LOCUS       NM_001130158            5069 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens myosin IB (MYO1B), transcript variant 1, mRNA.
ACCESSION   NM_001130158
VERSION     NM_001130158.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5069)
  AUTHORS   Li,Z., Qiu,X., He,Q., Fu,X., Ji,F. and Tian,X.
  TITLE     CCND1-associated ceRNA network reveal the critical pathway of
            TPRG1-AS1-hsa-miR-363-3p-MYO1B as a prognostic marker for head and
            neck squamous cell carcinoma
  JOURNAL   Sci Rep 13 (1), 11831 (2023)
   PUBMED   37481637
  REMARK    GeneRIF: CCND1-associated ceRNA network reveal the critical pathway
            of TPRG1-AS1-hsa-miR-363-3p-MYO1B as a prognostic marker for head
            and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5069)
  AUTHORS   Sun,Z., Guo,X., Chen,H., Ling,J., Zhao,H., Chang,A. and Zhuo,X.
  TITLE     MYO1B as a prognostic biomarker and a therapeutic target in
            Arecoline-associated oral carcinoma
  JOURNAL   Mol Carcinog 62 (7), 920-939 (2023)
   PUBMED   37014156
  REMARK    GeneRIF: MYO1B as a prognostic biomarker and a therapeutic target
            in Arecoline-associated oral carcinoma.
REFERENCE   3  (bases 1 to 5069)
  AUTHORS   Yu,Y., Ren,Y., Li,Z., Li,Y., Li,Y., Zhang,Y., Gui,R., Cui,Y.,
            Qian,L. and Xiong,Y.
  TITLE     Myo1b Promotes Premature Endothelial Senescence and Dysfunction via
            Suppressing Autophagy: Implications for Vascular Aging
  JOURNAL   Oxid Med Cell Longev 2023, 4654083 (2023)
   PUBMED   36654782
  REMARK    GeneRIF: Myo1b Promotes Premature Endothelial Senescence and
            Dysfunction via Suppressing Autophagy: Implications for Vascular
            Aging.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5069)
  AUTHORS   Chen,Y.H., Xu,N.Z., Hong,C., Li,W.Q., Zhang,Y.Q., Yu,X.Y.,
            Huang,Y.L. and Zhou,J.Y.
  TITLE     Myo1b promotes tumor progression and angiogenesis by inhibiting
            autophagic degradation of HIF-1alpha in colorectal cancer
  JOURNAL   Cell Death Dis 13 (11), 939 (2022)
   PUBMED   36347835
  REMARK    GeneRIF: Myo1b promotes tumor progression and angiogenesis by
            inhibiting autophagic degradation of HIF-1alpha in colorectal
            cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5069)
  AUTHORS   Li,S.H., Qian,L., Chen,Y.H., Lu,H.I., Tsai,H.T., Lyu,H., Yang,R.
            and Chen,C.H.
  TITLE     Targeting MYO1B impairs tumorigenesis via inhibiting the
            SNAI2/cyclin D1 signaling in esophageal squamous cell carcinoma
  JOURNAL   J Cell Physiol 237 (9), 3671-3686 (2022)
   PUBMED   35861939
  REMARK    GeneRIF: Targeting MYO1B impairs tumorigenesis via inhibiting the
            SNAI2/cyclin D1 signaling in esophageal squamous cell carcinoma.
REFERENCE   6  (bases 1 to 5069)
  AUTHORS   Dumont,R.A., Zhao,Y.D., Holt,J.R., Bahler,M. and Gillespie,P.G.
  TITLE     Myosin-I isozymes in neonatal rodent auditory and vestibular
            epithelia
  JOURNAL   J Assoc Res Otolaryngol 3 (4), 375-389 (2002)
   PUBMED   12486594
  REMARK    GeneRIF: At apical surfaces of supporting cells that surround hair
            cells in auditory epithelia of postnatal rats. In vestibular
            epithelia, present in ring within apical pole of hair cell.
            Expression was prominent only immediately after birth.
REFERENCE   7  (bases 1 to 5069)
  AUTHORS   Tang,N. and Ostap,E.M.
  TITLE     Motor domain-dependent localization of myo1b (myr-1)
  JOURNAL   Curr Biol 11 (14), 1131-1135 (2001)
   PUBMED   11509238
REFERENCE   8  (bases 1 to 5069)
  AUTHORS   Ruppert,C., Godel,J., Muller,R.T., Kroschewski,R., Reinhard,J. and
            Bahler,M.
  TITLE     Localization of the rat myosin I molecules myr 1 and myr 2 and in
            vivo targeting of their tail domains
  JOURNAL   J Cell Sci 108 (Pt 12), 3775-3786 (1995)
   PUBMED   8719884
REFERENCE   9  (bases 1 to 5069)
  AUTHORS   Bement,W.M., Hasson,T., Wirth,J.A., Cheney,R.E. and Mooseker,M.S.
  TITLE     Identification and overlapping expression of multiple
            unconventional myosin genes in vertebrate cell types
  JOURNAL   Proc Natl Acad Sci U S A 91 (14), 6549-6553 (1994)
   PUBMED   8022818
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11767. doi:
            10.1073/pnas.91.24.11767-c.. PMID: 7972138]
REFERENCE   10 (bases 1 to 5069)
  AUTHORS   Ruppert,C., Kroschewski,R. and Bahler,M.
  TITLE     Identification, characterization and cloning of myr 1, a mammalian
            myosin-I
  JOURNAL   J Cell Biol 120 (6), 1393-1403 (1993)
   PUBMED   8449985
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB461518.1, BC060849.1, AB290176.1, AI751497.1, AJ001381.1,
            BF061446.1 and CA435949.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001130158.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Both variants 1 and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB290176.1, SRR1803614.146141.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392318.8/ ENSP00000376132.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                DB461518.1         132-220
            90-369              BC060849.1         90-369
            370-1701            AB290176.1         410-1741
            1702-1953           AI751497.1         160-411
            1954-3322           AB290176.1         1994-3362
            3323-4853           AJ001381.1         990-2520
            4854-5057           BF061446.1         1-204               c
            5058-5069           CA435949.1         22-33               c
FEATURES             Location/Qualifiers
     source          1..5069
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q32.3"
     gene            1..5069
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /note="myosin IB"
                     /db_xref="GeneID:4430"
                     /db_xref="HGNC:HGNC:7596"
                     /db_xref="MIM:606537"
     exon            1..223
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            224..367
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..3643
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myosin-I alpha; MYO1B variant protein; unconventional
                     myosin-Ib"
                     /codon_start=1
                     /product="unconventional myosin-Ib isoform 1"
                     /protein_id="NP_001123630.1"
                     /db_xref="CCDS:CCDS46477.1"
                     /db_xref="GeneID:4430"
                     /db_xref="HGNC:HGNC:7596"
                     /db_xref="MIM:606537"
                     /translation="MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEI
                     YTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQ
                     CILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRN
                     DNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEE
                     LLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVA
                     AVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQE
                     KVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFE
                     IFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIE
                     NNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHS
                     CFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKR
                     PPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLEN
                     VRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGR
                     SKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRR
                     YAQQKRYQQTKSSALVIQSYIRGWKARKILRELKHQKRCKEAVTTIAAYWHGTQARRE
                     LRRLKEEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHAVAVIWAYWLGLKVRRE
                     YRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKEL
                     KRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINK
                     NPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVP
                     LVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQK
                     LNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP"
     exon            368..483
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..578
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..683
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..730
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..794
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..893
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..997
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1145
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1264
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1351
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1417
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1522
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1585
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1786
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..2013
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2214
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2308
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2458
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2527
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2614
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2701
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2788
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2789..2863
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2998
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2999..3105
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..3238
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3391
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3392..3519
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..5069
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4819..4824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /note="hexamer: AATAAA"
     polyA_site      4844
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /note="major polyA site"
     regulatory      4978..4983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /note="hexamer: TATAAA"
     polyA_site      5003
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
     regulatory      5051..5056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
                     /note="hexamer: CATAAA"
     polyA_site      5059
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
     polyA_site      5069
                     /gene="MYO1B"
                     /gene_synonym="MMI-alpha; MMIa; MYH-1c; myr1"
ORIGIN      
        1 gagcactccg cagctgggtg cgcacgggag cctcaaccgc ggcgcgtgga ggcagtacca
       61 gagcgcgcgg cgcgcagtcg gccggcagcc gcgggacagc cttggcagaa cagccgcggc
      121 gggagccccg cagccccggg ctgggcccgc gtcccggagc gccaccggag agcgaggacg
      181 acgtggaggc ggagtggcgc ccggcgaggt agcgccaggc gagctggaga ccatggccaa
      241 aatggaggtg aaaacctcac ttctggacaa tatgattgga gttggggata tggttctttt
      301 agaacctctc aatgaggaga ccttcatcaa caacctcaag aagcgctttg accacagtga
      361 aatatacaca tacattggaa gtgtggttat atctgttaac ccataccggt ctttacccat
      421 ttattcacca gagaaagtgg aagaatacag gaacagaaat ttttatgaac tgagccctca
      481 catctttgcc ctttcggatg aagcatacag atccctacga gatcaagata aggaccaatg
      541 tattctcatt actggggaaa gtggagcagg aaaaacagag gccagtaagc ttgtcatgtc
      601 ctatgtggca gctgtttgtg gaaaaggagc agaagttaat caagttaaag aacagctttt
      661 acagtccaac ccggtcctgg aagcttttgg aaatgccaaa actgtaagga atgacaactc
      721 ctctagattt ggcaaatata tggatattga atttgacttt aaaggcgatc cactaggagg
      781 agtaataagt aactatcttt tagagaaatc tcgggttgtt aaacagccaa gaggtgaaag
      841 aaacttccat gtgttctatc agctgctctc tggtgcctct gaagagctcc tcaataaact
      901 taagcttgag agggatttca gcaggtataa ctacctgagt ctggattcgg ccaaagtgaa
      961 tggagtggat gatgcagcaa attttagaac cgtgcggaat gccatgcaga ttgtgggctt
     1021 tatggatcat gaagctgagt ctgtcttggc ggtggtggca gcagtgttga aactggggaa
     1081 cattgagttc aagcccgaat ctcgagtgaa tggtctagat gaaagcaaaa tcaaagataa
     1141 aaatgagtta aaagaaattt gtgaattgac cggcattgat caatcagttc tagaacgagc
     1201 attcagtttc cgaacagttg aggccaaaca ggagaaagtt tcaactacac tgaatgtggc
     1261 tcaggcttat tatgcccgtg atgctctggc taaaaacctc tacagcaggt tgttttcatg
     1321 gttggtaaat cgaatcaatg aaagcattaa ggcacaaaca aaagtgagaa agaaggtcat
     1381 gggtgttctg gacatttatg gctttgagat tttcgaggac aacagctttg agcagttcat
     1441 tattaattat tgtaacgaaa agctgcaaca aatcttcatt gaacttactc ttaaagaaga
     1501 gcaggaggag tatatacggg aggatataga atggactcac attgactact tcaataatgc
     1561 tatcatttgt gacctaatag aaaataacac aaatggaatc ctggccatgc tggatgaaga
     1621 gtgcctcaga cctggcacag tcactgatga gaccttctta gaaaagctga accaagtatg
     1681 tgccacccac cagcattttg agagcaggat gagcaagtgc tctcggttcc tcaatgacac
     1741 gtctctgcct cacagctgct tcaggatcca gcattatgct ggaaaggtgc tgtaccaggt
     1801 ggaaggattc gttgacaaaa acaatgacct tctctatcga gacctgtccc aagccatgtg
     1861 gaaggccagc catgccctca tcaagtcttt gttccccgaa gggaatcccg ccaagatcaa
     1921 cctgaaaagg cctcctacag caggctcaca gttcaaggca tccgtggcca ctctgatgaa
     1981 aaacctacag accaagaacc caaactatat taggtgtatc aaaccgaatg ataaaaaagc
     2041 agcacacatc ttcaacgagg ctctagtgtg tcatcagatc aggtacctgg ggcttttgga
     2101 gaacgtccga gtgcggaggg caggctacgc cttcaggcag gcctatgaac cttgcctaga
     2161 aagatacaaa atgctttgta aacaaacatg gcctcattgg aaaggaccag ccaggtctgg
     2221 tgtggaggtc ctatttaatg aattagaaat tcccgtggaa gaatactcct ttggtagatc
     2281 aaagatattc atccgaaacc caagaacatt attcaaatta gaagacctga ggaagcaacg
     2341 cctggaggac ttggccactc tcattcagaa gatatatcgg gggtggaaat gccgcacaca
     2401 cttcctgcta atgaaaaaaa gccaaattgt gattgccgcc tggtacagga gatatgcgca
     2461 acaaaagagg taccagcaga caaagagttc cgccttagta attcagtctt atatccgggg
     2521 ttggaaggct cgaaaaattc tgcgggaact gaagcatcaa aagcgctgta aggaagcagt
     2581 cacgaccatt gctgcatatt ggcatgggac ccaggcacga agggaactga gacggctgaa
     2641 ggaggaggct aggaataaac atgctattgc agttatttgg gcttactggc ttggatctaa
     2701 ggctcgaagg gaattgaaac gcttgaagga ggaggctagg cgtaagcatg cagttgctgt
     2761 catttgggct tactggcttg gactgaaggt acgtagagaa tacaggaaat tcttcagagc
     2821 caatgctgga aagaaaatct atgagtttac gcttcagaga attgtgcaaa aatacttctt
     2881 ggaaatgaaa aataagatgc cttccttatc tccaatagac aagaattggc cctcaagacc
     2941 ttacttattc ttggattcta ctcacaagga gctaaaaagg attttccact tgtggaggtg
     3001 taaaaaatac agggaccaat tcacagacca gcagaaactt atttatgaag agaaactaga
     3061 agccagtgaa ctcttcaaag acaagaaggc tttataccca tctagtgttg ggcaaccatt
     3121 ccaaggggct tacctggaaa tcaacaagaa ccccaagtat aagaaactca aagatgccat
     3181 tgaagaaaag atcatcattg ctgaagtcgt gaacaaaatt aaccgtgcta atgggaagag
     3241 tacatctcgg attttcctct taacaaacaa taatctcctt cttgctgacc aaaagtctgg
     3301 acaaatcaag tcagaggttc cattggtgga tgtgaccaag gtatcaatga gctcacaaaa
     3361 tgatggcttc ttcgccgtcc acctcaaaga gggctcagaa gcagctagta aaggagactt
     3421 tctcttcagc agtgatcacc tgattgaaat ggccaccaag ctctatcgca caactctcag
     3481 ccaaaccaaa cagaagctca atattgagat ttccgatgag ttcctggtac agttcagaca
     3541 ggacaaagta tgtgtgaagt ttattcaggg aaaccagaaa aatgggagtg tcccaacatg
     3601 taaacgaaaa aacaaccgtc tccttgaagt tgctgtccct taactggcgc ctcctctcta
     3661 ctttcatgga cttgttcctt tgtaatagtg caatttggtt ttgttttatt tggggttcat
     3721 tgtatgtttg ggaatcacca aaggctttta gagttctttg gcaaaataaa aatatttgac
     3781 taatcaattt ttattattgg aatagtttta acctttcaaa tacatgttct gtcctggagc
     3841 aggattgtag aaactaacag tgtctatttt catgtctgat gtgttcttcc tttagtcatc
     3901 atgttaggtc tgtgtaccct aaatcagcat attactcata aatcattaat taatataagc
     3961 ataggaaatg gtcttaaaag atactgcatt cattcatcag atatttattc catgcctact
     4021 ctatgctagg cactgtgcta gatggtatga aaacttatta ggaacctttt tgtttttgag
     4081 accattgcat tctggctggt ttgtgctggt ttaacgacat ctaagaaggt ttagaaatgg
     4141 tgagaccaaa acaataactg ttaatgatgg acagcattat taggaaccct gtagtatgat
     4201 atttaacaat ataggcttca agaagggctg gtcctaagag ggggcagaaa tgaatgacca
     4261 ggttaaatcc ctctacatgt ggtttctgtt tgaaaaaaag aaaactgaca tttgaacagg
     4321 acttttaatt tgtttaaaac tctggtaatt acttgtaaca gtagaaaata gaagtcattc
     4381 ttattttaga aaaagtgaca gaagcagtcc agtaagatta tatgtttctg tttctggtaa
     4441 ataccatata tgatcctcga aatgataata tctccagaat attgttttca cccaaatttg
     4501 agtagatatt ttaaacacct aacaaagtaa agggctaaaa gccattcaga tagcagtaaa
     4561 acattctgta tgatgtgcaa taaaacatcc aagatctttt ttgaaagttt tatttataat
     4621 atacattttt gtatgagaaa ggtgattggt acagggtgcc tattttagtc atggatcaaa
     4681 atttgtgtaa cttgcagggc tttctttctt tttcttcaaa tttacaaggg ttcattttgg
     4741 aaactacatt ttaaactttg gaatcaaatt gtttcttatt tgggaggata atgtatatac
     4801 attggtatta tgttaaataa taaaattgtt ctaatttggt gccatttcct gaatcacaac
     4861 tgtatttttg tatctcaagc tattttcata tgttgtgtgt caatgtatca tctctcagaa
     4921 aggttttaca atccaaacat tatatgttct ctgtgtaact gaatttcact tatcttttat
     4981 aaaccagaaa cattaattga aaatattttc tggggatttt ctcttgactt gtatttttaa
     5041 aaattgctca cataaagaag ttctcagaa
//
