LOCUS       NM_001393586            6910 bp    mRNA    linear   PRI 08-FEB-2025
DEFINITION  Homo sapiens myosin VIIB (MYO7B), transcript variant 1, mRNA.
ACCESSION   NM_001393586 XM_006712539
VERSION     NM_001393586.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6910)
  AUTHORS   Choi,M.S., Graves,M.J., Matoo,S., Storad,Z.A., El Sheikh
            Idris,R.A., Weck,M.L., Smith,Z.B., Tyska,M.J. and Crawley,S.W.
  TITLE     The small EF-hand protein CALML4 functions as a critical myosin
            light chain within the intermicrovillar adhesion complex
  JOURNAL   J Biol Chem 295 (28), 9281-9296 (2020)
   PUBMED   32209652
REFERENCE   2  (bases 1 to 6910)
  AUTHORS   Li,J., He,Y., Weck,M.L., Lu,Q., Tyska,M.J. and Zhang,M.
  TITLE     Structure of Myo7b/USH1C complex suggests a general PDZ domain
            binding mode by MyTH4-FERM myosins
  JOURNAL   Proc Natl Acad Sci U S A 114 (19), E3776-E3785 (2017)
   PUBMED   28439001
  REMARK    GeneRIF: The structure of the Myo7b CMF/USH1C PDZ complex provides
            mechanistic explanations for >20 deafness-causing mutations in
            Myo7a CMF. Taken together, these findings suggest that binding to
            PDZ domains, such as those from USH1C, PDZD7, and Whirlin, is a
            common property of CMFs of Myo7a, Myo7b, and Myo15a.
REFERENCE   3  (bases 1 to 6910)
  AUTHORS   Weck,M.L., Crawley,S.W., Stone,C.R. and Tyska,M.J.
  TITLE     Myosin-7b Promotes Distal Tip Localization of the Intermicrovillar
            Adhesion Complex
  JOURNAL   Curr Biol 26 (20), 2717-2728 (2016)
   PUBMED   27666969
REFERENCE   4  (bases 1 to 6910)
  AUTHORS   Crawley,S.W., Weck,M.L., Grega-Larson,N.E., Shifrin,D.A. Jr. and
            Tyska,M.J.
  TITLE     ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation
  JOURNAL   Dev Cell 36 (2), 190-200 (2016)
   PUBMED   26812018
REFERENCE   5  (bases 1 to 6910)
  AUTHORS   Li,J., He,Y., Lu,Q. and Zhang,M.
  TITLE     Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated
            Brush Border Microvilli Tip-Link Complex
  JOURNAL   Dev Cell 36 (2), 179-189 (2016)
   PUBMED   26812017
REFERENCE   6  (bases 1 to 6910)
  AUTHORS   Crawley,S.W., Shifrin,D.A. Jr., Grega-Larson,N.E., McConnell,R.E.,
            Benesh,A.E., Mao,S., Zheng,Y., Zheng,Q.Y., Nam,K.T., Millis,B.A.,
            Kachar,B. and Tyska,M.J.
  TITLE     Intestinal brush border assembly driven by protocadherin-based
            intermicrovillar adhesion
  JOURNAL   Cell 157 (2), 433-446 (2014)
   PUBMED   24725409
REFERENCE   7  (bases 1 to 6910)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of gene polymorphisms with chronic kidney disease in
            Japanese individuals
  JOURNAL   Int J Mol Med 24 (4), 539-547 (2009)
   PUBMED   19724895
  REMARK    GeneRIF: Data revealed that six polymorphisms of F10, PITRM1,
            PCSK2, JPH3, MYO7B, and AKAP12 were related (P<0.05) to the
            prevalence of chronic kidney disease.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6910)
  AUTHORS   Chen,Z.Y., Hasson,T., Zhang,D.S., Schwender,B.J., Derfler,B.H.,
            Mooseker,M.S. and Corey,D.P.
  TITLE     Myosin-VIIb, a novel unconventional myosin, is a constituent of
            microvilli in transporting epithelia
  JOURNAL   Genomics 72 (3), 285-296 (2001)
   PUBMED   11401444
REFERENCE   9  (bases 1 to 6910)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   10 (bases 1 to 6910)
  AUTHORS   Bement,W.M., Hasson,T., Wirth,J.A., Cheney,R.E. and Mooseker,M.S.
  TITLE     Identification and overlapping expression of multiple
            unconventional myosin genes in vertebrate cell types
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6549-6553 (1994)
   PUBMED   8022818
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11767. doi:
            10.1073/pnas.91.24.11767-c.. PMID: 7972138]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010976.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 22, 2021 this sequence version replaced XM_006712539.3.
            
            Summary: The protein encoded by this gene is found in brush border
            microvilli of epithelial cells in the intestines and kidneys. The
            encoded protein is involved in linking protocadherins to the actin
            cytoskeleton and is essential for proper microvilli function. This
            protein aids in the accumulation of intermicrovillar adhesion
            components such as harmonin and ANKS4B, and this accumulation is
            necessary for normal brush border action. [provided by RefSeq, Jan
            2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853562.19645.1,
                                           SRR11853565.16906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409816.8/ ENSP00000386461.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AC010976.6         86352-86500
            150-190             AC010976.6         110368-110408
            191-304             AC010976.6         114821-114934
            305-457             AC010976.6         115901-116053
            458-642             AC010976.6         117311-117495
            643-764             AC010976.6         120457-120578
            765-907             AC010976.6         124588-124730
            908-1021            AC010976.6         127263-127376
            1022-1175           AC010976.6         128801-128954
            1176-1252           AC010976.6         131414-131490
            1253-1372           AC010976.6         132559-132678
            1373-1515           AC010976.6         132972-133114
            1516-1726           AC010976.6         134790-135000
            1727-1862           AC010976.6         135446-135581
            1863-2026           AC010976.6         139060-139223
            2027-2164           AC010976.6         140760-140897
            2165-2317           AC010976.6         143462-143614
            2318-2416           AC010976.6         144214-144312
            2417-2511           AC010976.6         147130-147224
            2512-2596           AC010976.6         156512-156596
            2597-2815           AC010976.6         157874-158092
            2816-2986           AC010976.6         159376-159546
            2987-3196           AC010976.6         160174-160383
            3197-3364           AC010976.6         160517-160684
            3365-3442           AC010976.6         162918-162995
            3443-3570           AC010976.6         163144-163271
            3571-3697           AC010976.6         171008-171134
            3698-3817           AC010976.6         172650-172769
            3818-3991           AC010976.6         173870-174043
            3992-4219           AC010976.6         174761-174988
            4220-4387           AC010976.6         176036-176203
            4388-4505           AC010976.6         177643-177760
            4506-4632           AC010976.6         177852-177978
            4633-4796           AC010976.6         179040-179203
            4797-4978           AC010976.6         180313-180494
            4979-5109           AC010976.6         181446-181576
            5110-5267           AC010976.6         181874-182031
            5268-5421           AC010976.6         182268-182421
            5422-5577           AC010976.6         182914-183069
            5578-5683           AC010976.6         183926-184031
            5684-5797           AC010976.6         184844-184957
            5798-5885           AC010976.6         185264-185351
            5886-5992           AC010976.6         185788-185894
            5993-6178           AC010976.6         186390-186575
            6179-6295           AC010976.6         186876-186992
            6296-6379           AC010976.6         187213-187296
            6380-6499           AC010976.6         187462-187581
            6500-6910           AC010976.6         187984-188394
FEATURES             Location/Qualifiers
     source          1..6910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.3"
     gene            1..6910
                     /gene="MYO7B"
                     /note="myosin VIIB"
                     /db_xref="GeneID:4648"
                     /db_xref="HGNC:HGNC:7607"
                     /db_xref="MIM:606541"
     exon            1..149
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            150..190
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..6601
                     /gene="MYO7B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     unconventional myosin-VIIb"
                     /codon_start=1
                     /product="unconventional myosin-VIIb isoform 1"
                     /protein_id="NP_001380515.1"
                     /db_xref="CCDS:CCDS92860.1"
                     /db_xref="GeneID:4648"
                     /db_xref="HGNC:HGNC:7607"
                     /db_xref="MIM:606541"
                     /translation="MSGFRLGDHVWLEPPSTHKTGVAIGGIIKEAKPGKVLVEDDEGK
                     EHWIRAEDFGVLSPMHPNSVQGVDDMIRLGDLNEAGMVHNLLIRYQQHKIYTYTGSIL
                     VAVNPFQVLPLYTLEQVQLYYSRHMGELPPHVFAIANNCYFSMKRNKRDQCCIISGES
                     GAGKTETTKLILQFLATISGQHSWIEQQVLEANPILEAFGNAKTIRNDNSSRFGKYID
                     IYFNPSGVIEGARIEQFLLEKSRVCRQAPEERNYHIFYCMLMGVSAEDKQLLSLGTPS
                     EYHYLTMGNCTSCEGLNDAKDYAHIRSAMKILQFSDSESWDVIKLLAAILHLGNVGFM
                     ASVFENLDASDVMETPAFPTVMKLLEVQHQELRDCLIKHTILIRGEFVTRSLNIAQAA
                     DRRDAFVKGIYGHLFLWIVKKINAAIFTPPAQDPKNVRRAIGLLDIFGFENFENNSFE
                     QLCINFANEHLQQFFVQHVFTMEQEEYRSENISWDYIHYTDNRPTLDLLALKPMSIIS
                     LLDEESRFPQGTDLTMLQKLNSVHANNKAFLQPKNIHDARFGIAHFAGEVYYQAEGFL
                     EKNRDVLSTDILTLVYSSKNKFLREIFNLELAETKLGHGTIRQAKAGNHLFKSADSNK
                     RPSTLGSQFKQSLDQLMKILTNCQPYFIRCIKPNEYKKPLLFDRELCLRQLRYSGMME
                     TVHIRKSGFPIRYTFEEFSQRFGVLLPNAMRMQLQGKLRQMTLGITDVWLRTDKDWKA
                     GKTKIFLRDHQDTLLEVQRSQVLDRAALSIQKVLRGYRYRKEFLRQRRAAVTLQAWWR
                     GYCNRRNFKLILVGFERLQAIARSQPLARQYQAMRQRTVQLQALCRGYLVRQQVQAKR
                     RAVVVIQAHARGMAARRNFQQRKANAPLVIPAEGQKSQGALPAKKRRSIYDTVTDTEM
                     VEKVFGFLPAMIGGQEGQASPHFEDLESKTQKLLEVDLDTVPMAEEPEEDVDGLAEYT
                     FPKFAVTYFQKSASHTHIRRPLRYPLLYHEDDTDCLAALVIWNVILRFMGDLPEPVLY
                     ARSSQQGSSVMRQIHDTLGREHGAQVPQHSRSAQRSGCKDKGTKDISSMKLKRSSRIT
                     GQVASQLNIGEEALEPDGLGADRPMSNLEKVHFIVGYAILRPSLRDEIYCQICKQLSE
                     NFKTSSLARGWILLSLCLGCFPPSERFMKYLLNFIGQGPATYGPFCAERLRRTYANGV
                     RAEPPTWLELQAVKSKKHIPIQVILATGESLTVPVDSASTSREMCMHIAHKQGLSDHL
                     GFSLQVAVYDKFWSLGSGRDHMMDAIARCEQMAQERGESQRQSPWRIYFRKEFFTPWH
                     DSREDPVSTELIYRQVLRGVWSGEYSFEKEEELVELLARHCYVQLGASAESKAVQELL
                     PSCIPHKLYRTKPPDRWASLVTAACAKAPYTQKQVTPLAVREQVVDAARLQWPLLFSR
                     LFEVITLSGPRLPKTQLILAVNWKGLCFLDQQEKMLLELSFPEVMGLATNREAQGGQR
                     LLLSTMHEEYEFVSPSSVAIAELVALFLEGLKERSIFAMALQDRKATDDTTLLAFKKG
                     DLLVLTKKQGLLASENWTLGQNDRTGKTGLVPMACLYTIPTVTKPSAQLLSLLAMSPE
                     KRKLAAQEGQFTEPRPEEPPKEKLHTLEEFSYEFFRAPEKDMVSMAVLPLARARGHLW
                     AYSCEPLRQPLLKRVHANVDLWDIACQIFVAILRYMGDYPSRQAWPTLELTDQIFTLA
                     LQHPALQDEVYCQILKQLTHNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTR
                     RGKLLAPDCSRRIQKVLRTGPRKQPPHQVEVEAAEQNVSRICHKIYFPNDTSEMLEVV
                     ANTRVRDVCDSIATRLQLASWEGCSLFIKISDKVISQKEGDFFFDSLREVSDWVKKNK
                     PQKEGAPVTLPYQVYFMRKLWLNISPGKDVNADTILHYHQELPKYLRGFHKCSREDAI
                     HLAGLIYKAQFNNDRSQLASVPKILRELVPENLTRLMSSEEWKKSILLAYDKHKDKTV
                     EEAKVAFLKWICRWPTFGSAFFEVKQTSEPSYPDVILIAINRHGVLLIHPKTKDLLTT
                     YPFTKISSWSSGSTYFHMALGSLGRGSRLLCETSLGYKMDDLLTSYVQQLLSAMNKQR
                     GSKAPALAST"
     exon            191..304
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            305..457
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            458..642
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            643..764
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            765..907
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1021
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1175
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1252
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1372
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1515
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1726
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1862
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2026
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2164
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2165..2317
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2416
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2511
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2512..2596
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2815
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2816..2986
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3196
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3197..3364
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..3442
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3570
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3571..3697
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..3817
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3818..3991
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            3992..4219
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4220..4387
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4388..4505
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4506..4632
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4633..4796
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4797..4978
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            4979..5109
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            5110..5267
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            5268..5421
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            5422..5577
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            5578..5683
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            5684..5797
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            5798..5885
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            5886..5992
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            5993..6178
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            6179..6295
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            6296..6379
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            6380..6499
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     exon            6500..6910
                     /gene="MYO7B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6889..6894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO7B"
                     /note="hexamer: AATAAA"
     polyA_site      6910
                     /gene="MYO7B"
                     /note="major polyA site"
ORIGIN      
        1 agtcatttcc tcttggagcc ctacctcttc ttcctctgtc ccttactccc tgacacaccc
       61 ggagtcccaa cattgcctcc tttcctggct ctttcagggt gcccagggtg gaggggaagg
      121 ggagtcagcc agacccccat cctgacaagg cttgtggaac tgctgactca ggatgtcggg
      181 gttcaggctg ggtgaccacg tgtggctgga gcctccctcc acccacaaga ccggcgtggc
      241 catcgggggc atcatcaaag aggcaaagcc aggcaaagtc ttggttgaag atgacgaggg
      301 caaggaacac tggatccgag cagaggactt tggtgtcctc agtcccatgc accccaactc
      361 agtccagggt gtggacgaca tgatccgcct gggggacctg aacgaggcag gcatggtgca
      421 caacctcctg atccgctacc agcagcacaa gatctataca tacacaggct ccatcctggt
      481 ggccgtcaac ccgttccagg tgctgccgct ctacaccctg gagcaggtac agctctacta
      541 cagccgccat atgggcgagc tgcccccgca tgtctttgcc atcgccaaca actgctactt
      601 cagcatgaag aggaacaaga gggaccagtg ctgcatcatc agcggcgagt ctggggctgg
      661 caagacggag accaccaagc tcatcctgca gttcctggcc accatcagtg gccagcattc
      721 gtggattgag cagcaggtcc tggaagccaa ccccatcctg gaggcctttg gaaatgccaa
      781 gacaatccgc aacgacaact caagccgctt tgggaagtac attgacatct actttaaccc
      841 cagcggggtg atcgagggcg cgcgcatcga gcaatttctc ctggagaagt cccgggtctg
      901 ccggcaggct cccgaggagc ggaactacca tatcttctac tgcatgctca tgggggtgag
      961 tgctgaggac aagcagctgc tgagcctggg cacgccctcc gagtaccact acctgaccat
     1021 ggggaactgc acttcctgtg aggggctcaa cgacgccaag gactacgccc acatccgctc
     1081 ggccatgaag atcctccagt tctccgactc cgagagctgg gacgtcatca agctgctggc
     1141 tgccattctc cacctgggga atgtggggtt catggcttcg gtcttcgaga acctggacgc
     1201 ctcagacgtg atggagacgc ccgcctttcc caccgtgatg aagttactgg aggtgcagca
     1261 ccaggagctc cgggactgtc tgatcaagca caccatcctc atccgagggg aatttgtcac
     1321 caggtccctg aacattgccc aggctgctga ccggagggac gcctttgtca agggcatcta
     1381 tgggcacctc ttcctgtgga ttgtcaagaa gatcaatgcc gccatcttca caccaccagc
     1441 ccaggacccc aaaaatgtgc ggagggccat cggcctcctg gacatatttg gctttgaaaa
     1501 tttcgagaac aatagcttcg agcagctctg catcaacttc gccaacgagc acctgcagca
     1561 gttctttgtg cagcacgtgt tcaccatgga gcaagaggag taccgctcgg agaacatctc
     1621 ctgggactat atccactaca ccgacaatcg gcccaccctg gacctgctgg ccctcaagcc
     1681 catgagcatc atctccctcc tggacgaaga aagccgcttc ccgcagggga cagatctcac
     1741 catgctgcaa aagctgaaca gcgtccatgc caacaacaag gccttcctac agcccaagaa
     1801 catccacgat gccagatttg gcattgccca ttttgccggc gaggtgtact accaagcaga
     1861 aggcttcctg gagaagaacc gagacgtgct gagcacagat atcctcaccc tggtttactc
     1921 ctccaaaaac aagtttctga gggagatatt caacttggag ttagcagaga ccaagctggg
     1981 ccatgggacc atccgccagg caaaggcagg aaaccatctc ttcaagtctg cagactcaaa
     2041 taaacggccc tccaccttag gaagccagtt caaacagtct ctggaccagc tgatgaaaat
     2101 cctgaccaac tgccagcctt acttcatccg ctgcatcaaa cctaatgagt acaagaagcc
     2161 gctgctgttc gaccgggagc tgtgcctgcg gcagctgcga tactcgggca tgatggagac
     2221 cgtgcacatc cgcaagtcgg gcttccccat ccgctacacg ttcgaggagt tctcgcagag
     2281 gttcggcgtg ttgctgccca acgccatgcg gatgcagctg caaggcaagc tccgccagat
     2341 gaccctgggc atcactgacg tgtggctgcg gacagacaaa gactggaaag cggggaagac
     2401 aaaaattttc ctgagggatc atcaggacac tctgctggag gtacagagaa gccaggtgct
     2461 agacagagcg gcgctcagca tccagaaagt ccttcggggc tacagataca ggaaggagtt
     2521 cctgaggcag aggcgggcag ctgtgaccct gcaggcctgg tggagaggct actgcaacag
     2581 gaggaatttc aagctgatcc tcgtgggctt tgagcgcctg caggctattg cccggagcca
     2641 gccgctggcg aggcagtacc aggccatgcg gcagaggaca gtccagctgc aggccctgtg
     2701 caggggatac ctggtgcgcc agcaagtcca ggccaagagg agggcagtgg tggtcattca
     2761 ggcccatgcc aggggcatgg ctgcccggcg caacttccag caaaggaagg ccaatgcgcc
     2821 gctggtcatc ccggccgagg ggcagaaaag ccaaggcgct ctccctgcca agaagcgcag
     2881 atccatctac gacaccgtca ctgacacgga gatggtggag aaggtgttcg gcttcctccc
     2941 tgccatgatt gggggccagg agggccaggc ctcgccgcac tttgaggatc tggaatcgaa
     3001 gacccagaag ctgcttgagg ttgacctgga cacagtcccc atggcggagg agcctgagga
     3061 ggatgtggat ggcctggccg agtacacctt ccccaagttt gctgtgactt acttccagaa
     3121 atcagccagc cacacacaca tccggcggcc cctccgatac ccgttgcttt accacgaaga
     3181 tgacactgac tgcttggccg ccctggtcat atggaacgtc atcctgaggt tcatgggtga
     3241 tctcccagag ccagtgctgt atgccaggag cagccagcag ggcagctcag tgatgcggca
     3301 gatccatgac acgctgggca gggagcacgg tgcccaggtt ccacagcaca gtagatctgc
     3361 acagagatct ggctgcaagg acaaggggac caaggatatc tcctccatga agctgaagcg
     3421 gtcctcccgg atcacaggcc aggtggccag ccagctgaac attggagagg aggcattgga
     3481 gcctgatggc cttggtgcag accggcccat gtccaacctg gagaaggtgc acttcatcgt
     3541 gggctacgcc atcctgcggc ccagcctcag ggatgagatt tactgccaga tctgcaagca
     3601 gctctcggag aacttcaaaa caagcagcct ggcccggggc tggatcctgc tcagcctctg
     3661 cctcggctgc ttcccaccct cagagaggtt catgaagtat ctactgaact tcatcggcca
     3721 agggccggcg acctacggcc ccttctgtgc cgagcgcctg agacgcacct atgccaatgg
     3781 ggtgcgtgcg gagcccccca cctggctgga gctgcaggct gtcaagtcca agaagcacat
     3841 ccccatccaa gtcatcttgg ccactggaga gagcctaacc gtccccgtgg actcagcctc
     3901 cacatctcgg gaaatgtgca tgcacatcgc tcacaagcag ggcctcagcg accacctggg
     3961 cttctccctc caggtcgccg tgtacgacaa gttctggtcc ctgggcagcg ggcgcgacca
     4021 catgatggat gccatcgccc ggtgtgagca gatggcccag gagaggggcg agagccagcg
     4081 ccagtcaccc tggcgcatct acttccggaa ggaattcttc accccctggc acgactcccg
     4141 ggaggaccct gtcagcaccg agcttattta ccgccaagtc ctccgaggag tctggtctgg
     4201 cgagtacagc ttcgagaagg aggaagagct ggttgagctg ctggcccggc actgctacgt
     4261 gcagctcggc gcctcagcag agagcaaggc tgtccaggag ctgctgccca gctgcatccc
     4321 ccacaagctg tacaggacca agcccccaga caggtgggcg agcctcgtca ctgccgcctg
     4381 cgccaaggcc ccatacactc agaagcaagt cacaccactg gccgtgcgag agcaggtggt
     4441 ggacgccgcc cgcctgcagt ggccgctgct cttctcccgg ctcttcgaag tcatcacact
     4501 ctcaggcccc cgcctgccca agacgcagct gatcttggct gttaactgga aggggctttg
     4561 cttcctggac cagcaggaga agatgctgct ggaactctct ttcccagagg tcatgggtct
     4621 ggccaccaac agggaggccc agggcgggca gaggctgctg ctctccacga tgcatgagga
     4681 gtacgagttt gtgtcaccca gcagtgtggc catcgctgag ctggtggccc tgttcctgga
     4741 gggcctgaag gagaggtcca ttttcgccat ggccctgcag gacaggaagg ccacagatga
     4801 caccaccctc ctggccttca agaaggggga cctgttggtc ctcacaaaga agcaggggct
     4861 gctggcctct gagaactgga ccctcggcca gaacgacagg acaggcaaga cggggctggt
     4921 gcccatggcc tgcctctaca ccatccccac ggtcactaag ccctcggcac agctgctgag
     4981 cttgcttgcc atgtcaccag agaagaggaa gctggcggct caggaggggc agttcacaga
     5041 gccacgtcct gaggagccac ccaaggaaaa gctgcacacc ctggaggagt tctcctatga
     5101 gttcttcagg gctccagaga aggacatggt gagcatggcc gtgctgcccc tggcccgtgc
     5161 ccgtggccac ctgtgggcct attcctgcga gccgctgcga cagccgctgc tcaagcgagt
     5221 ccacgccaac gtcgacctct gggacatcgc ctgccagatc tttgtcgcca tcctccggta
     5281 catgggcgac tacccttctc ggcaggcctg gcccaccctg gagctcaccg accagatctt
     5341 cacactggcc ctgcagcacc cggccctcca ggacgaggtc tactgccaga tcctgaagca
     5401 gctgacgcac aactccaaca ggcacagcga agagcggggc tggcagctgc tgtggctgtg
     5461 cacgggcctc ttcccgccca gcaaggggct gctgccccat gcccagaagt ttatagacac
     5521 tcggaggggg aagctgctgg cccccgactg cagccgccga atccagaagg tcctgaggac
     5581 ggggccccgg aagcagcccc cgcaccaggt ggaggtggag gccgcagagc agaacgtctc
     5641 ccgcatctgc cacaagatct acttccccaa tgacaccagt gagatgctgg aggtggttgc
     5701 caacacacgg gtgcgggatg tgtgtgacag cattgccacc aggctgcagc tggcctcctg
     5761 ggagggctgc agcctcttca tcaagatttc agacaaggtc atcagccaga aggagggaga
     5821 cttcttcttt gattccttga gggaggtgtc tgactgggtg aagaagaaca agccccagaa
     5881 agaaggggcc cccgtgacgc tcccctacca ggtgtacttc atgcggaaat tgtggctcaa
     5941 catatctcca gggaaggatg tgaatgcaga caccatactc cattaccacc aggagctgcc
     6001 caagtacctg cgcggattcc acaagtgttc gcgggaggat gccatccacc tggcgggcct
     6061 catctacaag gcccagttca acaacgaccg gtcccagctg gctagtgtcc ccaagatcct
     6121 gagggaactg gtgcctgaga acctcacacg cctgatgtcc tcggaggagt ggaaaaagag
     6181 catccttcta gcctatgaca agcataagga caagacagtg gaggaggcca aggtggcctt
     6241 cctgaagtgg atctgccggt ggcccacctt cggatccgcc ttcttcgagg tgaagcaaac
     6301 ctcggagcct tcctacccgg acgtcatcct catcgccatc aaccgacatg gggttctgct
     6361 catccacccc aagaccaagg acctgctcac cacctatccc ttcaccaaga tctccagctg
     6421 gagcagcggc agcacctact tccacatggc gctggggagc ctgggccgtg gcagccgcct
     6481 gctgtgcgag acctccctgg gctataagat ggatgacctg ctgacctcat atgtgcagca
     6541 gctcctgagt gccatgaaca agcagcgggg ctccaaggcc ccagccctgg ccagcaccta
     6601 gcagcggatg ctggcgtgtc tgctcaggcg cccttcccga cctctagcct ggcggcacct
     6661 tcccaggccc tctcaaccca gggcctgtcc ttggcgggca gccttccatg ctgcccccca
     6721 tacaaagccc actcagcccc gcaggcggcc ccctctgtcc tgggcgctgc ccagggaggc
     6781 caaaagacgg gcccagaatg gggtcgggag tctcggaccc ccaggctatt ggtggatgac
     6841 tgactgacag gacacctccc aaccccaccc caccccacca gaatgttcaa taaaaactcc
     6901 tggagcagga
//
