LOCUS       NP_061127                610 aa            linear   PRI 02-APR-2024
DEFINITION  myoneurin isoform A [Homo sapiens].
ACCESSION   NP_061127
VERSION     NP_061127.1
DBSOURCE    REFSEQ: accession NM_018657.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 610)
  AUTHORS   Mou,S.I., Sultana,T., Chatterjee,D., Faruk,M.O. and Hosen,M.I.
  TITLE     Comprehensive characterization of coding and non-coding single
            nucleotide polymorphisms of the Myoneurin (MYNN) gene using
            molecular dynamics simulation and docking approaches
  JOURNAL   PLoS One 19 (1), e0296361 (2024)
   PUBMED   38165846
  REMARK    GeneRIF: Comprehensive characterization of coding and non-coding
            single nucleotide polymorphisms of the Myoneurin (MYNN) gene using
            molecular dynamics simulation and docking approaches.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 610)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (residues 1 to 610)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 610)
  AUTHORS   Polat,F., Yilmaz,M. and Budak Diler,S.
  TITLE     The Association of MYNN and TERC Gene Polymorphisms and Bladder
            Cancer in a Turkish Population
  JOURNAL   Urol J 16 (1), 50-55 (2019)
   PUBMED   30120764
  REMARK    GeneRIF: there may exist an association between a combination of
            MYNN rs10936599 and TERC rs2293607 polymorphisms and development of
            bladder cancer in Turkish population.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 610)
  AUTHORS   Speedy,H.E., Di Bernardo,M.C., Sava,G.P., Dyer,M.J., Holroyd,A.,
            Wang,Y., Sunter,N.J., Mansouri,L., Juliusson,G., Smedby,K.E.,
            Roos,G., Jayne,S., Majid,A., Dearden,C., Hall,A.G.,
            Mainou-Fowler,T., Jackson,G.H., Summerfield,G., Harris,R.J.,
            Pettitt,A.R., Allsup,D.J., Bailey,J.R., Pratt,G., Pepper,C.,
            Fegan,C., Rosenquist,R., Catovsky,D., Allan,J.M. and Houlston,R.S.
  TITLE     A genome-wide association study identifies multiple susceptibility
            loci for chronic lymphocytic leukemia
  JOURNAL   Nat Genet 46 (1), 56-60 (2014)
   PUBMED   24292274
REFERENCE   6  (residues 1 to 610)
  AUTHORS   Guey,L.T., Garcia-Closas,M., Murta-Nascimento,C., Lloreta,J.,
            Palencia,L., Kogevinas,M., Rothman,N., Vellalta,G., Calle,M.L.,
            Marenne,G., Tardon,A., Carrato,A., Garcia-Closas,R., Serra,C.,
            Silverman,D.T., Chanock,S., Real,F.X. and Malats,N.
  CONSRTM   EPICURO/Spanish Bladder Cancer Study investigators
  TITLE     Genetic susceptibility to distinct bladder cancer subphenotypes
  JOURNAL   Eur Urol 57 (2), 283-292 (2010)
   PUBMED   19692168
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (residues 1 to 610)
  AUTHORS   Hosgood,H.D. 3rd, Menashe,I., Shen,M., Yeager,M., Yuenger,J.,
            Rajaraman,P., He,X., Chatterjee,N., Caporaso,N.E., Zhu,Y.,
            Chanock,S.J., Zheng,T. and Lan,Q.
  TITLE     Pathway-based evaluation of 380 candidate genes and lung cancer
            susceptibility suggests the importance of the cell cycle pathway
  JOURNAL   Carcinogenesis 29 (10), 1938-1943 (2008)
   PUBMED   18676680
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (residues 1 to 610)
  AUTHORS   Nanjundan,M., Nakayama,Y., Cheng,K.W., Lahad,J., Liu,J., Lu,K.,
            Kuo,W.L., Smith-McCune,K., Fishman,D., Gray,J.W. and Mills,G.B.
  TITLE     Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2
            amplicon, is associated with favorable patient prognosis in ovarian
            cancer
  JOURNAL   Cancer Res 67 (7), 3074-3084 (2007)
   PUBMED   17409414
REFERENCE   9  (residues 1 to 610)
  AUTHORS   Cifuentes-Diaz,C., Bitoun,M., Goudou,D., Seddiqi,N., Romero,N.,
            Rieger,F., Perin,J.P. and Alliel,P.M.
  TITLE     Neuromuscular expression of the BTB/POZ and zinc finger protein
            myoneurin
  JOURNAL   Muscle Nerve 29 (1), 59-65 (2004)
   PUBMED   14694499
REFERENCE   10 (residues 1 to 610)
  AUTHORS   Alliel,P.M., Seddiqi,N., Goudou,D., Cifuentes-Diaz,C., Romero,N.,
            Velasco,E., Rieger,F. and Perin,J.P.
  TITLE     Myoneurin, a novel member of the BTB/POZ-zinc finger family highly
            expressed in human muscle
  JOURNAL   Biochem Biophys Res Commun 273 (1), 385-391 (2000)
   PUBMED   10873615
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX648128.1, AC078795.19 and
            DB134736.1.
            
            Summary: This gene encodes a member of the BTB/POZ and zinc finger
            domain-containing protein family that are involved in the control
            of gene expression. Alternative splicing results in multiple
            transcript variants and a pseudogene has been identified on
            chromosome 14. [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (A). Both variants 1 and 2 encode the same protein (isoform A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.35341.1,
                                           SRR1660803.96190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349841.10/ ENSP00000326240.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..610
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.2"
     Protein         1..610
                     /product="myoneurin isoform A"
                     /note="zinc finger protein with BTB/POZ domain; zinc
                     finger and BTB domain-containing protein 31"
                     /calculated_mol_wt=68551
     Region          6..116
                     /region_name="BTB_POZ_ZBTB31_myoneurin"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in myoneurin;
                     cd18217"
                     /db_xref="CDD:349526"
     Region          169..197
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPC7.1)"
     Region          174..190
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPC7.1)"
     Region          257..262
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPC7.1)"
     Site            289
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q9NPC7.1)"
     Region          304..324
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          304..324
                     /region_name="zf-C2H2"
                     /note="Zinc finger, C2H2 type; pfam00096"
                     /db_xref="CDD:395048"
     Site            order(309,311,313,315..316,319..320,323,337,339,343..344,
                     347..348,351,365,367,369,371..372,375..376,379)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          316..341
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          332..352
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          345..369
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          <354..438
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     Region          360..380
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          389..409
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          417..437
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(422,424,426,428..429,432..433,436,450,452,456..457,
                     460..461,464,478,480,482,484..485,488..489,492)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          430..453
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          <439..522
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     Region          445..465
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          473..493
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          501..522
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          521..556
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NPC7.1)"
     CDS             1..610
                     /gene="MYNN"
                     /gene_synonym="OSZF; SBBIZ1; ZBTB31; ZNF902"
                     /coded_by="NM_018657.5:99..1931"
                     /note="isoform A is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS3207.1"
                     /db_xref="GeneID:55892"
                     /db_xref="HGNC:HGNC:14955"
                     /db_xref="MIM:606042"
ORIGIN      
        1 mqyshhcehl lerlnkqrea gflcdctivi gefqfkahrn vlasfseyfg aiyrstsenn
       61 vfldqsqvka dgfqkllefi ytgtlnldsw nvkeihqaad ylkveevvtk ckikmedfaf
      121 ianpssteis sitgnielnq qtclltlrdy nnreksevst dliqanpkqg alakkssqtk
      181 kkkkafnspk tgqnktvqyp sdilenasve lfldanklpt pvveqvaqin dnseleltsv
      241 ventfpaqdi vhtvtvkrkr gksqpncalk ehsmsniasv kspyeaensg eeldqryska
      301 kpmcntcgkv fseasslrrh mrihkgvkpy vchlcgkaft qcnqlkthvr thtgekpykc
      361 elcdkgfaqk cqlvfhsrmh hgeekpykcd vcnlqfatss nlkiharkhs gekpyvcdrc
      421 gqrfaqastl tyhvrrhtge kpyvcdtcgk afavssslit hsrkhtgekp yicgicgksf
      481 issgelnkhf rshtgerpfi celcgnsytd iknlkkhktk vhsgadktld ssaedhtlse
      541 qdsiqkspls etmdvkpsdm tlplalplgt edhhmllpvt dtqsptsdtl lrstvngyse
      601 pqliflqqly
//
