdlne kialrpgple
      121 lveknilpvd savkeaikgn qvsfskstda fafeedsssd glspdqtrse dpqnsagspp
      181 dakasdtpst gslgtnqdla sgsendrnds asqpshqsda gkqglgppst piavhaavks
      241 kslgdsknrh kkpkdpkpkv kklkyhqyip pdqkaekspp pmdsayarll qqqqlflqlq
      301 ilsqqqqqqq hrfsylgmhq aqlkepneqm vrnpnssstp lsntplspvk nsfsgqtgvs
      361 sfkpgplppn lddlkvselr qqlrirglpv sgtktalmdr lrpfqdcsgn pvpnfgditt
      421 vtfpvtpntl pnyqssssts alsngfyhfg stsssppisp assdlsvags lpdtfndasp
      481 sfglhpspvh vcteeslmss lnggsvpsel dgldsekdkm lvekqkvine ltwklqqeqr
      541 qveelrmqlq kqkrnncsek kplpflaasi kqeeavsscp fasqvpvkrq ssssechppa
      601 ceaaqlqplg nahcvessdq tnvlsstfls pqcspqhspl gavkspqhis lppspnnphf
      661 lpsssgaqge ghrvsspiss qvctaqnsga hdghppsfsp hssslhppfs gaqadsshga
      721 ggnpcpkspc vqqkmaglhs sdkvgpkfsi psptfsksss aisevtqpps yedavkqqmt
      781 rsqqmdelld vliesgempa daredhsclq kvpkiprssr sptavltkps asfeqassgs
      841 qipfdpyatd sdehlevlln sqsplgkmsd vtllkigsee phfdgimdgf sgkaaedlfn
      901 aheilpgpls pmqtqfspss vdsnglqlsf tespwetmew ldltppnstp gfsalttssp
      961 sifnidfldv tdlnlnssmd lhlqqw
//
