LOCUS       NM_001080467            9583 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens myosin VB (MYO5B), mRNA.
ACCESSION   NM_001080467 XM_371116
VERSION     NM_001080467.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9583)
  AUTHORS   Lapierre,L.A., Roland,J.T., Manning,E.H., Caldwell,C., Glenn,H.L.,
            Vidalain,P.O., Tangy,F., Hogue,B.G., de Haan,C.A.M. and
            Goldenring,J.R.
  TITLE     Coronavirus M Protein Trafficking in Epithelial Cells Utilizes a
            Myosin Vb Splice Variant and Rab10
  JOURNAL   Cells 13 (2), 126 (2024)
   PUBMED   38247817
  REMARK    GeneRIF: Coronavirus M Protein Trafficking in Epithelial Cells
            Utilizes a Myosin Vb Splice Variant and Rab10.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9583)
  AUTHORS   Engevik,K.A., Engevik,M.A. and Engevik,A.C.
  TITLE     Bioinformatics reveal elevated levels of Myosin Vb in uterine
            corpus endometrial carcinoma patients which correlates to increased
            cell metabolism and poor prognosis
  JOURNAL   PLoS One 18 (1), e0280428 (2023)
   PUBMED   36662766
  REMARK    GeneRIF: Bioinformatics reveal elevated levels of Myosin Vb in
            uterine corpus endometrial carcinoma patients which correlates to
            increased cell metabolism and poor prognosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9583)
  AUTHORS   Carton-Garcia,F., Brotons,B., Anguita,E., Dopeso,H., Tarragona,J.,
            Nieto,R., Garcia-Vidal,E., Macaya,I., Zagyva,Z., Dalmau,M.,
            Sanchez-Martin,M., van Ijzendoorn,S.C.D., Landolfi,S.,
            Hernandez-Losa,J., Schwartz,S. Jr., Matias-Guiu,X., Ramon Y
            Cajal,S., Martinez-Barriocanal,A. and Arango,D.
  TITLE     Myosin Vb as a tumor suppressor gene in intestinal cancer
  JOURNAL   Oncogene 41 (49), 5279-5288 (2022)
   PUBMED   36316444
  REMARK    GeneRIF: Myosin Vb as a tumor suppressor gene in intestinal cancer.
REFERENCE   4  (bases 1 to 9583)
  AUTHORS   Sakai,T., Choo,Y.Y., Sato,O., Ikebe,R., Jeffers,A., Idell,S.,
            Tucker,T. and Ikebe,M.
  TITLE     Myo5b Transports Fibronectin-Containing Vesicles and Facilitates
            FN1 Secretion from Human Pleural Mesothelial Cells
  JOURNAL   Int J Mol Sci 23 (9), 4823 (2022)
   PUBMED   35563212
  REMARK    GeneRIF: Myo5b Transports Fibronectin-Containing Vesicles and
            Facilitates FN1 Secretion from Human Pleural Mesothelial Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9583)
  AUTHORS   Li,Q., Zhou,Z., Sun,Y., Sun,C., Klappe,K. and van IJzendoorn,S.C.D.
  TITLE     A Functional Relationship Between UNC45A and MYO5B Connects Two
            Rare Diseases With Shared Enteropathy
  JOURNAL   Cell Mol Gastroenterol Hepatol 14 (2), 295-310 (2022)
   PUBMED   35421597
  REMARK    GeneRIF: A Functional Relationship Between UNC45A and MYO5B
            Connects Two Rare Diseases With Shared Enteropathy.
REFERENCE   6  (bases 1 to 9583)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   7  (bases 1 to 9583)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
REFERENCE   8  (bases 1 to 9583)
  AUTHORS   Bement,W.M., Hasson,T., Wirth,J.A., Cheney,R.E. and Mooseker,M.S.
  TITLE     Identification and overlapping expression of multiple
            unconventional myosin genes in vertebrate cell types
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6549-6553 (1994)
   PUBMED   8022818
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11767. doi:
            10.1073/pnas.91.24.11767-c.. PMID: 7972138]
REFERENCE   9  (bases 1 to 9583)
  AUTHORS   Amendola,M. and Squires,J.E.
  TITLE     Pediatric Genetic Cholestatic Liver Disease Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   36108118
REFERENCE   10 (bases 1 to 9583)
  AUTHORS   Huang,W.M., Reed-Fourquet,L., Wu,E. and Wu,J.Y.
  TITLE     Molecular cloning and amino acid sequence of brain L-glutamate
            decarboxylase
  JOURNAL   Proc Natl Acad Sci U S A 87 (21), 8491-8495 (1990)
   PUBMED   2236059
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105224.8, BC032511.2,
            AY274809.1, AB290160.1, AK025336.1, BX641287.1, DA350416.1 and
            Z38208.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001080467.2.
            
            Summary: The protein encoded by this gene, together with other
            proteins, may be involved in plasma membrane recycling. Mutations
            in this gene are associated with microvillous inclusion disease.
            [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB290160.1, AB032945.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285039.12/ ENSP00000285039.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC105224.8         26617-26682
            67-729              BC032511.2         1-663
            730-2259            AY274809.1         724-2253
            2260-3519           AB290160.1         2011-3270
            3520-4298           AK025336.1         597-1375
            4299-6865           AB290160.1         4053-6619
            6866-6945           BX641287.1         17-96
            6946-7821           AB290160.1         6700-7575
            7822-8172           DA350416.1         223-573
            8173-9556           AB290160.1         7927-9310
            9557-9583           Z38208.1           4-30                c
FEATURES             Location/Qualifiers
     source          1..9583
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..9583
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /note="myosin VB"
                     /db_xref="GeneID:4645"
                     /db_xref="HGNC:HGNC:7603"
                     /db_xref="MIM:606540"
     exon            1..381
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..5901
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /note="myosin-Vb; MYO5B variant protein"
                     /codon_start=1
                     /product="unconventional myosin-Vb"
                     /protein_id="NP_001073936.1"
                     /db_xref="CCDS:CCDS42436.1"
                     /db_xref="GeneID:4645"
                     /db_xref="HGNC:HGNC:7603"
                     /db_xref="MIM:606540"
                     /translation="MSVGELYSQCTRVWIPDPDEVWRSAELTKDYKEGDKSLQLRLED
                     ETILEYPIDVQRNQLPFLRNPDILVGENDLTALSYLHEPAVLHNLKVRFLESNHIYTY
                     CGIVLVAINPYEQLPIYGQDVIYTYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQSII
                     VSGESGAGKTVSAKYAMRYFATVGGSASETNIEEKVLASSPIMEAIGNAKTTRNDNSS
                     RFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAAGLPEFKE
                     LALTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIFKIIASILH
                     LGSVAIQAERDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTM
                     SLQQVINARNALAKHIYAQLFGWIVEHINKALHTSLKQHSFIGVLDIYGFETFEVNSF
                     EQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFYDNQPCIDLIEAKLGILD
                     LLDEECKVPKGTDQNWAQKLYDRHSSSQHFQKPRMSNTAFIIVHFADKVEYLSDGFLE
                     KNRDTVYEEQINILKASKFPLVADLFHDDKDPVPATTPGKGSSSKISVRSARPPMKVS
                     NKEHKKTVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEKLPFHFDPKRAVQQLRACG
                     VLETIRISAAGYPSRWAYHDFFNRYRVLVKKRELANTDKKAICRSVLENLIKDPDKFQ
                     FGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVRGWLQKVKYHRLKGATLTLQRYC
                     RGHLARRLAEHLRRIRAAVVLQKHYRMQRARQAYQRVRRAAVVIQAFTRAMFVRRTYR
                     QVLMEHKATTIQKHVRGWMARRHFQRLRDAAIVIQCAFRMLKARRELKALRIEARSAE
                     HLKRLNVGMENKVVQLQRKIDEQNKEFKTLSEQLSVTTSTYTMEVERLKKELVHYQQS
                     PGEDTSLRLQEEVESLRTELQRAHSERKILEDAHSREKDELRKRVADLEQENALLKDE
                     KEQLNNQILCQSKDEFAQNSVKENLMKKELEEERSRYQNLVKEYSQLEQRYDNLRDEM
                     TIIKQTPGHRRNPSNQSSLESDSNYPSISTSEIGDTEDALQQVEEIGLEKAAMDMTVF
                     LKLQKRVRELEQERKKLQVQLEKREQQDSKKVQAEPPQTDIDLDPNADLAYNSLKRQE
                     LESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAHEELEVRKEEVL
                     ILRTQIVSADQRRLAGRNAEPNINARSSWPNSEKHVDQEDAIEAYHGVCQTNSKTEDW
                     GYLNEDGELGLAYQGLKQVARLLEAQLQAQSLEHEEEVEHLKAQLEALKEEMDKQQQT
                     FCQTLLLSPEAQVEFGVQQEISRLTNENLDLKELVEKLEKNERKLKKQLKIYMKKAQD
                     LEAAQALAQSERKRHELNRQVTVQRKEKDFQGMLEYHKEDEALLIRNLVTDLKPQMLS
                     GTVPCLPAYILYMCIRHADYTNDDLKVHSLLTSTINGIKKVLKKHNDDFEMTSFWLSN
                     TCRLLHCLKQYSGDEGFMTQNTAKQNEHCLKNFDLTEYRQVLSDLSIQIYQQLIKIAE
                     GVLQPMIVSAMLENESIQGLSGVKPTGYRKRSSSMADGDNSYCLEAIIRQMNAFHTVM
                     CDQGLDPEIILQVFKQLFYMINAVTLNNLLLRKDVCSWSTGMQLRYNISQLEEWLRGR
                     NLHQSGAVQTMEPLIQAAQLLQLKKKTQEDAEAICSLCTSLSTQQIVKILNLYTPLNE
                     FEERVTVAFIRTIQAQLQERNDPQQLLLDAKHMFPVLFPFNPSSLTMDSIHIPACLNL
                     EFLNEV"
     exon            382..492
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            493..664
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            665..809
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            810..966
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1110
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1192
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1300
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1410
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1676
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1758
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1899
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2022
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2106
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2259
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2357
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2444
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2556
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2768
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..2925
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3165
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3399
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3484
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3630
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3750
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3891
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3892..3957
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            3958..4197
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            4198..4298
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            4299..4376
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            4377..4575
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            4576..4669
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            4670..4813
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            4814..4965
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            4966..5055
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            5056..5206
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            5207..5492
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            5493..5667
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            5668..5748
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     exon            5749..9583
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6092..6097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /note="hexamer: AATAAA"
     polyA_site      6112
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /note="major polyA site"
     regulatory      9540..9545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /note="hexamer: AATAAA"
     regulatory      9554..9559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
                     /note="hexamer: AATAAA"
     polyA_site      9559
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
     polyA_site      9583
                     /gene="MYO5B"
                     /gene_synonym="DIAR2; MVID1; PFIC10"
ORIGIN      
        1 agaggcgcgg cggcgcacgg gccgtccgct ctgacgcgag cgggtcctcc ctcctcgccg
       61 gccctcgcct cctccccaca cctgggaggg gagtggtgcg gcgcggcctc ctcccccggc
      121 gctcgcaact cctgtccggc cgtagctgcg ccgccgcggc gggagtaaag gtcgcgccgc
      181 cgggagcgag ccggccgcgg cgcctgcggg aagccggcgg ggcaggtcgg agaagagcga
      241 gaagatcgag aaactccagg ccagcccggg aacatggcgc caggcgggcc agccgcggac
      301 tgagagccgc ggggcagcca ggagccgggg cccgagcccc gcccggcccg ggccatgtcg
      361 gtgggcgagc tctacagcca gtgcacaagg gtctggatcc ctgaccctga tgaggtatgg
      421 cgctcagctg agttaaccaa ggactacaaa gaaggagaca agagcctaca gctcagactg
      481 gaggatgaaa cgattctgga atacccaatt gatgtacaac gcaaccagct gcccttctta
      541 cggaatccag atatcttggt gggagaaaat gacctgactg cccttagcta tcttcatgag
      601 cctgcagttt tgcataattt gaaggtccgt ttcctggagt ccaaccatat ctacacttac
      661 tgtggtatcg tacttgttgc cattaatcct tatgaacagt tgccaatcta tggacaagat
      721 gtcatctata cctacagtgg ccaaaacatg ggagacatgg acccccacat ctttgctgtg
      781 gcagaagaag cctacaagca gatggccaga gatgagaaga atcagtccat catagtcagt
      841 ggggagtctg gagccgggaa gacggtatca gccaagtatg ccatgcgcta tttcgccacc
      901 gttggtggct cggccagtga aaccaacatc gaagagaagg tgctggcatc cagtcccatc
      961 atggaggcca ttggaaatgc caagaccacc cgcaatgaca acagcagccg ttttggcaag
     1021 tacatccaga ttggctttga caaaaggtac cacatcatcg gggccaacat gaggacttac
     1081 ctcttggaga agtccagagt ggtcttccag gcagatgatg agaggaatta ccacatcttt
     1141 taccagctct gtgctgctgc cggtcttcca gaatttaaag agcttgcact aacaagtgca
     1201 gaggactttt tctatacatc acagggagga gacacttcca tcgagggtgt ggacgatgct
     1261 gaggactttg agaagactcg acaagccttc acactcctcg gagtgaaaga gtcccatcag
     1321 atgagcattt ttaagataat tgcttctatc ttgcaccttg gaagtgtggc gattcaggct
     1381 gagcgtgatg gtgattcctg tagtatatca ccccaggatg tatacctaag caacttctgc
     1441 cgactgctag gggtggagca cagtcagatg gagcactggc tgtgtcatcg caagctggtc
     1501 accacctcgg agacctacgt caagaccatg tccctgcagc aggtgatcaa tgcgcgcaac
     1561 gccctggcga agcacatcta tgcccagttg ttcggctgga ttgtggagca catcaacaag
     1621 gccctgcaca cctccctcaa gcagcactcc ttcatcgggg tcctggacat ctatgggttt
     1681 gagacatttg aggtaaacag ctttgagcag ttctgtatca actatgcaaa tgaaaagctc
     1741 cagcagcagt tcaactcgca tgttttcaaa ctggagcaag aagaatacat gaaggaacag
     1801 atcccttgga ccctgattga tttttatgat aaccaacctt gtatcgacct cattgaagcc
     1861 aagctgggta tcttggacct gttggatgaa gaatgtaagg tccccaaagg aactgaccag
     1921 aactgggctc agaagctcta tgaccggcac tccagcagcc agcacttcca gaagccccgc
     1981 atgtccaaca cggccttcat catcgtccac tttgcagaca aggtggagta cctctctgat
     2041 ggttttctgg agaaaaacag agacacggtg tatgaagagc agatcaatat cctgaaggcc
     2101 agcaagttcc cactagtggc tgacttgttt catgatgaca aggaccctgt tcctgccacc
     2161 acccctggga aggggtcatc ttcgaagatc agcgtccgtt ctgccagacc ccccatgaaa
     2221 gtctccaaca aggagcacaa gaaaaccgtt ggccaccagt tccgtacctc cctgcatctg
     2281 ctcatggaga ccctgaatgc cacgacacct cactatgtcc gctgcatcaa gcccaacgat
     2341 gagaagctcc cctttcactt tgacccaaag agagcagtgc agcaactcag agcctgcggg
     2401 gtgttggaga cgattcgaat cagtgcagct ggctacccat ccaggtgggc ctaccatgac
     2461 tttttcaacc ggtatcgggt gctggtcaag aagagagagc tcgccaacac agacaaaaag
     2521 gccatctgca ggtctgtcct ggagaacctc atcaaggacc ccgacaagtt ccagtttggc
     2581 cgcaccaaga tcttctttcg agcaggccag gtggcctacc tggagaagct gcgggctgac
     2641 aagttccgga cagccaccat catgatccag aaaactgtcc ggggatggct gcagaaggtg
     2701 aaatatcaca ggctgaaggg ggctacctta accctgcaga ggtactgccg gggacacctg
     2761 gcccgcaggc tggctgagca cctgcggagg atcagagcgg ctgtggtgct ccagaaacat
     2821 taccgcatgc agagggcccg ccaggcctac cagagggtcc gcagagctgc cgttgttatc
     2881 caggccttca cccgggccat gtttgtgcgg agaacctacc gccaggtcct catggagcac
     2941 aaggccacca ccatccagaa gcacgtgcgg ggctggatgg cacgcaggca cttccagcgg
     3001 ctgcgggatg cagccattgt catccagtgt gccttccgga tgctcaaggc caggcgggag
     3061 ctgaaggccc tcaggattga ggcccgctca gcagagcatc tgaaacgtct caacgtgggc
     3121 atggagaaca aggtggtcca gctgcagcgg aagatcgatg agcagaacaa agagttcaag
     3181 acactttcag agcagttgtc cgtgaccacc tcaacataca ccatggaggt agagcggctg
     3241 aagaaggagc tggtgcacta ccagcagagc ccaggtgagg acaccagcct caggctgcag
     3301 gaggaggtgg agagcctgcg cacagagctg cagagggccc actcggagcg caagatcttg
     3361 gaggacgccc acagcaggga gaaagatgag ctgaggaagc gagttgcaga cctggagcaa
     3421 gaaaatgctc tcttgaaaga tgagaaagaa cagctcaaca accaaatcct gtgccagtct
     3481 aaagatgaat ttgcccagaa ctctgtgaag gaaaatctca tgaagaaaga actggaggag
     3541 gagcgatccc ggtaccagaa ccttgtgaag gaatattcac agttggagca gagatacgac
     3601 aaccttcggg atgaaatgac catcataaag caaactccag gtcataggcg gaacccatca
     3661 aaccaaagta gcttagaatc tgactccaat tacccctcca tctccacatc tgagatcgga
     3721 gacactgagg atgccctcca gcaggtggag gaaattggcc tggagaaggc agccatggac
     3781 atgacggtct tcctgaagct gcagaagaga gtacgggagc tggagcagga gaggaaaaag
     3841 ctgcaagtgc agctggagaa gagagaacag caggacagca agaaagtcca ggcggaacca
     3901 ccacagactg acatagattt ggacccgaat gcagatctgg cctacaatag tctgaagagg
     3961 caagagctgg agtcagagaa caaaaagctg aagaatgacc tgaatgagct gaggaaagcc
     4021 gtggccgacc aagccacgca gaataactcc agccacggct ccccagatag ctacagcctc
     4081 ctgctgaacc agctcaagct ggcccacgag gagctcgagg tgcgcaagga ggaggtgctc
     4141 atcctcagga cccagatcgt gagcgccgac cagcggcgac tcgccggcag gaacgcggag
     4201 ccgaacatta atgccagatc aagttggcct aacagtgaaa agcatgttga ccaggaggat
     4261 gccattgagg cctatcacgg ggtctgccag acaaacagca agactgagga ttggggatat
     4321 ttaaatgaag atggagaact cggcttggcc taccaaggcc taaagcaagt tgccaggctg
     4381 ctggaggctc agctgcaggc ccagagcctg gagcatgagg aggaggtgga gcatctcaag
     4441 gctcagctcg aggccctgaa ggaggagatg gacaaacagc agcagacctt ctgccagacg
     4501 ctactgctct ccccagaggc ccaggtggaa ttcggcgttc agcaggaaat atcccggctg
     4561 accaacgaga atctggacct taaagaactg gtagaaaagc tggaaaagaa tgagaggaag
     4621 ctcaaaaagc aactgaagat ttacatgaag aaagcccagg acctagaagc tgcccaggca
     4681 ttggcccaga gtgagaggaa gcgccatgag ctcaacaggc aggtcacggt ccagcggaaa
     4741 gagaaggatt tccagggcat gctggagtac cacaaagagg acgaggccct cctcatccgg
     4801 aacctggtga cagacttgaa gccccagatg ctgtcgggca cagtgccctg tctccccgcc
     4861 tacatcctct acatgtgcat ccggcacgcg gactacacca acgacgatct caaggtgcac
     4921 tccctgctga cctccaccat caacggcatt aagaaagtcc tgaaaaagca caatgatgac
     4981 tttgagatga cgtcattctg gttatccaac acctgccgcc ttcttcactg tctgaagcag
     5041 tacagcgggg atgagggctt catgactcag aacactgcaa agcagaatga acactgtctt
     5101 aagaattttg acctcaccga ataccgtcag gtgctgagtg acctttccat tcagatctac
     5161 cagcagctca ttaaaattgc cgagggcgtg ttacagccga tgatagtttc tgccatgttg
     5221 gaaaatgaga gcattcaggg tctatctggt gtgaagccca ccggctaccg gaagcgctcc
     5281 tccagcatgg cagatgggga taactcatac tgcctggaag ctatcatccg ccagatgaat
     5341 gcctttcata cagtcatgtg tgaccagggc ttggaccctg agatcatcct gcaggtattc
     5401 aaacagctct tctacatgat caacgcagtg actcttaaca acctgctctt gcggaaggac
     5461 gtctgctctt ggagcacagg catgcaactc aggtacaata taagtcagct tgaggagtgg
     5521 cttcggggaa gaaaccttca ccagagtgga gcagttcaga ccatggaacc tctgatccaa
     5581 gcagcccagc tcctgcaatt aaagaagaaa acccaggagg acgcagaggc tatctgctcc
     5641 ctgtgtacct ccctcagcac ccagcagatt gtcaaaattt taaaccttta tactcccctg
     5701 aatgaatttg aagaacgggt aacagtggcc tttatacgaa caatccaggc acaactacaa
     5761 gagcggaatg accctcagca actgctatta gatgccaagc acatgtttcc tgttttgttt
     5821 ccatttaatc catcttctct aaccatggac tcaatccaca tcccagcgtg tctcaatctg
     5881 gaattcctca atgaagtctg aagatgcatg tttccagcat tagtttgatt cccaatgtga
     5941 gcaagaagga agtatataca gtaaagtaaa ttcaaggatc tgttaaatct ggtaaaagta
     6001 gatcaaatca gagattgaca gcctgtggag ggtgctgaac tatacagaat tagacacaac
     6061 tatgtcatta ttttttgtac ctactgctca gaataaaaac acttgaaata tggaagattt
     6121 taagtttgat ttcagtccaa cacatataca taatttatag acaccaagca gtccccatag
     6181 acatataaaa ggtgtcaatt ctataaaacg aagctgccta gttttgatct ttgcatagaa
     6241 ctagagaatg tccaaattaa aataccaaat atatataagt cacataaatt gccttcaaag
     6301 ggctttaaca aataatggta ctaataacca tgataatggc atatactgac atttcccaaa
     6361 gtttgcaaac cataggtgtg gttgagtttg tggtgagatg ttttaagaac aaaaatatgg
     6421 ggatgagact tctgagaaat attcccaaaa tattttttaa tggctgatta tacacagaca
     6481 gtggtgtaac tgacctccag accagacatt ttgagtactg gtttctgaag caaaattaga
     6541 agtgccagtc ctcagtgtgc tcaaacgctt ttgtgttatc ttgatttaat ggaagagatt
     6601 attaaaatgc tgctatccca aactccaagt gagaaagatg gaaaaatatt ttgtttctga
     6661 tgctagtcca tacactttcc aagtcccaca aaactttcac aaaaatgtat ataagctaaa
     6721 tattagaaac ggataacaaa cttgttttat ttatagatgt aaaaaccaaa caagtcaata
     6781 tgaaagcttt taatctctta ataccattaa gcttccagta agagcatcac ataatgctct
     6841 actgttccag aaaccaaata gtaaaacaaa ctaaagttcg cacatcagat catctgaaaa
     6901 accttcaaaa ataatcagtt cagggatatt atacaaaagt ttgggttttt tttttttaag
     6961 agaataaaat ggcttaggtc aactttccct tttcaggtta ttttcaacgt ttttcaaatt
     7021 tagcacacaa aaaattgtaa atatctctcc cacaaaataa ggattttaaa aaagtaattc
     7081 agtaatataa caggcttaga tgtttgctgc tcttagaatt ttttttaact tgtttttggt
     7141 ttcttcaaaa gcaagcattc aattggaaac ccatattctt tccacacttt tttttactgt
     7201 cttttctgta tttcttgata gcagtatgct gttcccataa gaaaaaaatg gtatttgcaa
     7261 atcatggaag aacagcctct gtattacatt gagaaaataa gatttatcca tgaattggaa
     7321 gtagaacagc ctgccttcac cctcttttac tcaaccaccc aacttaaaag gctcttggaa
     7381 acacagcaca ctccacgcta ccttctgcac tgtgccctta gagcacagct tcctcagttg
     7441 ttctctgcat ctcctggggc ttaggccagt cttagcctgg gttaaggctg ctgacattgt
     7501 gttccaatca gttgtcatgg gcattatccc ctctacatcc acattaaaca tgccggcttc
     7561 tcttgggcat cggcagagct gtgccttttt ctttcagtta cagttacata atcactgacg
     7621 tccatgacac ttacccatgg atccatgtgc tgacttcatt tagaaggcca atctaaaaca
     7681 actgggtttg tggctacctc tttaaagttg tttgtgaagg ataatttgtt ttttaatgca
     7741 ctttagtttg aaagtgagtc tcttatgtaa ggaccatcct taaaagacca aaaatgcctt
     7801 gttagagtgt taaggagttt tgacatgcag tggttccaca aacacagtgg cttactatcc
     7861 ttatacactg tcttatacca tcattctctc catctctctt ggtcactact ctctgctgtc
     7921 actggttaat cactaggtgc caagagctta ctgaataaaa gcttggcaat tagaataaat
     7981 ggggagggaa ggaccttatg aatagtccat ttagcctaag aaatggcaga tttagttctt
     8041 ctcttccaaa agataaaggt atatcctgga attgtactta aaacttacag atgactaaca
     8101 aatatatact ttatatgtag ttaatattta gatctgtctt atttaatact tggaggctag
     8161 aagaagcatc tttaggggaa ctatataatc ttttgttagc attttctctg cattttaaaa
     8221 aatcatttca attcaaacat ttatcagtgt catgaaatca gtaatgactc tttaacaatt
     8281 caggtttgaa ctctgcatta gatgtctctt taatttttta atatttaaaa tttagttgac
     8341 atttttttca ccaggtgcct ttagcggtta ctaagataac tgacatcagt tgtttctctg
     8401 aaataagtgt tgctgtggga ataattttaa tgttcaaggt gatatcatgg gggagttttg
     8461 tcttttaaaa cattagaagc attttaaata ttaagaatca aatatttata gatcaaaact
     8521 tgtgttttaa gtattatacg ggacctgttt acttatagta aatgtgaatg tacacatgag
     8581 ttgttgctga agctgacaag catattacat acatgcattt tccctgtgcc ctcatagttg
     8641 cagttagagt tccagtacct gtaggctcac ctgggaggca gattagaccc aaaggtagat
     8701 gtttttcccc tttccatgaa gcatgtcagt gggagttgct tcctttgatt tccctagtac
     8761 taaattttaa ggcttttgta aaaacaaaac aaaactagga gcttggaaca gttaaaaatc
     8821 aacactgcta ccatcaattc atcaaatatt tacttagagc tttcatacat taagattcca
     8881 gtaaccaata aattagaatt catttcttct gcataaagta aattttcata cacttgacct
     8941 actaagacag caagggtgtc ctaaattgag gcatttgtat aatgcctgca taactaaatg
     9001 gtcactaaaa tgggacagca tggggcaaga ccttgtagtt cttcacagaa tatttgtggt
     9061 cagtttctcc aattaatttg ctgcatgagc caaataacca taattcactt tttataccca
     9121 ctggtgccat aattagagaa ttagagggtg tagacagagg ttaatgccaa tgagaaacac
     9181 aggacagggt tttttttatt ataaaggtca ttagatacaa aagattgttt ttcaaaaaat
     9241 ttctaattct aacaaagggg atcaatcaga aatgaaacta agctactttc taaagtgaca
     9301 ctgtatcaga ataatccaga tttgaatata acattttgcc accaactgac atttagatga
     9361 aggactgcct ctctgaaaga gttcagatca tattcagggg tgaatccaac accatggaag
     9421 aaagactact gatgaaaata ttttcccact ttgcacaaat ctgtaaacta cacctttgtt
     9481 tatagaaaaa tgcttgtaat agtcactgta atatttagct gtggataaaa atttgtggaa
     9541 ataaatactt ttgaataaag aggtgtgcca aatctaaatg aaa
//
