LOCUS       NM_001080779            4931 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens myosin IC (MYO1C), transcript variant 1, mRNA.
ACCESSION   NM_001080779
VERSION     NM_001080779.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4931)
  AUTHORS   Elmubarak,I., Shril,S., Mansour,B., Bao,A., Kolvenbach,C.M.,
            Kari,J.A., Shalaby,M.A., El Desoky,S., Hildebrandt,F. and
            Schneider,R.
  TITLE     Recessive variants in MYO1C as a potential novel cause of
            proteinuric kidney disease
  JOURNAL   Pediatr Nephrol 39 (10), 2939-2945 (2024)
   PUBMED   38904753
  REMARK    GeneRIF: Recessive variants in MYO1C as a potential novel cause of
            proteinuric kidney disease.
REFERENCE   2  (bases 1 to 4931)
  AUTHORS   Xiong,S., Li,S., Li,Z., Song,Y., Yang,L., Yang,H., Xiong,J.,
            Pan,W., Guo,J., Fu,B. and Xu,S.
  TITLE     A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability
            promotes prostate cancer metastasis by inducing actin remodeling
  JOURNAL   Oncogene 43 (36), 2696-2707 (2024)
   PUBMED   39112516
  REMARK    GeneRIF: A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C
            stability promotes prostate cancer metastasis by inducing actin
            remodeling.
REFERENCE   3  (bases 1 to 4931)
  AUTHORS   Suo,J., Wang,Y., Wang,L., Qiu,B., Wang,Z., Yan,A., Qiang,B., Han,W.
            and Peng,X.
  TITLE     RAB31 in glioma-derived endothelial cells promotes glioma cell
            invasion via extracellular vesicle-mediated enrichment of MYO1C
  JOURNAL   FEBS Open Bio 14 (1), 138-147 (2024)
   PUBMED   37953466
  REMARK    GeneRIF: RAB31 in glioma-derived endothelial cells promotes glioma
            cell invasion via extracellular vesicle-mediated enrichment of
            MYO1C.
REFERENCE   4  (bases 1 to 4931)
  AUTHORS   Kit,Y., Starykovych,M., Manko,N., Orfin,A., Alexanyan,T.,
            Bozhko,L., Turchyna,T., Kit,O., Krishnankutty,R., Anand,A.,
            Sibirny,A., Souchelnytskyi,S. and Stoika,R.
  TITLE     Elevation of truncated (48 kDa) form of unconventional myosin 1C in
            blood serum correlates with severe Covid-19
  JOURNAL   J Immunol Methods 514, 113437 (2023)
   PUBMED   36736950
  REMARK    GeneRIF: Elevation of truncated (48 kDa) form of unconventional
            myosin 1C in blood serum correlates with severe Covid-19.
REFERENCE   5  (bases 1 to 4931)
  AUTHORS   Guan,H., Tian,K., Luo,W. and Li,M.
  TITLE     m6A-modified circRNA MYO1C participates in the tumor immune
            surveillance of pancreatic ductal adenocarcinoma through m6A/PD-L1
            manner
  JOURNAL   Cell Death Dis 14 (2), 120 (2023)
   PUBMED   36781839
  REMARK    GeneRIF: m[6]A-modified circRNA MYO1C participates in the tumor
            immune surveillance of pancreatic ductal adenocarcinoma through
            m[6]A/PD-L1 manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4931)
  AUTHORS   Fan,H.Y., He,X., Kingston,R.E. and Narlikar,G.J.
  TITLE     Distinct strategies to make nucleosomal DNA accessible
  JOURNAL   Mol Cell 11 (5), 1311-1322 (2003)
   PUBMED   12769854
REFERENCE   7  (bases 1 to 4931)
  AUTHORS   Pestic-Dragovich,L., Stojiljkovic,L., Philimonenko,A.A., Nowak,G.,
            Ke,Y., Settlage,R.E., Shabanowitz,J., Hunt,D.F., Hozak,P. and de
            Lanerolle,P.
  TITLE     A myosin I isoform in the nucleus
  JOURNAL   Science 290 (5490), 337-341 (2000)
   PUBMED   11030652
REFERENCE   8  (bases 1 to 4931)
  AUTHORS   Crozet,F., el Amraoui,A., Blanchard,S., Lenoir,M., Ripoll,C.,
            Vago,P., Hamel,C., Fizames,C., Levi-Acobas,F., Depetris,D.,
            Mattei,M.G., Weil,D., Pujol,R. and Petit,C.
  TITLE     Cloning of the genes encoding two murine and human cochlear
            unconventional type I myosins
  JOURNAL   Genomics 40 (2), 332-341 (1997)
   PUBMED   9119401
REFERENCE   9  (bases 1 to 4931)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
REFERENCE   10 (bases 1 to 4931)
  AUTHORS   Ruppert,C., Godel,J., Muller,R.T., Kroschewski,R., Reinhard,J. and
            Bahler,M.
  TITLE     Localization of the rat myosin I molecules myr 1 and myr 2 and in
            vivo targeting of their tail domains
  JOURNAL   J Cell Sci 108 (Pt 12), 3775-3786 (1995)
   PUBMED   8719884
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC068013.1, DB241937.1,
            CA422782.1 and AI220881.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001080779.1.
            
            Summary: This gene encodes a member of the unconventional myosin
            protein family, which are actin-based molecular motors. The protein
            is found in the cytoplasm, and one isoform with a unique N-terminus
            is also found in the nucleus. The nuclear isoform associates with
            RNA polymerase I and II and functions in transcription initiation.
            The mouse ortholog of this protein also functions in intracellular
            vesicle transport to the plasma membrane. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            The related gene myosin IE has been referred to as myosin IC in the
            literature, but it is a distinct locus on chromosome 19. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292910.1, SRR1803613.175300.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000648651.1/ ENSP00000496954.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2581              BC068013.1         16-2596
            2582-2911           DB241937.1         224-553
            2912-4301           BC068013.1         2927-4316
            4302-4928           CA422782.1         19-645              c
            4929-4931           AI220881.1         22-24               c
FEATURES             Location/Qualifiers
     source          1..4931
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..4931
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /note="myosin IC"
                     /db_xref="GeneID:4641"
                     /db_xref="HGNC:HGNC:7597"
                     /db_xref="MIM:606538"
     exon            1..274
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..3391
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /note="isoform a is encoded by transcript variant 1;
                     myosin-I beta; myosin-Ic; nuclear myosin I; unconventional
                     myosin-Ic"
                     /codon_start=1
                     /product="unconventional myosin-Ic isoform a"
                     /protein_id="NP_001074248.1"
                     /db_xref="CCDS:CCDS42226.1"
                     /db_xref="GeneID:4641"
                     /db_xref="HGNC:HGNC:7597"
                     /db_xref="MIM:606538"
                     /translation="MALQVELVPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARD
                     RVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHME
                     RYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAET
                     CPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHIL
                     SYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVS
                     SINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQ
                     LKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTW
                     LVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFI
                     ELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLT
                     FLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLL
                     FRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVATQFKMSLLQLVEILQSKEPAYVR
                     CIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPET
                     WPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATK
                     IQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFVLRH
                     APRCPENAFFLDHVRTSFLLNLRRQLPQNVLDTSWPTPPPALREASELLRELCIKNMV
                     WKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQAL
                     GSEPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQRIDYANLTGISVSSL
                     SDSLFVLHVQRADNKQKGDVVLQSDHVIETLTKTALSANRVNSININQGSITFAGGPG
                     RDGTIDFTPGSELLITKAKNGHLAVVAPRLNSR"
     exon            275..430
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            431..546
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            547..745
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            746..826
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1006
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1105
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1219
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1291
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1411
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1494
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1600
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1681
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1773
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1868
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1915
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..1996
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2102
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2220
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2334
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2411
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2480
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2565
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2725
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2809
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2903
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..2959
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            2960..3095
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3166
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3264
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3364
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     exon            3365..4931
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4908..4913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /note="hexamer: AATAAA"
     polyA_site      4931
                     /gene="MYO1C"
                     /gene_synonym="MMI-beta; MMIb; MyoIC; myr2; NMI"
                     /note="major polyA site"
ORIGIN      
        1 agacctggac ggctccagcc gtgtcctgag gagctggacc agccacatcc cctggggctg
       61 cagttgaagc agaaccaagt ggccatcccg gcgttagacc gtaggttcct ggtcccggag
      121 tggtcggagc ccgccagtgg gcaggcagct cttgctcaca ggccgcggtg cccaggccgc
      181 tggctctccg cagggcggaa tggcgctgca agtggagctg gtacccaccg gggagatcat
      241 ccgcgtggtt catccccaca ggccctgcaa gcttgccctg ggcagtgacg gggttcgggt
      301 gaccatggag agtgcgctca ccgcccgtga ccgggtgggg gtgcaggatt tcgtgctgct
      361 ggagaacttc accagcgagg ccgccttcat cgagaacctg cggcggcgat ttcgggagaa
      421 tctcatctac acctacattg gccccgtcct ggtctctgtc aatccctacc gggacctgca
      481 gatctacagc cggcagcata tggagcgtta ccgtggcgtc agcttctatg aagtgccccc
      541 tcacctgttt gccgtggcgg acactgtgta ccgagcactg cgcacggagc gtcgggacca
      601 ggctgtgatg atctctgggg agagcggggc aggcaagacc gaggccacca agaggctgct
      661 gcagttctat gcagagacct gcccagcccc cgagcgcgga ggtgccgtgc gggaccggct
      721 gctacagagc aacccggtgc tggaggcctt tggaaatgcc aagaccctcc ggaacgataa
      781 ctccagcagg ttcgggaagt acatggatgt gcagtttgac ttcaagggtg cccccgtggg
      841 tggccacatc ctcagttacc tcctggaaaa gtcacgagtg gtgcaccaga atcatgggga
      901 gcggaacttc cacatcttct accagctgct ggaggggggc gaggaggaga ctcttcgcag
      961 gctgggcttg gaacggaacc cccagagcta cctgtacctg gtgaagggcc agtgtgccaa
     1021 agtctcctcc atcaacgaca agagtgactg gaaggtcgtc aggaaggctc tgacagtcat
     1081 tgatttcacc gaggatgaag tggaggacct gctgagcatc gtggccagcg tccttcattt
     1141 gggcaacatc cactttgctg ccaacgagga gagcaatgcc caggtcacca ccgagaacca
     1201 gctcaagtat ctgaccaggc tcctcagcgt ggaaggctcg acgctgcgag aagccctgac
     1261 acacaggaag atcatcgcca agggggagga gctcctgagc ccgctgaacc tggagcaggc
     1321 cgcgtacgca cgagacgccc tcgccaaggc tgtgtacagc cgcactttta cctggctcgt
     1381 cgggaagatc aacaggtcgc tggcctccaa ggacgtggag agccccagct ggcggagcac
     1441 cacggttctc gggctcctgg atatttatgg ctttgaagtg tttcagcata acagctttga
     1501 gcagttctgc atcaattact gcaacgagaa gctgcagcag ctcttcatcg agctcacgct
     1561 caagtcggag caggaggagt acgaggcaga gggcatcgcg tgggagcccg tccagtattt
     1621 caacaacaaa atcatctgtg atctggtgga ggagaagttt aagggcatca tctcgatttt
     1681 ggatgaggag tgtctgcgcc ccggggaggc cacagacctg accttcctgg agaagctgga
     1741 ggatactgtc aagcaccatc cacacttcct gacgcacaag ctggctgacc agcggaccag
     1801 gaaatctctg ggccgagggg aattccgcct tctgcactat gcgggggagg tgacctacag
     1861 cgtgaccggg tttctggaca aaaacaatga ccttctcttc cggaacctta aggagaccat
     1921 gtgtagctca aagaatccca ttatgagcca gtgctttgac cggagcgagc tcagtgacaa
     1981 gaagcggcca gagacggtcg ccacccagtt caagatgagc ctcctgcagc tggtggagat
     2041 cctgcagtct aaggagcccg cctacgtccg ctgcatcaaa cccaatgatg ccaaacagcc
     2101 cggccgcttt gacgaggtgc tgatccgcca ccaggtgaag tacctggggc tgttggaaaa
     2161 cctgcgcgtg cgcagagccg gctttgccta tcgccgcaaa tacgaagctt tcctgcaaag
     2221 gtacaagtca ctgtgcccag agacgtggcc cacgtgggca ggacggccgc aggatggggt
     2281 ggctgtgctg gtccgacacc tgggctacaa gccagaagag tacaagatgg gcaggaccaa
     2341 gatcttcatc cgcttcccca agaccctgtt tgccacagag gatgccctgg aggtccggcg
     2401 gcagagcctg gccacaaaga tccaagctgc ctggaggggc tttcactggc ggcagaaatt
     2461 cctccgggtg aagagatcag ccatctgcat ccagtcgtgg tggcgtggaa cactgggccg
     2521 gaggaaggca gccaagagga agtgggcggc acagaccatc cggcggctca tccgaggctt
     2581 cgtcctgcgc cacgcccccc gctgccccga gaacgccttc ttcctggacc atgtgcgcac
     2641 ctcttttttg ctaaacctga ggcggcagct gccccagaat gtcctggaca cctcgtggcc
     2701 cacgccccca cctgccctgc gtgaggcctc agagcttctg cgggagttgt gcataaagaa
     2761 catggtgtgg aaatactgcc ggagtatcag ccctgagtgg aagcagcagc tgcagcagaa
     2821 ggccgtggct agtgagatct tcaagggcaa gaaggataat taccctcaga gtgtacccag
     2881 gctcttcatc agcactcggc ttggtacaga tgagatcagc ccccgagtgc tgcaggcctt
     2941 gggctctgag cccattcagt atgcggtgcc tgttgtgaaa tacgaccgca agggctacaa
     3001 gcctcgctcc cggcagctgc tgctcacgcc caacgccgtc gtcatcgtgg aggacgccaa
     3061 agtcaagcag aggattgatt acgccaacct gaccggaatc tctgtcagca gcctgagcga
     3121 cagtcttttt gtgcttcatg tacagcgtgc ggacaataag caaaagggag atgtggtgct
     3181 gcagagtgac cacgtgattg agacgctgac caagacagcc ctcagtgcca accgcgtgaa
     3241 cagcatcaac atcaaccagg gcagcatcac gtttgcaggg ggccccggca gggatggcac
     3301 cattgacttc acacccggct cggagctgct catcaccaag gccaagaacg ggcacctggc
     3361 tgtggtcgcc ccacggctga attctcggtg ataaaggcgc ccactggacc ctcccaacgc
     3421 ccaatgcttt gcttttctcc tcctcccctt cccagttacc aaagactcga acttccagac
     3481 agggacccag ggacaccccg aagcccacct gcaatctccc acctcctgcc catccctctc
     3541 ttgagggagc agcaggggcc aggagctacc ccaggagtgg gccaggccgg gccacagcaa
     3601 taggaaagcc agggccagag cgagccatgc cagccctact gccgatgcca aatatttgag
     3661 agaagggaac ttttgctgag gttttctctg aggttttttt gatgctttat aggaaactat
     3721 tttttaaaaa aagccatttc ccacccaagg acacagtgga tgtgttttcc ctgactccag
     3781 cagggcaagg aatgtagccg agaggttgtg tgggctgggc tctggtgccc tcttccctgg
     3841 ccaggacacc tctcctcctg attcccttgg caccttgtct ttctgtctgt ttacctgtct
     3901 ccctgcctgc ccatctgcat cttttgcagc ccactctgac ttccatctgg gggctgagac
     3961 cacccttgcc tgcccccttc tttctgcctt aagaatgtcc ttttaggctg ggcatggtgg
     4021 ctcacgcctg taaccccagc actttgggag gcggagacgg gcagataacc tgaggtcagg
     4081 atttcgagac caacctgacc tacatggaga aactccgcct ctagtaaaaa tacaaaatta
     4141 gccgggcatg gtggtgcacg cctctaatcc cagctactcg ggaggctgag gcaggagaat
     4201 cacttgaacc cgggaagtgg aggttgcagt gagccaagag tacaccactg cactccagcc
     4261 tgggcaacag agcgagactc cgtcttaaaa aaaaaaaaaa agaacgccct tttactgtcc
     4321 tcatcatccc agtttgaggc agtgctggag tggggaaggc cgtcttagac catagaggtt
     4381 ggaagacgct gagagatcat ccagcccagc cccttgatgt tacagagcag aagacagatg
     4441 cccaaacagg agaaggcact tgcccacggt catacggcag gttgccacaa aaccaagatg
     4501 gcagcccttc ctcagcgtgc ctcactgcca ctcccagagc cagggagccc cataaaaccc
     4561 acatcatgtc ttaagagtat atctggctcc ttgaccagca atcggccctg ggagccacca
     4621 ggtgggaaaa gcgcctctgc cagagtccag gccttgggat gacagacagc ttgcccgcac
     4681 actcgggccc cactcaagga tgtagggcct tttctggccc ctgacccctc cctggcatgg
     4741 gagcgtgggg acggggctgg ccttgggagg agcggcaggg gcatcacctc cttctgctgc
     4801 ttctccctgc tcctaccctc aagggcctgg gggctgccca gctgcctcta tgcccttctg
     4861 ggggtctcag cccactgctg acacttctgc aatccagaga aacactaaat aaagcaatac
     4921 gtgtttgcca a
//
