LOCUS       NM_001198950            7046 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens myosin XVI (MYO16), transcript variant 1, mRNA.
ACCESSION   NM_001198950
VERSION     NM_001198950.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7046)
  AUTHORS   Suetsugu,H., Kim,K., Yamamoto,T., Bang,S.Y., Sakamoto,Y.,
            Shin,J.M., Sugano,N., Kim,J.S., Mukai,M., Lee,Y.K., Ohmura,K.,
            Park,D.J., Takahashi,D., Ahn,G.Y., Karino,K., Kwon,Y.C.,
            Miyamura,T., Kim,J., Nakamura,J., Motomura,G., Kuroda,T., Niiro,H.,
            Miyamoto,T., Takeuchi,T., Ikari,K., Amano,K., Tada,Y., Yamaji,K.,
            Shimizu,M., Atsumi,T., Seki,T., Tanaka,Y., Kubo,T., Hisada,R.,
            Yoshioka,T., Yamazaki,M., Kabata,T., Kajino,T., Ohta,Y., Okawa,T.,
            Naito,Y., Kaneuji,A., Yasunaga,Y., Ohzono,K., Tomizuka,K.,
            Koido,M., Matsuda,K., Okada,Y., Suzuki,A., Kim,B.J., Kochi,Y.,
            Lee,H.S., Ikegawa,S., Bae,S.C. and Terao,C.
  TITLE     Novel susceptibility loci for steroid-associated osteonecrosis of
            the femoral head in systemic lupus erythematosus
  JOURNAL   Hum Mol Genet 31 (7), 1082-1095 (2022)
   PUBMED   34850884
  REMARK    GeneRIF: Novel susceptibility loci for steroid-associated
            osteonecrosis of the femoral head in systemic lupus erythematosus.
REFERENCE   2  (bases 1 to 7046)
  AUTHORS   Liu,Y.F., Sowell,S.M., Luo,Y., Chaubey,A., Cameron,R.S., Kim,H.G.
            and Srivastava,A.K.
  TITLE     Autism and Intellectual Disability-Associated KIRREL3 Interacts
            with Neuronal Proteins MAP1B and MYO16 with Potential Roles in
            Neurodevelopment
  JOURNAL   PLoS One 10 (4), e0123106 (2015)
   PUBMED   25902260
  REMARK    GeneRIF: KIRREL3 interacting proteins MAP1B and MYO16 are potential
            candidates for intellectual disability and autism spectrum
            disorder.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7046)
  AUTHORS   Rodriguez-Murillo,L., Xu,B., Roos,J.L., Abecasis,G.R., Gogos,J.A.
            and Karayiorgou,M.
  TITLE     Fine mapping on chromosome 13q32-34 and brain expression analysis
            implicates MYO16 in schizophrenia
  JOURNAL   Neuropsychopharmacology 39 (4), 934-943 (2014)
   PUBMED   24141571
  REMARK    GeneRIF: This study suggest that common variation within MYO16 may
            contribute to the genetic liability to schizophrenia.
REFERENCE   4  (bases 1 to 7046)
  AUTHORS   Sherva,R., Tripodis,Y., Bennett,D.A., Chibnik,L.B., Crane,P.K., de
            Jager,P.L., Farrer,L.A., Saykin,A.J., Shulman,J.M., Naj,A. and
            Green,R.C.
  CONSRTM   GENAROAD Consortium; Alzheimer's Disease Neuroimaging Initiative;
            Alzheimer's Disease Genetics Consortium
  TITLE     Genome-wide association study of the rate of cognitive decline in
            Alzheimer's disease
  JOURNAL   Alzheimers Dement 10 (1), 45-52 (2014)
   PUBMED   23535033
REFERENCE   5  (bases 1 to 7046)
  AUTHORS   Ong,B.A., Li,J., McDonough,J.M., Wei,Z., Kim,C., Chiavacci,R.,
            Mentch,F., Caboot,J.B., Spergel,J., Allen,J.L., Sleiman,P.M. and
            Hakonarson,H.
  TITLE     Gene network analysis in a pediatric cohort identifies novel lung
            function genes
  JOURNAL   PLoS One 8 (9), e72899 (2013)
   PUBMED   24023788
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7046)
  AUTHORS   Joslyn,G., Ravindranathan,A., Brush,G., Schuckit,M. and White,R.L.
  TITLE     Human variation in alcohol response is influenced by variation in
            neuronal signaling genes
  JOURNAL   Alcohol Clin Exp Res 34 (5), 800-812 (2010)
   PUBMED   20201926
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 7046)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 7046)
  AUTHORS   Cameron,R.S., Liu,C., Mixon,A.S., Pihkala,J.P., Rahn,R.J. and
            Cameron,P.L.
  TITLE     Myosin16b: The COOH-tail region directs localization to the nucleus
            and overexpression delays S-phase progression
  JOURNAL   Cell Motil Cytoskeleton 64 (1), 19-48 (2007)
   PUBMED   17029291
  REMARK    Erratum:[Cell Motil Cytoskeleton. 2007 Mar;64(3):233]
REFERENCE   9  (bases 1 to 7046)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   10 (bases 1 to 7046)
  AUTHORS   Patel,K.G., Liu,C., Cameron,P.L. and Cameron,R.S.
  TITLE     Myr 8, a novel unconventional myosin expressed during brain
            development associates with the protein phosphatase catalytic
            subunits 1alpha and 1gamma1
  JOURNAL   J Neurosci 21 (20), 7954-7968 (2001)
   PUBMED   11588169
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157771.11, AL136132.15,
            AL390918.7, AL353143.14 and AL161431.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001198950.2.
            
            Summary: This gene encodes an unconventional myosin protein. The
            encoded protein has been proposed to act as a serine/threonine
            phosphatase-1 targeting or regulatory subunit. Studies in a rat
            cell line suggest that this protein may regulate cell cycle
            progression. A variant within this gene may be associated with
            susceptibility to schizophrenia and elevated expression of this
            gene has been observed in the frontal cortex of human schizophrenia
            patients. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB290159.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457511.7/ ENSP00000401633.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-262               AL157771.11        27478-27739
            263-526             AL157771.11        63753-64016
            527-597             AL157771.11        110528-110598
            598-741             AL136132.15        163432-163575       c
            742-850             AL136132.15        105272-105380       c
            851-975             AL136132.15        97375-97499         c
            976-1101            AL136132.15        84211-84336         c
            1102-1177           AL136132.15        70603-70678         c
            1178-1331           AL136132.15        67737-67890         c
            1332-1482           AL136132.15        46522-46672         c
            1483-1593           AL136132.15        35462-35572         c
            1594-1659           AL136132.15        24773-24838         c
            1660-1787           AL136132.15        7829-7956           c
            1788-1893           AL136132.15        2538-2643           c
            1894-2011           AL390918.7         7102-7219
            2012-2159           AL390918.7         19089-19236
            2160-2271           AL390918.7         66774-66885
            2272-2389           AL390918.7         70625-70742
            2390-2461           AL390918.7         71510-71581
            2462-2603           AL390918.7         73847-73988
            2604-2676           AL353143.14        18012-18084
            2677-2829           AL353143.14        34533-34685
            2830-3030           AL353143.14        45347-45547
            3031-3106           AL353143.14        72552-72627
            3107-3282           AL353143.14        77936-78111
            3283-3363           AL353143.14        80682-80762
            3364-3569           AL353143.14        81026-81231
            3570-3672           AL353143.14        126421-126523
            3673-3769           AL353143.14        146006-146102
            3770-4016           AL353143.14        150748-150994
            4017-4285           AL353143.14        152918-153186
            4286-5398           AL353143.14        165900-167012
            5399-5557           AL161431.28        20361-20519
            5558-5649           AL161431.28        35002-35093
            5650-7046           AL161431.28        62069-63465
FEATURES             Location/Qualifiers
     source          1..7046
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q33.3"
     gene            1..7046
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /note="myosin XVI"
                     /db_xref="GeneID:23026"
                     /db_xref="HGNC:HGNC:29822"
                     /db_xref="MIM:615479"
     exon            1..262
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..5877
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /note="isoform 1 is encoded by transcript variant 1;
                     myosin heavy chain Myr 8; MYO16 variant protein;
                     unconventional myosin-16; neuronal tyrosine-phosphorylated
                     phosphoinositide-3-kinase adaptor 3; neuronal
                     tyrosine-phosphorylated phosphoinositide-3-kinase adapter
                     3; unconventional myosin-XVI; protein phosphatase 1,
                     regulatory subunit 107"
                     /codon_start=1
                     /product="unconventional myosin-XVI isoform 1"
                     /protein_id="NP_001185879.1"
                     /db_xref="CCDS:CCDS73598.1"
                     /db_xref="GeneID:23026"
                     /db_xref="HGNC:HGNC:29822"
                     /db_xref="MIM:615479"
                     /translation="MSHYHFIKCCCFQLCNVFRSHEMEIDQCLLESLPLGQRQRLVKR
                     MRCEQIKAYYEREKAFQKQEGFLKRLKHAKNPKVHFNLTDMLQDAIIHHNDKEVLRLL
                     KEGADPHTLVSSGGSLLHLCARYDNAFIAEILIDRGVNVNHQDEDFWTPMHIACACDN
                     PDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESSSILLTYLDENGVDLTSLRQMKLQ
                     RPMSMLTDVKHFLSSGGNVNEKNDEGVTLLHMACASGYKEVVSLILEHGGDLNIVDDQ
                     YWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFIEEMLLKAEIAWE
                     EKMKEPLSASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAKQDSLLEKDIMFKDATKG
                     LCKQQSQDSIPENPMMSGSTKPEQVKLMPPAPNDDLATLSELNDGSLLYEIQKRFGNN
                     QIYTFIGDILLLVNPYKELPIYSSMVSQLYFSSSGKLCSSLPPHLFSCVERAFHQLFR
                     EQRPQCFILSGERGSGKSEASKQIIRHLTCRAGASRATLDSRFKHVVCILEAFGHAKT
                     TLNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYLLMDG
                     LSAEEKYGLHLNNLCAHRYLNQTIQDDASTGERSLNREKLAVLKRALNVVGFSSLEVE
                     NLFVILAAILHLGDIRFTALNEGNSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQY
                     FKGDMIIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEQKSMQTLDIGI
                     LDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQ
                     NGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGN
                     VALKDHGTAFTIMHYAGRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKL
                     SQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQRL
                     ERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIG
                     VLEMVKIFRYGYPVRLSFSDFLSRYKPLADTFLREKKEQSAAERCRLVLQQCKLQGWQ
                     MGVRKVFLKYWHADQLNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSIN
                     SFLQNTEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRT
                     DDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSLHSVFSMDDSSSLPSPRKQPPP
                     KPKRDPNTRLSASYEAVSACLSAAREAANEALARPRPHSDDYSTMKKIPPRKPKRSPN
                     TKLSGSYEEISGSRPGDARPAGAPGAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIE
                     MLGHAARPDSPDPGESVYEEMKCCLPDDGGPGAGSFLLHGASPPLLHRAPEDEAAGPP
                     GDACDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPV
                     QPEGSSPLSPQYSKSQKGDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPPPAPYR
                     PCAHLAFPPEPAPVNAGKAGPSAEAPKVHPKPNSAPVAGPCSSFPKIPYSPVKATRAD
                     ARKAGSSASPPAPYSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIREAEGFETN
                     MNISSRDDPSTSEITSETQDRNANNHGIQLSNSLSSAITAENGNSISNGLPEEDGYSR
                     LSISGTGTSTFQRHRDSHTTQVIHQLRLSENESVALQELLDWRRKLCEEGQDWQQILH
                     HAEPRVPPPPPCKKPSLLKKPEGASCNRLPSELWDTTI"
     exon            263..526
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            527..597
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            598..741
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            742..850
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            851..975
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1101
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1177
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1331
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1482
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1593
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1659
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1787
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1893
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2011
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2159
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2271
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2389
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..2461
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..2603
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2676
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2829
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..3030
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3106
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            3107..3282
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            3283..3363
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3569
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3672
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..3769
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            3770..4016
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            4017..4285
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            4286..5398
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            5399..5557
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            5558..5649
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     exon            5650..7046
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6421..6426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /note="hexamer: AATACA"
     polyA_site      6441
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /note="major polyA site"
     regulatory      7019..7024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /note="hexamer: AATAAA"
     polyA_site      7046
                     /gene="MYO16"
                     /gene_synonym="MYAP3; Myo16b; MYR8; NYAP3; PPP1R107"
                     /note="major polyA site"
ORIGIN      
        1 accagtggtg cctcaagacc caccggggag aggcttatct taactccagc tgccgaatga
       61 gaatgagttt gaagcttttt gcaggatcat ggaacagagc ctccatgcaa tagtgcatcc
      121 tgaggtaaac tgttacctga gtaagggctt taagtaatgc atttcctggg aacgacagtt
      181 gtgacagaag agaatgctgg aacccgtagc aagattcctg tctgagatgg aaagatgtct
      241 cactatcatt ttatcaagtg ctgttgcttt cagctatgta acgtttttcg atcccatgag
      301 atggaaatcg accagtgctt gctagagtcc cttccccttg gccaacggca gcgtctagtg
      361 aagcgcatgc gctgtgagca aatcaaagcc tactatgagc gcgagaaggc ttttcagaag
      421 caggaagggt tcctgaaaag gctgaagcat gcgaagaatc cgaaagttca cttcaacctc
      481 acggacatgc tacaggacgc gattatccac cacaatgaca aagaagtgct tcggctcctg
      541 aaggaggggg cagaccccca caccctcgtc tcctcgggag ggtccctgct ccatctgtgt
      601 gctcggtatg ataatgcctt cattgcagaa attctgattg acagaggagt caacgtcaac
      661 caccaggatg aagacttctg gacgcccatg cacattgcct gtgcctgcga taaccctgat
      721 attgtcctgc ttcttgtatt agctggagcc aatgtccttc tccaggatgt gaatggaaat
      781 atcccattag attatgctgt agaagggaca gaatccagct ctatcctgtt gacctatctg
      841 gatgaaaatg gagtggattt gacctcactg cgccagatga agcttcagag accaatgagt
      901 atgttaacag atgtcaaaca cttcttatca tctggaggaa atgtcaatga gaaaaacgat
      961 gaaggagtaa ccctgttaca catggcgtgt gcgagtggct acaaggaggt ggtgtctctt
     1021 atcctggaac atggtggaga cctcaacata gtagatgatc agtactggac tcccctccac
     1081 ttggcagcca aatatggcca gacaaatctg gtgaaacttc tcctgatgca tcaggcaaac
     1141 ccacacctcg tgaactgtaa tgaggagaag gcgtcagata ttgctgcctc tgagtttatt
     1201 gaggaaatgc tgctgaaagc cgaaattgcc tgggaagaaa aaatgaaaga gcctttatct
     1261 gcttctacct tagctcaaga agagccctat gaagagatca ttcacgatct tcccgtactg
     1321 tcgagtaagc tcagtcccct ggtgttacca attgccaagc aagacagttt gttggaaaaa
     1381 gacattatgt tcaaagatgc aacaaaaggt ctgtgtaagc agcagtctca ggacagcatc
     1441 cctgaaaacc ccatgatgag cggttccacc aaacccgagc aggtcaagct aatgcctcct
     1501 gccccaaacg atgacctggc aacgctcagc gagctcaatg atggcagcct gctctatgag
     1561 attcagaagc gctttgggaa caatcagatc tatacattca ttggagacat tcttttgctt
     1621 gttaacccat acaaggagct tccaatttat tcttccatgg tgtcccagct gtatttcagc
     1681 tcctcaggga agctgtgttc ctcgctgcct cctcacctct tctcctgtgt ggagagagcc
     1741 tttcaccagc tcttccggga acagcggcct cagtgtttca tcctcagtgg agaaagggga
     1801 tcaggaaagt ctgaagccag caaacaaatc ataagacacc tcacctgcag ggctggcgcc
     1861 agcagggcca cactggattc cagattcaaa catgtcgtgt gcatcttaga agcctttgga
     1921 catgccaaga ccacacttaa tgatttgtcc agttgcttca tcaagtattt tgaactgcag
     1981 ttctgtgaga ggaaacaaca gctaaccgga gccagaattt atacatattt gctagagaaa
     2041 tccagacttg tttcacaacc tcttggccag agcaattttc tcattttcta cttgttgatg
     2101 gatgggttat ctgctgaaga aaaatatgga cttcatctta ataatttatg tgcacaccgg
     2161 tatttgaacc agaccataca ggatgatgca tccacagggg agcgttctct gaacagggag
     2221 aaattggctg ttttgaaacg agccctgaat gtagttggct tcagcagctt ggaggtggag
     2281 aatctgttcg taattctagc agcaatattg caccttggag acattcggtt tactgccctg
     2341 aatgagggga actccgcctt cgtttctgac ctccagctcc tggaacaagt ggctggaatg
     2401 ttacaagtat caacagatga attggcatct gccttaacaa ctgatattca atattttaaa
     2461 ggggatatga taatacgacg acataccata cagattgctg agtttttccg agacctcttg
     2521 gccaagtccc tgtacagtcg tttgtttagc tttttggtga ataccatgaa ttcttgcctc
     2581 cacagtcaag atgaacagaa aagcatgcag acattggata ttggaatatt ggacattttt
     2641 ggttttgaag agtttcaaaa gaatgaattt gaacaacttt gtgtcaacat gaccaatgag
     2701 aagatgcacc actatatcaa tgaagtgctt tttctccacg agcaagtgga atgtgtacaa
     2761 gagggagtta ccatggaaac agcatattct cctggtaacc agaatggagt tttggacttt
     2821 tttttccaga agccatctgg atttctcacc ttattggatg aagaaagtca aatgatttgg
     2881 tcagtggaat caaattttcc aaaaaaacta caaagtctcc tagaatcctc aaacacaaat
     2941 gcggtgtact cccccatgaa ggatgggaat gggaatgttg ccctcaaaga ccacggtaca
     3001 gccttcacca tcatgcacta cgcaggaagg gtaatgtatg atgttgttgg ggcgattgaa
     3061 aaaaataaag actccctttc acagaatctt ctatttgtaa tgaaaactag tgaaaatgtc
     3121 gtgatcaatc atttgttcca gtcgaaattg tcacaaacag gatccctcgt atctgcctat
     3181 ccttccttta aattccgagg acataagtct gccctgctca gtaagaaaat gacagcttct
     3241 tcaattattg gagaaaacaa gaattatcta gaacttagta agttattaaa aaagaaagga
     3301 acttctacat ttcttcaaag attggaacga ggagatccag tcaccatagc atcacaactc
     3361 aggaaatcac taatggatat tattggaaaa cttcagaagt gcactccaca cttcattcat
     3421 tgcatcaggc ccaataactc aaagctgcca gatacttttg ataattttta cgtgtctgct
     3481 cagctacaat atattggggt cctggagatg gtgaagatct tccgatatgg ataccctgtt
     3541 cgcctttcct tctcggattt cctgtcaagg tataagccac tggctgatac attcctgcgt
     3601 gagaagaagg aacagtcagc tgccgagcga tgtcgacttg ttctccagca gtgtaaatta
     3661 caaggctggc agatgggagt ccgaaaagtg tttctaaaat actggcatgc tgaccaactc
     3721 aatgatttgt gcctacagtt gcagagaaaa attataacct gccaaaaagt tatcagagga
     3781 tttttagcac gccagcacct gcttcagaga ataagcatca gacaacaaga ggtgacttct
     3841 atcaatagct ttctgcagaa cacagaggac atggggctga aaacctacga tgccctggtc
     3901 attcagaatg cttcagacat tgcccgggaa aatgaccggc tccgtagtga aatgaacgct
     3961 ccctaccata aagagaagtt agaggtcagg aacatgcaag aggaaggaag caaaagaacc
     4021 gatgacaaga gtggacccag gcatttccac cccagctcca tgtcagtctg cgcggccgtg
     4081 gatggcctgg gccagtgcct cgttggcccg tccatctggt ctccttcgct gcactcggtg
     4141 ttcagcatgg atgacagcag cagcctcccg tctccacgga aacagccccc gcccaagcca
     4201 aagagggacc ccaacacccg gctgagtgct tcctatgagg ctgtgagcgc ctgcctctcc
     4261 gcggccaggg aagcggccaa cgaagctctg gcccggccca gaccgcacag cgacgactac
     4321 agcaccatga agaagattcc tcctcgaaag cccaagcgca gccccaacac caagctcagc
     4381 ggctcctacg aggagatatc ggggtcccgg cccggggacg cgaggcccgc gggcgccccg
     4441 ggggcagcag cgcgcgttct gacccccggg actccgcagt gcgcgctgcc cccggcggcg
     4501 cctccgggtg acgaggacga cagcgagcct gtgtacatcg agatgctggg gcacgcggcc
     4561 aggcccgata gcccggaccc cggggagtcc gtgtacgagg agatgaagtg ttgcctgccc
     4621 gacgacggcg gcccgggcgc gggctccttc ctgctccacg gcgcatcgcc gcccctgctc
     4681 caccgcgcgc cggaggacga ggcggcgggg cccccagggg acgcgtgcga catcccgccg
     4741 cccttcccca acctgctgcc gcaccggccg cccctgctgg tgttcccccc gacccccgtc
     4801 acctgctccc ccgcctccga cgagtcgccc ctgacacccc tggaggtgaa gaagctgcca
     4861 gtcctggaga ccaacctcaa gtaccccgtg cagccggagg ggtcgagccc gctgtccccg
     4921 cagtactcca agagccagaa gggcgacggc gacaggcccg cgtcccccgg cctggcgctg
     4981 ttcaacgggt ccggccgagc ctccccgccg tccacgccgc ccccgccccc gcccccgccc
     5041 gggccgcccc ccgcgcccta caggccctgc gcgcacttgg ccttcccgcc ggagcccgcc
     5101 ccggtgaacg cggggaaagc ggggccgagc gcagaggcgc ccaaggttca cccaaagcca
     5161 aactctgccc ccgtggccgg gccctgcagc tccttcccca agatcccata ttcccccgtg
     5221 aaggccacca gggcggacgc caggaaggcc ggctccagtg cctcgccccc cgcgccctac
     5281 agccctccca gctccaggcc tctcagcagc cccctggacg agctcgccag cctcttcaac
     5341 tcggggagga gtgtgcttcg gaaatccgcg gcgggaagaa aaatcaggga agcagaaggt
     5401 tttgaaacta acatgaacat aagtagccga gatgacccta gtacgtcaga aattacttcc
     5461 gagactcaag acagaaatgc aaataaccat ggaattcagt tatctaattc actatctagt
     5521 gctataactg ctgaaaatgg aaattccatc tcaaatggtt tacctgaaga agatggatac
     5581 tcacggttgt ctataagtgg cacagggact tcgacatttc aaagacacag ggacagtcac
     5641 accactcagg taatccatca gctgaggctc tcagagaatg aaagtgtggc cctgcaggaa
     5701 ctcttggact ggaggagaaa gctctgtgag gaaggacaag actggcagca gatcctgcac
     5761 cacgctgagc ccagggtgcc tcccccacca ccttgcaaga agcccagcct tctgaagaag
     5821 ccggaagggg cctcctgcaa caggctgccg tctgagctct gggacaccac catttgatgt
     5881 ggcctgaact gcagacttac aaaatagaac tgcctactga ttccgggctg caacaacaga
     5941 aggctgcctt ctgacatgcg ctggggcttc tctccacgca tttagacaaa aaaagcacag
     6001 gacacagaca ctaaatatat gagatcccgt gtgtgtgtgt gtgtgtttgt gtgtgtgtgt
     6061 gtgggttctt tcttatccat ctcgtggtga tacactctga ttttcaagct cctcatttac
     6121 ggctctgtgc tacccctagg tagcaagaga gaggctggga aaagtgtgga cgtggccaga
     6181 gcgagagagt agcggaggaa aggagcaatc catgcacact ctgtacagtt gtttttctac
     6241 ggttcaacag tctgtttatt gtacttccaa tggttttatt ataatacagt atacgggaca
     6301 tatattttat ttctttgtag ctacttgtgt tttattggta ttataaacct gataattatt
     6361 tacatgttta ttactgtaat tttataaatt tatgcaattg gtggtgcttc ctttcttcaa
     6421 aatacagatt ttaaaaaatc atttctagat tatttttttc ctccacagtc cttttttttc
     6481 acctaacgca cctaaatctt gaaactacat tgttgtttta gcttcgccag tgtcacccct
     6541 tgcaaaacta tgaattgagc cccatgtttt aggtgttact catggatgag gaggctgttc
     6601 tttcctatgc cctgtatttc tggataagtg gattgtgtac cctttagtta aatttcacct
     6661 cccgacttca gcatagatca caggaaatca catggcacac ggttaaacac gtatggcttc
     6721 aaatccatag ccggtggtgt aaaatgatca tattcattca aaggcctaca cagtacaaat
     6781 gagcacgctg ccatgtactg gtttgagcag taggggctgc atcgcacagc gctcgtcccc
     6841 cgggacttac actgcatgat tccctcactg tatatcctca accctcccat aatgcaaggc
     6901 cttgttcatt gatgtgcttt cgtcggctgt cggaaagttc tgagcagtgg ctccagacca
     6961 ccttgtcttg ctacttggaa ctttttattc ataccagcct ttgaaaagtt actgtgccaa
     7021 taaagaggta caactgtgtt cttcta
//
