LOCUS       NM_078471               9980 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens myosin XVIIIA (MYO18A), transcript variant 1, mRNA.
ACCESSION   NM_078471
VERSION     NM_078471.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9980)
  AUTHORS   Yau,E., Yang,L., Chen,Y., Umstead,T.M., Stanley,A.E.,
            Halstead,E.S., Gandhi,C.K., Yewdell,J.W. and Chroneos,Z.C.
  TITLE     SP-R210 isoforms of Myosin18A modulate endosomal sorting and
            recognition of influenza A virus infection in macrophages
  JOURNAL   Microbes Infect 26 (3), 105280 (2024)
   PUBMED   38135024
  REMARK    GeneRIF: SP-R210 isoforms of Myosin18A modulate endosomal sorting
            and recognition of influenza A virus infection in macrophages.
REFERENCE   2  (bases 1 to 9980)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 9980)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9980)
  AUTHORS   Buschman,M.D. and Field,S.J.
  TITLE     MYO18A: An unusual myosin
  JOURNAL   Adv Biol Regul 67, 84-92 (2018)
   PUBMED   28942352
  REMARK    GeneRIF: a high proportion of MYO18A is found in complex with
            GOLPH3 at the trans Golgi, where it functions to promote vesicle
            budding for Golgi-to-plasma membrane trafficking.
            Review article
REFERENCE   5  (bases 1 to 9980)
  AUTHORS   Xing,M., Peterman,M.C., Davis,R.L., Oegema,K., Shiau,A.K. and
            Field,S.J.
  TITLE     GOLPH3 drives cell migration by promoting Golgi reorientation and
            directional trafficking to the leading edge
  JOURNAL   Mol Biol Cell 27 (24), 3828-3840 (2016)
   PUBMED   27708138
REFERENCE   6  (bases 1 to 9980)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   7  (bases 1 to 9980)
  AUTHORS   Schultz,L., Khera,S., Sleve,D., Heath,J. and Chang,N.S.
  TITLE     TIAF1 and p53 functionally interact in mediating apoptosis and
            silencing of TIAF1 abolishes nuclear translocation of serine
            15-phosphorylated p53
  JOURNAL   DNA Cell Biol 23 (1), 67-74 (2004)
   PUBMED   14965474
  REMARK    GeneRIF: TIAF1 and p53 functionally interact in regulating
            apoptosis, and TIAF1 is likely to participate in the nuclear
            translocation of activated p53.
REFERENCE   8  (bases 1 to 9980)
  AUTHORS   van der Leij,J., van den Berg,A., Albrecht,E.W., Blokzijl,T.,
            Roozendaal,R., Gouw,A.S., de Jong,K.P., Stegeman,C.A., van Goor,H.,
            Chang,N.S. and Poppema,S.
  TITLE     High expression of TIAF-1 in chronic kidney and liver allograft
            rejection and in activated T-helper cells
  JOURNAL   Transplantation 75 (12), 2076-2082 (2003)
   PUBMED   12829915
  REMARK    GeneRIF: Expression of TIAF-1 in the lymphocytes during chronic
            allograft rejection may be related to the predominance of a Th2
            response in this condition and may protect these cells from
            apoptosis
REFERENCE   9  (bases 1 to 9980)
  AUTHORS   Mori,K., Furusawa,T., Okubo,T., Inoue,T., Ikawa,S., Yanai,N.,
            Mori,K.J. and Obinata,M.
  TITLE     Genome structure and differential expression of two isoforms of a
            novel PDZ-containing myosin (MysPDZ) (Myo18A)
  JOURNAL   J Biochem 133 (4), 405-413 (2003)
   PUBMED   12761286
REFERENCE   10 (bases 1 to 9980)
  AUTHORS   Chroneos,Z.C., Abdolrasulnia,R., Whitsett,J.A., Rice,W.R. and
            Shepherd,V.L.
  TITLE     Purification of a cell-surface receptor for surfactant protein A
  JOURNAL   J Biol Chem 271 (27), 16375-16383 (1996)
   PUBMED   8663107
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005412.8, D86970.2,
            BM544214.1 and AC024619.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_078471.3.
            
            Summary: The protein encoded by this gene can bind GOLPH3, linking
            the Golgi to the cytoskeleton and influencing Golgi membrane
            trafficking. The encoded protein is also part of a complex that
            assembles lamellar actomyosin bundles and may be required for cell
            migration. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) contains an alternate in-frame
            exon and lacks two alternate in-frame exons compared to variant 3.
            The resulting isoform (a) has the same N- and C-termini but is
            shorter compared to isoform c.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86970.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000527372.7/ ENSP00000437073.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC005412.8         163575-163583
            10-7583             D86970.2           24-7597
            7584-7592           BM544214.1         364-372
            7593-9980           AC024619.16        104255-106642       c
FEATURES             Location/Qualifiers
     source          1..9980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..9980
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /note="myosin XVIIIA"
                     /db_xref="GeneID:399687"
                     /db_xref="HGNC:HGNC:31104"
                     /db_xref="MIM:609517"
                     /db_xref="MIM:610067"
     exon            1..86
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            87..1166
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..6332
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /note="isoform a is encoded by transcript variant 1;
                     myosin 18A; myosin containing PDZ domain; SP-A receptor
                     subunit SP-R210 alphaS; myosin containing a PDZ domain;
                     molecule associated with JAK3 N-terminus; unconventional
                     myosin-XVIIIa; surfactant protein receptor SP-R210;
                     TGFB1-induced anti-apoptotic factor 1; TGF-beta-1-induced
                     antiapoptotic factor 1; molecule associated with Jak-3
                     N-terminal; 12 kDa TGF-beta-1-induced antiapoptotic
                     factor; Putative TGFB1-induced anti-apoptotic factor 1"
                     /codon_start=1
                     /product="unconventional myosin-XVIIIa isoform a"
                     /protein_id="NP_510880.2"
                     /db_xref="CCDS:CCDS45642.1"
                     /db_xref="GeneID:399687"
                     /db_xref="HGNC:HGNC:31104"
                     /db_xref="MIM:609517"
                     /db_xref="MIM:610067"
                     /translation="MFNLMKKDKDKDGGRKEKKEKKEKKERMSAAELRSLEEMSLRRG
                     FFNLNRSSKRESKTRLEISNPIPIKVASGSDLHLTDIDSDSNRGSVILDSGHLSTASS
                     SDDLKGEEGSFRGSVLQRAAKFGSLAKQNSQMIVKRFSFSQRSRDESASETSTPSEHS
                     AAPSPQVEVRTLEGQLVQHPGPGIPRPGHRSRAPELVTKKFPVDLRLPPVVPLPPPTL
                     RELELQRRPTGDFGFSLRRTTMLDRGPEGQACRRVVHFAEPGAGTKDLALGLVPGDRL
                     VEINGHNVESKSRDEIVEMIRQSGDSVRLKVQPIPELSELSRSWLRSGEGPRREPSDA
                     KTEEQIAAEEAWNETEKVWLVHRDGFSLASQLKSEELNLPEGKVRVKLDHDGAILDVD
                     EDDVEKANAPSCDRLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGA
                     PAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIILLGSSGSGKTTSC
                     QHLVQYLATIAGISGNKVFSVEKWQALYTLLEAFGNSPTIINGNATRFSQILSLDFDQ
                     AGQVASASIQTMLLEKLRVARRPASEATFNVFYYLLACGDGTLRTELHLNHLAENNVF
                     GIVPLAKPEEKQKAAQQFSKLQAAMKVLGISPDEQKACWFILAAIYHLGAAGATKEAA
                     EAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKGGTLQRSTSFRQGPEESGLGD
                     GTGPKLSALECLEGMAAGLYSELFTLLVSLVNRALKSSQHSLCSMMIVDTPGFQNPEQ
                     GGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENIELAFDDLEPPTDDSVA
                     AVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLLERLFSYYGPQEGDKKG
                     QSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQNAPRLLQDSQKKIISN
                     LFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQMKLQVD
                     ALIDTIKKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQLD
                     VPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDER
                     RAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLA
                     RQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEE
                     IQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERL
                     RAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERA
                     VREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLT
                     AELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAE
                     AFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVK
                     DQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQ
                     MEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADA
                     QLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKA
                     KTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLE
                     EANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLE
                     SLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRK
                     KHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTK
                     YQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLA
                     PDRSDDEHDPLDNTSRPRYSHSYLSDSDTEAKLTETNA"
     exon            1167..1254
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1361
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1538
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1752
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1895
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1996
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2060
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2205
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2217
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2394
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2485
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2678
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2765
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2907
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3067
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3068..3254
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3498
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3499..3608
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3674
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3803
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3804..3947
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            3948..4037
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            4038..4157
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            4158..4269
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            4270..4397
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            4398..4552
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            4553..4676
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            4677..4877
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            4878..4988
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            4989..5093
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            5094..5240
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            5241..5354
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            5355..5471
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            5472..5555
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            5556..5693
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            5694..5879
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            5880..6019
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            6020..6064
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            6065..6187
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     exon            6188..9980
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7560..7565
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /note="hexamer: AATAAA"
     polyA_site      7581
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /note="major polyA site"
     regulatory      9953..9958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
                     /note="hexamer: AATAAA"
     polyA_site      9980
                     /gene="MYO18A"
                     /gene_synonym="MAJN; MYSPDZ; SP-R210; SPR210; TIAF1"
ORIGIN      
        1 gcgctctgct ccatccctga ccgggccgag gctgctggat gccgcgtctc cgcttctgct
       61 gcctgccggg cgggctccgg tggccgcagc aaagtggggc accaaggccc tgtgctaagc
      121 actcataatc ctctgggggt gctaccccta caaacagcac ccccaccatg tttaacctaa
      181 tgaagaaaga caaggacaaa gatggcgggc ggaaggagaa gaaggagaaa aaggagaaaa
      241 aggagcggat gtcagcggca gagcttcgga gcctggagga gatgagcctg cgacgtggct
      301 tcttcaacct gaaccgctcc tccaagcgtg aatccaagac gcgcctggaa atctccaacc
      361 ccatccccat caaggtggcc agcggctctg acctgcacct gactgacatt gactccgata
      421 gtaaccgggg cagcgtcatc ctggactcgg gccacctaag tacagccagc tccagcgatg
      481 acctcaaggg tgaggagggt agcttccgtg gctcggtgct gcagcgggca gccaagttcg
      541 gctcactggc caagcagaac tcacagatga ttgtcaagcg cttttccttc tcccagcgta
      601 gccgggatga gagcgcctca gaaacctcga cgccctcaga gcactctgcc gccccctcgc
      661 cacaggtgga ggtgaggact ctagagggac agctggtgca gcatcctggc ccaggcatcc
      721 ctcgaccagg gcaccgatcc cgagcccctg agctagtgac taaaaagttc ccagtcgacc
      781 tgcgcctgcc ccccgtggtg cccctgcccc cacctaccct ccgggagctg gagctgcaac
      841 gacggcccac tggagacttt ggcttctccc tgcggcgcac aaccatgctg gatcggggcc
      901 ccgagggcca ggcctgtcgg cgtgtggtcc actttgctga gcctggtgca ggcaccaagg
      961 acctggccct ggggctggtg ccaggagatc gactggtgga gattaatggg cacaatgtgg
     1021 agagcaagtc cagggatgag attgtggaga tgatccggca gtcaggggac agcgtgcggc
     1081 tcaaggtgca gcccattcca gagctcagcg agctcagcag gagctggctg cggagcggcg
     1141 agggacctcg cagggagcca tccgatgcga aaacagaaga acagattgca gcagaagagg
     1201 cctggaatga gacggagaag gtgtggctgg tccataggga cggcttctca ctggccagtc
     1261 aactcaaatc tgaggagctc aacttgcctg aggggaaggt gcgtgtgaag ctggaccacg
     1321 atggggccat cctggatgtg gatgaggatg acgttgagaa ggctaatgct ccctcctgcg
     1381 accgtctgga ggatctggcc tcactggtgt acctcaatga gtccagcgtc ctgcacacct
     1441 tgcgccagcg ctatggcgct agcctgctgc acacgtatgc tggccccagc ctgctggttc
     1501 ttggcccccg tggggcccct gctgtgtact ctgagaaggt gatgcacatg ttcaagggtt
     1561 gtcggcggga ggacatggca ccccacatct atgcagtggc ccagaccgca tacagggcga
     1621 tgctgatgag ccgtcaggat cagtcaatca tcctcctggg cagtagtggc agtggcaaga
     1681 ccaccagctg ccagcatctg gtgcagtacc tggccaccat cgcgggcatc agcgggaaca
     1741 aggtgttttc tgtggagaag tggcaggctc tgtacaccct cctggaagcc tttgggaaca
     1801 gccccaccat cattaatggc aatgccaccc gcttctccca gatcctctcc ctggactttg
     1861 accaagctgg ccaggtggcc tcagcctcca ttcagacaat gcttctggag aagctgcgtg
     1921 tggctcggcg cccagccagt gaagccacat tcaacgtctt ctactacctg ctggcctgtg
     1981 gggatggcac cctcaggaca gagctccacc tcaaccactt ggcagagaac aatgtgtttg
     2041 ggattgtgcc actggccaag cctgaggaaa agcagaaggc agctcagcag tttagtaagc
     2101 tgcaggcggc catgaaggtg ctgggcatct cccccgatga acagaaggcc tgctggttca
     2161 ttctggctgc catctaccac ctgggggctg cgggagccac caaagaagct gctgaagctg
     2221 ggcgcaagca gtttgcccgc catgagtggg cccagaaggc tgcgtaccta ctgggctgca
     2281 gcctggagga gctgtcctca gccatcttca agcaccagca caagggtggc accctgcagc
     2341 gctccacctc cttccgccag ggccccgagg agagtggcct gggagatggg acaggcccga
     2401 aactgagtgc actggagtgc cttgagggca tggcggccgg cctctacagc gagctcttca
     2461 cccttctcgt ctccctggtg aatagggctc tcaagtccag ccagcactca ctctgctcca
     2521 tgatgattgt cgacaccccg ggcttccaga accctgagca gggtgggtca gcccgcggag
     2581 cctcctttga ggagctgtgc cacaactaca cccaagaccg gctgcagagg ctcttccacg
     2641 agcgcacctt cgtgcaggag ttggaaagat acaaggagga gaacatcgag ctggcgtttg
     2701 acgacttgga acccccgacg gatgactctg tggctgctgt ggaccaggcc tcccatcagt
     2761 ccctggtccg ctcgctggcc cgcacagacg aggcgagggg cctgctctgg ctattggaag
     2821 aggaggctct ggtgccaggg gccagtgagg acaccctcct ggagcgcctt ttctcctatt
     2881 atggccccca ggaaggtgac aaaaaaggcc aaagccccct tctgcacagc agcaaaccac
     2941 accactttct cctgggccac agccatggca ccaactgggt agagtacaat gtgactggct
     3001 ggctgaacta caccaagcag aacccagcca cccagaatgc cccccggctc ctgcaggact
     3061 cccagaaaaa aatcatcagc aacctgtttc tgggccgcgc aggcagtgcc acggtgctct
     3121 ctggctccat cgcgggcctg gagggcggct cgcagctggc actgcgccgg gccaccagca
     3181 tgcggaaaac ctttaccaca ggcatggcgg ctgtcaaaaa gaagtcactg tgcatccaga
     3241 tgaagctaca ggtggacgcc ctcatcgaca ccatcaagaa gtcaaagctg cattttgtgc
     3301 actgcttcct gcctgtagct gagggctggg ctggggagcc ccgttccgcc tcctcccgcc
     3361 gagtcagcag cagcagtgag ctggacctgc cctcgggaga ccactgcgag gctgggctcc
     3421 tgcagctcga cgtgcccctg ctccgcaccc agctccgcgg ctcccgcctg ctcgatgcca
     3481 tgcgcatgta ccgccaaggt taccctgacc acatggtgtt ttccgagttc cgccgccgct
     3541 ttgatgtcct ggccccgcac ctgaccaaga aacacgggcg taactacatc gtggtggatg
     3601 aaaggcgggc agtggaggag ctgctggagt gcttggatct ggagaagagc agctgctgca
     3661 tgggcctgag ccgggtgttc ttccgggcgg gcaccttggc acggctggag gagcagcggg
     3721 atgaacaaac cagcaggaac ctaaccctgt tccaagcagc ctgcaggggc tacctggccc
     3781 gccagcactt caagaagaga aagatccagg acctggccat tcgctgtgta cagaagaaca
     3841 tcaagaagaa caaaggggtg aaggactggc cctggtggaa gctttttacc acagtgaggc
     3901 ccctcatcga agtacagctg tcagaggagc agatccggaa caaagacgag gagatccagc
     3961 agctgcggag caagctcgag aaggcggaga aggagaggaa cgagctgcgg ctcaacagtg
     4021 accggctgga gagccggatc tcagagctga catcggagct gacagatgag cgtaacacag
     4081 gagagtccgc ctcccagctg ctggacgcgg agacagcaga gaggctccgg gctgagaagg
     4141 agatgaagga actgcagacc cagtacgatg cactgaagaa gcagatggag gttatggaaa
     4201 tggaggtgat ggaggcccgt ctcatccggg cagcggagat caacggggaa gtggatgatg
     4261 atgatgcagg tggcgagtgg cggctgaagt atgagcgggc tgtgcgggag gtggacttca
     4321 ccaagaaacg gctccagcag gagtttgagg acaagctgga ggtggagcag cagaacaaga
     4381 ggcagctgga acggcggctc ggggacctgc aggcagatag tgaggagagt cagcgggctc
     4441 tgcagcagct caagaagaag tgccagcgac tgacggctga gctgcaagac accaagctgc
     4501 acctggaggg ccagcaggtc cgcaaccacg aactggagaa gaagcagagg aggtttgaca
     4561 gtgagctctc gcaggcgcat gaggaggccc agcgggagaa gctgcagcgg gagaagctgc
     4621 agcgggagaa ggacatgctc ctcgctgagg ctttcagcct gaagcagcaa ctagaggaaa
     4681 aagacatgga cattgcaggg ttcacccaga aggttgtgtc tctagaggca gagctccagg
     4741 acatttcttc ccaagagtcc aaggatgagg cttctctggc caaggtcaag aaacagctcc
     4801 gggacctgga ggccaaagtc aaggatcagg aagaagagct ggatgagcag gcagggacca
     4861 tccagatgct ggaacaggcc aagctgcgtc tggagatgga gatggagcgg atgagacaga
     4921 cccattctaa ggagatggag agtcgggatg aggaggtgga ggaggcccgg cagtcgtgtc
     4981 agaagaagtt aaaacagatg gaggtgcagc tagaggaaga gtatgaggac aagcagaagg
     5041 ttctgcgaga gaagcgggag ctggagggca agctcgccac cctcagcgac caggtgaacc
     5101 ggcgggactt tgagtcagag aagcggctgc ggaaggacct gaagcgcacc aaggccctgc
     5161 tggcagatgc ccagctcatg ctggaccacc tgaagaacag tgctcccagc aagcgagaga
     5221 ttgcccagct caagaaccag ctggaggagt cagagttcac ctgtgcggca gccgtgaaag
     5281 cacggaaagc aatggaggtg gagatcgaag acctgcacct gcagattgat gacatcgcca
     5341 aagccaagac agcgctggag gagcagctga gccgccttca gcgtgagaag aatgagatcc
     5401 agaaccggct ggaggaagat caggaagaca tgaacgaatt gatgaagaag cacaaggctg
     5461 ccgtggctca ggcttcccgg gacctggctc agataaatga tctccaagct cagctagaag
     5521 aagccaacaa agagaagcag gagctgcagg agaagctaca agccctccag agccaggtgg
     5581 agttcctgga gcagtccatg gtggacaagt ccctggtgag caggcaggaa gctaagatac
     5641 gggagctgga gacacgcctg gagtttgaaa ggacgcaagt gaaacggctg gagagcctgg
     5701 ctagccgtct caaggaaaac atggagaagc tgactgagga gcgggatcag cgcattgcag
     5761 ccgagaaccg ggagaaggaa cagaacaagc ggctacagag gcagctccgg gacaccaagg
     5821 aggagatggg cgagcttgcc aggaaggagg ccgaggcgag ccgcaagaag cacgaactgg
     5881 agatggatct agaaagcctg gaggctgcta accagagcct gcaggctgac ctaaagttgg
     5941 cattcaagcg catcggggac ctgcaggctg ccattgagga tgagatggag agtgatgaga
     6001 atgaggacct catcaacagt ttgcaggaca tggtgacaaa gtatcagaaa agaaagaata
     6061 aacttgaggg agactctgat gtggactcgg agctggagga ccgtgttgac ggggtcaagt
     6121 cctggttgtc aaaaaacaag ggaccttcca aggcagcttc tgatgatggc agcttaaaga
     6181 gttccagccc caccagctac tggaagtccc ttgcccctga tcggtcagat gatgagcacg
     6241 accctctcga caacacctcc agaccgcgat actcccacag ttatctgagt gacagcgaca
     6301 cagaggccaa gctgacggag actaacgcat agcccagggg agtggttggc agccctctca
     6361 ccccagggcc tgtggctgcc tgggcacctc tcccaggaag tggtggggca ccggtctccc
     6421 ccacccgact gctgatctgc atgggaaaca ccctgacctt cttctgtcag gggcactttc
     6481 caggctatgg gtgtctgatg tctccacgtg gaagaggtgg gggaaagagg agtttctgaa
     6541 gagaactttt tgctcctctg tctcaaaatg ccagactctt ggcttctacc ctgtgtcacc
     6601 gtgggcagtg gcaggtggcc tggcactgca tggagccagc acgttgacct ccctctcagc
     6661 tccctgctca gggacggtgg acaggttgcc tactgggaca ctctaggttg ctgggtccat
     6721 ggggaggatt gggggaggag aagcagtgcc ttccctctcg tgtggggtgg gggctctctc
     6781 ttcttggtgc ctgctgtctt tctacttttt aatttaaata cccaacctct ccatcacagc
     6841 tgcatccctg agagtgggag ggggctgtag tggtagctgg ggctcccaag aacgactcgg
     6901 gaatgtcatc tccatcttca cccttcagag agcagtcctt tctctgtgca gctggagacg
     6961 ctggtgagga gagccgggtc caggttctta agaatgaggt gcggaggggc tctccggtgc
     7021 tgctgggctg ggttgagcaa gcctacgcag acaagtgtgt gtgtggacca tccgcacctc
     7081 cagcccccac cccaccctct ttgtctcagc gtgttatgtg caatgaccta tttaaggtaa
     7141 acccattcca actacagcag ttcagggctg atccaagcac tgcctccctc ctgctctgtc
     7201 caggtggtct ggaccataaa ctcaacttga gagggaaggc ttggggttga ggacttgtga
     7261 tcagaaaaac tgaagatgga agttttggcc ggtgctcatt agacatgagt cctcactctg
     7321 tgtcctgagc ccgtgtcatt cttccaacct ccctgccccc acacacttat cccagacaca
     7381 acaccatgtg gtctggaggt cccagccccc accctaaaaa ggttatccct gagaactcca
     7441 ccagacttgg gagcccaagt gcagtgcctg gtgctgctcc catctgccgc cccccttctc
     7501 tcctgcaatt ggtttgtact cactgggctg tgctctcccc tgtttacccg atgtatggaa
     7561 ataaaggccc ttttcctcct ggctgcgcca gttttcctgc ctgttccttc aggctcaggc
     7621 aaagtctgga ttggtcctgg gggtggtggg cagaggcagg attctgatgg ggaccgtgag
     7681 ggcatcaccc tggtctctgg cctgctcccc aaagtgtcag accagtgcca cttaaagagc
     7741 ctaggcagct cattttgggg caggcagagg tagtggaatg aggggattgg ccaaggaaga
     7801 cacaagcccc accttttatg tgaagagcct agggactgtg attcaggtta gcaagggtgg
     7861 cagagactcc aagcctcatc ctccctagcc tccacaaggg aatgttgagg tccctctgat
     7921 tgttaaatct caccaattac agagattctc ttctcttctc ttctcttcct ccttccgtcc
     7981 ctccctctct ccctctctct ctctctttct ttctttcatt ctctttcttt ttggattcaa
     8041 gcccttctca ttagaacatt ttttaaaagc ttaattttag ccatttcaaa ggtgactttt
     8101 tgatcaaaac ttggcagaac tagctcgggc ccacagggca atgtgaatag gttgggagtg
     8161 ctgtctctgc cctgctcggt ccctgtcttc atgccctact ccatgctttg ttccttcatt
     8221 gacagctaag aggcagctca tgcagaaagg caagaaacaa atgacacccc tcctcctctt
     8281 ctaccttcta ccttctcatt ctgtagtgtg gccagttata atccctgaat gaataaagta
     8341 gtttggacag atgggtggga aaaaatagca aacagcccaa gtgccgaggc tctgataatg
     8401 tcagccatcc agaaagagtc caaaagggaa gaagggagaa aagtctcccc caaaatgaat
     8461 gggacagagt gtgaagtgga tctgtctcga acagagactg ccccctccat tgccccacga
     8521 tagaacagag aagaggatag aaacaatagt aaaagggaag ttacttgtct tttggagaca
     8581 gagtcttgct atgtcgccca agctggaatg cagtggcatg atctcaactc actgcaacct
     8641 ctacctcccg aggttcaagc gattctcctg cctaaaccct ccgagtagct gggacttaac
     8701 agacgtgtac caccacgcct ggctaatttt tgtattttta atagagacgg ggtttcgcca
     8761 tgttgagcag gctggtctcg aacttctgac ctcaagtgat ctgcctgcct cgcctcccaa
     8821 agtgctagga ttataggcat gagccactgt gcctggccta agttactttt ttttacaaaa
     8881 aaaaaaaaaa aaaaaaaaag gctgctagct tatgttcagt tctgtcactc tcatctttta
     8941 ttcctgtttt cacatagcgt ggtacatttt ctgtttctac tagggactag tgtgacaaac
     9001 tccctgccac ctttagatga attcccaaat ctgttcactc atactgagtc aagcctctgg
     9061 ttaactggaa actccaacat caacctccaa taacccggcc tggggtaaaa agctttgttc
     9121 aagtcagaaa acatattcat ttgcttaaca gttgagaaat atttcatgac tgcctgctgt
     9181 gcctaggccc cattctgggt gctggtgatg gataaggtcc cttccttcat aaagtggagg
     9241 aaggtagaca caaaatacat gctgcacctg ctagtatgca taagcttaga gtgggtagag
     9301 aggaacacat catagtatcc atcctccagg gttttgcgga cgagggctgg agcagaccca
     9361 tgtggaaata attacataag acctaacaag gatgaagagg ttgctttgga catactatgg
     9421 agggagatgc tctctttggc ggggaggatt gggaaagcct ctaaaaggag ctgctatttt
     9481 gaccagggct tgaaaatagc acttccacag gtacagttgc tgggaaaggc atattgagaa
     9541 gaagaagagt ttaagtaaag gtcctggggc agggaaagag aggtgctggt agaacatgcc
     9601 acaggctggc tgtgcattgt cacatgacca gtgcttctcc aagtttcagt tgagaaggag
     9661 acaattccct tggccccaga ggagtccagg agcctttagg gccaccaaag cccatcttta
     9721 ttttgggtgt accttgaagg ctctgctgtt gaccttacct gtacactcat ggtacctctg
     9781 gtccctaaga tgttgcagaa ggcaaatctg gccctttgcc aggctcaaag ccagcctgct
     9841 agatcctcct ctataactgc agatccccgg gattgctctg actcctgaat aagcatgggc
     9901 gggaaccagt gcccctgtgg gactccccat ggtgcccagt ctgtgcccag aaaataaagt
     9961 ggcaggcagt gacccctaaa
//
