LOCUS       NM_012335               4180 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens myosin IF (MYO1F), transcript variant 1, mRNA.
ACCESSION   NM_012335
VERSION     NM_012335.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4180)
  AUTHORS   Liu,W., Yang,H., Xu,Q., Lee,J., Sun,J., Xue,S., Yang,X., Sun,X. and
            Che,C.
  TITLE     Role of MYO1F in neutrophil and macrophage recruitment and
            pro-inflammatory cytokine production in Aspergillus fumigatus
            keratitis
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113094 (2024)
   PUBMED   39276460
  REMARK    GeneRIF: Role of MYO1F in neutrophil and macrophage recruitment and
            pro-inflammatory cytokine production in Aspergillus fumigatus
            keratitis.
REFERENCE   2  (bases 1 to 4180)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4180)
  AUTHORS   Navines-Ferrer,A., Ainsua-Enrich,E., Serrano-Candelas,E.,
            Proano-Perez,E., Munoz-Cano,R., Gastaminza,G., Olivera,A. and
            Martin,M.
  TITLE     MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis
  JOURNAL   J Immunol 206 (10), 2277-2289 (2021)
   PUBMED   33941653
  REMARK    GeneRIF: MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell
            Exocytosis.
            Erratum:[J Immunol. 2021 Dec 1;207(11):2894. doi:
            10.4049/jimmunol.2100908.. PMID: 34716186]
REFERENCE   4  (bases 1 to 4180)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4180)
  AUTHORS   Mo,X.G., Liu,W., Yang,Y., Imani,S., Lu,S., Dan,G., Nie,X., Yan,J.,
            Zhan,R., Li,X., Deng,Y., Chen,B. and Cai,Y.
  TITLE     NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic
            biomarkers in patients with obstructive coronary artery: A weighted
            gene co-expression network analysis
  JOURNAL   J Cell Biochem 120 (10), 18219-18235 (2019)
   PUBMED   31245869
  REMARK    GeneRIF: NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive
            diagnostic biomarkers in patients with obstructive coronary artery:
            A weighted gene co-expression network analysis.
REFERENCE   6  (bases 1 to 4180)
  AUTHORS   Zadro,C., Alemanno,M.S., Bellacchio,E., Ficarella,R., Donaudy,F.,
            Melchionda,S., Zelante,L., Rabionet,R., Hilgert,N., Estivill,X.,
            Van Camp,G., Gasparini,P. and Carella,M.
  TITLE     Are MYO1C and MYO1F associated with hearing loss?
  JOURNAL   Biochim Biophys Acta 1792 (1), 27-32 (2009)
   PUBMED   19027848
  REMARK    GeneRIF: identification of 6 heterozygous missense mutations in
            MYO1C and additional 5 heterozygous missense mutations in MYO1F in
            bilateral sensorineural hearing loss
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4180)
  AUTHORS   Krugmann,S., Anderson,K.E., Ridley,S.H., Risso,N., McGregor,A.,
            Coadwell,J., Davidson,K., Eguinoa,A., Ellson,C.D., Lipp,P.,
            Manifava,M., Ktistakis,N., Painter,G., Thuring,J.W., Cooper,M.A.,
            Lim,Z.Y., Holmes,A.B., Dove,S.K., Michell,R.H., Grewal,A.,
            Nazarian,A., Erdjument-Bromage,H., Tempst,P., Stephens,L.R. and
            Hawkins,P.T.
  TITLE     Identification of ARAP3, a novel PI3K effector regulating both Arf
            and Rho GTPases, by selective capture on phosphoinositide affinity
            matrices
  JOURNAL   Mol Cell 9 (1), 95-108 (2002)
   PUBMED   11804589
REFERENCE   8  (bases 1 to 4180)
  AUTHORS   Crozet,F., el Amraoui,A., Blanchard,S., Lenoir,M., Ripoll,C.,
            Vago,P., Hamel,C., Fizames,C., Levi-Acobas,F., Depetris,D.,
            Mattei,M.G., Weil,D., Pujol,R. and Petit,C.
  TITLE     Cloning of the genes encoding two murine and human cochlear
            unconventional type I myosins
  JOURNAL   Genomics 40 (2), 332-341 (1997)
   PUBMED   9119401
REFERENCE   9  (bases 1 to 4180)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   10 (bases 1 to 4180)
  AUTHORS   Bement,W.M., Hasson,T., Wirth,J.A., Cheney,R.E. and Mooseker,M.S.
  TITLE     Identification and overlapping expression of multiple
            unconventional myosin genes in vertebrate cell types
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6549-6553 (1994)
   PUBMED   8022818
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11767. doi:
            10.1073/pnas.91.24.11767-c.. PMID: 7972138]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA380582.1, BC028071.1,
            AB210037.1 and AC092298.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_012335.3.
            
            Summary: Myosins are molecular motors that use the energy from ATP
            hydrolysis to generate force on actin filaments. The protein
            encoded by this gene is an unconventional myosin that may be
            involved in the intracellular movement of membrane-enclosed
            compartments. There is evidence to suggest that mutations in this
            gene can result in hearing loss. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB290178.1, AB210037.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000644032.2/ ENSP00000494550.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA380582.1         6-24
            20-3846             BC028071.1         1-3827
            3847-4168           AB210037.1         3851-4172
            4169-4180           AC092298.2         25299-25310         c
FEATURES             Location/Qualifiers
     source          1..4180
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..4180
                     /gene="MYO1F"
                     /note="myosin IF"
                     /db_xref="GeneID:4542"
                     /db_xref="HGNC:HGNC:7600"
                     /db_xref="MIM:601480"
     exon            1..136
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..3430
                     /gene="MYO1F"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myosin-ID; myosin-Ie; unconventional myosin-If"
                     /codon_start=1
                     /product="unconventional myosin-If isoform 1"
                     /protein_id="NP_036467.2"
                     /db_xref="CCDS:CCDS42494.1"
                     /db_xref="GeneID:4542"
                     /db_xref="HGNC:HGNC:7600"
                     /db_xref="MIM:601480"
                     /translation="MGSKERFHWQSHNVKQSGVDDMVLLPQITEDAIAANLRKRFMDD
                     YIFTYIGSVLISVNPFKQMPYFTDREIDLYQGAAQYENPPHIYALTDNMYRNMLIDCE
                     NQCVIISGESGAGKTVAAKYIMGYISKVSGGGEKVQHVKDIILQSNPLLEAFGNAKTV
                     RNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVMQNENERNFHIYYQLLEGAS
                     QEQRQNLGLMTPDYYYYLNQSDTYQVDGTDDRSDFGETLSAMQVIGIPPSIQQLVLQL
                     VAGILHLGNISFCEDGNYARVESVDLLAFPAYLLGIDSGRLQEKLTSRKMDSRWGGRS
                     ESINVTLNVEQAAYTRDALAKGLYARLFDFLVEAINRAMQKPQEEYSIGVLDIYGFEI
                     FQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIQYFNNKVVCDLIEN
                     KLSPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFNSWSAGFVIHHYAGK
                     VSYDVSGFCERNRDVLFSDLIELMQTSEQAFLRMLFPEKLDGDKKGRPSTAGSKIKKQ
                     ANDLVATLMRCTPHYIRCIKPNETKRPRDWEENRVKHQVEYLGLKENIRVRRAGFAYR
                     RQFAKFLQRYAILTPETWPRWRGDERQGVQHLLRAVNMEPDQYQMGSTKVFVKNPESL
                     FLLEEVRERKFDGFARTIQKAWRRHVAVRKYEEMREEASNILLNKKERRRNSINRNFV
                     GDYLGLEERPELRQFLGKRERVDFADSVTKYDRRFKPIKRDLILTPKCVYVIGREKVK
                     KGPEKGQVCEVLKKKVDIQALRGVSLSTRQDDFFILQEDAADSFLESVFKTEFVSLLC
                     KRFEEATRRPLPLTFSDTLQFRVKKEGWGGGGTRSVTFSRGFGDLAVLKVGGRTLTVS
                     VGDGLPKSSKPTRKGMAKGKPRRSSQAPTRAAPAPPRGMDRNGVPPSARGGPLPLEIM
                     SGGGTHRPPRGPPSTSLGASRRPRARPPSEHNTEFLNVPDQGMAGMQRKRSVGQRPVP
                     GVGRPKPQPRTHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDPSGWWKGRLHGQEG
                     LFPGNYVEKI"
     exon            137..274
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            275..364
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            365..459
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            460..547
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            548..637
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            638..769
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            770..904
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1037
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1234
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1315
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1402
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1489
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1657
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1743
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1825
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1932
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2031
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2176
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2291
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2292..2461
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2607
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2754
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2903
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..2987
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3183
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3353
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     exon            3354..4180
                     /gene="MYO1F"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3825..3830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1F"
                     /note="hexamer: AATAAA"
     polyA_site      3846
                     /gene="MYO1F"
                     /note="major polyA site"
ORIGIN      
        1 aactaaagcc gggagtccgg tgaacgggca gaagcagggc catgcccaag ccacccccaa
       61 gatccccctg aacctgcacc tccatcacga cccattcagg agcctccagg agcccagaca
      121 ccagcccccc accatgggca gcaaggagcg cttccactgg cagagccaca acgtgaagca
      181 gagcggcgtg gatgacatgg tgcttcttcc ccagatcacc gaagacgcca ttgccgccaa
      241 cctccggaag cgcttcatgg acgactacat cttcacctac atcggctctg tgctcatctc
      301 tgtaaacccc ttcaagcaga tgccctactt caccgaccgt gagatcgacc tctatcaggg
      361 cgcggcccag tatgagaatc ccccgcacat ctacgccctc acggacaaca tgtaccggaa
      421 catgcttatc gactgtgaga accagtgtgt catcattagt ggagagagtg gagctgggaa
      481 gacagtggca gccaaatata tcatgggcta catctccaag gtgtctggcg gaggcgagaa
      541 ggtccagcac gtcaaagata tcatcctgca gtccaacccg ctgctcgagg ccttcggcaa
      601 cgccaagact gtgcgcaaca acaattccag ccgctttggc aagtactttg agatccagtt
      661 cagccgaggt ggggagccag atgggggcaa gatctccaac ttcttgctgg agaagtcccg
      721 cgtggtcatg caaaatgaaa atgagaggaa cttccacatc tactaccagc tgctggaagg
      781 ggcctcccag gagcaaaggc agaacctggg cctcatgaca ccggactact attactacct
      841 caaccaatcg gacacctacc aggtggacgg cacggacgac agaagcgact ttggtgagac
      901 tctgagtgct atgcaggtta ttgggatccc gcccagcatc cagcagctgg tcctgcagct
      961 cgtggcgggg atcttgcacc tggggaacat cagtttctgt gaagacggga attacgcccg
     1021 agtggagagt gtggacctcc tggcctttcc cgcctacctg ctgggcattg acagcgggcg
     1081 actgcaggag aagctgacca gccgcaagat ggacagccgc tggggcgggc gcagcgagtc
     1141 catcaatgtg accctcaacg tggagcaggc agcctacacc cgtgatgccc tggccaaggg
     1201 gctctatgcc cgcctcttcg acttcctcgt ggaggccatc aaccgtgcta tgcagaaacc
     1261 ccaggaagag tacagcatcg gtgtgctgga catttacggc ttcgagatct tccagaaaaa
     1321 tggcttcgag cagttttgca tcaacttcgt caatgagaag ctgcagcaaa tctttatcga
     1381 acttaccctg aaggccgagc aggaggagta tgtgcaggaa ggcatccgct ggactccaat
     1441 ccagtacttc aacaacaagg tcgtctgtga cctcatcgaa aacaagctga gccccccagg
     1501 catcatgagc gtcttggacg acgtgtgcgc caccatgcac gccacgggcg ggggagcaga
     1561 ccagacactg ctgcagaagc tgcaggcggc tgtggggacc cacgagcatt tcaacagctg
     1621 gagcgccggc ttcgtcatcc accactacgc tggcaaggtc tcctacgacg tcagcggctt
     1681 ctgcgagagg aaccgagacg ttctcttctc cgacctcata gagctgatgc agaccagtga
     1741 gcaggccttc ctccggatgc tcttccccga gaagctggat ggagacaaga aggggcgccc
     1801 cagcaccgcc ggctccaaga tcaagaaaca agccaacgac ctggtggcca cactgatgag
     1861 gtgcacaccc cactacatcc gctgcatcaa acccaacgag accaagaggc cccgagactg
     1921 ggaggagaac agagtcaagc accaggtgga atacctgggc ctgaaggaga acatcagggt
     1981 gcgcagagcc ggcttcgcct accgccgcca gttcgccaaa ttcctgcaga ggtatgccat
     2041 tctgaccccc gagacgtggc cgcggtggcg tggggacgaa cgccagggcg tccagcacct
     2101 gcttcgggcg gtcaacatgg agcccgacca gtaccagatg gggagcacca aggtctttgt
     2161 caagaaccca gagtcgcttt tcctcctgga ggaggtgcga gagcgaaagt tcgatggctt
     2221 tgcccgaacc atccagaagg cctggcggcg ccacgtggct gtccggaagt acgaggagat
     2281 gcgggaggaa gcttccaaca tcctgctgaa caagaaggag cggaggcgca acagcatcaa
     2341 tcggaacttc gtcggggact acctggggct ggaggagcgg cccgagctgc gtcagttcct
     2401 gggcaagagg gagcgggtgg acttcgccga ttcggtcacc aagtacgacc gccgcttcaa
     2461 gcccatcaag cgggacttga tcctgacgcc caagtgtgtg tatgtgattg ggcgagagaa
     2521 agtgaagaag ggacctgaga agggccaggt gtgtgaagtc ttgaagaaga aagtggacat
     2581 ccaggctctg cggggagtct ccctcagcac gcgacaggac gacttcttca tcctccaaga
     2641 ggatgccgcc gacagcttcc tggagagcgt cttcaagacc gagtttgtca gccttctgtg
     2701 caagcgcttc gaggaggcga cgcggaggcc cctgcccctc accttcagcg acacactaca
     2761 gtttcgggtg aagaaggagg gctggggcgg tggcggcacc cgcagcgtca ccttctcccg
     2821 cggcttcggc gacttggcag tgctcaaggt tggcggtcgg accctcacgg tcagcgtggg
     2881 cgatgggctg cccaagagct ccaagcctac gcggaaggga atggccaagg gaaaacctcg
     2941 gaggtcgtcc caagccccta cccgggcggc ccctgcgccc cccagaggca tggatcgcaa
     3001 tggggtgccc ccctctgcca gagggggccc cctgcccctg gagatcatgt ctggaggggg
     3061 cacccacagg cctccccggg gccctccgtc cacatccctg ggagccagca gacgaccccg
     3121 ggcacgtccg ccctcagagc acaacacaga attcctcaac gtgcctgacc agggcatggc
     3181 cggcatgcag aggaagcgca gcgtggggca acggccagtg cctggtgtgg gccgacccaa
     3241 gccccagcct cggacacatg gtcccaggtg ccgggcccta taccagtacg tgggccaaga
     3301 tgtggacgag ctgagcttca acgtgaacga ggtcattgag atcctcatgg aagatccctc
     3361 gggctggtgg aagggccggc ttcacggcca ggagggcctt ttcccaggaa actacgtgga
     3421 gaagatctga gctgggccct gggatactgc cttctctttc gcccgcctat ctgcctgccg
     3481 gcctggtggg gagccaggcc ctgccaatga gagcctcgtt tacctgggct gcaatagcct
     3541 aaaagtccag tcctttggcc tccagtcctg cccaggccct gggtcaccag gtcactgctg
     3601 cagcccccgc ccctgggccc tggtcttcct ccaacatcac acctgctgcc cattctccat
     3661 ttctgtgtgt gtcaaagggg actaacagca gaatctacct cccaactgcc atgtgattaa
     3721 gaaatgggtc ttgagtcctg tgctgttggc aaagtgccag gcacagttgg ggaggggggg
     3781 gtccttaaca agcgtgactt tgctcattct gtcatcacta aggcaataaa cctttgccag
     3841 gtgaaagcac gagttaactt actaagtgcc caacaaggac gatgttttca cagccctgtg
     3901 aggtaggagc tgtgaaggac cccatcttac aggtggaaca atggaggttc agagaggttc
     3961 actgacccaa gactgcacag agccatgcct tgcattcata tgtgaccata aagcttgaat
     4021 ttgtcccagt ttgggctggg cgcagtggct cacgcctgta atcccagcac tttgggaggc
     4081 tgaggcgggc agatcacgtg agaccaggag ttcaagacca gcctggataa cacagcaaaa
     4141 ccctgtttct actaaaaatt taaaaaagaa aaaaaaaaaa
//
