LOCUS       NM_033375               4737 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens myosin IC (MYO1C), transcript variant 3, mRNA.
ACCESSION   NM_033375
VERSION     NM_033375.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4737)
  AUTHORS   Elmubarak,I., Shril,S., Mansour,B., Bao,A., Kolvenbach,C.M.,
            Kari,J.A., Shalaby,M.A., El Desoky,S., Hildebrandt,F. and
            Schneider,R.
  TITLE     Recessive variants in MYO1C as a potential novel cause of
            proteinuric kidney disease
  JOURNAL   Pediatr Nephrol 39 (10), 2939-2945 (2024)
   PUBMED   38904753
  REMARK    GeneRIF: Recessive variants in MYO1C as a potential novel cause of
            proteinuric kidney disease.
REFERENCE   2  (bases 1 to 4737)
  AUTHORS   Xiong,S., Li,S., Li,Z., Song,Y., Yang,L., Yang,H., Xiong,J.,
            Pan,W., Guo,J., Fu,B. and Xu,S.
  TITLE     A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability
            promotes prostate cancer metastasis by inducing actin remodeling
  JOURNAL   Oncogene 43 (36), 2696-2707 (2024)
   PUBMED   39112516
  REMARK    GeneRIF: A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C
            stability promotes prostate cancer metastasis by inducing actin
            remodeling.
REFERENCE   3  (bases 1 to 4737)
  AUTHORS   Suo,J., Wang,Y., Wang,L., Qiu,B., Wang,Z., Yan,A., Qiang,B., Han,W.
            and Peng,X.
  TITLE     RAB31 in glioma-derived endothelial cells promotes glioma cell
            invasion via extracellular vesicle-mediated enrichment of MYO1C
  JOURNAL   FEBS Open Bio 14 (1), 138-147 (2024)
   PUBMED   37953466
  REMARK    GeneRIF: RAB31 in glioma-derived endothelial cells promotes glioma
            cell invasion via extracellular vesicle-mediated enrichment of
            MYO1C.
REFERENCE   4  (bases 1 to 4737)
  AUTHORS   Kit,Y., Starykovych,M., Manko,N., Orfin,A., Alexanyan,T.,
            Bozhko,L., Turchyna,T., Kit,O., Krishnankutty,R., Anand,A.,
            Sibirny,A., Souchelnytskyi,S. and Stoika,R.
  TITLE     Elevation of truncated (48 kDa) form of unconventional myosin 1C in
            blood serum correlates with severe Covid-19
  JOURNAL   J Immunol Methods 514, 113437 (2023)
   PUBMED   36736950
  REMARK    GeneRIF: Elevation of truncated (48 kDa) form of unconventional
            myosin 1C in blood serum correlates with severe Covid-19.
REFERENCE   5  (bases 1 to 4737)
  AUTHORS   Guan,H., Tian,K., Luo,W. and Li,M.
  TITLE     m6A-modified circRNA MYO1C participates in the tumor immune
            surveillance of pancreatic ductal adenocarcinoma through m6A/PD-L1
            manner
  JOURNAL   Cell Death Dis 14 (2), 120 (2023)
   PUBMED   36781839
  REMARK    GeneRIF: m[6]A-modified circRNA MYO1C participates in the tumor
            immune surveillance of pancreatic ductal adenocarcinoma through
            m[6]A/PD-L1 manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4737)
  AUTHORS   Fan,H.Y., He,X., Kingston,R.E. and Narlikar,G.J.
  TITLE     Distinct strategies to make nucleosomal DNA accessible
  JOURNAL   Mol Cell 11 (5), 1311-1322 (2003)
   PUBMED   12769854
REFERENCE   7  (bases 1 to 4737)
  AUTHORS   Pestic-Dragovich,L., Stojiljkovic,L., Philimonenko,A.A., Nowak,G.,
            Ke,Y., Settlage,R.E., Shabanowitz,J., Hunt,D.F., Hozak,P. and de
            Lanerolle,P.
  TITLE     A myosin I isoform in the nucleus
  JOURNAL   Science 290 (5490), 337-341 (2000)
   PUBMED   11030652
REFERENCE   8  (bases 1 to 4737)
  AUTHORS   Crozet,F., el Amraoui,A., Blanchard,S., Lenoir,M., Ripoll,C.,
            Vago,P., Hamel,C., Fizames,C., Levi-Acobas,F., Depetris,D.,
            Mattei,M.G., Weil,D., Pujol,R. and Petit,C.
  TITLE     Cloning of the genes encoding two murine and human cochlear
            unconventional type I myosins
  JOURNAL   Genomics 40 (2), 332-341 (1997)
   PUBMED   9119401
REFERENCE   9  (bases 1 to 4737)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   10 (bases 1 to 4737)
  AUTHORS   Ruppert,C., Godel,J., Muller,R.T., Kroschewski,R., Reinhard,J. and
            Bahler,M.
  TITLE     Localization of the rat myosin I molecules myr 1 and myr 2 and in
            vivo targeting of their tail domains
  JOURNAL   J Cell Sci 108 (Pt 12), 3775-3786 (1995)
   PUBMED   8719884
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100748.2, BP255642.1,
            BC068013.1, DB241937.1, CA422782.1 and AI220881.1.
            
            On May 31, 2019 this sequence version replaced NM_033375.4.
            
            Summary: This gene encodes a member of the unconventional myosin
            protein family, which are actin-based molecular motors. The protein
            is found in the cytoplasm, and one isoform with a unique N-terminus
            is also found in the nucleus. The nuclear isoform associates with
            RNA polymerase I and II and functions in transcription initiation.
            The mouse ortholog of this protein also functions in intracellular
            vesicle transport to the plasma membrane. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            The related gene myosin IE has been referred to as myosin IC in the
            literature, but it is a distinct locus on chromosome 19. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) contains a distinct 5' UTR and
            lacks an in-frame portion of the 5' coding region, compared to
            variant 1. The resulting isoform (c) has a shorter N terminus when
            compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2054396.1,
                                           SRR1803614.195172.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC100748.2         78294-78294
            2-397               BP255642.1         1-396
            398-2387            BC068013.1         607-2596
            2388-2717           DB241937.1         224-553
            2718-4107           BC068013.1         2927-4316
            4108-4734           CA422782.1         19-645              c
            4735-4737           AI220881.1         22-24               c
FEATURES             Location/Qualifiers
     source          1..4737
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..4737
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /note="myosin IC"
                     /db_xref="GeneID:4641"
                     /db_xref="HGNC:HGNC:7597"
                     /db_xref="MIM:606538"
     exon            1..80
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            81..236
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..3197
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /note="isoform c is encoded by transcript variant 3;
                     myosin-I beta; myosin-Ic; nuclear myosin I; unconventional
                     myosin-Ic"
                     /codon_start=1
                     /product="unconventional myosin-Ic isoform c"
                     /protein_id="NP_203693.3"
                     /db_xref="CCDS:CCDS11003.1"
                     /db_xref="GeneID:4641"
                     /db_xref="HGNC:HGNC:7597"
                     /db_xref="MIM:606538"
                     /translation="MESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTY
                     IGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVM
                     ISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNS
                     SRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLR
                     RLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASV
                     LHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPL
                     NLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEV
                     FQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEE
                     KFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFR
                     LLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVA
                     TQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRR
                     AGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFI
                     RFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRR
                     KAAKRKWAAQTIRRLIRGFVLRHAPRCPENAFFLDHVRTSFLLNLRRQLPQNVLDTSW
                     PTPPPALREASELLRELCIKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQS
                     VPRLFISTRLGTDEISPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVI
                     VEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQRADNKQKGDVVLQSDHVIETLTKTA
                     LSANRVNSININQGSITFAGGPGRDGTIDFTPGSELLITKAKNGHLAVVAPRLNSR"
     exon            237..352
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            353..551
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            552..632
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            633..812
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            813..911
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1025
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1097
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1217
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1300
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1406
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1487
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1579
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1674
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1721
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1802
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1908
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2026
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2140
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2217
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2286
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2371
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2531
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2615
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2709
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2765
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2901
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..2972
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3070
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3170
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            3171..4737
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4714..4719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /note="hexamer: AATAAA"
     polyA_site      4737
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /note="major polyA site"
ORIGIN      
        1 gagagtgcgc ccgggccgcg gatccccaag cccgccacgc cgcccagccc ggccccgccc
       61 gcgccggaag agccacgccg gccctgggca gtgacggggt tcgggtgacc atggagagtg
      121 cgctcaccgc ccgtgaccgg gtgggggtgc aggatttcgt gctgctggag aacttcacca
      181 gcgaggccgc cttcatcgag aacctgcggc ggcgatttcg ggagaatctc atctacacct
      241 acattggccc cgtcctggtc tctgtcaatc cctaccggga cctgcagatc tacagccggc
      301 agcatatgga gcgttaccgt ggcgtcagct tctatgaagt gccccctcac ctgtttgccg
      361 tggcggacac tgtgtaccga gcactgcgca cggagcgtcg ggaccaggct gtgatgatct
      421 ctggggagag cggggcaggc aagaccgagg ccaccaagag gctgctgcag ttctatgcag
      481 agacctgccc agcccccgag cgcggaggtg ccgtgcggga ccggctgcta cagagcaacc
      541 cggtgctgga ggcctttgga aatgccaaga ccctccggaa cgataactcc agcaggttcg
      601 ggaagtacat ggatgtgcag tttgacttca agggtgcccc cgtgggtggc cacatcctca
      661 gttacctcct ggaaaagtca cgagtggtgc accagaatca tggggagcgg aacttccaca
      721 tcttctacca gctgctggag gggggcgagg aggagactct tcgcaggctg ggcttggaac
      781 ggaaccccca gagctacctg tacctggtga agggccagtg tgccaaagtc tcctccatca
      841 acgacaagag tgactggaag gtcgtcagga aggctctgac agtcattgat ttcaccgagg
      901 atgaagtgga ggacctgctg agcatcgtgg ccagcgtcct tcatttgggc aacatccact
      961 ttgctgccaa cgaggagagc aatgcccagg tcaccaccga gaaccagctc aagtatctga
     1021 ccaggctcct cagcgtggaa ggctcgacgc tgcgagaagc cctgacacac aggaagatca
     1081 tcgccaaggg ggaggagctc ctgagcccgc tgaacctgga gcaggccgcg tacgcacgag
     1141 acgccctcgc caaggctgtg tacagccgca cttttacctg gctcgtcggg aagatcaaca
     1201 ggtcgctggc ctccaaggac gtggagagcc ccagctggcg gagcaccacg gttctcgggc
     1261 tcctggatat ttatggcttt gaagtgtttc agcataacag ctttgagcag ttctgcatca
     1321 attactgcaa cgagaagctg cagcagctct tcatcgagct cacgctcaag tcggagcagg
     1381 aggagtacga ggcagagggc atcgcgtggg agcccgtcca gtatttcaac aacaaaatca
     1441 tctgtgatct ggtggaggag aagtttaagg gcatcatctc gattttggat gaggagtgtc
     1501 tgcgccccgg ggaggccaca gacctgacct tcctggagaa gctggaggat actgtcaagc
     1561 accatccaca cttcctgacg cacaagctgg ctgaccagcg gaccaggaaa tctctgggcc
     1621 gaggggaatt ccgccttctg cactatgcgg gggaggtgac ctacagcgtg accgggtttc
     1681 tggacaaaaa caatgacctt ctcttccgga accttaagga gaccatgtgt agctcaaaga
     1741 atcccattat gagccagtgc tttgaccgga gcgagctcag tgacaagaag cggccagaga
     1801 cggtcgccac ccagttcaag atgagcctcc tgcagctggt ggagatcctg cagtctaagg
     1861 agcccgccta cgtccgctgc atcaaaccca atgatgccaa acagcccggc cgctttgacg
     1921 aggtgctgat ccgccaccag gtgaagtacc tggggctgtt ggaaaacctg cgcgtgcgca
     1981 gagccggctt tgcctatcgc cgcaaatacg aagctttcct gcaaaggtac aagtcactgt
     2041 gcccagagac gtggcccacg tgggcaggac ggccgcagga tggggtggct gtgctggtcc
     2101 gacacctggg ctacaagcca gaagagtaca agatgggcag gaccaagatc ttcatccgct
     2161 tccccaagac cctgtttgcc acagaggatg ccctggaggt ccggcggcag agcctggcca
     2221 caaagatcca agctgcctgg aggggctttc actggcggca gaaattcctc cgggtgaaga
     2281 gatcagccat ctgcatccag tcgtggtggc gtggaacact gggccggagg aaggcagcca
     2341 agaggaagtg ggcggcacag accatccggc ggctcatccg aggcttcgtc ctgcgccacg
     2401 ccccccgctg ccccgagaac gccttcttcc tggaccatgt gcgcacctct tttttgctaa
     2461 acctgaggcg gcagctgccc cagaatgtcc tggacacctc gtggcccacg cccccacctg
     2521 ccctgcgtga ggcctcagag cttctgcggg agttgtgcat aaagaacatg gtgtggaaat
     2581 actgccggag tatcagccct gagtggaagc agcagctgca gcagaaggcc gtggctagtg
     2641 agatcttcaa gggcaagaag gataattacc ctcagagtgt acccaggctc ttcatcagca
     2701 ctcggcttgg tacagatgag atcagccccc gagtgctgca ggccttgggc tctgagccca
     2761 ttcagtatgc ggtgcctgtt gtgaaatacg accgcaaggg ctacaagcct cgctcccggc
     2821 agctgctgct cacgcccaac gccgtcgtca tcgtggagga cgccaaagtc aagcagagga
     2881 ttgattacgc caacctgacc ggaatctctg tcagcagcct gagcgacagt ctttttgtgc
     2941 ttcatgtaca gcgtgcggac aataagcaaa agggagatgt ggtgctgcag agtgaccacg
     3001 tgattgagac gctgaccaag acagccctca gtgccaaccg cgtgaacagc atcaacatca
     3061 accagggcag catcacgttt gcagggggcc ccggcaggga tggcaccatt gacttcacac
     3121 ccggctcgga gctgctcatc accaaggcca agaacgggca cctggctgtg gtcgccccac
     3181 ggctgaattc tcggtgataa aggcgcccac tggaccctcc caacgcccaa tgctttgctt
     3241 ttctcctcct ccccttccca gttaccaaag actcgaactt ccagacaggg acccagggac
     3301 accccgaagc ccacctgcaa tctcccacct cctgcccatc cctctcttga gggagcagca
     3361 ggggccagga gctaccccag gagtgggcca ggccgggcca cagcaatagg aaagccaggg
     3421 ccagagcgag ccatgccagc cctactgccg atgccaaata tttgagagaa gggaactttt
     3481 gctgaggttt tctctgaggt ttttttgatg ctttatagga aactattttt taaaaaaagc
     3541 catttcccac ccaaggacac agtggatgtg ttttccctga ctccagcagg gcaaggaatg
     3601 tagccgagag gttgtgtggg ctgggctctg gtgccctctt ccctggccag gacacctctc
     3661 ctcctgattc ccttggcacc ttgtctttct gtctgtttac ctgtctccct gcctgcccat
     3721 ctgcatcttt tgcagcccac tctgacttcc atctgggggc tgagaccacc cttgcctgcc
     3781 cccttctttc tgccttaaga atgtcctttt aggctgggca tggtggctca cgcctgtaac
     3841 cccagcactt tgggaggcgg agacgggcag ataacctgag gtcaggattt cgagaccaac
     3901 ctgacctaca tggagaaact ccgcctctag taaaaataca aaattagccg ggcatggtgg
     3961 tgcacgcctc taatcccagc tactcgggag gctgaggcag gagaatcact tgaacccggg
     4021 aagtggaggt tgcagtgagc caagagtaca ccactgcact ccagcctggg caacagagcg
     4081 agactccgtc ttaaaaaaaa aaaaaaagaa cgccctttta ctgtcctcat catcccagtt
     4141 tgaggcagtg ctggagtggg gaaggccgtc ttagaccata gaggttggaa gacgctgaga
     4201 gatcatccag cccagcccct tgatgttaca gagcagaaga cagatgccca aacaggagaa
     4261 ggcacttgcc cacggtcata cggcaggttg ccacaaaacc aagatggcag cccttcctca
     4321 gcgtgcctca ctgccactcc cagagccagg gagccccata aaacccacat catgtcttaa
     4381 gagtatatct ggctccttga ccagcaatcg gccctgggag ccaccaggtg ggaaaagcgc
     4441 ctctgccaga gtccaggcct tgggatgaca gacagcttgc ccgcacactc gggccccact
     4501 caaggatgta gggccttttc tggcccctga cccctccctg gcatgggagc gtggggacgg
     4561 ggctggcctt gggaggagcg gcaggggcat cacctccttc tgctgcttct ccctgctcct
     4621 accctcaagg gcctgggggc tgcccagctg cctctatgcc cttctggggg tctcagccca
     4681 ctgctgacac ttctgcaatc cagagaaaca ctaaataaag caatacgtgt ttgccaa
//
