LOCUS       NM_012334              11442 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens myosin X (MYO10), mRNA.
ACCESSION   NM_012334
VERSION     NM_012334.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11442)
  AUTHORS   Mayca Pozo,F., Geng,X., Miyagi,M., Amin,A.L., Huang,A.Y. and
            Zhang,Y.
  TITLE     MYO10 regulates genome stability and cancer inflammation through
            mediating mitosis
  JOURNAL   Cell Rep 42 (5), 112531 (2023)
   PUBMED   37200188
  REMARK    GeneRIF: MYO10 regulates genome stability and cancer inflammation
            through mediating mitosis.
REFERENCE   2  (bases 1 to 11442)
  AUTHORS   Ou,H., Wang,L., Xi,Z., Shen,H., Jiang,Y., Zhou,F., Liu,Y. and
            Zhou,Y.
  TITLE     MYO10 contributes to the malignant phenotypes of colorectal cancer
            via RACK1 by activating integrin/Src/FAK signaling
  JOURNAL   Cancer Sci 113 (11), 3838-3851 (2022)
   PUBMED   35912545
  REMARK    GeneRIF: MYO10 contributes to the malignant phenotypes of
            colorectal cancer via RACK1 by activating integrin/Src/FAK
            signaling.
REFERENCE   3  (bases 1 to 11442)
  AUTHORS   Peuhu,E., Jacquemet,G., Scheele,C.L.G.J., Isomursu,A., Laisne,M.C.,
            Koskinen,L.M., Paatero,I., Thol,K., Georgiadou,M., Guzman,C.,
            Koskinen,S., Laiho,A., Elo,L.L., Bostrom,P., Hartiala,P., van
            Rheenen,J. and Ivaska,J.
  TITLE     MYO10-filopodia support basement membranes at pre-invasive tumor
            boundaries
  JOURNAL   Dev Cell 57 (20), 2350-2364 (2022)
   PUBMED   36283390
  REMARK    GeneRIF: MYO10-filopodia support basement membranes at pre-invasive
            tumor boundaries.
REFERENCE   4  (bases 1 to 11442)
  AUTHORS   Granados-Aparici,S., Volodarsky-Perel,A., Yang,Q., Anam,S.,
            Tulandi,T., Buckett,W., Son,W.Y., Younes,G., Chung,J.T., Jin,S.,
            Terret,M.E. and Clarke,H.J.
  TITLE     MYO10 promotes transzonal projection-dependent germ line-somatic
            contact during mammalian folliculogenesisdagger
  JOURNAL   Biol Reprod 107 (2), 474-487 (2022)
   PUBMED   35470858
  REMARK    GeneRIF: MYO10 promotes transzonal projection-dependent germ
            line-somatic contact during mammalian folliculogenesisdagger.
REFERENCE   5  (bases 1 to 11442)
  AUTHORS   Miihkinen,M., Gronloh,M.L.B., Popovic,A., Vihinen,H., Jokitalo,E.,
            Goult,B.T., Ivaska,J. and Jacquemet,G.
  TITLE     Myosin-X and talin modulate integrin activity at filopodia tips
  JOURNAL   Cell Rep 36 (11), 109716 (2021)
   PUBMED   34525374
  REMARK    GeneRIF: Myosin-X and talin modulate integrin activity at filopodia
            tips.
REFERENCE   6  (bases 1 to 11442)
  AUTHORS   Cox,D., Berg,J.S., Cammer,M., Chinegwundoh,J.O., Dale,B.M.,
            Cheney,R.E. and Greenberg,S.
  TITLE     Myosin X is a downstream effector of PI(3)K during phagocytosis
  JOURNAL   Nat Cell Biol 4 (7), 469-477 (2002)
   PUBMED   12055636
REFERENCE   7  (bases 1 to 11442)
  AUTHORS   Rogers,M.S. and Strehler,E.E.
  TITLE     The tumor-sensitive calmodulin-like protein is a specific light
            chain of human unconventional myosin X
  JOURNAL   J Biol Chem 276 (15), 12182-12189 (2001)
   PUBMED   11278607
REFERENCE   8  (bases 1 to 11442)
  AUTHORS   Berg,J.S., Derfler,B.H., Pennisi,C.M., Corey,D.P. and Cheney,R.E.
  TITLE     Myosin-X, a novel myosin with pleckstrin homology domains,
            associates with regions of dynamic actin
  JOURNAL   J Cell Sci 113 Pt 19, 3439-3451 (2000)
   PUBMED   10984435
REFERENCE   9  (bases 1 to 11442)
  AUTHORS   Rojas,K., Serrano de la Pena,L., Gallardo,T., Simmons,A., Nyce,K.,
            McGrath,R., Considine,E., Vasko,A.J., Peterson,E., Grady,D.,
            Cox,R., Andrew,L.J., Lovett,M., Overhauser,J. and Williams,C.J.
  TITLE     Physical map and characterization of transcripts in the candidate
            interval for familial chondrocalcinosis at chromosome 5p15.1
  JOURNAL   Genomics 62 (2), 177-183 (1999)
   PUBMED   10610710
REFERENCE   10 (bases 1 to 11442)
  AUTHORS   Hasson,T., Skowron,J.F., Gilbert,D.J., Avraham,K.B., Perry,W.L.,
            Bement,W.M., Anderson,B.L., Sherr,E.H., Chen,Z.Y., Greene,L.A.,
            Ward,D.C., Corey,D.P., Mooseker,M.S., Copeland,N.G. and
            Jenkins,N.A.
  TITLE     Mapping of unconventional myosins in mouse and human
  JOURNAL   Genomics 36 (3), 431-439 (1996)
   PUBMED   8884266
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010607.8, DA504301.1,
            BC014956.1, BC150285.1, CA488271.1, AF234532.1, AC024588.4 and
            AI086647.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012334.2.
            
            Summary: This gene encodes a member of the myosin superfamily. The
            protein represents an unconventional myosin; it should not be
            confused with the conventional non-muscle myosin-10 (MYH10).
            Unconventional myosins contain the basic domains of conventional
            myosins and are further distinguished from class members by their
            tail domains. This gene functions as an actin-based molecular motor
            and plays a role in integration of F-actin and microtubule
            cytoskeletons during meiosis. [provided by RefSeq, Dec 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150285.1, AB018342.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000513610.6/ ENSP00000421280.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC010607.8         77867-77878         c
            13-556              DA504301.1         1-544
            557-1449            BC014956.1         541-1433
            1450-5467           BC150285.1         1425-5442
            5468-5933           CA488271.1         299-764
            5934-8045           AF234532.1         5676-7787
            8046-11020          AC024588.4         92006-94980         c
            11021-11442         AI086647.1         7-428               c
FEATURES             Location/Qualifiers
     source          1..11442
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.1"
     gene            1..11442
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /note="myosin X"
                     /db_xref="GeneID:4651"
                     /db_xref="HGNC:HGNC:7593"
                     /db_xref="MIM:601481"
     exon            1..501
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..6657
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /note="unconventional myosin-10; unconventionnal myosin-X"
                     /codon_start=1
                     /product="unconventional myosin-X"
                     /protein_id="NP_036466.2"
                     /db_xref="CCDS:CCDS54834.1"
                     /db_xref="GeneID:4651"
                     /db_xref="HGNC:HGNC:7593"
                     /db_xref="MIM:601481"
                     /translation="MDNFFTEGTRVWLRENGQHFPSTVNSCAEGIVVFRTDYGQVFTY
                     KQSTITHQKVTAMHPTNEEGVDDMASLTELHGGSIMYNLFQRYKRNQIYTYIGSILAS
                     VNPYQPIAGLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISGESG
                     AGKTESTKLILKFLSVISQQSLELSLKEKTSCVERAILESSPIMEAFGNAKTVYNNNS
                     SRFGKFVQLNICQKGNIQGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEERE
                     EFYLSTPENYHYLNQSGCVEDKTISDQESFREVITAMDVMQFSKEEVREVSRLLAGIL
                     HLGNIEFITAGGAQVSFKTALGRSAELLGLDPTQLTDALTQRSMFLRGEEILTPLNVQ
                     QAVDSRDSLAMALYACCFEWVIKKINSRIKGNEDFKSIGILDIFGFENFEVNHFEQFN
                     INYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDNGECLDLIEKKLGLLALINE
                     ESHFPQATDSTLLEKLHSQHANNHFYVKPRVAVNNFGVKHYAGEVQYDVRGILEKNRD
                     TFRDDLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRRPTVSSQFKDSLHSLMA
                     TLSSSNPFFVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDF
                     YKRYKVLMRNLALPEDVRGKCTSLLQLYDASNSEWQLGKTKVFLRESLEQKLEKRREE
                     EVSHAAMVIRAHVLGFLARKQYRKVLYCVVIIQKNYRAFLLRRRFLHLKKAAIVFQKQ
                     LRGQIARRVYRQLLAEKREQEEKKKQEEEEKKKREEEERERERERREAELRAQQEEET
                     RKQQELEALQKSQKEAELTRELEKQKENKQVEEILRLEKEIEDLQRMKEQQELSLTEA
                     SLQKLQERRDQELRRLEEEACRAAQEFLESLNFDEIDECVRNIERSLSVGSEFSSELA
                     ESACEEKPNFNFSQPYPEEEVDEGFEADDDAFKDSPNPSEHGHSDQRTSGIRTSDDSS
                     EEDPYMNDTVVPTSPSADSTVLLAPSVQDSGSLHNSSSGESTYCMPQNAGDLPSPDGD
                     YDYDQDDYEDGAITSGSSVTFSNSYGSQWSPDYRCSVGTYNSSGAYRFSSEGAQSSFE
                     DSEEDFDSRFDTDDELSYRRDSVYSCVTLPYFHSFLYMKGGLMNSWKRRWCVLKDETF
                     LWFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQSKLMYFENDSEEKLKGTVE
                     VRTAKEIIDNTTKENGIDIIMADRTFHLIAESPEDASQWFSVLSQVHASTDQEIQEMH
                     DEQANPQNAVGTLDVGLIDSVCASDSPDRPNSFVIITANRVLHCNADTPEEMHHWITL
                     LQRSKGDTRVEGQEFIVRGWLHKEVKNSPKMSSLKLKKRWFVLTHNSLDYYKSSEKNA
                     LKLGTLVLNSLCSVVPPDEKIFKETGYWNVTVYGRKHCYRLYTKLLNEATRWSSAIQN
                     VTDTKAPIDTPTQQLIQDIKENCLNSDVVEQIYKRNPILRYTHHPLHSPLLPLPYGDI
                     NLNLLKDKGYTTLQDEAIKIFNSLQQLESMSDPIPIIQGILQTGHDLRPLRDELYCQL
                     IKQTNKVPHPGSVGNLYSWQILTCLSCTFLPSRGILKYLKFHLKRIREQFPGSEMEKY
                     ALFTYESLKKTKCREFVPSRDEIEALIHRQEMTSTVYCHGGGSCKITINSHTTAGEVV
                     EKLIRGLAMEDSRNMFALFEYNGHVDKAIESRTVVADVLAKFEKLAATSEVGDLPWKF
                     YFKLYCFLDTDNVPKDSVEFAFMFEQAHEAVIHGHHPAPEENLQVLAALRLQYLQGDY
                     TLHAAIPPLEEVYSLQRLKARISQSTKTFTPCERLEKRRTSFLEGTLRRSFRTGSVVR
                     QKVEEEQMLDMWIKEEVSSARASIIDKWRKFQGMNQEQAMAKYMALIKEWPGYGSTLF
                     DVECKEGGFPQELWLGVSADAVSVYKRGEGRPLEVFQYEHILSFGAPLANTYKIVVDE
                     RELLFETSEVVDVAKLMKAYISMIVKKRYSTTRSASSQGSSR"
     exon            502..600
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            601..759
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            760..947
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1082
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1207
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1221
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1306
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1410
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1540
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1659
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1806
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1907
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..1974
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2067
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2136
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2219
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2328
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2409
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2534
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            2535..2649
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2756
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2990
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3036
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3912
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4036
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            4037..4280
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            4281..4376
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            4377..4470
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            4471..4526
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            4527..4669
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            4670..4864
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            4865..5022
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            5023..5146
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            5147..5444
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            5445..5652
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            5653..5789
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            5790..5910
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            5911..6363
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            6364..6555
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     exon            6556..11442
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8029..8034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /note="hexamer: AATAAA"
     polyA_site      8047
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /note="major polyA site"
     regulatory      11421..11426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYO10"
                     /gene_synonym="MyoX"
                     /note="hexamer: AATAAA"
     polyA_site      11442
                     /gene="MYO10"
                     /gene_synonym="MyoX"
ORIGIN      
        1 agtcccgcgg gcgagagctg gctgagccgc ggcgcgggac tgctcacctc caagcgctcg
       61 cgcggggatc gcggctcctg ctcactttgc ggcccgctgt cctcctgccc gccccgaggg
      121 cccccggccg gagcgcagag ggagggggcc gcgctcgcca gcaccccgcc gccttccccc
      181 gcctggggga agaatgtgcc accagctgtt ctccgcttgc gagcgctgcg cccagtagtg
      241 aggaacttgg aggaagaaga gacaaaggct gccgtcggga cgggcgagtt agggacttgg
      301 gtttgggcga acaaaaggtg agaaggacaa gaagggaccg ggcgatggca gcaggggagc
      361 cccgcgggcg cgcgtcctcg ggagtggcgc cgtgacacgc atggtttccc cggacccgcg
      421 gcggcgctga cttccgcgag tcggagcggc actcggcgag tccgggactg cgctggaaca
      481 atggataact tcttcaccga gggaacacgg gtctggctga gagaaaatgg ccagcatttt
      541 ccaagtactg taaattcctg tgcagaaggc atcgtcgtct tccggacaga ctatggtcag
      601 gtattcactt acaagcagag cacaattacc caccagaagg tgactgctat gcaccccacg
      661 aacgaggagg gcgtggatga catggcgtcc ttgacagagc tccatggcgg ctccatcatg
      721 tataacttat tccagcggta taagagaaat caaatatata cctacatcgg ctccatcctg
      781 gcctccgtga acccctacca gcccatcgcc gggctgtacg agcctgccac catggagcag
      841 tacagccggc gccacctggg cgagctgccc ccgcacatct tcgccatcgc caacgagtgc
      901 taccgctgcc tgtggaagcg ccacgacaac cagtgcatcc tcatcagtgg tgaaagtggg
      961 gcaggtaaaa ccgaaagcac taaattgatc ctcaagtttc tgtcagtcat cagtcaacag
     1021 tctttggaat tgtccttaaa ggagaagaca tcctgtgttg aacgagctat tcttgaaagc
     1081 agccccatca tggaagcttt cggcaatgcg aagaccgtgt acaacaacaa ctctagtcgc
     1141 tttgggaagt ttgttcagct gaacatctgt cagaaaggaa atattcaggg cgggagaatt
     1201 gtagattatt tattagaaaa aaaccgagta gtaaggcaaa atcccgggga aaggaattat
     1261 cacatatttt atgcactgct ggcagggctg gaacatgaag aaagagaaga attttattta
     1321 tctacgccag aaaactacca ctacttgaat cagtctggat gtgtagaaga caagacaatc
     1381 agtgaccagg aatcctttag ggaagttatt acggcaatgg acgtgatgca gttcagcaag
     1441 gaggaagttc gggaagtgtc gaggctgctt gctggtatac tgcatcttgg gaacatagaa
     1501 tttatcactg ctggtggggc acaggtttcc ttcaaaacag ctttgggcag atctgcggag
     1561 ttacttgggc tggacccaac acagctcaca gatgctttga cccagagatc aatgttcctc
     1621 aggggagaag agatcctcac gcctctcaat gttcaacagg cagtagacag cagggactcc
     1681 ctggccatgg ctctgtatgc gtgctgcttt gagtgggtaa tcaagaagat caacagcagg
     1741 atcaaaggca atgaggactt caagtctatt ggcatcctcg acatctttgg atttgaaaac
     1801 tttgaggtta atcactttga acagttcaat ataaactatg caaacgagaa acttcaggag
     1861 tacttcaaca agcatatttt ttctttagaa caactagaat atagccggga aggattagtg
     1921 tgggaagata ttgactggat agacaatgga gaatgcctgg acttgattga gaagaaactt
     1981 ggcctcctag cccttatcaa tgaagaaagc cattttcctc aagccacaga cagcacctta
     2041 ttggagaagc tacacagtca gcatgcgaat aaccactttt atgtgaagcc cagagttgca
     2101 gttaacaatt ttggagtgaa gcactatgct ggagaggtgc aatatgatgt ccgaggtatc
     2161 ttggagaaga acagagatac atttcgagat gaccttctca atttgctaag agaaagccga
     2221 tttgacttta tctacgatct ttttgaacat gtttcaagcc gcaacaacca ggataccttg
     2281 aaatgtggaa gcaaacatcg gcggcctaca gtcagctcac agttcaagga ctcactgcat
     2341 tccttaatgg caacgctaag ctcctctaat cctttctttg ttcgctgtat caagccaaac
     2401 atgcagaaga tgccagacca gtttgaccag gcggttgtgc tgaaccagct gcggtactca
     2461 gggatgctgg agactgtgag aatccgcaaa gctgggtatg cggtccgaag accctttcag
     2521 gacttttaca aaaggtataa agtgctgatg aggaatctgg ctctgcctga ggacgtccga
     2581 gggaagtgca cgagcctgct gcagctctat gatgcctcca acagcgagtg gcagctgggg
     2641 aagaccaagg tctttcttcg agaatccttg gaacagaaac tggagaagcg gagggaagag
     2701 gaagtgagcc acgcggccat ggtgattcgg gcccatgtct tgggcttctt agcacgaaaa
     2761 caatacagaa aggtccttta ttgtgtggtg ataatacaga agaattacag agcattcctt
     2821 ctgaggagga gatttttgca cctgaaaaag gcagccatag ttttccagaa gcaactcaga
     2881 ggtcagattg ctcggagagt ttacagacaa ttgctggcag agaaaaggga gcaagaagaa
     2941 aagaagaaac aggaagagga agaaaagaag aaacgggagg aagaagaaag agaaagagag
     3001 agagagcgaa gagaagccga gctccgcgcc cagcaggaag aagaaacgag gaagcagcaa
     3061 gaactcgaag ccttgcagaa gagccagaag gaagctgaac tgacccgtga actggagaaa
     3121 cagaaggaaa ataagcaggt ggaagagatc ctccgtctgg agaaagaaat cgaggacctg
     3181 cagcgcatga aggagcagca ggagctgtcg ctgaccgagg cttccctgca gaagctgcag
     3241 gagcggcggg accaggagct ccgcaggctg gaggaggaag cgtgcagggc ggcccaggag
     3301 ttcctcgagt ccctcaattt cgacgagatc gacgagtgtg tccggaatat cgagcggtcc
     3361 ctgtcggtgg gaagcgaatt ttccagcgag ctggctgaga gcgcatgcga ggagaagccc
     3421 aacttcaact tcagccagcc ctacccagag gaggaggtcg atgagggctt cgaagccgac
     3481 gacgacgcct tcaaggactc ccccaacccc agcgagcacg gccactcaga ccagcgaaca
     3541 agtggcatcc ggaccagcga tgactcttca gaggaggacc catacatgaa cgacacggtg
     3601 gtgcccacca gccccagtgc ggacagcacg gtgctgctcg ccccatcagt gcaggactcc
     3661 gggagcctac acaactcctc cagcggcgag tccacctact gcatgcccca gaacgctggg
     3721 gacttgccct ccccagacgg cgactacgac tacgaccagg atgactatga ggacggtgcc
     3781 atcacttccg gcagcagcgt gaccttctcc aactcctacg gcagccagtg gtcccccgac
     3841 taccgctgct ctgtggggac ctacaacagc tcgggtgcct accggttcag ctctgagggg
     3901 gcgcagtcct cgtttgaaga tagtgaagag gactttgatt ccaggtttga tacagatgat
     3961 gagctttcat accggcgtga ctctgtgtac agctgtgtca ctctgccgta tttccacagc
     4021 tttctgtaca tgaaaggtgg cctgatgaac tcttggaaac gccgctggtg cgtcctcaag
     4081 gatgaaacct tcttgtggtt ccgctccaag caggaggccc tcaagcaagg ctggctccac
     4141 aaaaaagggg ggggctcctc cacgctgtcc aggagaaatt ggaagaagcg ctggtttgtc
     4201 ctccgccagt ccaagctgat gtactttgaa aacgacagcg aggagaagct caagggcacc
     4261 gtagaagtgc gaacggcaaa agagatcata gataacacca ccaaggagaa tgggatcgac
     4321 atcattatgg ccgataggac tttccacctg attgcagagt ccccagaaga tgccagccag
     4381 tggttcagcg tgctgagtca ggtccacgcg tccacggacc aggagatcca ggagatgcat
     4441 gatgagcagg caaacccaca gaatgctgtg ggcaccttgg atgtggggct gattgattct
     4501 gtgtgtgcct ctgacagccc tgatagaccc aactcgtttg tgatcatcac ggccaaccgg
     4561 gtgctgcact gcaacgccga cacgccggag gagatgcacc actggataac cctgctgcag
     4621 aggtccaaag gggacaccag agtggagggc caggaattca tcgtgagagg atggttgcac
     4681 aaagaggtga agaacagtcc aaagatgtct tcactgaaac tgaagaaacg gtggtttgta
     4741 ctcacccaca attccctgga ttactacaag agttcagaga agaacgcgct caaactgggg
     4801 accctggtcc tcaacagcct ctgctctgtc gtccccccag atgagaagat attcaaagag
     4861 acaggctact ggaacgtcac cgtgtacggg cgcaagcact gttaccggct ctacaccaag
     4921 ctgctcaacg aggccacccg gtggtccagt gccattcaaa acgtgactga caccaaggcc
     4981 ccgatcgaca cccccaccca gcagctgatt caagatatca aggagaactg cctgaactcg
     5041 gatgtggtgg aacagattta caagcggaac ccgatccttc gatacaccca tcaccccttg
     5101 cactccccgc tcctgcccct tccgtatggg gacataaatc tcaacttgct caaagacaaa
     5161 ggctatacca cccttcagga tgaggccatc aagatattca attccctgca gcaactggag
     5221 tccatgtctg acccaattcc aataatccag ggcatcctac agacagggca tgacctgcga
     5281 cctctgcggg acgagctgta ctgccagctt atcaaacaga ccaacaaagt gccccacccc
     5341 ggcagtgtgg gcaacctgta cagctggcag atcctgacat gcctgagctg caccttcctg
     5401 ccgagtcgag ggattctcaa gtatctcaag ttccatctga aaaggatacg ggaacagttt
     5461 ccaggaagcg agatggaaaa atacgctctc ttcacttacg aatctcttaa gaaaaccaaa
     5521 tgccgagagt ttgtgccttc ccgagatgaa atagaagctc tgatccacag gcaggaaatg
     5581 acatccacgg tctattgcca tggcggcggc tcctgcaaga tcaccatcaa ctcccacacc
     5641 accgctgggg aggtggtgga gaagctgatc cgaggcctgg ccatggagga cagcaggaac
     5701 atgtttgctt tgtttgaata caacggccac gtcgacaaag ccattgaaag tcgaaccgtc
     5761 gtagctgatg tcttagccaa gtttgaaaag ctggctgcca catccgaggt tggggacctg
     5821 ccatggaaat tctacttcaa actttactgc ttcctggaca cagacaacgt gccaaaagac
     5881 agtgtggagt ttgcatttat gtttgaacag gcccacgaag cggttatcca tggccaccat
     5941 ccagccccgg aagaaaacct ccaggttctt gctgccctgc gactccagta tctgcagggg
     6001 gattatactc tgcacgctgc catcccacct ctcgaagagg tttattccct gcagagactc
     6061 aaggcccgca tcagccagtc aaccaaaacc ttcacccctt gtgaacggct ggagaagagg
     6121 cggacgagct tcctagaggg gaccctgagg cggagcttcc ggacaggatc cgtggtccgg
     6181 cagaaggtcg aggaggagca gatgctggac atgtggatta aggaagaagt ctcctctgct
     6241 cgagccagta tcattgacaa gtggaggaaa tttcagggaa tgaaccagga acaggccatg
     6301 gccaagtaca tggccttgat caaggagtgg cctggctatg gctcgacgct gtttgatgtg
     6361 gagtgcaagg aaggtggctt ccctcaggaa ctctggttgg gtgtcagcgc ggacgccgtc
     6421 tccgtctaca agcgtggaga gggaagacca ctggaagtct tccagtatga acacatcctc
     6481 tcttttgggg cacccctggc gaatacgtat aagatcgtgg tcgatgagag ggagctgctc
     6541 tttgaaacca gtgaggtggt ggatgtggcc aagctcatga aagcctacat cagcatgatc
     6601 gtgaagaagc gctacagcac gacacgctcc gccagcagcc agggcagctc caggtgaagg
     6661 cgggacagag cccacctgtc tttgctacct gaacgcacca ccctctggcc taggctggct
     6721 ccagtgtgcc atgcccagcc aaaacaaaca cagagctgcc caggctttct ggaagcttct
     6781 ggtctgaggg aggtgtctcc gaggatcctt ttgcctgccg ccttcattga tcctgtatta
     6841 agctgtcaac tttaacagtc tgcacagttt ccaaagcttt actactctta gaggacacat
     6901 gccttaaaaa aggaggggag gaaccacgct gccaccaaag cagccggaag tgccttaact
     6961 tgtggaacca acactaatcg accgtaactg tgctactgaa gggaactgcc tttccccctt
     7021 ctgggggaga cttaacagag cgtggaaggg gggcattctc tgtcaatgat gcactaacct
     7081 cccaacctga tttccccgaa tctgagggaa ggtgagggag tgggaagggg gatggagagc
     7141 tcgaggggac agtgtgtttg agctggagtg ctgcgggcag cctttctcat ggaatgacat
     7201 gaatcaactt ttttctttgt ttcatctttt aagtgtacgt gcttgcctgt tcgtgcatgt
     7261 gttcataaac tcaacacttt aatcatggtt tcatgagcat taaaaagcaa agggaaaaag
     7321 gatgtgtaat ggtgtacaca gtctgtatat tttaataatg cagagctata gtctcaattg
     7381 ttactttata aggtggtttt attaacaaac ccaaatcctg gattttcctg tctttgctgt
     7441 attttgaaaa acacgtgttg actccattgt tttacatgta gcaaagtctg ccatctgtgt
     7501 ctgctgtatt ataaacagat aagcagccta caagataact gtatttataa accactcttc
     7561 aacagctggc tccagtgctg gttttagaac aagaatgaag tcattttgga gtctttcatg
     7621 tctaaaagat ttaagttaaa aacaaagtgt tacttggaag gttagcttct atcattctgg
     7681 atagattaca gatataataa ccatgttgac tatgggggag agacgctgca ttccagaaac
     7741 gtcttaacac ttgagtgaat cttcaaagga ccctgacatt aaatgctgag gctttaatac
     7801 acacatattt tatcccaagt ttataatggt ggtctgaaca aggcacctgt aaataaatca
     7861 gcatttatga ccagaagaaa aataatctgg tcttggactt tttattttta tatggaaaag
     7921 ttttaaggac ttgggccaac taagtctacc cacacgaaaa aagaaatttg ccttgtccct
     7981 ttgtgtacaa ccatgcaaaa ctgtttgttg gctcacagaa gttctgacaa taaaagatac
     8041 tagctaacac gctgtgtgtt tcctttatca gaggaggctc taaaaaccat ggaggggagg
     8101 cttatttttg ttttggcttt ttggtggttt tttttttttt tctttagaga cagagtctca
     8161 ctctgttacc caggctggag tacagtggcg tgatctcggc tcactgcagc ctctgcctcc
     8221 tgggttctag cgattctcct gcctcagcct cccaaggagt tgggagtaca ggcatgcatc
     8281 accacgcctg gctaggtttt gtatttttag tagagatggg gtttcaccat gttggccagg
     8341 ctggtctcga tccacctgcc tcagcctccc aaagtgctgg gattacaggt gtgagctacc
     8401 gcacccggcc ggctttttgg tgttaatgct atggtttcag tgtctgggct ttgtgtttgt
     8461 ttcatggact tgctcatcag gtctaaacac agatctgcag ctgtctccac tgctcttgta
     8521 gacactgagt gtgacttcaa gaaagcaaaa gaagggactg gtaaatgaag tcacacacag
     8581 ctgaggactt gaaatgtgtt tatgtcagac agtcccctat gtcagcccca aagtgtgcct
     8641 gatcttgcaa ccctggatcc tagaacctgc ctgcacctcc ctgtggacca gaacacacag
     8701 gtaggcagtt tggttgccaa tgtacccaaa ccaccaggcc aggcgtctag catgagcaag
     8761 cgccacttct cttgcagacc actgactccc accctctgct catgctcacg gatggcttct
     8821 tcccattctg cagggattgg gatggaacct gaagccaggt gctgcctgaa gcctgtggcc
     8881 ccgccaggca cccaaggaaa gccggcaaag acttggatgt gtgttgtctt tgtttttatt
     8941 ttaggctcag aaagaatttg acagaagtct tctttctact gctcacctct caggattccc
     9001 tctgtgactt aatttactct ggaaggctgt cgcccgccct caattataga tggggaaata
     9061 ggcaaggaaa ggcatgactc agattggggg ggttagagca gcaccatagt tagaacatag
     9121 atttacatgt gagcctttac atggcatagt tgtggttttg ttttagcctt ttatttagaa
     9181 ataattacag actcagagaa agttgcaaca gaacgtacag ggaggcctgc gtgcccttca
     9241 gtttccccag tggtagcatc ccccatcact gtagagcagc atcacagctg acaaagtacc
     9301 gttgagcttc ccctagccac agaacctatt ccaattttac tgcttttaca tgcactcatt
     9361 ggtgtgtgtg atgtcagttg ctttcaacaa ggtcagtgaa gtgcagtcgt cccttggtat
     9421 ccaagggaga ttggttccag gaccccctcc ccccacccct gaggatacaa aattcacaga
     9481 tgctcaagtc cctgctatac agtggtataa tatttgcata gaacctgcac acatctttcc
     9541 ttacccttta aatcatctcc aggttacaga tacctagcac aacataaatg ctgcataaat
     9601 agctgttata ccgtgtgtgt ctgtgtttta aacattgttt atttgagaca gggtctcact
     9661 ctgtcaccag gctacagtgc agaggcacag tcacagctca ttgcagcctc aacctcctgg
     9721 gctcaagcag tcctccacct cagcctccca aagtgctagg atgacaggtg tgagccactg
     9781 tgccccacca aaaaaagttt tttcaaatat tttctatctg tggttggatt cagaccacat
     9841 gaacactgag ggctgactgt agttttgaat gtctgttact gaggaggcac cagcataaag
     9901 tattttatca cttcagacgc tgacaatcta gtatttttaa tttttaaatc ttttgaaagc
     9961 taatacatat aggtgatttg taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
    10021 caactagaag taaaatgtta cttttttcca gctgtagccc taattaccca ttttcctttc
    10081 ccagaaacag ctatttttac tgttttattg aatattctct caaaaataat ttaagctgtc
    10141 caatcattta ctcatacata catatatatc cccatcctca tttttaatag atggaaacaa
    10201 actgttgtag cttacttttt tctcagcata gtattttagc tctaatccta cattaatacc
    10261 tatagaattg ccttattctt tttgatgatt atatagtacc tcagatagct ctgtggaaaa
    10321 acaggataag gccatctgta ttagtccatt ctcacactgc tagaaggaca tgcctgagac
    10381 tgggtaattt ataaagaaaa agaagttgaa tggactcagt ctcacatgcc tggggaggcc
    10441 tcacaatcat ggtggacagc aaaggaggag aaaaggcaca tcttatatgg cagcaggcaa
    10501 gagagcttgc acaggggaac tcccttttat aaaaccatta gctcttccga gacatactca
    10561 ctatggacaa gaacagcatg ggaaaaccca cccccatgat tcaattacct cccatcaggt
    10621 ccctcccgtg acaggtgggg attatgggag ctataattca agatgagatt tgggtgggga
    10681 cagagccaaa ccatatcacc acctaagttc tctgtaaaaa tagtttcagc caggcatgct
    10741 ggctcacgcc tgtaatccca gcatgttgga aggccgaggc aagaggatcg cttgagctcc
    10801 ggagttcaag accagtctgg gcaacatgac aagaccctgt ctccacagaa aattaacatt
    10861 agccaggtgt ggtggtgcgc atctgtagtc ccagctactg gggaggctga gatgagaaaa
    10921 tcgtttgaac ccaggaggtc aaagctgcag ggagccatga tggtgccact gcattctggt
    10981 gtgggtgaca gagcaagact ctgtctccaa aaaaaaaaaa aaaaaaaaaa aatagttcag
    11041 aaatctaaga cagcactttt tttagttact aagcctttta ttcagatagc acactaaatt
    11101 ggggtcaaaa atctgctata gtaaagttct gtatttgtgt gtattgggta taaaaataag
    11161 cgctttaatt aatttgaaaa tccctattca ccaaaagttt atactgtaat aggggacaaa
    11221 acaagtgcat aaagctaaat ttagccagta catttataac tgtttcattc agttgatcag
    11281 agaagcatca cgattgctgg aaaatatcgg acctggattc aaggtttggc attgctgttt
    11341 tcaaagtatg taatctttta gatcaggggt cagtgaacta cagtacagag accaaatcta
    11401 ccctgccacc tgtttttgtg aataaagttt tattgaaaca ga
//
