LOCUS       NM_033054               3188 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens myosin IG (MYO1G), mRNA.
ACCESSION   NM_033054 XM_291223 XM_374431
VERSION     NM_033054.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3188)
  AUTHORS   Lv,D., Wang,Y., Li,S., Shao,X. and Jin,Q.
  TITLE     Activation of MYO1G by lncRNA MNX1-AS1 Drives the Progression in
            Lung Cancer
  JOURNAL   Mol Biotechnol 65 (1), 72-83 (2023)
   PUBMED   35819746
  REMARK    GeneRIF: Activation of MYO1G by lncRNA MNX1-AS1 Drives the
            Progression in Lung Cancer.
REFERENCE   2  (bases 1 to 3188)
  AUTHORS   Rodriguez-Tellez,R.I., Ribas-Aparicio,R.M. and Patino-Lopez,G.
  TITLE     Detection of Myosin 1g Overexpression in Pediatric Leukemia by
            Novel Monoclonal Antibodies
  JOURNAL   Int J Mol Sci 23 (7), 3912 (2022)
   PUBMED   35409272
  REMARK    GeneRIF: Detection of Myosin 1g Overexpression in Pediatric
            Leukemia by Novel Monoclonal Antibodies.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3188)
  AUTHORS   Gonseth,S., de Smith,A.J., Roy,R., Zhou,M., Lee,S.T., Shao,X.,
            Ohja,J., Wrensch,M.R., Walsh,K.M., Metayer,C. and Wiemels,J.L.
  TITLE     Genetic contribution to variation in DNA methylation at maternal
            smoking-sensitive loci in exposed neonates
  JOURNAL   Epigenetics 11 (9), 664-673 (2016)
   PUBMED   27403598
  REMARK    GeneRIF: Maternal-smoking sensitive CpG sites in newborns were
            significantly associated with rs61087368 SNP located proximal to
            MYO1G.
REFERENCE   4  (bases 1 to 3188)
  AUTHORS   Lio,H.Y., Tang,J.L., Wu,J., Wu,S.J., Lin,C.Y. and Yang,Y.C.
  TITLE     Minor histocompatibility antigen HA-1 and HA-2 polymorphisms in
            Taiwan: frequency and application in hematopoietic stem cell
            transplantation
  JOURNAL   Clin Chem Lab Med 48 (9), 1287-1293 (2010)
   PUBMED   20509834
  REMARK    GeneRIF: the information on allele and genotype frequencies of HA-1
            and HA-2 in a Taiwanese population
REFERENCE   5  (bases 1 to 3188)
  AUTHORS   Patino-Lopez,G., Aravind,L., Dong,X., Kruhlak,M.J., Ostap,E.M. and
            Shaw,S.
  TITLE     Myosin 1G is an abundant class I myosin in lymphocytes whose
            localization at the plasma membrane depends on its ancient
            divergent pleckstrin homology (PH) domain (Myo1PH)
  JOURNAL   J Biol Chem 285 (12), 8675-8686 (2010)
   PUBMED   20071333
  REMARK    GeneRIF: Myosin 1G is an abundant class I myosin in lymphocytes
            whose localization at the plasma membrane depends on its ancient
            divergent pleckstrin homology (PH) domain
REFERENCE   6  (bases 1 to 3188)
  AUTHORS   Olety,B., Walte,M., Honnert,U., Schillers,H. and Bahler,M.
  TITLE     Myosin 1G (Myo1G) is a haematopoietic specific myosin that
            localises to the plasma membrane and regulates cell elasticity
  JOURNAL   FEBS Lett 584 (3), 493-499 (2010)
   PUBMED   19968988
REFERENCE   7  (bases 1 to 3188)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 3188)
  AUTHORS   Sellami,M.H., Torjemane,L., Espadas de Arias,A., Kaabi,H.,
            Ladeb,S., Ben Othman,T., Poli,F. and Hmida,S.
  TITLE     Mismatch for the minor histocompatibility antigen HA-2 and GVHD
            occurrence in HLA-A*0201-positive Tunisian recipients of HSCs
  JOURNAL   Immunol Invest 39 (6), 611-620 (2010)
   PUBMED   20653428
  REMARK    GeneRIF: gene polymorphism does not have any significant effect on
            the occurrence of GVHD in Tunisia
REFERENCE   9  (bases 1 to 3188)
  AUTHORS   Pierce,R.A., Field,E.D., Mutis,T., Golovina,T.N., Von Kap-Herr,C.,
            Wilke,M., Pool,J., Shabanowitz,J., Pettenati,M.J., Eisenlohr,L.C.,
            Hunt,D.F., Goulmy,E. and Engelhard,V.H.
  TITLE     The HA-2 minor histocompatibility antigen is derived from a
            diallelic gene encoding a novel human class I myosin protein
  JOURNAL   J Immunol 167 (6), 3223-3230 (2001)
   PUBMED   11544309
REFERENCE   10 (bases 1 to 3188)
  AUTHORS   den Haan,J.M., Sherman,N.E., Blokland,E., Huczko,E., Koning,F.,
            Drijfhout,J.W., Skipper,J., Shabanowitz,J., Hunt,D.F.,
            Engelhard,V.H. et al.
  TITLE     Identification of a graft versus host disease-associated human
            minor histocompatibility antigen
  JOURNAL   Science 268 (5216), 1476-1480 (1995)
   PUBMED   7539551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC117241.1, AC004847.3 and AA651942.1.
            
            On Nov 24, 2018 this sequence version replaced NM_033054.2.
            
            Summary: MYO1G is a plasma membrane-associated class I myosin (see
            MIM 601478) that is abundant in T and B lymphocytes and mast cells
            (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010
            [PubMed 20071333]).[supplied by OMIM, Jun 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB290179.1, BC117241.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258787.12/ ENSP00000258787.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1301              BC117241.1         38-1338
            1302-1302           AC004847.3         72632-72632
            1303-1519           BC117241.1         1340-1556
            1520-1536           AC004847.3         73014-73030
            1537-2635           BC117241.1         1574-2672
            2636-2636           AC004847.3         78292-78292
            2637-3170           BC117241.1         2674-3207
            3171-3188           AA651942.1         36-53               c
FEATURES             Location/Qualifiers
     source          1..3188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..3188
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /note="myosin IG"
                     /db_xref="GeneID:64005"
                     /db_xref="HGNC:HGNC:13880"
                     /db_xref="MIM:600642"
     exon            1..149
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..3111
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /note="minor histocompatibility antigen HA-2; myosin-Ig"
                     /codon_start=1
                     /product="unconventional myosin-Ig"
                     /protein_id="NP_149043.2"
                     /db_xref="CCDS:CCDS34629.1"
                     /db_xref="GeneID:64005"
                     /db_xref="HGNC:HGNC:13880"
                     /db_xref="MIM:600642"
                     /translation="MEDEEGPEYGKPDFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGE
                     VLVSVNPYQELPLYGPEAIARYQGRELYERPPHLYAVANAAYKAMKHRSRDTCIVISG
                     ESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVLLKSTCVLEAFGNARTNRNHNSS
                     RFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDKQLHE
                     LHLERNPAVYNFTHQGAGLNMTVHSALDSDEQSHQAVTEAMRVIGFSPEEVESVHRIL
                     AAILHLGNIEFVETEEGGLQKEGLAVAEEALVDHVAELTATPRDLVLRSLLARTVASG
                     GRELIEKGHTAAEASYARDACAKAVYQRLFEWVVNRINSVMEPRGRDPRRDGKDTVIG
                     VLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGITWQSVEYFNN
                     ATIVDLVERPHRGILAVLDEACSSAGTITDRIFLQTLDMHHRHHLHYTSRQLCPTDKT
                     MEFGRDFRIKHYAGDVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMWPDGQQDI
                     TEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAY
                     LGLLENVRVRRAGFASRQPYSRFLLRYKMTCEYTWPNHLLGSDKAAVSALLEQHGLQG
                     DVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWRGTLARWRCRRLRAIYTIM
                     RWFRRHKVRAHLAELQRRFQAARQPPLYGRDLVWPLPPAVLQPFQDTCHALFCRWRAR
                     QLVKNIPPSDMPQIKAKVAAMGALQGLRQDWGCRRAWARDYLSSATDNPTASSLFAQR
                     LKTLQDKDGFGAVLFSSHVRKVNRFHKIRNRALLLTDQHLYKLDPDRQYRVMRAVPLE
                     AVTGLSVTSGGDQLVVLHARGQDDLVVCLHRSRPPLDNRVGELVGVLAAHCQGEGRTL
                     EVRVSDCIPLSHRGVRRLISVEPRPEQPEPDFRCARGSFTLLWPSR"
     exon            150..358
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            359..452
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            453..618
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            619..672
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            673..783
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            784..900
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1125
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1271
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1386
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1557
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1628
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1703
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1836
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2003
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2211
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2435
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2580
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..2685
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2799
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2954
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3188
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /note="hexamer: AATAAA"
     polyA_site      3188
                     /gene="MYO1G"
                     /gene_synonym="HA2; HLA-HA2; MHAG"
                     /note="major polyA site"
ORIGIN      
        1 actgtccttc cagcaggcac aggaaggtga ggcaaggtgt ttccagccgg caggatggag
       61 gacgaggaag gccctgagta tggcaaacct gactttgtgc ttttggacca agtgaccatg
      121 gaggacttca tgaggaacct gcagctcagg ttcgagaagg gccgcatcta cacctacatc
      181 ggtgaggtgc tggtgtccgt gaacccctac caggagctgc ccctgtatgg gcctgaggcc
      241 atcgccaggt accagggccg tgagctctat gagcggccac cccatctcta tgctgtggcc
      301 aacgccgcct acaaggcaat gaagcaccgg tccagggaca cctgcatcgt catctcaggg
      361 gagagtgggg cagggaagac agaagccagt aagcacatca tgcagtacat cgctgctgtc
      421 accaatccaa gccagagggc tgaggtggag agggtcaagg acgtgctgct caagtccacc
      481 tgtgtgctgg aggcctttgg caatgcccgc accaaccgca atcacaactc cagccgcttt
      541 ggcaagtaca tggacatcaa ctttgacttc aagggggacc cgatcggagg acacatccac
      601 agctacctac tggagaagtc tcgggtcctc aagcagcacg tgggtgaaag aaacttccac
      661 gccttctacc aattgctgag aggcagtgag gacaagcagc tgcatgaact gcacttggag
      721 agaaaccctg ctgtatacaa tttcacacac cagggagcag gactcaacat gactgtgcac
      781 agtgccttgg acagtgatga gcagagccac caggcagtga ccgaggccat gagggtcatc
      841 ggcttcagtc ctgaagaggt ggagtctgtg catcgcatcc tggctgccat attgcacctg
      901 ggaaacatcg agtttgtgga gacggaggag ggtgggctgc agaaggaggg cctggcagtg
      961 gccgaggagg cactggtgga ccatgtggct gagctgacgg ccacaccccg ggacctcgtg
     1021 ctccgctccc tgctggctcg cacagttgcc tcgggaggca gggaactcat agagaagggc
     1081 cacactgcag ctgaggccag ctatgcccgg gatgcctgtg ccaaggcagt gtaccagcgg
     1141 ctgtttgagt gggtggtgaa caggatcaac agtgtcatgg aaccccgggg ccgggatcct
     1201 cggcgtgatg gcaaggacac agtcattggc gtgctggaca tctatggctt cgaggtgttt
     1261 cccgtcaaca gtttcgagca gttctgcatc aactactgca acgagaagct gcagcagcta
     1321 ttcatccagc tcatcctgaa gcaggaacag gaagagtacg agcgcgaggg catcacctgg
     1381 cagagcgttg agtatttcaa caacgccacc attgtggatc tggtggagcg gccccaccgt
     1441 ggcatcctgg ccgtgctgga cgaggcctgc agctctgctg gcaccatcac tgaccgaatc
     1501 ttcctgcaga ccctggacat gcaccaccgc catcacctac actacaccag ccgccagctc
     1561 tgccccacag acaagaccat ggagtttggc cgagacttcc ggatcaagca ctatgcaggg
     1621 gacgtcacgt actccgtgga aggcttcatc gacaagaaca gagatttcct cttccaggac
     1681 ttcaagcggc tgctgtacaa cagcacggac cccactctac gggccatgtg gccggacggg
     1741 cagcaggaca tcacagaggt gaccaagcgc cccctgacgg ctggcacact cttcaagaac
     1801 tccatggtgg ccctggtgga gaaccttgcc tccaaggagc ccttctacgt ccgctgcatc
     1861 aagcccaatg aggacaaggt agctgggaag ctggatgaga accactgtcg ccaccaggtc
     1921 gcatacctgg ggctgctgga gaatgtgagg gtccgcaggg ctggcttcgc ttcccgccag
     1981 ccctactctc gattcctgct caggtacaag atgacctgtg aatacacatg gcccaaccac
     2041 ctgctgggct ccgacaaggc agccgtgagc gctctcctgg agcagcacgg gctgcagggg
     2101 gacgtggcct ttggccacag caagctgttc atccgctcac cccggacact ggtcacactg
     2161 gagcagagcc gagcccgcct catccccatc attgtgctgc tattgcagaa ggcatggcgg
     2221 ggcaccttgg cgaggtggcg ctgccggagg ctgagggcta tctacaccat catgcgctgg
     2281 ttccggagac acaaggtgcg ggctcacctg gctgagctgc agcggcgatt ccaggctgca
     2341 aggcagccgc cactctacgg gcgtgacctt gtgtggccgc tgccccctgc tgtgctgcag
     2401 cccttccagg acacctgcca cgcactcttc tgcaggtggc gggcccggca gctggtgaag
     2461 aacatccccc cttcagacat gccccagatc aaggccaagg tggccgccat gggggccctg
     2521 caagggcttc gtcaggactg gggctgccga cgggcctggg cccgagacta cctgtcctct
     2581 gccactgaca atcccacagc atcaagcctg tttgctcagc gactaaagac acttcaggac
     2641 aaagatggct tcggggctgt gctcttttca agccatgtcc gcaaggtgaa ccgcttccac
     2701 aagatccgga accgggccct cctgctcaca gaccagcacc tctacaagct ggaccctgac
     2761 cggcagtacc gggtgatgcg ggccgtgccc cttgaggcgg tgacggggct gagcgtgacc
     2821 agcggaggag accagctggt ggtgctgcac gcccgcggcc aggacgacct cgtggtgtgc
     2881 ctgcaccgct cccggccgcc attggacaac cgcgttgggg agctggtggg cgtgctggcc
     2941 gcacactgcc agggggaggg ccgcaccctg gaggttcgcg tctccgactg catcccacta
     3001 agccatcgcg gggtccggcg cctcatctcc gtggagccca ggccggagca gccagagccc
     3061 gatttccgct gcgctcgcgg ctccttcacc ctgctctggc ccagccgctg agcgcccgca
     3121 cccgccgcac cccgaggccg ccaattgtcc gccccgccag cgctgcaaat aaaccttctg
     3181 agtcagcc
//
