LOCUS       NM_004145               7606 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens myosin IXB (MYO9B), transcript variant 1, mRNA.
ACCESSION   NM_004145
VERSION     NM_004145.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7606)
  AUTHORS   Zhang,J., Zou,Y., Chen,L., Sun,F., Xu,Q., Zhou,Q., Wang,Y., Luo,X.,
            Wang,N., Li,Y., Zhang,S., Xiong,F., Yang,P., Liu,S., Yang,T.,
            Weng,J., Eizirik,D.L., Yan,J., Zhou,Z. and Wang,C.Y.
  TITLE     Myo9b mutations are associated with altered dendritic cell
            functions and increased susceptibility to autoimmune diabetes onset
  JOURNAL   Nat Commun 14 (1), 5977 (2023)
   PUBMED   37749140
  REMARK    GeneRIF: Myo9b mutations are associated with altered dendritic cell
            functions and increased susceptibility to autoimmune diabetes
            onset.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7606)
  AUTHORS   Cipriani,S., Guerrero-Valero,M., Tozza,S., Zhao,E., Vollmer,V.,
            Beijer,D., Danzi,M., Rivellini,C., Lazarevic,D., Pipitone,G.B.,
            Grosz,B.R., Lamperti,C., Marzoli,S.B., Carrera,P., Devoto,M.,
            Pisciotta,C., Pareyson,D., Kennerson,M., Previtali,S.C.,
            Zuchner,S., Scherer,S.S., Manganelli,F., Bahler,M. and Bolino,A.
  TITLE     Mutations in MYO9B are associated with Charcot-Marie-Tooth disease
            type 2 neuropathies and isolated optic atrophy
  JOURNAL   Eur J Neurol 30 (2), 511-526 (2023)
   PUBMED   36260368
  REMARK    GeneRIF: Mutations in MYO9B are associated with Charcot-Marie-Tooth
            disease type 2 neuropathies and isolated optic atrophy.
REFERENCE   3  (bases 1 to 7606)
  AUTHORS   Hemkemeyer,S.A., Vollmer,V., Schwarz,V., Lohmann,B., Honnert,U.,
            Taha,M., Schnittler,H.J. and Bahler,M.
  TITLE     Local Myo9b RhoGAP activity regulates cell motility
  JOURNAL   J Biol Chem 296, 100136 (2021)
   PUBMED   33268376
  REMARK    GeneRIF: Local Myo9b RhoGAP activity regulates cell motility.
REFERENCE   4  (bases 1 to 7606)
  AUTHORS   Yi,F.S., Zhang,X., Zhai,K., Huang,Z.Y., Wu,X.Z., Wu,M.T., Shi,X.Y.,
            Pei,X.B., Dong,S.F., Wang,W., Yang,Y., Du,J., Luo,Z.T. and Shi,H.Z.
  TITLE     TSAd Plays a Major Role in Myo9b-Mediated Suppression of Malignant
            Pleural Effusion by Regulating TH1/TH17 Cell Response
  JOURNAL   J Immunol 205 (10), 2926-2935 (2020)
   PUBMED   33046503
  REMARK    GeneRIF: TSAd Plays a Major Role in Myo9b-Mediated Suppression of
            Malignant Pleural Effusion by Regulating TH1/TH17 Cell Response.
REFERENCE   5  (bases 1 to 7606)
  AUTHORS   Comer,S., Nagy,Z., Bolado,A., von Kriegsheim,A., Gambaryan,S.,
            Walter,U., Pagel,O., Zahedi,R.P., Jurk,K. and Smolenski,A.
  TITLE     The RhoA regulators Myo9b and GEF-H1 are targets of cyclic
            nucleotide-dependent kinases in platelets
  JOURNAL   J Thromb Haemost 18 (11), 3002-3012 (2020)
   PUBMED   32692911
  REMARK    GeneRIF: The RhoA regulators Myo9b and GEF-H1 are targets of cyclic
            nucleotide-dependent kinases in platelets.
REFERENCE   6  (bases 1 to 7606)
  AUTHORS   Post,P.L., Tyska,M.J., O'Connell,C.B., Johung,K., Hayward,A. and
            Mooseker,M.S.
  TITLE     Myosin-IXb is a single-headed and processive motor
  JOURNAL   J Biol Chem 277 (14), 11679-11683 (2002)
   PUBMED   11801597
  REMARK    GeneRIF: Myosin-IXb is a single-headed and processive motor
REFERENCE   7  (bases 1 to 7606)
  AUTHORS   Post,P.L., Bokoch,G.M. and Mooseker,M.S.
  TITLE     Human myosin-IXb is a mechanochemically active motor and a GAP for
            rho
  JOURNAL   J Cell Sci 111 (Pt 7), 941-950 (1998)
   PUBMED   9490638
REFERENCE   8  (bases 1 to 7606)
  AUTHORS   Bahler,M., Kehrer,I., Gordon,L., Stoffler,H.E. and Olsen,A.S.
  TITLE     Physical mapping of human myosin-IXB (MYO9B), the human orthologue
            of the rat myosin myr 5, to chromosome 19p13.1
  JOURNAL   Genomics 43 (1), 107-109 (1997)
   PUBMED   9226381
REFERENCE   9  (bases 1 to 7606)
  AUTHORS   Wirth,J.A., Jensen,K.A., Post,P.L., Bement,W.M. and Mooseker,M.S.
  TITLE     Human myosin-IXb, an unconventional myosin with a chimerin-like
            rho/rac GTPase-activating protein domain in its tail
  JOURNAL   J Cell Sci 109 (Pt 3), 653-661 (1996)
   PUBMED   8907710
REFERENCE   10 (bases 1 to 7606)
  AUTHORS   Bement,W.M., Hasson,T., Wirth,J.A., Cheney,R.E. and Mooseker,M.S.
  TITLE     Identification and overlapping expression of multiple
            unconventional myosin genes in vertebrate cell types
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6549-6553 (1994)
   PUBMED   8022818
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11767. doi:
            10.1073/pnas.91.24.11767-c.. PMID: 7972138]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020908.7, BI827217.1,
            AB290184.1, BF905466.1, BI001923.1, CN284963.1, DR006748.1 and
            BC018108.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_004145.3.
            
            Summary: This gene encodes a member of the myosin family of
            actin-based molecular motor heavy chain proteins. The protein
            represents an unconventional myosin; it should not be confused with
            the conventional non-muscle myosin-9 (MYH9). The protein has four
            IQ motifs located in the neck domain that bind calmodulin, which
            serves as a light chain. The protein complex has a single-headed
            structure and exhibits processive movement on actin filaments
            toward the minus-end. The protein also has rho-GTPase activity.
            Polymorphisms in this gene are associated with celiac disease and
            ulcerative colitis susceptibility. Multiple transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2011].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB290184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682292.1/ ENSP00000507803.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC020908.7         146797-146800
            5-9                 BI827217.1         1-5
            10-1787             AB290184.1         1-1778
            1788-1818           BF905466.1         27-57
            1819-2180           AB290184.1         1810-2171
            2181-2231           BI001923.1         196-246
            2232-3950           AB290184.1         2223-3941
            3951-4348           CN284963.1         381-778
            4349-5744           AB290184.1         4340-5735
            5745-5893           DR006748.1         378-526
            5894-7184           AB290184.1         5885-7175
            7185-7606           BC018108.1         2063-2484
FEATURES             Location/Qualifiers
     source          1..7606
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..7606
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /note="myosin IXB"
                     /db_xref="GeneID:4650"
                     /db_xref="HGNC:HGNC:7609"
                     /db_xref="MIM:602129"
     exon            1..98
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            99..996
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..6630
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myosin-IXb; unconventional myosin-9b; unconventional
                     myosin-IXb"
                     /codon_start=1
                     /product="unconventional myosin-IXb isoform 1"
                     /protein_id="NP_004136.2"
                     /db_xref="CCDS:CCDS92551.1"
                     /db_xref="GeneID:4650"
                     /db_xref="HGNC:HGNC:7609"
                     /db_xref="MIM:602129"
                     /translation="MSVKEAGSSGRREQAAYHLHIYPQLSTTESQASCRVTATKDSTT
                     SDVIKDAIASLRLDGTKCYVLVEVKESGGEEWVLDANDSPVHRVLLWPRRAQDEHPQE
                     DGYYFLLQERNADGTIKYVHMQLVAQATATRRLVERGLLPRQQADFDDLCNLPELTEG
                     NLLKNLKHRFLQQKIYTYAGSILVAINPFKFLPIYNPKYVKMYENQQLGKLEPHVFAL
                     ADVAYYTMLRKRVNQCIVISGESGSGKTQSTNFLIHCLTALSQKGYASGVERTILGAG
                     PVLEAFGNAKTAHNNNSSRFGKFIQVSYLESGIVRGAVVEKYLLEKSRLVSQEKDERN
                     YHVFYYLLLGVSEEERQEFQLKQPEDYFYLNQHNLKIEDGEDLKHDFERLKQAMEMVG
                     FLPATKKQIFAVLSAILYLGNVTYKKRATGREEGLEVGPPEVLDTLSQLLKVKREILV
                     EVLTKRKTVTVNDKLILPYSLSEAITARDSMAKSLYSALFDWIVLRINHALLNKKDVE
                     EAVSCLSIGVLDIFGFEDFERNSFEQFCINYANEQLQYYFNQHIFKLEQEEYQGEGIT
                     WHNIGYTDNVGCIHLISKKPTGLFYLLDEESNFPHATSQTLLAKFKQQHEDNKYFLGT
                     PVMEPAFIIQHFAGKVKYQIKDFREKNMDYMRPDIVALLRGSDSSYVRELIGMDPVAV
                     FRWAVLRAAIRAMAVLREAGRLRAERAEKAAGMSSPGAQSHPEELPRGASTPSEKLYR
                     DLHNQMIKSIKGLPWQGEDPRSLLQSLSRLQKPRAFILKSKGIKQKQIIPKNLLDSKS
                     LKLIISMTLHDRTTKSLLHLHKKKKPPSISAQFQTSLNKLLEALGKAEPFFIRCIRSN
                     AEKKELCFDDELVLQQLRYTGMLETVRIRRSGYSAKYTFQDFTEQFQVLLPKDAQPCR
                     EVISTLLEKMKIDKRNYQIGKTKVFLKETERQALQETLHREVVRKILLLQSWFRMVLE
                     RRHFLQMKRAAVTIQACWRSYRVRRALERTQAAVYLQASWRGYWQRKLYRHQKQSIIR
                     LQSLCRGHLQRKSFSQMISEKQKAEEKEREALEAARAGAEEGGQGQAAGGQQVAEQGP
                     EPAEDGGHLASEPEVQPSDRSPLEHSSPEKEAPSPEKTLPPQKTVAAESHEKVPSSRE
                     KRESRRQRGLEHVKFQNKHIQSCKEESALREPSRRVTQEQGVSLLEDKKESREDETLL
                     VVETEAENTSQKQPTEQPQAMAVGKVSEETEKTLPSGSPRPGQLERPTSLALDSRVSP
                     PAPGSAPETPEDKSKPCGSPRVQEKPDSPGGSTQIQRYLDAERLASAVELWRGKKLVA
                     AASPSAMLSQSLDLSDRHRATGAALTPTEERRTSFSTSDVSKLLPSLAKAQPAAETTD
                     GERSAKKPAVQKKKPGDASSLPDAGLSPGSQVDSKSTFKRLFLHKTKDKKYSLEGAEE
                     LENAVSGHVVLEATTMKKGLEAPSGQQHRHAAGEKRTKEPGGKGKKNRNVKIGKITVS
                     EKWRESVFRQITNANELKYLDEFLLNKINDLRSQKTPIESLFIEATEKFRSNIKTMYS
                     VPNGKIHVGYKDLMENYQIVVSNLATERGQKDTNLVLNLFQSLLDEFTRGYTKNDFEP
                     VKQSKAQKKKRKQERAVQEHNGHVFASYQVSIPQSCEQCLSYIWLMDKALLCSVCKMT
                     CHKKCVHKIQSHCSYTYGRKGEPGVEPGHFGVCVDSLTSDKASVPIVLEKLLEHVEMH
                     GLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHAITGVLKQWLRELPEPLMT
                     FAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIFHLVKVALLEDVNRMS
                     PGALAIIFAPCLLRCPDNSDPLTSMKDVLKITTCVEMLIKEQMRKYKVKMEEISQLEA
                     AESIAFRRLSLLRQNAPWPLKLGFSSPYEGVLNKSPKTRDIQEEELEVLLEEEAAGGD
                     EDREKEILIERIQSIKEEKEDITYRLPELDPRGSDEENLDSETSASTESLLEERAGRG
                     ASEGPPAPALPCPGAPTPSPLPTVAAPPRRRPSSFVTVRVKTPRRTPIMPTANIKLPP
                     GLPSHLPRWAPGAREAAAPVRRREPPARRPDQIHSVYITPGADLPVQGALEPLEEDGQ
                     PPGAKRRYSDPPTYCLPPASGQTNG"
     exon            997..1091
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1154
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1254
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1355
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1485
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1575
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1692
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1827
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1949
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2091
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2296
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2375
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2489
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2529
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2652
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2733
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2844
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2967
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3284
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..4202
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            4203..4269
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            4270..4394
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            4395..4528
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            4529..4719
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            4720..4818
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            4819..4992
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            4993..5034
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5035..5146
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5147..5220
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5221..5413
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5414..5542
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5543..5648
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5649..5780
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5781..5904
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5905..5952
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            5953..6086
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            6087..6214
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     exon            6215..7606
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7588..7593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /note="hexamer: AATAAA"
     polyA_site      7606
                     /gene="MYO9B"
                     /gene_synonym="CELIAC4; MYR5"
                     /note="major polyA site"
ORIGIN      
        1 gcggcggggc ggagcggctc gagcagcggc gggctggcag gcggtcgtcc ggccggggac
       61 ccggcccggg accggcggcg cgcggcggcc gaggccagct ccaggacacg cgcgccccga
      121 gcctgggagg catgctgaag ccaggcggcc ggcaggatga gtgtgaaaga ggcaggcagc
      181 tcgggccgcc gggagcaggc ggcctaccac ctgcacatct acccccagct gtccaccacc
      241 gagagccagg cctcgtgccg cgtgactgcc accaaggaca gcaccacctc ggacgtcatc
      301 aaggacgcca ttgccagcct gcggctggac ggcaccaaat gttatgtgct ggtggaggtc
      361 aaagagtcgg gaggcgagga atgggtgctg gacgccaacg actcgcctgt gcaccgggtg
      421 ctgctatggc cccggcgggc acaggacgag caccctcagg aggatggcta ctacttcctg
      481 ctgcaggagc gcaacgcaga tggaaccatc aagtacgtgc atatgcagct ggtggcgcag
      541 gccacagcca cccggcgcct agtggagcgt ggcctcctgc cacggcagca ggcggacttt
      601 gatgacctgt gtaacctccc cgagctaacc gagggcaacc tcctgaagaa cctcaagcac
      661 cgcttcctgc aacaaaagat ctacacgtac gcggggagca tcctggtggc catcaacccc
      721 tttaagttcc tgcccatcta caaccccaag tacgtgaaga tgtatgagaa ccagcagctg
      781 ggcaagctgg agccacacgt cttcgcgctg gccgacgtgg cctactacac catgctcagg
      841 aagcgcgtga accagtgcat cgtgatctcg ggtgagagcg gctccggcaa gacccagagc
      901 accaacttcc tcatccactg cctcaccgcc ctcagccaga agggctacgc cagcggcgtc
      961 gagaggacca tcctgggtgc tggccctgtg ctggaggctt ttggaaatgc caagacagcc
     1021 cacaacaaca actccagccg gtttgggaaa ttcatccaag tcagctacct agagagtggc
     1081 atcgtgagag gagctgtcgt cgagaaatat ctgcttgaaa agtctcgcct ggtgtctcag
     1141 gagaaggatg agaggaacta ccatgtgttt tattatttgt tacttggggt cagcgaggaa
     1201 gagcgccaag aatttcagct caagcagcct gaagattatt tctacctcaa ccagcataac
     1261 ttgaagattg aagatgggga ggacctgaag catgactttg agaggctcaa gcaggccatg
     1321 gagatggtgg gcttcctccc cgccaccaag aagcagattt ttgccgtcct ctcggccatc
     1381 ctgtacctgg gcaacgtcac ttataagaag agagctacag gccgagagga agggttggag
     1441 gtcgggccac ccgaggtgct ggacaccctg tcgcagcttc tgaaggtgaa gcgagaaatc
     1501 ttggtggagg ttctgaccaa aagaaaaacg gtgaccgtca acgacaagct tatccttccc
     1561 tacagcctca gcgaggccat cactgcccgc gactccatgg ccaagtctct gtacagcgcc
     1621 ctgttcgact ggattgtgct gcggatcaac cacgcactcc tcaacaagaa ggacgtggaa
     1681 gaggcagtct cgtgcctgtc cattggggtc ctggacatct tcgggtttga agacttcgag
     1741 aggaacagct ttgagcagtt ctgcatcaac tacgccaatg agcagctgca gtattacttc
     1801 aaccagcaca tcttcaagct ggagcaggag gaatatcagg gcgaggggat cacgtggcac
     1861 aacatcggct acacagacaa tgtcggctgc atccatctca tcagcaagaa acccacgggc
     1921 ctcttctacc tgctggacga ggagagcaac ttcccccacg ccacgagcca gaccctgctg
     1981 gccaagttca aacagcaaca tgaggacaat aagtacttcc tgggcacccc ggtcatggag
     2041 ccagctttca tcatccagca cttcgcaggg aaggtgaaat atcagatcaa ggacttccgg
     2101 gagaagaaca tggactacat gcggccagac atcgtggccc tgctgcgggg cagtgacagc
     2161 tcctacgtgc gggagctcat cggcatggac cccgtggccg tgttccgctg ggccgtgctc
     2221 cgggctgcta tccgggccat ggcagtgctt cgggaggccg gacgcctgcg ggccgagagg
     2281 gccgaaaagg ctgcaggtat gagcagccct ggtgcccaaa gtcacccaga agagctgcca
     2341 agaggagcca gcaccccttc ggaaaaactt taccgcgatt tgcataacca aatgatcaag
     2401 agcatcaaag gattgccctg gcagggcgag gacccccgta gccttctcca gtccctcagt
     2461 cggctccaga aaccccgcgc cttcatcctg aaaagtaaag gtatcaaaca aaagcagatc
     2521 attccaaaga acctactgga ctccaagtcc ctgaaactca tcatcagcat gactctgcac
     2581 gaccgcacca ccaagtccct actgcacctg cacaagaaga aaaagccacc aagcatcagc
     2641 gcccagttcc agacatccct taacaagctc ttggaggcac tggggaaggc ggagcccttc
     2701 tttatccgct gcatccgttc caatgctgaa aagaaagagc tgtgctttga cgacgagctg
     2761 gtcctgcagc agctgcgcta caccggcatg ctggagaccg tgcgcatccg gaggtcaggg
     2821 tacagcgcca agtacacgtt ccaggatttc accgagcagt tccaggtgct cctgcccaag
     2881 gatgcccagc cctgcaggga ggtcatctcc accctcctgg agaaaatgaa gatagacaag
     2941 aggaactacc agatcgggaa gaccaaggtc ttcctgaagg agacggagcg gcaagccctg
     3001 caggagacgc tgcaccggga ggtggtgcgg aaaatcctgc tgctgcagag ctggttccgg
     3061 atggtgctgg agcgtcggca cttcctgcag atgaagcggg ccgccgtcac catccaggcc
     3121 tgctggcggt cctaccgggt ccggagggcg ctggagagga cgcaggctgc cgtgtacctc
     3181 caggcctcat ggaggggcta ctggcagcgg aagctctacc ggcaccagaa acagagcatc
     3241 atccgcctgc agagcctgtg tcgggggcac ctgcagcgca agagcttcag ccagatgatc
     3301 tcggagaagc agaaggcaga agagaaggag agggaagccc tggaagccgc aagagcaggt
     3361 gctgaggagg gcggacaggg tcaggcggct ggagggcagc aggtagctga gcaggggccg
     3421 gagccagcgg aggatggcgg gcacctggca tcggagcctg aggtgcagcc aagtgacagg
     3481 tcccccctag agcactcctc acctgagaag gaggccccaa gcccagagaa gactctccca
     3541 ccccagaaaa ccgtggcggc tgaaagtcac gagaaagtcc ccagcagccg ggagaagcgt
     3601 gagtcgcgtc ggcaaagagg gctggagcac gtcaagttcc agaacaaaca catccagtcc
     3661 tgcaaggagg agagtgccct cagagaacct tccagaaggg tcacccagga gcaaggggtg
     3721 agtctcctgg aagacaaaaa ggagagcaga gaagatgaaa cccttctagt cgtagagacg
     3781 gaggctgaga acacatctca aaagcagccc acagagcaac cccaggccat ggcagttggc
     3841 aaggtctctg aagaaactga gaagacgctg cccagtggga gccccaggcc tggccagttg
     3901 gagcggccga ccagcctggc cctggacagc agggtcagcc caccggcccc tggcagcgcc
     3961 cccgagaccc ccgaggacaa gagcaaacca tgtggcagcc caagggttca ggaaaagccc
     4021 gacagccccg gaggctccac gcagatccag cggtacctgg acgccgagcg gctggccagc
     4081 gccgtggaac tgtggcgggg caagaagctg gtggccgccg ccagccctag tgccatgctc
     4141 agccagtccc tggacctcag cgacagacac cgggccacag gggccgccct cacgcccaca
     4201 gaggagaggc gcacctcctt ctccacgagc gacgtctcca agctcctccc gtccctggcc
     4261 aaggctcagc ctgcagcaga aaccacggac ggagagcgaa gtgcgaaaaa gccagctgtc
     4321 cagaagaaga agccaggcga cgcatcctcc ctcccagacg cagggctgtc cccgggctct
     4381 caggtcgact ctaaatccac gtttaagagg ctttttctgc ataaaaccaa ggataaaaaa
     4441 tacagcctgg agggcgcaga ggagctggag aatgcagtgt ccgggcacgt ggtgctggaa
     4501 gccaccacca tgaagaaggg cctggaagcc ccctccggac agcagcatcg ccacgctgca
     4561 ggtgagaagc gcaccaagga accaggaggc aaagggaaga agaaccgaaa tgtcaagatt
     4621 gggaagatca cagtgtcaga gaagtggcgg gaatcggtgt tccgccagat caccaacgcc
     4681 aatgagctca agtacctgga cgagttcctg ctcaacaaga taaatgacct ccgttcccag
     4741 aagacgccca ttgagagctt gtttatcgaa gccaccgaga agttcaggag caacatcaaa
     4801 acgatgtact ctgtcccgaa cgggaagatc cacgtgggct acaaggatct gatggagaac
     4861 taccagatcg tcgtcagcaa cctggccact gagcgtggcc agaaggacac caacctggtc
     4921 ctcaacctct tccagtcact gctagatgag ttcacccgtg gctacaccaa gaacgacttc
     4981 gagccagtga agcagagcaa agctcagaag aagaagcgga agcaggagcg tgctgtccag
     5041 gagcacaacg ggcacgtgtt cgccagctac caggttagca tcccgcagtc gtgcgagcag
     5101 tgcctctcct atatctggct catggacaag gccctgctct gcagcgtgtg caagatgacc
     5161 tgccacaaga agtgcgtgca caagattcag agccactgct cctacaccta cgggaggaag
     5221 ggcgagccag gcgttgagcc tggccacttc ggcgtgtgcg tagacagcct gaccagcgac
     5281 aaggcctcgg tgcccatcgt gctggagaag ctcctggaac acgtggagat gcacggcctg
     5341 tacaccgagg gcctctaccg caagtcgggt gctgccaacc gcactcggga gctccggcag
     5401 gcgctgcaga cagaccccgc agcagtcaag ctggagaact tccccatcca cgccatcaca
     5461 ggggtgctga agcagtggct gcgggagctg cccgagcccc tcatgacctt cgcacagtac
     5521 ggcgacttcc tccgagccgt cgagctgccg gagaagcagg agcagctggc tgccatctat
     5581 gccgtcctgg agcaccttcc agaagccaac cacaactccc tggagagact catcttccac
     5641 cttgtcaagg tggccctgct cgaggatgtc aaccgcatgt cacctggggc gctggccatt
     5701 atcttcgcac cctgcctcct gcgctgccct gacaactcgg acccgctgac cagcatgaag
     5761 gacgtcctca agatcaccac gtgcgtggag atgctgatca aggagcagat gaggaaatac
     5821 aaagtgaaga tggaggagat cagccaactg gaggctgcag agagtatcgc cttccgcagg
     5881 ctttcgctcc tgcgacaaaa tgctccatgg cctctcaaac tggggttttc gtctccctat
     5941 gagggggtcc tgaacaagag ccccaagacc cgggacatcc aggaggagga gctggaggtg
     6001 ctgctggagg aggaggcagc cggcggcgat gaggaccggg aaaaggagat tctcattgaa
     6061 cggatccagt ccatcaagga ggagaaggag gacatcacct accggctgcc ggagctggac
     6121 ccaaggggct cggacgagga gaacctggac tcggagacgt cggccagcac cgagagcctg
     6181 ctggaggagc gggccgggcg gggggcctcg gaagggcccc ctgcgcctgc tctcccttgc
     6241 cccggcgcgc ccaccccgag ccccctcccc accgtggccg cccctccacg acgaaggccg
     6301 tcgtccttcg taacggtcag agtgaagacc ccccggcgga cccccatcat gcccacggcc
     6361 aacatcaagc tcccaccagg cctgccctcc cacctgcctc gctgggcacc gggtgcccgg
     6421 gaggcggctg ccccagtgcg gcgccgggag ccacctgccc gccgcccgga ccagatacat
     6481 tccgtgtaca tcacgcccgg ggcagacctg ccagtgcagg gcgccctgga gcccctagaa
     6541 gaggatggcc agccacctgg ggccaagcgg aggtactcgg atcccccaac gtactgcctg
     6601 ccccccgcct cgggccagac caatggctga gagccacagc tgacaaagtc tgcatgtccg
     6661 aggacggccc ctgcactgga gctgggcgcc agagctgcag agctagtgtt cggccctcag
     6721 agaaggatcc agaatcaaaa gctcaagagt gacgtgaggt gggcaccggc cccaagtgca
     6781 gagtcaaggc agggagaggc cggctggagc caggccccct cgcacgcagc ccccaaatca
     6841 tggacgcacc tgtggggagc accacatctc cacctgcggc ctcacatctc cccactcccc
     6901 tttttgtacg tttaactgtt tctttgtacg tggtttacgt aactttaaac tgtaacagcc
     6961 ttaatggaag accaaatggt tttttatatg tgtatgtaca aagttttcta ttaacgctgc
     7021 ccgtctccct tataacctgg acgtgagctg tcagagcaga agccactagg ccactgcgcg
     7081 tctgaggctc agaccctgct gtggttggct tggggtggcc aatgggctgg gaccctccat
     7141 gagagttttg gacacttggg tcacctgacc cgtgcctctc tgacacatgt ctccgggggg
     7201 cagccacctg gccaatgtgc atttttgcac atgctggaac cttccatggg ggtctgggct
     7261 attggctgga gccaggacat gagtcagggg caccatggac ctcacgtgcc agggagactt
     7321 gaatgtggct gtcactcttc cggacgccaa gggctgcagg aggctgcttt tggcactacc
     7381 caccccgtgt gacagaatag gagccagcga ctcaggactg ctcacgggtc aggagggcaa
     7441 cgcctgaagt cagacctccc tataggtcaa cagggacaac ctggggatct ctggagcagg
     7501 gccctcctct ctcaggcttg gcccactccc ccagacacct ggacacgtgg ccacaaatct
     7561 gggacaaggg gcccccgcac agcatgaaat aaaaagtgcc tgagaa
//
