LOCUS       NM_001368139            2592 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens myosin VI (MYO6), transcript variant 6, mRNA.
ACCESSION   NM_001368139
VERSION     NM_001368139.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2592)
  AUTHORS   Zheng,S., Hong,Z., Tan,Y., Wang,Y., Li,J., Zhang,Z., Feng,T.,
            Hong,Z., Lin,G. and Ye,D.
  TITLE     MYO6 contributes to tumor progression and enzalutamide resistance
            in castration-resistant prostate cancer by activating the focal
            adhesion signaling pathway
  JOURNAL   Cell Commun Signal 22 (1), 517 (2024)
   PUBMED   39449086
  REMARK    GeneRIF: MYO6 contributes to tumor progression and enzalutamide
            resistance in castration-resistant prostate cancer by activating
            the focal adhesion signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2592)
  AUTHORS   Raghuvanshi,R., Panda,K.C., Ray,C.S. and Ramchander,P.V.
  TITLE     Targeted Next-Generation Sequencing Analysis Reveals a Novel
            Genetic Variant in MYO6 Gene in an Indian Family with Postlingual
            Nonsyndromic Hearing Loss
  JOURNAL   Genet Test Mol Biomarkers 28 (8), 328-336 (2024)
   PUBMED   39019031
  REMARK    GeneRIF: Targeted Next-Generation Sequencing Analysis Reveals a
            Novel Genetic Variant in MYO6 Gene in an Indian Family with
            Postlingual Nonsyndromic Hearing Loss.
REFERENCE   3  (bases 1 to 2592)
  AUTHORS   Canon,L., Kikuti,C., Planelles-Herrero,V.J., Lin,T., Mayeux,F.,
            Sirkia,H., Lee,Y.I., Heidsieck,L., Velikovsky,L., David,A., Liu,X.,
            Moussaoui,D., Forest,E., Hook,P., Petersen,K.J., Morgan,T.E., Di
            Cicco,A., Sires-Campos,J., Derivery,E., Levy,D., Delevoye,C.,
            Sweeney,H.L. and Houdusse,A.
  TITLE     How myosin VI traps its off-state, is activated and dimerizes
  JOURNAL   Nat Commun 14 (1), 6732 (2023)
   PUBMED   37872146
  REMARK    GeneRIF: How myosin VI traps its off-state, is activated and
            dimerizes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2592)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2592)
  AUTHORS   Yang,A., Liu,X., Liu,P., Feng,Y., Liu,H., Gao,S., Huo,L., Han,X.,
            Wang,J. and Kong,W.
  TITLE     LncRNA UCA1 promotes development of gastric cancer via the
            miR-145/MYO6 axis
  JOURNAL   Cell Mol Biol Lett 26 (1), 33 (2021)
   PUBMED   34238213
  REMARK    GeneRIF: LncRNA UCA1 promotes development of gastric cancer via the
            miR-145/MYO6 axis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2592)
  AUTHORS   Avraham,K.B., Hasson,T., Sobe,T., Balsara,B., Testa,J.R.,
            Skvorak,A.B., Morton,C.C., Copeland,N.G. and Jenkins,N.A.
  TITLE     Characterization of unconventional MYO6, the human homologue of the
            gene responsible for deafness in Snell's waltzer mice
  JOURNAL   Hum Mol Genet 6 (8), 1225-1231 (1997)
   PUBMED   9259267
REFERENCE   7  (bases 1 to 2592)
  AUTHORS   Avraham,K.B., Hasson,T., Steel,K.P., Kingsley,D.M., Russell,L.B.,
            Mooseker,M.S., Copeland,N.G. and Jenkins,N.A.
  TITLE     The mouse Snell's waltzer deafness gene encodes an unconventional
            myosin required for structural integrity of inner ear hair cells
  JOURNAL   Nat Genet 11 (4), 369-375 (1995)
   PUBMED   7493015
REFERENCE   8  (bases 1 to 2592)
  AUTHORS   Hasson,T. and Mooseker,M.S.
  TITLE     Porcine myosin-VI: characterization of a new mammalian
            unconventional myosin
  JOURNAL   J Cell Biol 127 (2), 425-440 (1994)
   PUBMED   7929586
REFERENCE   9  (bases 1 to 2592)
  AUTHORS   Bement,W.M., Hasson,T., Wirth,J.A., Cheney,R.E. and Mooseker,M.S.
  TITLE     Identification and overlapping expression of multiple
            unconventional myosin genes in vertebrate cell types
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6549-6553 (1994)
   PUBMED   8022818
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11767. doi:
            10.1073/pnas.91.24.11767-c.. PMID: 7972138]
REFERENCE   10 (bases 1 to 2592)
  AUTHORS   Shearer,A.E., Hildebrand,M.S., Odell,A.M. and Smith,R.J.H.
  TITLE     Genetic Hearing Loss Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301607
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL109897.30 and AL136093.8.
            
            Summary: This gene encodes a reverse-direction motor protein that
            moves toward the minus end of actin filaments and plays a role in
            intracellular vesicle and organelle transport. The protein consists
            of a motor domain containing an ATP- and an actin-binding site and
            a globular tail which interacts with other proteins. This protein
            maintains the structural integrity of inner ear hair cells and
            mutations in this gene cause non-syndromic autosomal dominant and
            recessive hearing loss. Alternative splicing results in multiple
            transcript variants encoding distinct isoforms. [provided by
            RefSeq, Jul 2014].
            
            Transcript Variant: This variant (6), as well as variant 7, encodes
            isoform 6.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.188092.1,
                                           SRR1660807.418212.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968540,
                                           SAMEA2163459 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AL109897.30        37330-37514
            186-303             AL109897.30        65544-65661
            304-467             AL109897.30        105592-105755
            468-537             AL109897.30        110873-110942
            538-611             AL109897.30        116631-116704
            612-741             AL109897.30        118507-118636
            742-847             AL109897.30        120933-121038
            848-903             AL136093.8         2328-2383
            904-1001            AL136093.8         7012-7109
            1002-2592           AL136093.8         7641-9231
FEATURES             Location/Qualifiers
     source          1..2592
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q14.1"
     gene            1..2592
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /note="myosin VI"
                     /db_xref="GeneID:4646"
                     /db_xref="HGNC:HGNC:7605"
                     /db_xref="MIM:600970"
     exon            1..185
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /inference="alignment:Splign:2.1.0"
     exon            186..303
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /inference="alignment:Splign:2.1.0"
     exon            304..467
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..1196
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /note="isoform 6 is encoded by transcript variant 6;
                     unconventional myosin-6; unconventional myosin-VI"
                     /codon_start=1
                     /product="unconventional myosin-VI isoform 6"
                     /protein_id="NP_001355068.1"
                     /db_xref="GeneID:4646"
                     /db_xref="HGNC:HGNC:7605"
                     /db_xref="MIM:600970"
                     /translation="MEDGKPVWAPHPTDGFQMGNIVDIGPDSLTIEPLNQKGKTFLAL
                     INQVFPAEEDSKKDVEDNCSLMYLNEATLLHNIKVRYSKDRIYTYVANILIAVNPYFD
                     IPKIYSSEAIKSYQGKSLGTRPPHVFAIADKAFRDMKVLKMSQSIIVSGESGAGKTEN
                     TKFVLRYLTESYGTGQDIDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKS
                     SVVGGFVSHYLLEKSRICVQGKEERNYHIFYRLCAGASEDIREKLHLSSPDNFRVGQK
                     KRNFI"
     exon            468..537
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /inference="alignment:Splign:2.1.0"
     exon            538..611
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /inference="alignment:Splign:2.1.0"
     exon            612..741
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /inference="alignment:Splign:2.1.0"
     exon            742..847
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /inference="alignment:Splign:2.1.0"
     exon            848..903
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1001
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..2592
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1827..1832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /note="hexamer: AATAAA"
     polyA_site      1855
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /note="major polyA site"
     regulatory      2568..2573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
                     /note="hexamer: AATAAA"
     polyA_site      2592
                     /gene="MYO6"
                     /gene_synonym="DFNA22; DFNB37"
ORIGIN      
        1 ggagaccgac tcgggatctg tccgagcagg aagccagcct cagcccggcc gctgtcgccg
       61 ccctgtcctg gtgcccgtcc gcgtcgtcgc cctcttcact ggccctcatc acttctcacc
      121 gcgccctcca gcttcacccg tacaggtagc cccgccgccg cgcacctgcc ttcgctcccg
      181 caccgggtct cactgtgtca cctgggctac agtgcagtgg cgcaatttca gttcactgca
      241 actttgactt cctgggctca gatgatcctg gcacctcagt ctccccagta gctgggacta
      301 caggtgacag tggatagtgg aaacaggaga tcgtggatcc tccttcaaaa atggaggatg
      361 gaaagcccgt ttgggcgcca caccctacag atggatttca gatgggcaat attgtggata
      421 ttggccccga cagcttaaca attgaaccct tgaatcagaa aggcaagaca tttttggctc
      481 tcataaacca agtgtttcct gcagaagagg acagtaaaaa agatgtggaa gataactgtt
      541 cactaatgta tttaaatgaa gccacactgc tccataatat caaagttcga tatagtaaag
      601 acagaattta tacatatgtc gccaacattc tgattgcagt gaatccatac tttgacatac
      661 ctaaaatata ttcttcagaa gcaataaagt catatcaagg aaaatctctt gggacaagac
      721 cacctcatgt ctttgcaatt gctgataaag cttttcgaga catgaaggtg ctcaagatga
      781 gtcagtctat cattgtatct ggagaatcag gagccggcaa aacagaaaat acaaaatttg
      841 ttctaagata cctgactgaa tcctatggaa caggtcaaga tattgatgac agaattgttg
      901 aagctaaccc actcctagaa gcctttggaa atgcgaagac tgttcgcaac aataatagca
      961 gtcgatttgg gaaatttgta gaaatacatt ttaatgaaaa gagctcagtt gttggaggat
     1021 ttgtttcaca ttatctccta gagaaatcta ggatctgtgt tcaaggcaaa gaggaaagaa
     1081 attatcatat cttttatagg ttgtgtgctg gtgcttctga agatattaga gaaaaacttc
     1141 atttgagttc accagataat tttcgggtag gtcagaagaa aagaaatttc atatagccag
     1201 gtgcagtggc tcatgcctgt aatcccaaca ctttgggagg ctgaggcgga tggattgctt
     1261 gagcctggga gttcgagagc agcctgggca atgtagcgag accctgtctc taaaaaaaaa
     1321 aaatacaaaa aattagctga gcatggtggc actcacctgt agttccagct actcgggagg
     1381 ctgaggtggg aggatcacct gagcccagga ggttgaggct gcagtgagcc atgattgtgc
     1441 cactgcactc cagcctgggt aacagagcga gaccctatct caaagaaaaa aaaattttgt
     1501 ataatttttg aaaatataat tgccatcaag cctaatactt attttagtga attttgaaat
     1561 ctacttgttg tgtgtatgta acttacattg gatcaagtat aacatgttag aatgaccact
     1621 gtactgagaa gatctctatt aaggtgtact gctgagttta tagtataaca ctgtatgagg
     1681 aggcacataa tggaatagat aaaaggatag atgttaaacc ctacgtcaat ttaaactcaa
     1741 ttagaaattg ataatagctc tgtaatacta gctttaaagt tacctttgac ttatctgtaa
     1801 aaatgtttga acactaaatt aatattaata aaggacacat gattgaattt cttaatttac
     1861 ttcaacaaca aatatttatt gcttgcccat tgggtgccag gcattgggcc aggattaaaa
     1921 agataaataa tacacagtcc ctgctcttga tcaacttaga tgtggtggga aacgcacaca
     1981 cacacacatg cacacacaca cacacacaca cctgagcatt acaagcgagt agagtttcta
     2041 ggagcggtga ctggggatgg tttggttaac acaattttca gattctcagg ttagaaaaca
     2101 gtgtacttgt atggagtatg ggaatgtagt ttatacaaag gaatgcaatg tgagtaagga
     2161 atgtcgtctg tatagagttc cccagctgat tctgatagtc ttttttggtc agaaagcctc
     2221 catttgagaa tcataacaca cataattact gctctgtggt tgtgtgtgtg cgtgtgtgtt
     2281 tgcagacagc ttttctttta cttcaatttc ttttaatgtg tgtttgcaaa ttttaaaagt
     2341 ctgttgtctt aaaacacttt ataaatgtat ctctttatat acttctaaaa tgtccagtct
     2401 tttctagagc tctccaaatt aattggaatt tgaagctagt tgcccacatt tccatgaaag
     2461 taaaggaagc atttcttttt tactatggtt tttaaaaaag gaataaatta ctaggaatta
     2521 catgaaatat aataatgatg atacggtttt gtcaatactt agctgacaat aaagtgatgt
     2581 gactgttctg gc
//
