LOCUS       NM_015194               5510 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens myosin ID (MYO1D), transcript variant 1, mRNA.
ACCESSION   NM_015194 XM_050041
VERSION     NM_015194.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5510)
  AUTHORS   Yuan,Z., Zhu,X., Xie,X., Wang,C., Gu,H., Yang,J., Fan,L., Xiang,R.,
            Yang,Y. and Tan,Z.
  TITLE     Identification of a novel MYO1D variant associated with laterality
            defects, congenital heart diseases, and sperm defects in humans
  JOURNAL   Front Med 18 (3), 558-564 (2024)
   PUBMED   38684630
  REMARK    GeneRIF: Identification of a novel MYO1D variant associated with
            laterality defects, congenital heart diseases, and sperm defects in
            humans.
REFERENCE   2  (bases 1 to 5510)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5510)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 5510)
  AUTHORS   Benesh,A.E., Fleming,J.T., Chiang,C., Carter,B.D. and Tyska,M.J.
  TITLE     Expression and localization of myosin-1d in the developing nervous
            system
  JOURNAL   Brain Res 1440, 9-22 (2012)
   PUBMED   22284616
REFERENCE   5  (bases 1 to 5510)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   6  (bases 1 to 5510)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   7  (bases 1 to 5510)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030602.2, AB018270.2, AC007982.2 and BC030796.2.
            
            On Nov 23, 2018 this sequence version replaced NM_015194.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146763.1, AB018270.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318217.10/ ENSP00000324527.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               BC030602.2         54-293
            241-1421            AB018270.2         1-1181
            1422-1422           AC007982.2         103024-103024
            1423-3665           AB018270.2         1183-3425
            3666-5510           BC030796.2         887-2731
FEATURES             Location/Qualifiers
     source          1..5510
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..5510
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /note="myosin ID"
                     /db_xref="GeneID:4642"
                     /db_xref="HGNC:HGNC:7598"
                     /db_xref="MIM:606539"
     exon            1..347
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..3273
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myosin-I gamma; unconventional myosin-Id; protein
                     phosphatase 1, regulatory subunit 108"
                     /codon_start=1
                     /product="unconventional myosin-Id isoform 1"
                     /protein_id="NP_056009.1"
                     /db_xref="CCDS:CCDS32615.1"
                     /db_xref="GeneID:4642"
                     /db_xref="HGNC:HGNC:7598"
                     /db_xref="MIM:606539"
                     /translation="MAEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGE
                     VVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISG
                     ESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSS
                     RFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQGGSEQMLRS
                     LHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEEIQTVYKILAAILH
                     LGNLKFVVDGDTPLIENGKVVSIIAELLSTKTDMVEKALLYRTVATGRDIIDKQHTEQ
                     EASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLDIYGFEIFDN
                     NSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDYFNNQIIVDLVEQQHK
                     GIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHY
                     AGDVVYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKLSITEVTKRPLTAAT
                     LFKNSMIALVDNLASKEPYYVRCIKPNDKKSPQIFDDERCRHQVEYLGLLENVRVRRA
                     GFAFRQTYEKFLHRYKMISEFTWPNHDLPSDKEAVKKLIERCGFQDDVAYGKTKIFIR
                     TPRTLFTLEELRAQMLIRIVLFLQKVWRGTLARMRYKRTKAALTIIRYYRRYKVKSYI
                     HEVARRFHGVKTMRDYGKHVKWPSPPKVLRRFEEALQTIFNRWRASQLIKSIPASDLP
                     QVRAKVAAVEMLKGQRADLGLQRAWEGNYLASKPDTPQTSGTFVPVANELKRKDKYMN
                     VLFSCHVRKVNRFSKVEDRAIFVTDRHLYKMDPTKQYKVMKTIPLYNLTGLSVSNGKD
                     QLVVFHTKDNKDLIVCLFSKQPTHESRIGELVGVLVNHFKSEKRHLQVNVTNPVQCSL
                     HGKKCTVSVETRLNQPQPDFTKNRSGFILSVPGN"
     exon            348..556
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            557..650
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            651..816
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            817..870
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            871..966
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1083
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1287
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1433
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1548
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1719
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1790
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1865
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1998
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2165
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2373
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2597
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2742
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            2743..2847
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2961
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            2962..3116
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..5510
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5405..5410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /note="hexamer: AATAAA"
     regulatory      5413..5418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /note="hexamer: ATTAAA"
     polyA_site      5423
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /note="major polyA site"
     polyA_site      5431
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
     regulatory      5479..5484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
                     /note="hexamer: AATAAA"
     polyA_site      5510
                     /gene="MYO1D"
                     /gene_synonym="myr4; PPP1R108"
ORIGIN      
        1 acagcgcccg gcagccgcgg cgggaggagc ggaaactgtc gggtgcgtcc cgttcggagc
       61 cgcgccggcc gagaaggcgc cgaggagcag cgaggcggcc tctgtccggc ccggacccgc
      121 cgagcggcgt gcgcgccccc tccccgtagc ctcgcggcgc ggcctcgccc cggcccctcc
      181 cgagctcatc gcgggcccac ggagcggccc cggaggcccg agcgcgccca cctgagcccc
      241 cgcgctggcg ccatggcgga gcaggagagc ctggaattcg gcaaggcaga cttcgtgctg
      301 atggacaccg tctccatgcc cgagttcatg gccaacctca ggctcagatt tgaaaaaggg
      361 cgcatctata cgttcattgg agaagtcgtc gtttctgtga acccttacaa gttgttgaac
      421 atctatggaa gagacacaat tgagcagtat aaaggccgtg agctgtatga gagaccgcct
      481 cacctttttg ctattgcgga tgctgcttac aaggctatga agaggcgatc aaaagacact
      541 tgtattgtga tatcagggga aagtggagct ggtaaaacgg aagccagtaa gtacattatg
      601 cagtatattg cggccatcac caaccccagt cagagagcag aggttgaaag agtgaagaat
      661 atgttgctta agtccaactg tgttttggaa gcttttggaa atgccaaaac caaccgtaat
      721 gacaactcaa gcaggtttgg aaaatacatg gatatcaact ttgacttcaa gggtgaccct
      781 attggtgggc atatcaataa ctacttacta gaaaagtctc gagtgattgt gcaacagcca
      841 ggagaaagaa gctttcattc tttctatcag ctactccaag gaggttcaga acaaatgcta
      901 cgctctctac atctccagaa atccctttca tcctacaact atattcatgt gggagctcaa
      961 ttaaagtctt ctatcaatga tgctgccgaa ttcagagttg ttgctgatgc catgaaagtc
     1021 attggcttca aacctgagga gatccaaaca gtgtataaga ttttggctgc tattctgcac
     1081 ttgggaaatt taaaatttgt agtagatggt gacacgcctc ttattgagaa tggcaaagta
     1141 gtatctatca tagcagaatt gctctctact aagacagata tggttgagaa agcccttctt
     1201 taccggactg tggccacagg ccgtgacatc attgacaagc agcacacaga acaagaggcc
     1261 agctacggca gagacgcctt tgccaaggca atatatgagc gccttttttg ttggatcgtt
     1321 actcgcatca atgatattat tgaggtcaag aactatgaca ccacaatcca tgggaaaaac
     1381 actgttattg gtgtcttgga tatctatggc tttgaaatct ttgacaacaa cagttttgaa
     1441 caattctgta tcaattactg caatgagaaa ctgcagcagc tatttattca gctggttctg
     1501 aagcaagaac aagaggaata ccagcgggaa gggatcccct ggaaacatat tgactacttc
     1561 aacaatcaga tcattgttga cctcgtggag caacagcaca aagggatcat tgcaatcctt
     1621 gatgatgctt gcatgaatgt cggcaaagtc accgatgaaa tgtttcttga agcacttaac
     1681 agtaaattgg gcaaacacgc ccatttttcc agccgaaagc tctgtgcctc agacaaaatt
     1741 ctggagtttg atcgagattt tcgaattcga cattatgcag gcgatgtagt ctattctgtc
     1801 attggtttta ttgacaaaaa taaagatact ttatttcaag atttcaagcg ccttatgtat
     1861 aacagttcaa atcctgtgct caagaatatg tggcctgaag gcaaactgag cattacagag
     1921 gtgaccaagc gacctctgac tgctgctacc ttgtttaaga attctatgat tgctctagta
     1981 gacaaccttg catcaaagga accatattac gttcgttgca tcaaacccaa tgacaagaaa
     2041 tctccacaga tatttgatga tgaacgctgc cggcaccaag tagaatatct tggactactg
     2101 gaaaatgtga gagtgcgtcg ggcaggattt gccttccgcc agacatacga gaagtttctt
     2161 cacaggtata agatgatctc tgaattcacc tggcccaacc atgaccttcc ttcagacaaa
     2221 gaggctgtca agaaactaat tgaacggtgt ggttttcagg atgatgtagc ttatgggaag
     2281 accaaaattt tcattcgaac accccgaaca ttgtttacct tggaagaact ccgtgcccag
     2341 atgctcataa ggattgtcct ctttctacaa aaggtgtggc ggggcaccct ggcccgcatg
     2401 cggtacaaaa gaaccaaggc agctctgaca ataatcaggt actaccggcg ctacaaagtg
     2461 aagtcgtaca tccacgaggt ggccagacgc ttccatggcg tcaagaccat gcgagactac
     2521 gggaagcacg tgaagtggcc aagccctcct aaagttcttc gccgttttga ggaggccctg
     2581 cagacgattt tcaatagatg gagagcatcc cagctcatca agagcattcc ggcctcagac
     2641 ctgccccagg tcagggcaaa ggttgcagcc gtggaaatgt tgaagggtca aagggctgac
     2701 ctcgggctcc agagggcctg ggagggcaac tatcttgctt caaagccaga tacacctcag
     2761 acctcaggca cttttgtccc tgttgctaat gaattgaaac ggaaggacaa atacatgaat
     2821 gtcctctttt cctgtcacgt ccgtaaggta aatcgattta gtaaggtgga agacagagca
     2881 atttttgtca ctgaccgtca cctgtataaa atggatccca ctaaacagta caaggtgatg
     2941 aagactatcc ctctatacaa tttgactggt ctgagtgtct ccaatggaaa ggaccaactt
     3001 gtagtgttcc atacgaaaga caacaaagac ctcattgtct gcctcttcag caaacagcca
     3061 acccatgaga gtcgaattgg agaacttgtt ggagtgctgg tgaatcattt caagagtgag
     3121 aagcgccacc ttcaagtgaa cgtcaccaac ccagtacagt gcagcctgca cgggaagaag
     3181 tgcaccgtct ccgtggagac gcggctcaac cagccccagc ccgacttcac caagaatcgc
     3241 tcgggcttca tcctcagcgt gcccgggaac tgacgccccg cggaggcctg gcccggagcc
     3301 cggccacact ccgagtcctg ggtcccagtc cagctgctgc ctcccaaccc atgcccgcta
     3361 gaaacctgct gcgagggccc ctcccagagg agccccgccc ctgtaagatt tccttcctgg
     3421 ttttctgcct ttggtatcat cttcctctgt ccttactgtc cacggtccct gttcaataag
     3481 ccaaagaccc tggtgccccg cccagacccc tgggctgacg tccagaccaa tctcacccca
     3541 gaggcaactg gatggtgcct ttagttggtg cggatgcccc gtggccaggt caagtcagag
     3601 cacctggaca ggtgtcctcc ctgctgctga ccctgcagag ggaaggggtg gggatgcagg
     3661 accccactct gcgggagccc catagccacc tctcttgccc aaggtgagcc agccctgggg
     3721 acccagctca gggaggctct gctcagagtt cggcggaccc accccaaccc aactcccagc
     3781 cgccagccaa agccactggg tgagcagagt cacccacagg gccagcccct cagccaggag
     3841 ccagtggcag gagcggaaca gcccatccag cagagtgagt ccatccttcc caggttctcc
     3901 cctgggagac tccctttgcc accaaggccc ccaccagggc ctctgaccac cgctctggag
     3961 aggacagtgt ggcatgctcc aaggatcatc ttacttaact cgcagcctgt ggctgtggtc
     4021 ctcttataga tactttcacc gtttgcaggg ttgctaatca gatacctgct gtcaccacac
     4081 ttgggtcagg aaccctaatg agaacgggga gctgccaggg tgagggcagc cctcagggtc
     4141 ggccgctttc cctctggacc acctcccgct gcgtttccta ctcagagaaa cagcaagggc
     4201 ggggtcaaga cacgggatga cgggaagcag gaagcggggc agcagcacag cgtggggtcc
     4261 tggcactgca ggccaggcca ggatgcccac cccgccctct acacggcccc ttggggcctg
     4321 cgcccgtgaa actggtgcca gggagcactg ccagcttgcc agtttctgcc cagcaaaagc
     4381 acgtatgctt caggggcctt ctgagaccac cttccccact gagccccagc tgctgagaag
     4441 gccttgaggg aagtagaggc tgggagcaaa tgccccatgc ggtgagagga tgaggggagc
     4501 ctacgcctca ggcatgtggt gagaggatga gggggaggga gccaacgcct caggtggagt
     4561 gggcagaggt gcaagagagg gatgtactga agcttcttcc cgtcctgcca cagacacttc
     4621 tcctgccttc ccaccctgac ccggcagaac ccaccaagtg cctgtgtgca gcctcctgtg
     4681 cctcacccag ggcctgaccc cagagtggtc ccaacaaccc ggtctcatgc ccactcccca
     4741 tccctgcttc ccaaaaattg cactgtgtgc agtttgcaac aaagaatccc gctggcatcc
     4801 tgtccttggg aaccctttct cattctccaa gcctggtcag ctgcctgcac aggcagaggt
     4861 gccctcagcc cagattagca acactcatag ttttgccaat taccagtaga cactagtgga
     4921 accatctaac tggaacttcc tctctccttc cacttatttc ctcaaacttg ttgctttaca
     4981 ctagacacat gcaaatgtat gttttaaaca caccaaaaca gatcatgcca aatgagttgc
     5041 ctgtcaaagg ctggagggca ggaggagggc ctgggtttgg gttctttcct cccagccttt
     5101 ggatggtgcc ttgggcccct tagccccagc gccagggcct cccagctgag gccacaggac
     5161 aagcactttt ttatgatgta ctaaaagcca cagtatgtgg caactgcaaa aggatcagga
     5221 atttagggta tgatctcggt cacgtgtccc gggcgctgag gggaaaggaa gcgggcatga
     5281 ttgtagacaa tgagggggtt ctcttgatgt aatgaaatgc aattttatgg tttggtgcaa
     5341 aaactcctat tttccagtaa attaacttta tttctaaagc atattttgat ttgccatcaa
     5401 gagcaataaa gcattaaatc ttatttttaa aggtgttctg cttatctgtc actgaaaact
     5461 tggtgaaatt tttgcttaaa taaagtcaac cattatctgg gaggatagaa
//
