LOCUS       NM_001101421            4375 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens myosin IH (MYO1H), mRNA.
ACCESSION   NM_001101421 XM_001125815 XM_001132344
VERSION     NM_001101421.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4375)
  AUTHORS   Selcuk,E., Kirimtay,K., Temizci,B., Akarsu,S., Everest,E.,
            Baslo,M.B., Demirkiran,M., Yapici,Z. and Karabay,A.
  TITLE     MYO1H is a novel candidate gene for autosomal dominant pure
            hereditary spastic paraplegia
  JOURNAL   Mol Genet Genomics 297 (4), 1141-1150 (2022)
   PUBMED   35704118
  REMARK    GeneRIF: MYO1H is a novel candidate gene for autosomal dominant
            pure hereditary spastic paraplegia.
REFERENCE   2  (bases 1 to 4375)
  AUTHORS   Dalaie,K., Yassaee,V.R., Behnaz,M., Yazdanian,M., Jafari,F. and
            Farimani,R.M.
  TITLE     Relationship of the rs10850110 and rs11611277 polymorphisms of the
            MYO1H gene with non-syndromic mandibular prognathism in the Iranian
            population
  JOURNAL   Dent Med Probl 57 (4), 433-440 (2020)
   PUBMED   33448167
  REMARK    GeneRIF: Relationship of the rs10850110 and rs11611277
            polymorphisms of the MYO1H gene with non-syndromic mandibular
            prognathism in the Iranian population.
REFERENCE   3  (bases 1 to 4375)
  AUTHORS   Cunha,A., Nelson-Filho,P., Maranon-Vasquez,G.A., Ramos,A.G.C.,
            Dantas,B., Sebastiani,A.M., Silverio,F., Omori,M.A.,
            Rodrigues,A.S., Teixeira,E.C., Levy,S.C., Araujo,M.C.,
            Matsumoto,M.A.N., Romano,F.L., Antunes,L.A.A., Costa,D.J.D.,
            Scariot,R., Antunes,L.S., Vieira,A.R. and Kuchler,E.C.
  TITLE     Genetic variants in ACTN3 and MYO1H are associated with sagittal
            and vertical craniofacial skeletal patterns
  JOURNAL   Arch Oral Biol 97, 85-90 (2019)
   PUBMED   30366217
  REMARK    GeneRIF: ACTN3 and MYO1H are associated with sagittal and vertical
            craniofacial skeletal patterns in Brazilian populations.
REFERENCE   4  (bases 1 to 4375)
  AUTHORS   Sun,R., Wang,Y., Jin,M., Chen,L., Cao,Y. and Chen,F.
  TITLE     Identification and Functional Studies of MYO1H for Mandibular
            Prognathism
  JOURNAL   J Dent Res 97 (13), 1501-1509 (2018)
   PUBMED   29986156
  REMARK    GeneRIF: A nonsynonymous common variant of MYO1H rs3825393, C>T,
            p.Pro1001Leu, was identified to be significantly associated with
            MP.
REFERENCE   5  (bases 1 to 4375)
  AUTHORS   Spielmann,M., Hernandez-Miranda,L.R., Ceccherini,I.,
            Weese-Mayer,D.E., Kragesteen,B.K., Harabula,I., Krawitz,P.,
            Birchmeier,C., Leonard,N. and Mundlos,S.
  TITLE     Mutations in MYO1H cause a recessive form of central
            hypoventilation with autonomic dysfunction
  JOURNAL   J Med Genet 54 (11), 754-761 (2017)
   PUBMED   28779001
  REMARK    GeneRIF: MYO1H is an important gene in CO2 sensitivity and
            respiratory control and has been associated with a rare recessive
            form of congenital central hypoventilation.
REFERENCE   6  (bases 1 to 4375)
  AUTHORS   Arun,R.M., Lakkakula,B.V. and Chitharanjan,A.B.
  TITLE     Role of myosin 1H gene polymorphisms in mandibular retrognathism
  JOURNAL   Am J Orthod Dentofacial Orthop 149 (5), 699-704 (2016)
   PUBMED   27131252
  REMARK    GeneRIF: The single nucleotide polymorphism rs3825393 of the MYO1H
            gene showed a statistically significant association with mandibular
            retrognathism
REFERENCE   7  (bases 1 to 4375)
  AUTHORS   Tassopoulou-Fishell,M., Deeley,K., Harvey,E.M., Sciote,J. and
            Vieira,A.R.
  TITLE     Genetic variation in myosin 1H contributes to mandibular
            prognathism
  JOURNAL   Am J Orthod Dentofacial Orthop 141 (1), 51-59 (2012)
   PUBMED   22196185
  REMARK    GeneRIF: can contribute to mandibular prognathism
REFERENCE   8  (bases 1 to 4375)
  AUTHORS   Dumont,R.A., Zhao,Y.D., Holt,J.R., Bahler,M. and Gillespie,P.G.
  TITLE     Myosin-I isozymes in neonatal rodent auditory and vestibular
            epithelia
  JOURNAL   J Assoc Res Otolaryngol 3 (4), 375-389 (2002)
   PUBMED   12486594
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012384.16 and AC007570.23.
            
            On Jul 8, 2021 this sequence version replaced NM_001101421.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1968968
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000310903.10/ ENSP00000439182.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC012384.16        90791-90863         c
            74-235              AC012384.16        49919-50080         c
            236-351             AC012384.16        45317-45432         c
            352-550             AC012384.16        42181-42379         c
            551-631             AC012384.16        40951-41031         c
            632-811             AC012384.16        37491-37670         c
            812-910             AC012384.16        34683-34781         c
            911-1024            AC012384.16        32728-32841         c
            1025-1096           AC012384.16        31903-31974         c
            1097-1216           AC012384.16        30850-30969         c
            1217-1284           AC012384.16        29139-29206         c
            1285-1390           AC012384.16        28695-28800         c
            1391-1471           AC012384.16        27995-28075         c
            1472-1563           AC012384.16        26778-26869         c
            1564-1658           AC012384.16        23143-23237         c
            1659-1705           AC012384.16        17736-17782         c
            1706-1786           AC012384.16        13935-14015         c
            1787-1892           AC012384.16        12712-12817         c
            1893-2010           AC012384.16        11177-11294         c
            2011-2124           AC012384.16        5753-5866           c
            2125-2201           AC012384.16        3650-3726           c
            2202-2270           AC012384.16        2207-2275           c
            2271-2355           AC012384.16        143-227             c
            2356-2515           AC007570.23        166378-166537       c
            2516-2599           AC007570.23        165341-165424       c
            2600-2693           AC007570.23        164460-164553       c
            2694-2749           AC007570.23        163896-163951       c
            2750-2885           AC007570.23        162519-162654       c
            2886-2956           AC007570.23        161885-161955       c
            2957-3054           AC007570.23        161639-161736       c
            3055-3154           AC007570.23        160556-160655       c
            3155-4375           AC007570.23        157789-159009       c
FEATURES             Location/Qualifiers
     source          1..4375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..4375
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /note="myosin IH"
                     /db_xref="GeneID:283446"
                     /db_xref="HGNC:HGNC:13879"
                     /db_xref="MIM:614636"
     exon            1..73
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..3178
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /note="myosin-Ih; myosin-1H"
                     /codon_start=1
                     /product="unconventional myosin-Ih"
                     /protein_id="NP_001094891.4"
                     /db_xref="CCDS:CCDS53826.2"
                     /db_xref="GeneID:283446"
                     /db_xref="HGNC:HGNC:13879"
                     /db_xref="MIM:614636"
                     /translation="MESKKEDVRRKHIRLHMEGALTARDKVGVQDFVLLDAYTSESAF
                     VDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTVSQMELYQGVNFFELPPHVYAIAD
                     NAYRMMCAELNNHFILISGESGAGKTEASKKILEYFAVTCPMTQSLQIARDRLLFSNP
                     VLEAFGNARTLRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQNEGERNF
                     HIFYQLLAGGEEERLSYLGLERDPQLYKYLSQGHCAKESSISDKNDWKTVSNAFSVID
                     FTEADLENLFGIIASVLHLGNIGFEEDDQGCATIPDTHEIKWIAKLLGVHPSVLLEAL
                     THRKIEAKTEEVICPLTLELSVYARDAMAKAVYGRTFTWLVNKINSSLVNKDFTRKTV
                     IGLLDIYGFEVFDKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIKYF
                     NNKIICDLVEERHKGIISILDEECIRPGPATDLSFLEKLEEKVGKHAHFETRKLAGPK
                     GRKRIGWMEFRLLHYAGEVTYCTKGFLEKNNDLLYRHLKEVLCKSKNIILRECFLLAE
                     LENRRRPPTVGTQFKNSLSSLLETLISKEPSYIRCIKPNDRKEPSKFDDFLIRHQIKY
                     LGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWHGPPAEGVERLIKYIGYKPE
                     EYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVARIQATYKRCLGRREYVKKRQAAIKL
                     EAHWRGALARKAIQRRKWAVRIIRKFIKGFISRNKPLCPDNEEFIVFVRKNYILNLRY
                     HLPKTVLDKSWLRPPGILENASDLLRKMCVRNLVQKYCRGITAERKAMMQQKVVTSEI
                     FRGRKDGYTESLNQPFVNSRIDEGDINPKVLQLISHEKIQYGVPVIKYDRKGFKARQR
                     QLILTQKAAYVVELAKIKQKIEYSALKGVSTSNLSDGILVIHVSPEDSKQKGDAVLQC
                     GHVFEAVTKLVMLVKKENIVNVVQGSLQFFISPGKEGTIVFDTGLEEQVYKNKNGQLT
                     VVSVRRKS"
     exon            74..235
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            236..351
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            352..550
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..631
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..811
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..910
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1024
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1096
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1216
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1284
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1390
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1471
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1563
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1658
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1705
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1786
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1892
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2010
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2124
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2201
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2270
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2355
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2515
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2599
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2693
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2749
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..2885
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2956
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3054
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3154
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..4375
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3881..3886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /note="hexamer: AATAAA"
     polyA_site      3901
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /note="major polyA site"
     regulatory      3921..3926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /note="hexamer: AATAAA"
     polyA_site      3944
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
     regulatory      4302..4307
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /note="hexamer: AGTAAA"
     polyA_site      4321
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /note="major polyA site"
     regulatory      4347..4352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
                     /note="hexamer: AATAAA"
     polyA_site      4375
                     /gene="MYO1H"
                     /gene_synonym="CCHS2"
ORIGIN      
        1 agcaactttt gaatggctca agaggaatag ttgttaacaa cctgctctcc ctctgtgcgt
       61 gatggaatcc aagaaagaag acgtgaggag gaaacacatc cgtctgcaca tggaaggggc
      121 gctgactgcc cgggacaagg tcggggttca ggattttgtg ctattggacg cgtacaccag
      181 cgaatctgcc tttgtcgaca acctccgcaa gcgtttcagc gagaacctca tatacacata
      241 tattggcacc ctccttgtgt ctgtgaatcc ataccaggag ctcggaatct acactgtgag
      301 ccagatggaa ctttatcaag gggtcaattt ctttgaactg ccaccacatg tctacgctat
      361 agccgacaac gcttaccgaa tgatgtgtgc tgaactaaat aaccatttca tcctcatttc
      421 tggagagagt ggggcaggga aaacagaggc ctccaagaaa attctcgagt attttgcagt
      481 gacctgccca atgacccagt cactacaaat agcccgtgac agactgctgt tctccaaccc
      541 agtgctggag gcttttggaa atgccagaac gctccggaat gacaactcca gcagatttgg
      601 gaaatacatg gatatacaat ttgattttca gggcattccc gtaggtgggc atatcatcag
      661 ttacttgata gagaagtccc gagttgtcta ccaaaacgaa ggcgagcgga atttccacat
      721 cttctaccag ctgctggcag gtggcgaaga ggagcgcctg tcttacctgg gactcgagcg
      781 agacccccag ctgtataaat acctctcaca gggtcattgt gccaaagagt catccattag
      841 tgacaagaat gactggaaaa ctgtttccaa cgccttttct gtcattgatt ttactgaagc
      901 tgacctcgag aatctctttg gaattattgc cagtgtctta cacctgggga acattggttt
      961 tgaagaagac gaccaaggct gtgccactat cccagacacc catgagatca agtggatagc
     1021 caagctcctg ggggtccacc catcagtcct tctggaagct ctcacccaca gaaaaattga
     1081 agccaaaact gaggaggtga tctgcccgtt gacactagaa ctctctgtct acgctagaga
     1141 tgcaatggca aaggctgttt atggacgaac gtttacttgg ctggtcaaca aaatcaattc
     1201 ctccttagtt aacaaggatt tcaccaggaa aactgtaatt ggattactgg acatctatgg
     1261 gtttgaagtc tttgacaaga atggttttga acagttctgt ataaattact gcaatgagaa
     1321 actccagcaa ctgttaattg agaggactct aaaagcagaa caggcagaat atgaaatgga
     1381 aggcatagag tgggagccaa ttaaatattt caacaacaag atcatctgtg atttggtaga
     1441 agagagacat aaaggaatca tatctattct ggatgaagaa tgcattcggc ctggtcctgc
     1501 tacagacttg agtttcctgg agaaattgga agagaaagtg ggcaaacatg cacacttcga
     1561 aacccgtaag ctggctggtc caaagggccg aaagaggatt ggctggatgg agttccgact
     1621 cctccactat gcaggagagg tcacatactg caccaaggga ttcttggaaa aaaacaatga
     1681 tcttctttac agacatctga aagaagtgct gtgcaagtcc aagaacatta tcctgaggga
     1741 atgcttcctg ctggccgagt tagaaaaccg gaggaggccc ccaacagtgg ggactcagtt
     1801 taaaaacagt ctgagcagcc ttctagaaac cctcatctct aaggagccct cctacatccg
     1861 ttgcatcaag cccaacgaca ggaaagaacc cagcaaattt gatgacttcc tcataaggca
     1921 tcagatcaaa tacctggggc tgatggagca cctgcgggtg agacgggctg gttttgcata
     1981 ccgaaggaaa tacgagcatt tcttgcaaag gtacaagtcc ttatgcccag acacctggcc
     2041 gcactggcac gggcctccag cagagggcgt ggaacggctg atcaagtaca tcggctacaa
     2101 acccgaggaa tacaagttag gcaaaaccaa aatattcatt cgtttcccca gaactctgtt
     2161 tgctaccgaa gatgcctttg aatttagtaa acatcaacta gttgcaagaa tccaagccac
     2221 ttacaaacgc tgcctaggaa ggagagaata cgtgaaaaaa agacaagcag ccatcaaact
     2281 ggaagcccac tggcgtgggg ccctggctcg gaaggcaatc caaaggagaa agtgggccgt
     2341 gcggattatc agaaagttca ttaaaggatt catcagtcgc aacaaacccc tctgtcctga
     2401 caacgaggaa tttatcgtgt ttgtgcggaa gaattacatc ttgaatctcc ggtatcacct
     2461 tccaaagact gtcctggaca agagctggct gaggcctcct ggcatcttgg aaaatgcatc
     2521 agatctgctc aggaaaatgt gcgtgaggaa cctggtgcag aagtactgcc gcgggatcac
     2581 agctgagcgg aaagcaatga tgcagcaaaa ggtagttaca agtgaaatct tcaggggaag
     2641 gaaagacggc tacacagaaa gtttaaatca accctttgtc aacagtcgga tagatgaagg
     2701 agacattaat ccgaaagtgc ttcagctaat tagccatgag aaaatccagt atggtgtccc
     2761 ggtcattaaa tatgacagaa aaggcttcaa agcacggcag cggcaactca ttcttactca
     2821 gaaagcagct tacgtggtgg aacttgccaa aatcaagcag aaaatagagt actcagctct
     2881 caaaggtgtc tccactagca atctgagtga tggaatctta gtcattcatg tttcaccaga
     2941 ggacagcaag caaaaggggg atgccgtttt gcagtgtgga cacgtgtttg aagcagttac
     3001 taaactcgtc atgctggtta agaaggagaa cattgtcaat gttgttcaag gaagtttaca
     3061 gttttttatt agtccgggaa aagaaggcac aatagttttc gacactggac tggaagaaca
     3121 agtctataaa aataaaaatg gacaattaac agtggtgtca gtccggagga agtcctgata
     3181 gaggatgacg tctgacctct accatcgcca tttttgctcc aactgaggaa actacagggg
     3241 aagtggggat tggatccagt tagctacctc ttcaaggtac caggcccgca gcactaacag
     3301 atcacatctg aagaaactga ggggcgttag gccaaagcct aatcccagct cctcagctgc
     3361 cccatggcac cttatttaaa atgtcacctt ctggaagcag accccaggtc acccgaaggc
     3421 gcaattctaa acaccctcga caggatctat gttcagtgcg cagtccaacg tgtcattaga
     3481 gggtgggcaa gattctctac ctctgtcaag ctgccctgag acatgatgaa atactgtgta
     3541 cagcaagttc tcaaataaca tttcgttata tgttgataag acatctgatt cctgggcagg
     3601 gccactgtct gggtggagtc tgtatgttct ccccatgtct ctgggtttct tctgggtgct
     3661 ctggtttcct cccacgtccc caaggtgtgt gtgtcaggtg cactggcgtg tctatgcggt
     3721 cccagtctga gtgagtgtgg gtgcgtgagc cccgtgagag gaggacatcc tgtccagggt
     3781 gggtcccgcc ttctgccctg agctgctggg attgggctct ggccatctgc aaccctgaac
     3841 gtgcaggttg gagaacgaat gaatacaaat tttattgtaa aataaaaatg tatataaagc
     3901 atatgagcac acaaatggac aataaatgcc acagcgcaaa agcgtgtagc gagcctgcca
     3961 cgcttgtgac tggggagggg ctccgtataa tctcaccttt gcaagcgttt atttactgat
     4021 gtatgcggcc accactgtga ccaccatcac ttaccgattc accaaaactt aggtaatatg
     4081 gtcttatttt tgatttaatt aaatatacgt gtagctcatg tatttcacag tttaatatga
     4141 gaagtgcttt ggtctttatt tagaaattgg gtgatgtttt tgtgcccagc aacatgctgt
     4201 aggaatttaa ctcttgttta catccattag cctcatggtt ttgcttcaag tctcagcttc
     4261 caagaaccta tcgatgactt actgtgcatg gtctgagact aagtaaagga aatttcctaa
     4321 agctgtgaaa tttgaatttt gctttaaata aatggaactc acatgtgtca aggga
//
