LOCUS       NM_138995               6213 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens myosin IIIB (MYO3B), transcript variant 2, mRNA.
ACCESSION   NM_138995
VERSION     NM_138995.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6213)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   2  (bases 1 to 6213)
  AUTHORS   Raval,M.H., Quintero,O.A., Weck,M.L., Unrath,W.C., Gallagher,J.W.,
            Cui,R., Kachar,B., Tyska,M.J. and Yengo,C.M.
  TITLE     Impact of the Motor and Tail Domains of Class III Myosins on
            Regulating the Formation and Elongation of Actin Protrusions
  JOURNAL   J Biol Chem 291 (43), 22781-22792 (2016)
   PUBMED   27582493
  REMARK    GeneRIF: MYO3A is more efficient than MYO3B at increasing formation
            and elongation of stable microvilli on the surface of cultured
            epithelial cells.
REFERENCE   3  (bases 1 to 6213)
  AUTHORS   Liu,H., Li,J., Raval,M.H., Yao,N., Deng,X., Lu,Q., Nie,S., Feng,W.,
            Wan,J., Yengo,C.M., Liu,W. and Zhang,M.
  TITLE     Myosin III-mediated cross-linking and stimulation of actin bundling
            activity of Espin
  JOURNAL   Elife 5, e12856 (2016)
   PUBMED   26785147
  REMARK    GeneRIF: The structures of Myo3 in complex with Espin1 not only
            elucidate the mechanism of the binding, but also reveal a
            Myo3-induced release of Espin1 auto-inhibition mechanism.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6213)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   5  (bases 1 to 6213)
  AUTHORS   Taipale,M., Krykbaeva,I., Koeva,M., Kayatekin,C., Westover,K.D.,
            Karras,G.I. and Lindquist,S.
  TITLE     Quantitative analysis of HSP90-client interactions reveals
            principles of substrate recognition
  JOURNAL   Cell 150 (5), 987-1001 (2012)
   PUBMED   22939624
REFERENCE   6  (bases 1 to 6213)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   7  (bases 1 to 6213)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   8  (bases 1 to 6213)
  AUTHORS   Dose,A.C., Hillman,D.W., Wong,C., Sohlberg,L., Lin-Jones,J. and
            Burnside,B.
  TITLE     Myo3A, one of two class III myosin genes expressed in vertebrate
            retina, is localized to the calycal processes of rod and cone
            photoreceptors and is expressed in the sacculus
  JOURNAL   Mol Biol Cell 14 (3), 1058-1073 (2003)
   PUBMED   12631723
REFERENCE   9  (bases 1 to 6213)
  AUTHORS   Dose,A.C. and Burnside,B.
  TITLE     A class III myosin expressed in the retina is a potential candidate
            for Bardet-Biedl syndrome
  JOURNAL   Genomics 79 (5), 621-624 (2002)
   PUBMED   11991710
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF391555.1, BC136620.1,
            AC012594.7, BX647895.1 and AC007277.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_138995.4.
            
            SUMMARY: This gene encodes one of the class III myosins. Myosins
            are ATPases, activated by actin, that move along actin filaments in
            the cell. This class of myosins are characterized by an
            amino-terminal kinase domain and shown to be present in
            photoreceptors. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Mar
            2014].
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF391555.1, BC136620.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408978.9/ ENSP00000386213.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AF391555.1         3-63
            62-2448             BC136620.1         1-2387
            2449-2749           AF391555.1         2451-2751
            2750-3251           BC136620.1         2689-3190
            3252-3252           AC012594.7         17487-17487         c
            3253-3385           BC136620.1         3192-3324
            3386-3386           AC012594.7         16411-16411         c
            3387-5527           AF391555.1         3389-5529
            5528-5718           BX647895.1         4615-4805
            5719-5719           AC007277.2         41717-41717         c
            5720-6210           BX647895.1         4806-5296
            6211-6213           AC007277.2         41223-41225         c
FEATURES             Location/Qualifiers
     source          1..6213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..6213
                     /gene="MYO3B"
                     /note="myosin IIIB"
                     /db_xref="GeneID:140469"
                     /db_xref="HGNC:HGNC:15576"
                     /db_xref="MIM:610040"
     exon            1..143
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..4167
                     /gene="MYO3B"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="myosin-IIIb isoform 2"
                     /protein_id="NP_620482.3"
                     /db_xref="CCDS:CCDS42773.1"
                     /db_xref="GeneID:140469"
                     /db_xref="HGNC:HGNC:15576"
                     /db_xref="MIM:610040"
                     /translation="MKHLYGLFHYNPMMLGLESLPDPTDTWEIIETIGKGTYGKVYKV
                     TNKRDGSLAAVKILDPVSDMDEEIEAEYNILQFLPNHPNVVKFYGMFYKADHCVGGQL
                     WLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGN
                     NILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCD
                     VWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIK
                     DFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNPVAKTRHERMHTRRPY
                     HVEDAEKYCLEDDLVNLEVLDEDTIIHQLQKRYADLLIYTYVGDILIALNPFQNLSIY
                     SPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQCIVISGESGSGKTESAHLIV
                     QHLTFLGKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRFGKYLEMMFTPTGVVMG
                     ARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSDFRLPEEKPPRYIADETG
                     RVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISSQH
                     QTDKSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDA
                     MSKALYGRLFSWIVNRINTLLQPDENICSAGGGMNVGILDIFGFENFQRNSFEQLCIN
                     IANEQIQYYFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEE
                     SRFPQATDQTLVDKFEDNLRCKYFWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTL
                     PADVVVVLRTSENKLLQQLFSIPLTKTGNLAQTRARITVASSSLPPHFSAGKAKVDTL
                     EVIRHPEETTNMKRQTVASYFRYSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRER
                     VLAQLRSTGILETVSIRRQGYSHRILFEEFVKRYYYLAFTAHQTPLASKESCVAILEK
                     SRLDHWVLGKTKVFLKYYHVEQLNLLLREVIGRVVVLQAYTKGWLGARRYKRVREKRE
                     KGAIAIQSAWRGYDARRKFKKISNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGSAE
                     VQDCSEPGDHKVLRGSVHRRSHSQAESNNGRTQTSSNSPAVTEKNGHSQAQSSPKGCD
                     IFAGHANKHSVSGTDLLSSRICHPAPDQQGLSLWGAPQKPGSENGLAQKHRTPRRRCQ
                     QPKMLSSPEDTMYYNQLNGTLEYQGSKRKPRKLGQIKVLDGEDEYYKSLSPVDCIPEE
                     NNSAHPSFFSSSSKGDSFAQH"
     exon            144..327
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            328..462
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            463..567
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            568..667
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            668..744
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            745..890
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            891..956
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1112
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1209
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1326
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1431
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1515
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1718
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1817
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1932
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2059
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2270
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2418
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2572
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2661
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2791
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2792..2871
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..2949
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3155
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3267
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3430
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3431..3511
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3613
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3614..3716
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..3777
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..3874
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3875..3981
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            3982..4028
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..6213
                     /gene="MYO3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6190..6195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO3B"
                     /note="hexamer: AATAAA"
     polyA_site      6213
                     /gene="MYO3B"
                     /note="major polyA site"
ORIGIN      
        1 agatcgaaag tcctttggta atgatgtgtc atacattcta gtcatcaaag acaccatttt
       61 ctgggcctga agtgttctgc tggtttttgg aggaatgaga atccaatctc tcataagccg
      121 gattcagaaa ataggtcatc gatgaaacat ctgtatggat tatttcacta taatcctatg
      181 atgcttggac ttgaatcact tccagatccc acagacacct gggaaattat agagaccatt
      241 ggtaaaggca cctatggcaa agtctacaag gtaactaaca agagagatgg gagcctggct
      301 gcagtgaaaa ttctggatcc agtcagtgat atggatgaag aaattgaggc agaatacaac
      361 attttgcagt tccttcctaa tcatcccaat gttgtaaagt tttatgggat gttttacaaa
      421 gcggatcact gtgtaggggg acagctgtgg ctggtcctgg agctgtgtaa tgggggctca
      481 gtcactgagc ttgtcaaagg tctactcaga tgtggccagc ggttggatga agcaatgatc
      541 tcatacatct tgtacggggc cctcttgggc cttcagcatt tgcacaacaa ccgaatcatc
      601 caccgtgatg tgaaggggaa taacattctt ctgacaacag aaggaggagt taagctcgtt
      661 gactttggtg tttcagctca actcaccagt acacgtctgc ggagaaacac atctgttggc
      721 accccgttct ggatggcccc tgaggtcatt gcctgtgagc agcagtatga ctcttcctat
      781 gacgctcgct gtgacgtctg gtccttgggg atcacagcta ttgaactggg ggatggagac
      841 cctcccctct ttgacatgca tcctgtgaaa acactcttta agattccaag aaatcctcca
      901 cctactttac ttcatccaga aaaatggtgt gaagaattca accactttat ttcacagtgt
      961 cttattaagg attttgaaag gcgaccttcc gtcacacatc tccttgacca cccatttatt
     1021 aaaggagtac atggaaaagt tctgtttctg caaaaacagc tggccaaggt tctccaagac
     1081 cagaagcatc aaaatcctgt tgctaaaacc aggcatgaga ggatgcatac cagaagacct
     1141 tatcatgtgg aagatgctga aaaatactgc cttgaggatg atttggtcaa cctagaggtt
     1201 ctggatgagg atacaattat ccatcagttg cagaaacgtt atgcagactt gctaatttac
     1261 acatatgttg gagacatctt aattgcctta aaccccttcc agaatctaag catatactct
     1321 ccacagtttt ccagacttta tcatggggtg aaacgcgcct ccaatccccc ccacatattt
     1381 gcatcagcag atgctgctta ccagtgcatg gttactctca gcaaagacca gtgcattgtc
     1441 atcagcggag agagtggctc tgggaagaca gaaagcgccc acctgattgt tcagcatttg
     1501 actttcttgg gaaaggccaa taatcagacc ttgagagaga aaattctaca agtcaactcc
     1561 ctggtggaag cctttgggaa ctcatgcact gccatcaatg acaactcgag ccgttttgga
     1621 aaatatctgg aaatgatgtt tacaccaact ggagttgtga tgggggcaag aatctctgaa
     1681 tatctcctgg aaaaatccag agttataaaa caggcagcga gagagaaaaa ttttcatata
     1741 ttttactata tttatgctgg tcttcatcac caaaagaagc tttctgattt cagacttcct
     1801 gaggaaaaac ctcctaggta catagctgat gaaactggaa gggtgatgca cgacataact
     1861 tccaaggagt cttacagaag acaattcgaa gcaattcagc attgcttcag gattataggg
     1921 ttcacggaca aagaggtgca ctcagtgtac agaattttgg ctgggatttt gaatattggg
     1981 aacattgagt tcgcagctat ttcctctcaa catcagactg ataaaagtga ggtgcccaat
     2041 gctgaagctt tgcaaaatgc tgcctctgtt ctgtgcatta gccctgaaga gctccaggag
     2101 gccctcacct cccactgtgt ggtcacccgg ggcgagacca tcatccgtgc caacactgta
     2161 gacagggctg cggacgttcg agacgccatg tccaaagccc tgtatgggag gctcttcagc
     2221 tggattgtga atcgcattaa tacactcctg cagccagacg aaaacatatg tagtgcagga
     2281 ggtggaatga atgtggggat cttggatatc tttggattcg agaattttca gagaaattca
     2341 tttgagcagc tctgcataaa catcgccaat gagcaaatcc agtactattt caatcagcat
     2401 gtttttgctc ttgagcagat ggaatatcag aatgaaggca ttgatgctgt acccgtggaa
     2461 tatgaggaca accgcccgct cttggacatg ttcctccaga aacccctggg actgcttgca
     2521 cttttggatg aggaaagtcg gtttccccaa gcaactgacc agaccctggt tgataaattt
     2581 gaagataatc tacgatgcaa atacttctgg aggcccaaag gagtggaact gtgctttggc
     2641 attcagcatt atgctggaaa ggtattatat gatgcttctg gggttcttga gaaaaataga
     2701 gacactctcc ctgccgatgt ggttgtggtc ctgagaacgt cagaaaacaa gcttcttcag
     2761 cagctcttct caatccctct gaccaaaaca ggtaatttgg cccagacaag agctaggata
     2821 acagtggcct caagttcttt gcctccacat ttcagtgctg ggaaagccaa ggtggacact
     2881 ctggaggtga tacggcatcc ggaagaaacc accaacatga agaggcaaac tgtggcttct
     2941 tacttccggt attctctgat ggacctgctc tccaaaatgg tggttggaca gccccacttt
     3001 gtgcgctgca ttaaacccaa tgatgaccga gaggccctgc agttctctcg agagagggtg
     3061 ctggcccagc tccgctccac agggattctg gagacagtca gcatccgccg ccagggctat
     3121 tcccaccgca tcctttttga agaatttgtg aaaaggtatt attacttggc attcacagca
     3181 catcaaacac ctcttgctag caaagagagc tgtgtggcta tcttggaaaa gtccagatta
     3241 gatcactggg tactgggaaa aacaaaggtt tttctcaaat attaccatgt tgagcaatta
     3301 aatttgctgc ttcgagaagt cataggcaga gtggttgtgc tgcaggcata taccaagggg
     3361 tggcttggag ccaggagata caaaagggtc agagagaaga gagagaaggg agccattgcc
     3421 atccagtcag cctggagagg atatgatgct cggaggaaat ttaagaaaat aagcaacaga
     3481 aggaatgagt ctgctgctca taatcaagca ggggacactt caaaccaaag cagtgggcca
     3541 cattcccccg tcgcagcagg tacgagggga agtgccgagg ttcaagactg cagcgagcct
     3601 ggtgaccata aagttctcag gggctctgta catcgtagga gccattcaca agcagaatcc
     3661 aacaatggcc gtacacagac ttcaagcaac tctcctgctg tcacagagaa aaatgggcat
     3721 tcacaagccc agagttctcc aaaagggtgc gatatcttcg caggacatgc aaacaagcac
     3781 tcggtttctg ggactgattt gctgtcttct cggatatgcc atcctgctcc agatcagcaa
     3841 ggattgagtc tctggggagc ccctcaaaag cctggttcag aaaatggtct tgcacagaag
     3901 catcgaacac ctcgccgacg atgtcagcag cccaaaatgc tgagtagccc tgaggacacc
     3961 atgtactata accagttaaa tggaactcta gaatatcaag ggagcaagag gaagccaaga
     4021 aaacttggcc aaatcaaagt acttgatggg gaagatgaat attacaaatc tctgtcacca
     4081 gtggactgta tccctgagga gaacaactca gcccaccctt cctttttttc ttcatcctca
     4141 aaaggagact cttttgctca acattaaatt gtgcttccta accctaaatc tgtccagagt
     4201 aggaacattc atggtaatcg actgtctgtc attgcgtaag aaagcactga tatggggtca
     4261 gcttctttgg acatatggtc catgcctgaa ccttactgaa ccacttgcag attccaaaac
     4321 atcttatcct atcctctacc actctcccac atgtgttgtg cagcctgagc tgggcgctgc
     4381 cttcctttct catcccatgg ggccctgtgg gacactgaga acacctttac aatagtttaa
     4441 acagtcattc atgcccccag tgtctaggaa gataacagcc agtctcaccc cagtctaatc
     4501 atggaccctg ataatattgc ttgatttttc ctatcaagtt acttttcaat ccattcagaa
     4561 tctgccccag tggagaccca ggagttcctt tcctgcactc ttctccatcc tcccaccttt
     4621 gctgggcttt tctatcactc ccacctcccc cagagtcagg gctccattgc tgagtgcccc
     4681 atcctggagg attggcccca agatctccta gaacaggata attgcctgtg tttaggcaga
     4741 taggcctaaa tctttcagat tctttctaca aggcaaataa cccctctctt gttaattatg
     4801 atgctgagaa agcctctgtc tctttatttc accttgccaa gacacccaca ctactttggt
     4861 gatgaaaaga aaggaatgag agggaaagtt tggacctgtc actttggtga cagggaaagt
     4921 ccaggtcact ttattctgta actctccatt cactggtcaa ataactccat gaggctatca
     4981 gtggctacag tggaaggacc tgatcttgtc catctttgtg tgcacagagc ctagcacagg
     5041 gcttggtaga gggtatatct agtgaatgga gaatacatgg agaaacttaa ctaagttaca
     5101 caagcatatc tgacaggaat gttaccttca attgtatgtt acatatgatt agtcactttt
     5161 catacactat aacctctgat ttttcactca agtttgggct gattatattg taatgatgtt
     5221 agataatact caacatgatt cagtatgaca aacttttttg agcacctact ttatataaaa
     5281 catgacaaat tgcagtgtga tgtaatcaaa aacaaagaag ccctataaga ccatttctct
     5341 agaacagatg ttcttaatat ttttcttact ctaaaatatg tggtagatag tatgcaagaa
     5401 aagccgggtg cggtggctca ggcctgtaat cccagcactt tgggaggcca agatgggcgg
     5461 atcatgaagt caggagttcg agaccagcct gaccaacatg gtgaaacccc gtctctacta
     5521 aaaaaaataa tgataataca aaaattagcc cagcatggtg gtgcatacct gtaatcccag
     5581 ctactcagga ggctgacgca ggagaatcac ttgaacccgg gaagcaaagg ttgcagtcag
     5641 ctgagagcgc accactgcac tccagcctgg gcgacagggc aagactctgt ctcaaaaaaa
     5701 aaaaaaaaaa aaaaaaaaag agatagtatg caagaagaca cctaaatttt gagagaaata
     5761 accttgaaga aaatcttgtt atcagagttt tgaaagggag cacattaata ggccttttat
     5821 gaagataaat aatgaaatga ggtatttaaa gatctcagaa attgtaattt tacaagtaaa
     5881 ataaatatag ccaatttttc aatagctgaa cttcacccaa aaggtaatgt ttataagtag
     5941 agcagaaaaa atgcagataa attttatttt attgtttaaa aaataatgtg tagaatatat
     6001 aaatttttta tgttactgtt aatatacgag tgcttttgga agtttcactt ttgtcactga
     6061 ttgtctactt ttggtttgat aatatgagct gcttttcaaa ttgttgaatg gaaatgttca
     6121 taactccctg cttgtccgtg cacaatgtaa ttctaaacct ggcttgtttc tcatttaaat
     6181 atatctataa ataaacttaa aaagaaaaca gaa
//
