LOCUS       NM_001382347           12130 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens myosin VA (MYO5A), transcript variant 3, mRNA.
ACCESSION   NM_001382347 XM_005254397
VERSION     NM_001382347.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12130)
  AUTHORS   Xing,J., Gu,Y., Song,Y., Liu,Q., Chen,Q., Han,P., Shen,Z., Li,H.,
            Zhang,S., Bai,Y., Ma,J. and Sui,F.
  TITLE     MYO5A overexpression promotes invasion and correlates with low
            lymphocyte infiltration in head and neck squamous carcinoma
  JOURNAL   BMC Cancer 23 (1), 1267 (2023)
   PUBMED   38129784
  REMARK    GeneRIF: MYO5A overexpression promotes invasion and correlates with
            low lymphocyte infiltration in head and neck squamous carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 12130)
  AUTHORS   Walcott,S. and Warshaw,D.M.
  TITLE     Modeling myosin Va liposome transport through actin filament
            networks reveals a percolation threshold that modulates transport
            properties
  JOURNAL   Mol Biol Cell 33 (2), ar18 (2022)
   PUBMED   34935414
  REMARK    GeneRIF: Modeling myosin Va liposome transport through actin
            filament networks reveals a percolation threshold that modulates
            transport properties.
REFERENCE   3  (bases 1 to 12130)
  AUTHORS   Christen,M., de le Roi,M., Jagannathan,V., Becker,K. and Leeb,T.
  TITLE     MYO5A Frameshift Variant in a Miniature Dachshund with Coat Color
            Dilution and Neurological Defects Resembling Human Griscelli
            Syndrome Type 1
  JOURNAL   Genes (Basel) 12 (10), 1479 (2021)
   PUBMED   34680875
  REMARK    GeneRIF: MYO5A Frameshift Variant in a Miniature Dachshund with
            Coat Color Dilution and Neurological Defects Resembling Human
            Griscelli Syndrome Type 1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12130)
  AUTHORS   Dhekne,H.S., Yanatori,I., Vides,E.G., Sobu,Y., Diez,F., Tonelli,F.
            and Pfeffer,S.R.
  TITLE     LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during
            ciliogenesis blockade
  JOURNAL   Life Sci Alliance 4 (5), e202101050 (2021)
   PUBMED   33727250
  REMARK    GeneRIF: LRRK2-phosphorylated Rab10 sequesters Myosin Va with
            RILPL2 during ciliogenesis blockade.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12130)
  AUTHORS   Huang,K., Chen,S., Xie,R., Jiang,P., Yu,C., Fang,J., Liu,X. and
            Yu,F.
  TITLE     Identification of three predictors of gastric cancer progression
            and prognosis
  JOURNAL   FEBS Open Bio 10 (9), 1891-1899 (2020)
   PUBMED   32735728
  REMARK    GeneRIF: Identification of three predictors of gastric cancer
            progression and prognosis.
REFERENCE   6  (bases 1 to 12130)
  AUTHORS   Lambert,J., Naeyaert,J.M., Callens,T., De Paepe,A. and Messiaen,L.
  TITLE     Human myosin V gene produces different transcripts in a cell
            type-specific manner
  JOURNAL   Biochem Biophys Res Commun 252 (2), 329-333 (1998)
   PUBMED   9826529
REFERENCE   7  (bases 1 to 12130)
  AUTHORS   Pastural,E., Barrat,F.J., Dufourcq-Lagelouse,R., Certain,S.,
            Sanal,O., Jabado,N., Seger,R., Griscelli,C., Fischer,A. and de
            Saint Basile,G.
  TITLE     Griscelli disease maps to chromosome 15q21 and is associated with
            mutations in the myosin-Va gene
  JOURNAL   Nat Genet 16 (3), 289-292 (1997)
   PUBMED   9207796
  REMARK    Erratum:[Nat Genet 1999 Nov;23(3):373]
REFERENCE   8  (bases 1 to 12130)
  AUTHORS   Moore,K.J., Testa,J.R., Francke,U., Milatovich,A., Copeland,N.G.
            and Jenkins,N.A.
  TITLE     Cloning and regional assignment of the human myosin heavy chain 12
            (MYH12) gene to chromosome band 15q21
  JOURNAL   Cytogenet Cell Genet 69 (1-2), 53-58 (1995)
   PUBMED   7835087
REFERENCE   9  (bases 1 to 12130)
  AUTHORS   Bement,W.M., Hasson,T., Wirth,J.A., Cheney,R.E. and Mooseker,M.S.
  TITLE     Identification and overlapping expression of multiple
            unconventional myosin genes in vertebrate cell types
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6549-6553 (1994)
   PUBMED   8022818
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11767. doi:
            10.1073/pnas.91.24.11767-c.. PMID: 7972138]
REFERENCE   10 (bases 1 to 12130)
  AUTHORS   Engle,L.J. and Kennett,R.H.
  TITLE     Cloning, analysis, and chromosomal localization of myoxin (MYH12),
            the human homologue to the mouse dilute gene
  JOURNAL   Genomics 19 (3), 407-416 (1994)
   PUBMED   8188282
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025917.8, AC018902.8,
            KF459554.1 and AC010674.11.
            
            On Apr 30, 2020 this sequence version replaced XM_005254397.4.
            
            Summary: This gene is one of three myosin V heavy-chain genes,
            belonging to the myosin gene superfamily. Myosin V is a class of
            actin-based motor proteins involved in cytoplasmic vesicle
            transport and anchorage, spindle-pole alignment and mRNA
            translocation. The protein encoded by this gene is abundant in
            melanocytes and nerve cells. Mutations in this gene cause Griscelli
            syndrome type-1 (GS1) and neuroectodermal melanolysosomal disease,
            or Elejalde disease. [provided by RefSeq, Sep 2023].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399233.7/ ENSP00000382179.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC025917.8         73201-73301         c
            102-212             AC018902.8         126178-126288       c
            213-384             AC018902.8         121401-121572       c
            385-529             AC018902.8         118833-118977       c
            530-686             AC018902.8         109148-109304       c
            687-830             AC018902.8         103336-103479       c
            831-912             AC018902.8         101062-101143       c
            913-1020            AC018902.8         100295-100402       c
            1021-1127           AC018902.8         98290-98396         c
            1128-1218           AC018902.8         90379-90469         c
            1219-1393           KF459554.1         4-178               c
            1394-1475           AC018902.8         89319-89400         c
            1476-1616           AC018902.8         84933-85073         c
            1617-1742           AC018902.8         82241-82366         c
            1743-1826           AC018902.8         80832-80915         c
            1827-1988           AC018902.8         77164-77325         c
            1989-2086           AC018902.8         76094-76191         c
            2087-2173           AC018902.8         72825-72911         c
            2174-2282           AC018902.8         72628-72736         c
            2283-2494           AC018902.8         69350-69561         c
            2495-2651           AC018902.8         68307-68463         c
            2652-2891           AC018902.8         65127-65366         c
            2892-3140           AC018902.8         63172-63420         c
            3141-3234           AC018902.8         60034-60127         c
            3235-3383           AC018902.8         57557-57705         c
            3384-3497           AC018902.8         52971-53084         c
            3498-3641           AC018902.8         46874-47017         c
            3642-3695           AC018902.8         46608-46661         c
            3696-3923           AC018902.8         44257-44484         c
            3924-3932           AC018902.8         41821-41829         c
            3933-4033           AC018902.8         39364-39464         c
            4034-4114           AC010674.11        213340-213420       c
            4115-4313           AC010674.11        210419-210617       c
            4314-4388           AC010674.11        208033-208107       c
            4389-4482           AC010674.11        206686-206779       c
            4483-4629           AC010674.11        200576-200722       c
            4630-4784           AC010674.11        198075-198229       c
            4785-4874           AC010674.11        193578-193667       c
            4875-5025           AC010674.11        191582-191732       c
            5026-5308           AC010674.11        189283-189565       c
            5309-5483           AC010674.11        187271-187445       c
            5484-5564           AC010674.11        184346-184426       c
            5565-12130          AC010674.11        177506-184071       c
FEATURES             Location/Qualifiers
     source          1..12130
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.2"
     gene            1..12130
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /note="myosin VA"
                     /db_xref="GeneID:4644"
                     /db_xref="HGNC:HGNC:7602"
                     /db_xref="MIM:160777"
     exon            1..101
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..5717
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /note="isoform 3 is encoded by transcript variant 3;
                     myosin-Va; myoxin; myosin V; myosin, heavy polypeptide
                     kinase; myosin-12; dilute myosin heavy chain, non-muscle;
                     unconventional myosin-Va; myosin VA (heavy chain 12,
                     myoxin)"
                     /codon_start=1
                     /product="unconventional myosin-Va isoform 3"
                     /protein_id="NP_001369276.1"
                     /db_xref="CCDS:CCDS92001.1"
                     /db_xref="GeneID:4644"
                     /db_xref="HGNC:HGNC:7602"
                     /db_xref="MIM:160777"
                     /translation="MAASELYTKFARVWIPDPEEVWKSAELLKDYKPGDKVLLLHLEE
                     GKDLEYHLDPKTKELPHLRNPDILVGENDLTALSYLHEPAVLHNLRVRFIDSKLIYTY
                     CGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSII
                     VSGESGAGKTVSAKYAMRYFATVSGSASEANVEEKVLASNPIMESIGNAKTTRNDNSS
                     RFGKYIEIGFDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKM
                     LRLGNADNFNYTKQGGSPVIEGVDDAKEMAHTRQACTLLGISESHQMGIFRILAGILH
                     LGNVGFTSRDADSCTIPPKHEPLCIFCELMGVDYEEMCHWLCHRKLATATETYIKPIS
                     KLQATNARDALAKHIYAKLFNWIVDNVNQALHSAVKQHSFIGVLDIYGFETFEINSFE
                     QFCINYANEKLQQQFNMHVFKLEQEEYMKEQIPWTLIDFYDNQPCINLIESKLGILDL
                     LDEECKMPKGTDDTWAQKLYNTHLNKCALFEKPRLSNKAFIIQHFADKVEYQCEGFLE
                     KNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPTSATSSGRTPLTRTPAKPTKGRP
                     GQMAKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLR
                     ACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLSDRKQTCKNVLEKLILDKDK
                     YQFGKTKIFFRAGQVAYLEKLRADKLRAACIRIQKTIRGWLLRKKYLRMRKAAITMQR
                     YVRGYQARCYAKFLRRTKAATIIQKYWRMYVVRRRYKIRRAATIVLQSYLRGFLARNR
                     YRKILREHKAVIIQKRVRGWLARTHYKRSMHAIIYLQCCFRRMMAKRELKKLKIEARS
                     VERYKKLHIGMENKIMQLQRKVDEQNKDYKCLVEKLTNLEGIYNSETEKLRSDLERLQ
                     LSEEEAKVATGRVLSLQEEIAKLRKDLEQTRSEKKCIEEHADRYKQETEQLVSNLKEE
                     NTLLKQEKEALNHRIVQQAKEMTETMEKKLVEETKQLELDLNDERLRYQNLLNEFSRL
                     EERYDDLKEEMTLMVHVPKPGHKRTDSTHSSNESEYIFSSEIAEMEDIPSRTEEPSEK
                     KVPLDMSLFLKLQKRVTELEQEKQVMQDELDRKEEQVLRSKAKEEERPQIRGAELEYE
                     SLKRQELESENKKLKNELNELRKALSEKSAPEVTAPGAPAYRVLMEQLTSVSEELDVR
                     KEEVLILRSQLVSQKEAIQPKDDKNTMTDSTILLEDVQKMKDKGEIAQAYIGLKETNR
                     SSALDYHELNEDGELWLVYEGLKQANRLLESQLQSQKRSHENEAEALRGEIQSLKEEN
                     NRQQQLLAQNLQLPPEARIEASLQHEITRLTNENLYFEELYADDPKKYQSYRISLYKR
                     MIDLMEQLEKQDKTVRKLKKQLKVFAKKIGELEVGQMENISPGQIIDEPIRPVNIPRK
                     EKDFQGMLEYKKEDEQKLVKNLILELKPRGVAVNLIPGLPAYILFMCVRHADYLNDDQ
                     KVRSLLTSTINSIKKVLKKRGDDFETVSFWLSNTCRFLHCLKQYSGEEGFMKHNTSRQ
                     NEHCLTNFDLAEYRQVLSDLAIQIYQQLVRVLENILQPMIVSGMLEHETIQGVSGVKP
                     TGLRKRTSSIADEGTYTLDSILRQLNSFHSVMCQHGMDPELIKQVVKQMFYIIGAITL
                     NNLLLRKDMCSWSKGMQIRYNVSQLEEWLRDKNLMNSGAKETLEPLIQAAQLLQVKKK
                     TDDDAEAICSMCNALTTAQIVKVLNLYTPVNEFEERVSVSFIRTIQMRLRDRKDSPQL
                     LMDAKHIFPVTFPFNPSSLALETIQIPASLGLGFISRV"
     exon            102..212
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            213..384
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            385..529
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            530..686
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            687..830
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            831..912
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1020
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1127
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1393
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1475
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1616
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1742
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1826
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1988
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2086
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2173
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2282
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2494
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2651
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2891
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..3140
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3234
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            3235..3383
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3497
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            3498..3641
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            3642..3695
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3923
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            3924..3932
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            3933..4033
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            4034..4114
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            4115..4313
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            4314..4388
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            4389..4482
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            4483..4629
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            4630..4784
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            4785..4874
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            4875..5025
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            5026..5308
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            5309..5483
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            5484..5564
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     exon            5565..12130
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12111..12116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /note="hexamer: AATAAA"
     polyA_site      12130
                     /gene="MYO5A"
                     /gene_synonym="GS1; MYH12; MYO5; MYR12"
                     /note="major polyA site"
ORIGIN      
        1 agtccgctcg ggcggccgcc caggcgaggt gcggcctccg cacaggcggg gggcgtaggc
       61 gcgcggggcc cgccatggct gcgtcggagc tctacacaaa gtttgccagg gtttggatac
      121 ctgatccaga ggaagtctgg aagtcagcag agctgctcaa agattataag ccaggagata
      181 aagtcctcct gcttcacctc gaggaaggaa aggatttgga ataccatcta gatccaaaga
      241 ccaaggagct gcctcactta cgaaatcctg acatacttgt tggtgaaaat gacctcacag
      301 ccctcagcta tcttcatgag cctgctgtgc tccataatct cagagtccgc tttattgatt
      361 ccaaacttat ttatacgtat tgtggtatag tcctagtagc tataaatccc tatgaacagc
      421 tgcctattta tggagaagat attattaatg catacagtgg tcagaacatg ggtgatatgg
      481 atccacatat ctttgcagta gctgaagaag cttacaagca aatggccaga gatgaacgaa
      541 atcagtccat catcgtaagt ggagagtctg gggcaggaaa aacagtctca gctaagtatg
      601 ccatgcgata ctttgcaact gtgagtggtt ctgccagtga ggccaatgtg gaggaaaagg
      661 tcttggcctc caaccccatc atggagtcca ttggaaatgc taaaacaacc aggaatgata
      721 atagcagccg ttttgggaag tatattgaga ttggttttga taagagatat cgaatcattg
      781 gtgccaatat gagaacttat cttttagaga aatccagagt ggtattccag gcagaagagg
      841 agagaaacta tcatatcttc tatcagcttt gtgcctcagc aaagttacct gaatttaaaa
      901 tgctacgatt aggaaatgca gataacttta attacacaaa acaaggaggc agtcctgtga
      961 ttgaaggagt ggatgatgca aaggagatgg cacatactag gcaggcctgc actttgctag
     1021 gaattagtga atctcatcaa atgggaattt tccgaatact tgctggcatc cttcacttag
     1081 gcaatgttgg atttacatcc cgagatgcag acagctgcac aatacctccc aagcatgaac
     1141 ctctctgcat cttctgtgaa ctcatgggtg tggactatga ggagatgtgt cactggctct
     1201 gccatcggaa actggctact gccacagaga catacatcaa gcccatctcc aagctgcagg
     1261 ccacgaatgc ccgcgatgct ttggccaagc acatctatgc caagctcttt aactggattg
     1321 tagataatgt caatcaggct ctccattctg ctgtcaaaca gcactctttt attggtgtgc
     1381 tagacattta cggatttgaa acatttgaga taaatagttt tgaacagttt tgcataaatt
     1441 atgcaaatga aaaactacag caacaattca atatgcatgt cttcaaattg gagcaagaag
     1501 aatatatgaa ggaacaaatt ccatggacac tcatagattt ttatgataat cagccttgta
     1561 ttaatcttat agaatcaaaa ctaggcattc tagatttact ggatgaggaa tgcaagatgc
     1621 ctaaaggcac agatgacacc tgggcccaaa aattgtacaa cacacatttg aacaaatgtg
     1681 cactctttga aaagcctcgt ctatcaaaca aagctttcat catccaacat tttgctgaca
     1741 aagtggaata ccagtgtgaa ggatttctcg aaaagaataa agacaccgtt tttgaagaac
     1801 aaattaaagt tcttaaatca agcaagttta agatgctacc agaactattt caagatgatg
     1861 agaaggccat cagtccaact tcagccacct cctcagggcg cacacccctc acacgaactc
     1921 ctgcaaagcc caccaaaggc agaccaggcc aaatggccaa agagcacaag aaaacagtgg
     1981 ggcatcagtt cagaaactcc ctgcacctgc ttatggagac actcaatgcc actacccctc
     2041 actatgtgcg ctgtatcaag cctaatgact tcaagttccc attcacgttt gatgagaaga
     2101 gggcagtgca gcagctgaga gcatgtggtg tcctggaaac catccgaatc agtgcggccg
     2161 gtttcccctc acggtggact taccaagaat ttttcagccg ctaccgtgtc ctaatgaagc
     2221 agaaagatgt gctgagtgac agaaagcaaa catgcaagaa tgtgttagag aaactgatac
     2281 tggacaagga caaataccag tttggtaaga caaagatctt tttccgtgcc ggtcaagtgg
     2341 cctatctaga aaaattgaga gctgacaaac tgagagctgc ctgcatccgg atccagaaga
     2401 ccatccgagg gtggctgctg agaaagaagt acctacgcat gcggaaggca gccatcacca
     2461 tgcagagata cgtgcggggc taccaggccc gatgctatgc taagtttctg cgcagaacca
     2521 aggcagcaac catcattcaa aagtactggc gcatgtatgt ggtccgcagg aggtacaaga
     2581 ttagacgagc tgccactatc gttcttcagt cttacttgcg aggcttcttg gccagaaata
     2641 ggtatcgcaa gatactccgt gagcacaaag cagtcatcat tcagaagcga gtccggggct
     2701 ggctggcccg cacacactac aagaggagca tgcatgccat catctacctt cagtgctgct
     2761 tcaggcggat gatggccaag cgtgagctaa agaagctcaa aatcgaggct cgctcagtgg
     2821 agcgctataa gaagctgcac atcggcatgg agaacaagat catgcagctg cagcgcaaag
     2881 ttgatgagca gaacaaagac tacaaatgcc ttgtggagaa actaaccaat ctggaaggaa
     2941 tatacaactc tgagactgag aaactacgaa gtgacttaga acgtcttcaa ctaagtgaag
     3001 aggaagcgaa agttgccact gggcgggtcc ttagtctgca ggaagaaatt gccaagctcc
     3061 ggaaagacct ggagcaaact cgttcagaga aaaaatgcat tgaggaacat gcagatcgat
     3121 acaaacaaga aacagagcag ctggtatcaa atctgaagga agaaaatact ttgctgaagc
     3181 aagaaaaaga agccctcaat caccgcatcg tgcagcaggc taaggagatg acagaaacta
     3241 tggagaagaa gttagtagaa gaaacgaaac aactggaact cgaccttaat gatgaaaggc
     3301 tgagatatca gaaccttctg aatgagttca gtcgcctgga agaaagatat gatgacctca
     3361 aggaagagat gacccttatg gtgcatgtgc ctaagcctgg acacaagaga acagactcca
     3421 cccacagcag caacgagtct gaatatatct ttagctctga aattgcagaa atggaagaca
     3481 ttccatcaag gacagaggaa ccaagtgaga agaaggtacc tctggacatg tcattgttcc
     3541 ttaagctcca gaagcgggtc acagagctgg agcaggagaa gcaggtgatg caggatgagc
     3601 tggaccgcaa ggaggagcag gtgctccgca gcaaggccaa ggaagaagaa agaccacaaa
     3661 ttagaggtgc agaactggaa tatgagtcac tcaagcgtca agaactagaa tcagaaaaca
     3721 aaaaactgaa gaatgagcta aatgagttgc gcaaggccct cagtgagaaa agtgccccag
     3781 aggtgaccgc cccaggtgca cctgcctacc gtgtcctcat ggagcagctg acctctgtga
     3841 gcgaggagct tgatgtccgc aaggaggaag tcctcatctt aaggtctcaa ctggtgagcc
     3901 agaaagaggc catccaaccc aaggatgaca agaatacaat gacagattcc acaatacttt
     3961 tggaagatgt acaaaaaatg aaagataaag gtgaaatagc acaagcatac attggtttga
     4021 aagaaacaaa tagatcatct gctctggatt accatgagtt gaatgaggat ggagagctgt
     4081 ggctggttta tgaagggtta aaacaagcca acaggctcct ggaatcccag ctgcagtcac
     4141 agaagaggag ccatgagaat gaggccgagg ccctccgtgg ggagatccag agcctgaagg
     4201 aggagaacaa ccgacagcag cagctgctgg cccagaacct gcagctgccc ccagaggccc
     4261 gcattgaggc cagcctgcag cacgagatca cccggctgac caacgaaaac ttgtattttg
     4321 aggaattata tgcagatgac cctaagaagt atcaatcata tcggatttcc ctttacaaac
     4381 ggatgattga tttgatggaa caacttgaaa aacaggataa gacggtccgt aaactgaaaa
     4441 aacaactgaa agtatttgcc aaaaaaattg gcgaactaga agtgggccag atggagaaca
     4501 tatccccagg acagatcatt gatgaaccca tccgaccagt caacattccc aggaaagaaa
     4561 aggatttcca agggatgctg gaatacaaga aggaggatga gcaaaaactt gttaagaacc
     4621 tgattctgga actgaagcca cgtggtgtag cagtcaattt gattccagga ttaccggcat
     4681 atatcctgtt catgtgtgtt cgacatgctg actacctgaa tgatgatcag aaagtaaggt
     4741 cgttgctaac atcaacaatt aacagcatca aaaaagtatt gaagaaaaga ggtgatgatt
     4801 ttgaaaccgt ctccttctgg ctctctaaca catgccgatt tttgcactgc ttgaaacagt
     4861 acagtggaga agagggcttt atgaagcaca acacatctcg ccagaatgaa cactgcctca
     4921 ccaattttga cctggctgag tatcggcagg tgctgagtga cttggccatt cagatctacc
     4981 agcagctcgt gcgggtgtta gagaacatcc ttcagccaat gattgtctca ggcatgctgg
     5041 aacatgaaac gattcagggc gtgtctgggg tgaagcccac agggttgaga aagcgaacct
     5101 ccagtatcgc cgatgagggc acctacacac tggactccat cctccggcag ctcaactcct
     5161 tccactcggt catgtgtcag catggcatgg accctgaact gatcaagcag gtggtcaagc
     5221 agatgttcta catcataggg gccatcaccc tgaacaacct tctcctgcgg aaggacatgt
     5281 gctcctggag taaaggcatg cagatcaggt acaatgtcag tcaactggaa gaatggctgc
     5341 gtgacaagaa tctgatgaat agtggggcta aagaaaccct ggaacctctc attcaggctg
     5401 ctcaactttt gcaagtgaaa aagaaaacag atgatgatgc agaagccatt tgttctatgt
     5461 gcaatgcttt aactactgcc cagattgtga aagtgttgaa tttgtatact ccagttaatg
     5521 agtttgaaga aagagtctct gtgtcgttca ttcgtactat acagatgcgt ttacgagaca
     5581 ggaaagactc tccccagctg ctcatggatg ctaaacacat ctttcctgtc acctttcctt
     5641 tcaacccatc ttccctcgca ctagaaacca tccagattcc agccagcctc ggcctgggct
     5701 tcatttcacg ggtctgaaag tgatgtccag gcaaaaattg acaatacatt tcttgcccga
     5761 aataagaacc cattatttcc agtgagttac tgaaaataca tttttaaaga gaaagtactg
     5821 attatctccc aaatgagaag tcattaactg gaaatctccc tagaatactt tcatcacttt
     5881 ggaaacaaag ataggctctt tcgtgctgtg ttatctttat agcaacactc atccttaacc
     5941 aactaggtac cgtgagttta catacaggag aatgatggaa ggaagggagg aaggaaagga
     6001 ggagaaaaat gtgtcttcag ctggcagcat ttattttaaa tccttagcac tgagtttgaa
     6061 tggtataaaa agtataactt ccatagatga gctgttgtta ggaaggcacc aaagaacctc
     6121 ctctgcacta aacaggagaa tggaaagaaa agtctccatt gagtacatat catgtcagtt
     6181 tagtaatcaa ttatgttgat attgttaaac tggttcaaag aaataaactg gcaatatgta
     6241 aagtaattcc tcatttgtgt cactatgata tagagatatt aaaggaatgt tggtttgcta
     6301 aatagtatag atgtccattt gtactatagt ttactgagca ttttaaattg ctgctacata
     6361 ctgtcttctt aaaatgtaag tgatattagg cactacaata agtttctctt gtcaattctg
     6421 tttacaattc aatcagatca cagttttaac tggattatat gcaaatacct acagattcac
     6481 ctgcacaagt agcagacact ggaaagtcat gtagtaatat gacaaaatgc ttgacattta
     6541 ggggtaggat tagacaaagt ggctattgtt gatgtcatta tttattcagg atgtattaca
     6601 ttgatgtgct cattaatttt ccctgggtgg atattgcgtc agggtacagt gttctgtgaa
     6661 gtgacttatt tttaactacc agatctgatt ccttcagtgc atattttcaa ccttgacagg
     6721 ttttctctct tcttaattta ttaagaatta atctcggctg ggcgcggtgg ctcacgcctg
     6781 taatcccagc actttgggaa gccaaggtgg gcggatcact tcaggttagg agttggagac
     6841 cagcctggcc aacatggcga aaccctgtct ctactaaaaa tacaaaaatt agccgggcgt
     6901 ggtggcactt gcctgtaatc ccagctactc gggaggctga ggcacgagaa tcgattaaac
     6961 ctgggaggcg gagattgcaa tgagatcgaa ccactgcact ccagcctggg tgacagagag
     7021 agacactgcc ttggaaaaaa aaagaatctc actcactatc tagagaggat tgtcagaata
     7081 ttcacgattc aggtcttgaa actttgatta tgcaaaagaa ggtatataat aaatatttca
     7141 ttatgattca gtttttaagg ctttgcagct tctataagtg ttctcagatg ccactagata
     7201 attttaaaag catcatatta gaaatacttt aagaagactt atataagaaa tagaagattg
     7261 ttgaatttta cagaggattt ggttcattaa gacccagatt ctgtaagttt tcattctgaa
     7321 attctagtta aacatattca ccatttttct taggaatctt atacaataaa tccttcaggt
     7381 tgcacaaaag caaattatta gttttcatta gaaactctgg ttctgaatta caatcatagg
     7441 ttatataaat ttaactgtta gatggtctat aaatcttatt aaaatatgtg caatatttat
     7501 ggaagtcaaa cagcttcata tcagtgataa agattgttat taaaagataa atactgtctg
     7561 ttaatttaca tgggcctcaa gttcctcgtt tataaaataa gagagttgga cactgattct
     7621 taacatctcc tccacattta aaattctctc ttctcagccc ttagattcta gagagaaaaa
     7681 gctgcagtta ctcagtaagt ccattctctg atggaaagac cagtgtgtag tgcctgtcaa
     7741 ttccttagga ttaatcaaat gtaaaatcac aagtttgtgt agctgtaacc tttcttaaat
     7801 gtacatgatt tatgtacatg cttttagaag gtcctactat atttgtatta taattagttt
     7861 aagtaatttt tattacatca tgtattgctt tattcagttt gaatacattt atttatttat
     7921 ttgcagtatc aaccagaaac actaccaatt gcatcaaatt ctcccagttt ttcctggttg
     7981 tcaatgcggt tttcaatgca caattaagtc atagccattt ggttcgtacc aaatgtgtca
     8041 gaatctaaca gcatccgata ggctgtaagt tggggagttg ctaagaaaat gcaacgtggt
     8101 acaggctgtc cgcctcagcc ctggaaatct cccagacctc ccccagcttc atcctgtgta
     8161 gcacgactca acgtgcaccc tgaatcttct caggtcttcc aggtcatgct gtagctgtca
     8221 ctgccatgca gccctttttt ttactccgga cagctcatgt actgaagcgt catgaaagaa
     8281 aggctgtggt ctgagccctt ctctcccatc tcctgtcttt gtcctgtcaa gtgctggagc
     8341 cagagctcct acagctgccc ttggtggttt ctcctgttca gcgatggtgg cacaaaggtt
     8401 ctgctattcc agggctccag cttcctccca ggtctaccca gagctccaga tgggggtctg
     8461 aattaacctc tcttggtggc ctggagattt ttagtcattg acaagaatac cttgtaacca
     8521 gggaacccca aggcccagta aatgattctg tataccattt tcttgaaggt acaagaagat
     8581 tctgccgact atggggatct ttgggccagt ttgaggattg ctttccctct gaggttcttt
     8641 ctctctgtca gccacacttt ctcacccaac ttcagacaca ccctgccagc ctttccccta
     8701 ctcattcact cttccccttc cctcaactta atcgtctatc ccgttgcctg ctgtttgact
     8761 gtgcactgaa ggcaggtgga tggagtcagt cctcagttgc ccctgctggc cttcctggtg
     8821 cttaccatca gcccaatctt tgcacagtcc ttgttgttct tacttctctg catgcattcc
     8881 ttcagaagat cagtcatcaa ctttttctta attcctctgt gacacacaat gggaattcaa
     8941 aggaagagat cttaaaagtc acaacagttc tttatcttaa taatcccctc cccattcacc
     9001 ttactacatg cagactcacc tcacaccctt acaacttgaa gctgaaaatt taaaagtaat
     9061 ttcccttttt gcagcttttc ctcaggttaa ggctttgatc tgcctgagag taactctaaa
     9121 aggagggaag ataaatatgg gataaaatcc acaaagtgta gcttctaatt cctttggaag
     9181 tttaaaaaat ttccacatat ctgatgcttc ttttgtcagg tgcagaagca caaaaacata
     9241 ttccgaagcc aactgatagg gaatttgggg attattgtca gtttggagaa tttgctgtgt
     9301 tatttcttca tttccatgga tagctcatag ttggctcttt ctgggtgagt aattatgtgt
     9361 aatatagatc aaatctttta ctaaggttac agctacatgt taggggaggc tatgaaaata
     9421 ctatattatt ataatttcag tgcagtgatt gttgtgagaa ataactttca tggtaaccct
     9481 aggaaaatgg gcacctgcca ccatcctgag aagtcctcac acaatgccct ttctctctta
     9541 cacacacaca cacacacata cacacacaca cacccccgtc actaattcat agagttcctt
     9601 agcaggcata gtcaaggatc ctctgggtaa tgtcagctgc ttagtgataa aacagagcca
     9661 aaactagtgc atcctgttga aagtaatgca gaaacagtac ctgggtccag atatgctttc
     9721 ctgcggcgct ttcctctgtt acctcgtttc atcctcacag cagcatggac ggtaggtggg
     9781 gtcgcttcta caatcatttc tgatgatagc ttgggaatag agataggggc agtgacttgc
     9841 ctgatgtcgc acagccctct ggctgtcctg ctttcccata tggagcagtg gtggtgtggg
     9901 cacctgtgat gcaggagact ttaaaaatgt cgtgaggtca cgtgctgccc ctcctggtac
     9961 gtgtggaatg cccctggcca gcaaggggtg cttttttatc agagttggca gctggcatgt
    10021 gggaaccgag caagtgctgc gtaccaagtt acttgtttta aggagaccaa gtgctcagcg
    10081 ccaggtggtt ttcttttttg tcatagttac ttgctataac tcagcttgac ttctgtcatg
    10141 aatcagtgct ctctgggagg atgcaatact ctgtttgggc attaattggt agcaggttgt
    10201 ctcaaccaaa aagacaggaa acagcaaaag cctctctgaa attaagagga aagttactct
    10261 ccccacaccc atcagagtct ttattggagc caccaggtga gctgtgcagc ctggacaggc
    10321 ctgcagctat aggccacctt cccagtttag gtcctcagca caggggagcc caagtcactg
    10381 ggtgccttcc gagggctgtc actgggcagg ccatatacaa gtcagtgtgt gcgtgggcac
    10441 tgcagtgtgt gcatgccgta ggtgttgatg ggtgctagga ggggtgtcgt gtgcatgcgc
    10501 gttgaagagg atctgtattg ccgtgacctc tgttcatgga tgagtgcatt gtaatttgtt
    10561 ctcaggctgt gctgtgaggg ccgccttaac ccttgctccc ttcccttcta gagctgcctt
    10621 aagttctcca gaacttttct tctgtaaagg atatcttgcc tggaagggat atcttgccct
    10681 gtttctcaag gttttgtgag agttttgact ggatgtggcc ctgcatgacc ctccttctcc
    10741 tgtacttcct ctttcctttc caaatgggaa ttagaactgt ggggcagcaa cagtctcaga
    10801 gccagtgaga ggccagctta gagaatgctt ctgagttagt gggactctgt gtcacaagta
    10861 agcaaatgaa tatatgaaag aaattatgga gataagttag attcttggta atacttaaat
    10921 gtcttgcttt ctactaacct tttgttacta aaggtaaagg gtataactca aactttttgt
    10981 ggacattctt ttcaaaattt tttaagaacc ctgtactata aaaggttgag taaaaacagg
    11041 aaagcgtgct ataagttcaa atctgttgta ttaccctaaa ttagataaac caacctgaat
    11101 tatagtagat ttctcaatag atgaggaact gaaaaatact atgtaaaata tcttccaaaa
    11161 tgctttttat acttttttta tttgtaattt ggtctatcta aaatgttcgt tagcttaact
    11221 taatgggcgt tattggattc atatgactaa cgtttcctca gtattgtaat gcttgaaata
    11281 tttgaaagaa aaaatgttgt tttttagttg aaactggtat atataattca gtgcttggca
    11341 ggttagtata tttttatgca tttttcagag tcagcagttt caaatcttat tgttatcatg
    11401 ttataaaatt ttagcccaca tttcaggctc cgtaaatcat ttgagccatt attttttccc
    11461 aacaaatggt gaattttttc tttaaatgtg gatatatatg ttgtaattta tgattcctgg
    11521 ttatgtattt ttgtgggatc ctgcagtaaa attgactttt ttgtgtcttt gggagattta
    11581 aattgcgcta acagtgttgc gcaaaaatga gttcatgcca tttaacatat tgtattttaa
    11641 ttattaactg tattaattta ctatgaaatg gacatccttt taactaaaat ggaattgaac
    11701 attgcagttt tcaaatattt ttccttgttg ggtctggaaa aggaattcta ctttgatctg
    11761 catagaaaat tttgatacaa ttttttgaaa gttcttaggt gaaacattta cccattaaaa
    11821 aggaagcaga aatactgaga catgaaaggc attatcaact aactctagac tctagaaccc
    11881 attctagcat atctcacgtg caatttttaa aaataagtta ataattcatc tcatatcaac
    11941 aaaagccttt gaaacatggg ttttcactag atatcaccta gtgctaagat aaaaaccaaa
    12001 acaatatcag aattacattt atgctctaaa tttgtagttg tccattgttg tgcttagtaa
    12061 atgtgtgtca ttaatgctgt attctcctag ctattatgga aacttgttta aataaagata
    12121 tggatataaa
//
