LOCUS       NM_001080950            4724 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens myosin IC (MYO1C), transcript variant 2, mRNA.
ACCESSION   NM_001080950
VERSION     NM_001080950.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4724)
  AUTHORS   Elmubarak,I., Shril,S., Mansour,B., Bao,A., Kolvenbach,C.M.,
            Kari,J.A., Shalaby,M.A., El Desoky,S., Hildebrandt,F. and
            Schneider,R.
  TITLE     Recessive variants in MYO1C as a potential novel cause of
            proteinuric kidney disease
  JOURNAL   Pediatr Nephrol 39 (10), 2939-2945 (2024)
   PUBMED   38904753
  REMARK    GeneRIF: Recessive variants in MYO1C as a potential novel cause of
            proteinuric kidney disease.
REFERENCE   2  (bases 1 to 4724)
  AUTHORS   Xiong,S., Li,S., Li,Z., Song,Y., Yang,L., Yang,H., Xiong,J.,
            Pan,W., Guo,J., Fu,B. and Xu,S.
  TITLE     A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability
            promotes prostate cancer metastasis by inducing actin remodeling
  JOURNAL   Oncogene 43 (36), 2696-2707 (2024)
   PUBMED   39112516
  REMARK    GeneRIF: A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C
            stability promotes prostate cancer metastasis by inducing actin
            remodeling.
REFERENCE   3  (bases 1 to 4724)
  AUTHORS   Suo,J., Wang,Y., Wang,L., Qiu,B., Wang,Z., Yan,A., Qiang,B., Han,W.
            and Peng,X.
  TITLE     RAB31 in glioma-derived endothelial cells promotes glioma cell
            invasion via extracellular vesicle-mediated enrichment of MYO1C
  JOURNAL   FEBS Open Bio 14 (1), 138-147 (2024)
   PUBMED   37953466
  REMARK    GeneRIF: RAB31 in glioma-derived endothelial cells promotes glioma
            cell invasion via extracellular vesicle-mediated enrichment of
            MYO1C.
REFERENCE   4  (bases 1 to 4724)
  AUTHORS   Kit,Y., Starykovych,M., Manko,N., Orfin,A., Alexanyan,T.,
            Bozhko,L., Turchyna,T., Kit,O., Krishnankutty,R., Anand,A.,
            Sibirny,A., Souchelnytskyi,S. and Stoika,R.
  TITLE     Elevation of truncated (48 kDa) form of unconventional myosin 1C in
            blood serum correlates with severe Covid-19
  JOURNAL   J Immunol Methods 514, 113437 (2023)
   PUBMED   36736950
  REMARK    GeneRIF: Elevation of truncated (48 kDa) form of unconventional
            myosin 1C in blood serum correlates with severe Covid-19.
REFERENCE   5  (bases 1 to 4724)
  AUTHORS   Guan,H., Tian,K., Luo,W. and Li,M.
  TITLE     m6A-modified circRNA MYO1C participates in the tumor immune
            surveillance of pancreatic ductal adenocarcinoma through m6A/PD-L1
            manner
  JOURNAL   Cell Death Dis 14 (2), 120 (2023)
   PUBMED   36781839
  REMARK    GeneRIF: m[6]A-modified circRNA MYO1C participates in the tumor
            immune surveillance of pancreatic ductal adenocarcinoma through
            m[6]A/PD-L1 manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4724)
  AUTHORS   Fan,H.Y., He,X., Kingston,R.E. and Narlikar,G.J.
  TITLE     Distinct strategies to make nucleosomal DNA accessible
  JOURNAL   Mol Cell 11 (5), 1311-1322 (2003)
   PUBMED   12769854
REFERENCE   7  (bases 1 to 4724)
  AUTHORS   Pestic-Dragovich,L., Stojiljkovic,L., Philimonenko,A.A., Nowak,G.,
            Ke,Y., Settlage,R.E., Shabanowitz,J., Hunt,D.F., Hozak,P. and de
            Lanerolle,P.
  TITLE     A myosin I isoform in the nucleus
  JOURNAL   Science 290 (5490), 337-341 (2000)
   PUBMED   11030652
REFERENCE   8  (bases 1 to 4724)
  AUTHORS   Crozet,F., el Amraoui,A., Blanchard,S., Lenoir,M., Ripoll,C.,
            Vago,P., Hamel,C., Fizames,C., Levi-Acobas,F., Depetris,D.,
            Mattei,M.G., Weil,D., Pujol,R. and Petit,C.
  TITLE     Cloning of the genes encoding two murine and human cochlear
            unconventional type I myosins
  JOURNAL   Genomics 40 (2), 332-341 (1997)
   PUBMED   9119401
REFERENCE   9  (bases 1 to 4724)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   10 (bases 1 to 4724)
  AUTHORS   Ruppert,C., Godel,J., Muller,R.T., Kroschewski,R., Reinhard,J. and
            Bahler,M.
  TITLE     Localization of the rat myosin I molecules myr 1 and myr 2 and in
            vivo targeting of their tail domains
  JOURNAL   J Cell Sci 108 (Pt 12), 3775-3786 (1995)
   PUBMED   8719884
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100748.2, CN313279.1,
            BP284965.1, BC068013.1, DB241937.1, CA422782.1 and AI220881.1.
            
            On May 31, 2019 this sequence version replaced NM_001080950.1.
            
            Summary: This gene encodes a member of the unconventional myosin
            protein family, which are actin-based molecular motors. The protein
            is found in the cytoplasm, and one isoform with a unique N-terminus
            is also found in the nucleus. The nuclear isoform associates with
            RNA polymerase I and II and functions in transcription initiation.
            The mouse ortholog of this protein also functions in intracellular
            vesicle transport to the plasma membrane. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            The related gene myosin IE has been referred to as myosin IC in the
            literature, but it is a distinct locus on chromosome 19. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and 5'
            CDS, compared to variant 1. The resulting isoform (b) has a shorter
            and unique N-terminus when compared to isoform a. This isoform is
            also known as nuclear myosin I.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.123046.1,
                                           SRR1803614.30742.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC100748.2         84213-84215
            4-8                 CN313279.1         1-5
            9-524               BP284965.1         1-516
            525-2374            BC068013.1         747-2596
            2375-2704           DB241937.1         224-553
            2705-4094           BC068013.1         2927-4316
            4095-4721           CA422782.1         19-645              c
            4722-4724           AI220881.1         22-24               c
FEATURES             Location/Qualifiers
     source          1..4724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..4724
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /note="myosin IC"
                     /db_xref="GeneID:4641"
                     /db_xref="HGNC:HGNC:7597"
                     /db_xref="MIM:606538"
     exon            1..67
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..3184
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /note="isoform b is encoded by transcript variant 2;
                     myosin-I beta; myosin-Ic; nuclear myosin I; unconventional
                     myosin-Ic"
                     /codon_start=1
                     /product="unconventional myosin-Ic isoform b"
                     /protein_id="NP_001074419.1"
                     /db_xref="CCDS:CCDS45562.1"
                     /db_xref="GeneID:4641"
                     /db_xref="HGNC:HGNC:7597"
                     /db_xref="MIM:606538"
                     /translation="MRYRASALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAF
                     IENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVAD
                     TVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNP
                     VLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNF
                     HIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVID
                     FTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREAL
                     THRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSW
                     RSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWE
                     PVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHK
                     LADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQC
                     FDRSELSDKKRPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIR
                     HQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHL
                     GYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFLRVKR
                     SAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFVLRHAPRCPENAFFLDHVRTSFL
                     LNLRRQLPQNVLDTSWPTPPPALREASELLRELCIKNMVWKYCRSISPEWKQQLQQKA
                     VASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQALGSEPIQYAVPVVKYDRKGY
                     KPRSRQLLLTPNAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQRADNKQKGD
                     VVLQSDHVIETLTKTALSANRVNSININQGSITFAGGPGRDGTIDFTPGSELLITKAK
                     NGHLAVVAPRLNSR"
     exon            68..223
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            224..339
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            340..538
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            539..619
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            620..799
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            800..898
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1012
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1084
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1204
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1287
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1393
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1474
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1566
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1661
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1708
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1789
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1895
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2013
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2127
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2204
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2273
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2358
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2518
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2602
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2696
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2752
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2888
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..2959
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3057
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            3058..3157
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            3158..4724
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4701..4706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /note="hexamer: AATAAA"
     polyA_site      4724
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /note="major polyA site"
ORIGIN      
        1 gggacccgga gcgcgggcag cggagcgggc gccaggccgg ccgggcagga tgcgctaccg
       61 ggcgtcggcc ctgggcagtg acggggttcg ggtgaccatg gagagtgcgc tcaccgcccg
      121 tgaccgggtg ggggtgcagg atttcgtgct gctggagaac ttcaccagcg aggccgcctt
      181 catcgagaac ctgcggcggc gatttcggga gaatctcatc tacacctaca ttggccccgt
      241 cctggtctct gtcaatccct accgggacct gcagatctac agccggcagc atatggagcg
      301 ttaccgtggc gtcagcttct atgaagtgcc ccctcacctg tttgccgtgg cggacactgt
      361 gtaccgagca ctgcgcacgg agcgtcggga ccaggctgtg atgatctctg gggagagcgg
      421 ggcaggcaag accgaggcca ccaagaggct gctgcagttc tatgcagaga cctgcccagc
      481 ccccgagcgc ggaggtgccg tgcgggaccg gctgctacag agcaacccgg tgctggaggc
      541 ctttggaaat gccaagaccc tccggaacga taactccagc aggttcggga agtacatgga
      601 tgtgcagttt gacttcaagg gtgcccccgt gggtggccac atcctcagtt acctcctgga
      661 aaagtcacga gtggtgcacc agaatcatgg ggagcggaac ttccacatct tctaccagct
      721 gctggagggg ggcgaggagg agactcttcg caggctgggc ttggaacgga acccccagag
      781 ctacctgtac ctggtgaagg gccagtgtgc caaagtctcc tccatcaacg acaagagtga
      841 ctggaaggtc gtcaggaagg ctctgacagt cattgatttc accgaggatg aagtggagga
      901 cctgctgagc atcgtggcca gcgtccttca tttgggcaac atccactttg ctgccaacga
      961 ggagagcaat gcccaggtca ccaccgagaa ccagctcaag tatctgacca ggctcctcag
     1021 cgtggaaggc tcgacgctgc gagaagccct gacacacagg aagatcatcg ccaaggggga
     1081 ggagctcctg agcccgctga acctggagca ggccgcgtac gcacgagacg ccctcgccaa
     1141 ggctgtgtac agccgcactt ttacctggct cgtcgggaag atcaacaggt cgctggcctc
     1201 caaggacgtg gagagcccca gctggcggag caccacggtt ctcgggctcc tggatattta
     1261 tggctttgaa gtgtttcagc ataacagctt tgagcagttc tgcatcaatt actgcaacga
     1321 gaagctgcag cagctcttca tcgagctcac gctcaagtcg gagcaggagg agtacgaggc
     1381 agagggcatc gcgtgggagc ccgtccagta tttcaacaac aaaatcatct gtgatctggt
     1441 ggaggagaag tttaagggca tcatctcgat tttggatgag gagtgtctgc gccccgggga
     1501 ggccacagac ctgaccttcc tggagaagct ggaggatact gtcaagcacc atccacactt
     1561 cctgacgcac aagctggctg accagcggac caggaaatct ctgggccgag gggaattccg
     1621 ccttctgcac tatgcggggg aggtgaccta cagcgtgacc gggtttctgg acaaaaacaa
     1681 tgaccttctc ttccggaacc ttaaggagac catgtgtagc tcaaagaatc ccattatgag
     1741 ccagtgcttt gaccggagcg agctcagtga caagaagcgg ccagagacgg tcgccaccca
     1801 gttcaagatg agcctcctgc agctggtgga gatcctgcag tctaaggagc ccgcctacgt
     1861 ccgctgcatc aaacccaatg atgccaaaca gcccggccgc tttgacgagg tgctgatccg
     1921 ccaccaggtg aagtacctgg ggctgttgga aaacctgcgc gtgcgcagag ccggctttgc
     1981 ctatcgccgc aaatacgaag ctttcctgca aaggtacaag tcactgtgcc cagagacgtg
     2041 gcccacgtgg gcaggacggc cgcaggatgg ggtggctgtg ctggtccgac acctgggcta
     2101 caagccagaa gagtacaaga tgggcaggac caagatcttc atccgcttcc ccaagaccct
     2161 gtttgccaca gaggatgccc tggaggtccg gcggcagagc ctggccacaa agatccaagc
     2221 tgcctggagg ggctttcact ggcggcagaa attcctccgg gtgaagagat cagccatctg
     2281 catccagtcg tggtggcgtg gaacactggg ccggaggaag gcagccaaga ggaagtgggc
     2341 ggcacagacc atccggcggc tcatccgagg cttcgtcctg cgccacgccc cccgctgccc
     2401 cgagaacgcc ttcttcctgg accatgtgcg cacctctttt ttgctaaacc tgaggcggca
     2461 gctgccccag aatgtcctgg acacctcgtg gcccacgccc ccacctgccc tgcgtgaggc
     2521 ctcagagctt ctgcgggagt tgtgcataaa gaacatggtg tggaaatact gccggagtat
     2581 cagccctgag tggaagcagc agctgcagca gaaggccgtg gctagtgaga tcttcaaggg
     2641 caagaaggat aattaccctc agagtgtacc caggctcttc atcagcactc ggcttggtac
     2701 agatgagatc agcccccgag tgctgcaggc cttgggctct gagcccattc agtatgcggt
     2761 gcctgttgtg aaatacgacc gcaagggcta caagcctcgc tcccggcagc tgctgctcac
     2821 gcccaacgcc gtcgtcatcg tggaggacgc caaagtcaag cagaggattg attacgccaa
     2881 cctgaccgga atctctgtca gcagcctgag cgacagtctt tttgtgcttc atgtacagcg
     2941 tgcggacaat aagcaaaagg gagatgtggt gctgcagagt gaccacgtga ttgagacgct
     3001 gaccaagaca gccctcagtg ccaaccgcgt gaacagcatc aacatcaacc agggcagcat
     3061 cacgtttgca gggggccccg gcagggatgg caccattgac ttcacacccg gctcggagct
     3121 gctcatcacc aaggccaaga acgggcacct ggctgtggtc gccccacggc tgaattctcg
     3181 gtgataaagg cgcccactgg accctcccaa cgcccaatgc tttgcttttc tcctcctccc
     3241 cttcccagtt accaaagact cgaacttcca gacagggacc cagggacacc ccgaagccca
     3301 cctgcaatct cccacctcct gcccatccct ctcttgaggg agcagcaggg gccaggagct
     3361 accccaggag tgggccaggc cgggccacag caataggaaa gccagggcca gagcgagcca
     3421 tgccagccct actgccgatg ccaaatattt gagagaaggg aacttttgct gaggttttct
     3481 ctgaggtttt tttgatgctt tataggaaac tattttttaa aaaaagccat ttcccaccca
     3541 aggacacagt ggatgtgttt tccctgactc cagcagggca aggaatgtag ccgagaggtt
     3601 gtgtgggctg ggctctggtg ccctcttccc tggccaggac acctctcctc ctgattccct
     3661 tggcaccttg tctttctgtc tgtttacctg tctccctgcc tgcccatctg catcttttgc
     3721 agcccactct gacttccatc tgggggctga gaccaccctt gcctgccccc ttctttctgc
     3781 cttaagaatg tccttttagg ctgggcatgg tggctcacgc ctgtaacccc agcactttgg
     3841 gaggcggaga cgggcagata acctgaggtc aggatttcga gaccaacctg acctacatgg
     3901 agaaactccg cctctagtaa aaatacaaaa ttagccgggc atggtggtgc acgcctctaa
     3961 tcccagctac tcgggaggct gaggcaggag aatcacttga acccgggaag tggaggttgc
     4021 agtgagccaa gagtacacca ctgcactcca gcctgggcaa cagagcgaga ctccgtctta
     4081 aaaaaaaaaa aaaagaacgc ccttttactg tcctcatcat cccagtttga ggcagtgctg
     4141 gagtggggaa ggccgtctta gaccatagag gttggaagac gctgagagat catccagccc
     4201 agccccttga tgttacagag cagaagacag atgcccaaac aggagaaggc acttgcccac
     4261 ggtcatacgg caggttgcca caaaaccaag atggcagccc ttcctcagcg tgcctcactg
     4321 ccactcccag agccagggag ccccataaaa cccacatcat gtcttaagag tatatctggc
     4381 tccttgacca gcaatcggcc ctgggagcca ccaggtggga aaagcgcctc tgccagagtc
     4441 caggccttgg gatgacagac agcttgcccg cacactcggg ccccactcaa ggatgtaggg
     4501 ccttttctgg cccctgaccc ctccctggca tgggagcgtg gggacggggc tggccttggg
     4561 aggagcggca ggggcatcac ctccttctgc tgcttctccc tgctcctacc ctcaagggcc
     4621 tgggggctgc ccagctgcct ctatgccctt ctgggggtct cagcccactg ctgacacttc
     4681 tgcaatccag agaaacacta aataaagcaa tacgtgtttg ccaa
//
