LOCUS       NM_001315494             828 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens myomixer, myoblast fusion factor (MYMX), transcript
            variant 1, mRNA.
ACCESSION   NM_001315494 XR_242025 XR_252012
VERSION     NM_001315494.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 828)
  AUTHORS   Yang,J.H., Chang,M.W., Tsitsipatis,D., Yang,X., Martindale,J.L.,
            Munk,R., Cheng,A., Izydore,E., Pandey,P.R., Piao,Y.,
            Mazan-Mamczarz,K., De,S., Abdelmohsen,K. and Gorospe,M.
  TITLE     LncRNA OIP5-AS1-directed miR-7 degradation promotes MYMX production
            during human myogenesis
  JOURNAL   Nucleic Acids Res 50 (12), 7115-7133 (2022)
   PUBMED   35736212
  REMARK    GeneRIF: LncRNA OIP5-AS1-directed miR-7 degradation promotes MYMX
            production during human myogenesis.
REFERENCE   2  (bases 1 to 828)
  AUTHORS   Ramirez-Martinez,A., Zhang,Y., van den Boogaard,M.J.,
            McAnally,J.R., Rodriguez-Caycedo,C., Chai,A.C., Chemello,F.,
            Massink,M.P., Cuppen,I., Elferink,M.G., van Es,R.J., Janssen,N.G.,
            Walraven-van Oijen,L.P., Liu,N., Bassel-Duby,R., van Jaarsveld,R.H.
            and Olson,E.N.
  TITLE     Impaired activity of the fusogenic micropeptide Myomixer causes
            myopathy resembling Carey-Fineman-Ziter syndrome
  JOURNAL   J Clin Invest 132 (11) (2022)
   PUBMED   35642635
REFERENCE   3  (bases 1 to 828)
  AUTHORS   Chen,B., You,W., Wang,Y. and Shan,T.
  TITLE     The regulatory role of Myomaker and Myomixer-Myomerger-Minion in
            muscle development and regeneration
  JOURNAL   Cell Mol Life Sci 77 (8), 1551-1569 (2020)
   PUBMED   31642939
  REMARK    GeneRIF: This articles reviews and discusses the latest studies
            related to Myomaker and Myomixer-Myomerger-Minion, including the
            discovery, structure, expression pattern, functions of the two
            proteins. [review]
            Review article
REFERENCE   4  (bases 1 to 828)
  AUTHORS   Quinn,M.E., Goh,Q., Kurosaka,M., Gamage,D.G., Petrany,M.J.,
            Prasad,V. and Millay,D.P.
  TITLE     Myomerger induces fusion of non-fusogenic cells and is required for
            skeletal muscle development
  JOURNAL   Nat Commun 8, 15665 (2017)
   PUBMED   28569755
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 828)
  AUTHORS   Zhang,Q., Vashisht,A.A., O'Rourke,J., Corbel,S.Y., Moran,R.,
            Romero,A., Miraglia,L., Zhang,J., Durrant,E., Schmedt,C.,
            Sampath,S.C. and Sampath,S.C.
  TITLE     The microprotein Minion controls cell fusion and muscle formation
  JOURNAL   Nat Commun 8, 15664 (2017)
   PUBMED   28569745
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 828)
  AUTHORS   Bi,P., Ramirez-Martinez,A., Li,H., Cannavino,J., McAnally,J.R.,
            Shelton,J.M., Sanchez-Ortiz,E., Bassel-Duby,R. and Olson,E.N.
  TITLE     Control of muscle formation by the fusogenic micropeptide myomixer
  JOURNAL   Science 356 (6335), 323-327 (2017)
   PUBMED   28386024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139392.10, BX107578.1 and AI286144.1.
            
            On May 17, 2019 this sequence version replaced NM_001315494.1.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.306826.1, BX107578.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142680, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000573382.3/ ENSP00000490143.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL139392.10        1403-1419
            18-110              BX107578.1         33-125
            111-121             AL139392.10        1994-2004
            122-758             BX107578.1         137-773
            759-828             AI286144.1         5-74                c
FEATURES             Location/Qualifiers
     source          1..828
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..828
                     /gene="MYMX"
                     /gene_synonym="CFZS2; hMINION; MINION"
                     /note="myomixer, myoblast fusion factor"
                     /db_xref="GeneID:101929726"
                     /db_xref="HGNC:HGNC:52391"
                     /db_xref="MIM:619912"
     exon            1..43
                     /gene="MYMX"
                     /gene_synonym="CFZS2; hMINION; MINION"
                     /inference="alignment:Splign:2.1.0"
     exon            44..828
                     /gene="MYMX"
                     /gene_synonym="CFZS2; hMINION; MINION"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..320
                     /gene="MYMX"
                     /gene_synonym="CFZS2; hMINION; MINION"
                     /note="microprotein inducer of fusion; myomerger; protein
                     minion"
                     /codon_start=1
                     /product="protein myomixer"
                     /protein_id="NP_001302423.1"
                     /db_xref="CCDS:CCDS83093.1"
                     /db_xref="GeneID:101929726"
                     /db_xref="HGNC:HGNC:52391"
                     /db_xref="MIM:619912"
                     /translation="MPTPLLPLLLRLLLSCLLLPAARLARQYLLPLLRRLARRLGSQD
                     MREALLGCLLFILSQRHSPDAGEASRVDRLERRERLGPQK"
     regulatory      805..810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MYMX"
                     /gene_synonym="CFZS2; hMINION; MINION"
                     /note="hexamer: AATAAA"
     polyA_site      828
                     /gene="MYMX"
                     /gene_synonym="CFZS2; hMINION; MINION"
                     /note="major polyA site"
ORIGIN      
        1 gcaaatccag ccagagactg attctgagca gcagttctgc ccggcactga ctcactggcc
       61 ctgccatgcc cacgccactg ctcccgctgc tgcttcgatt gctgctgtcc tgcctgctgc
      121 tgcctgctgc ccgcctggcc cgccaatacc tcctgcccct gctgcgccga ttggcccgcc
      181 gcctgggctc ccaggacatg cgagaggctt tgctgggctg tctgctgttc attctcagcc
      241 agcgacactc gccagacgct ggggaggcct caagagtgga ccgcctggag aggagggaga
      301 ggttaggccc ccaaaagtga ggccacaagt cctggcagca gctgtatcca caaaatgctt
      361 tcttttggag taggataatc ctggcaccag cactgaccga agcctgccca gtggacagaa
      421 gatatagtga gggttgtgca tgagagggat ctgccacaga catgcctctc cactcccaac
      481 agaaatgtct ttctggaaga atgccttgca tctagcacaa aactgattat tgcccctctg
      541 tcctccagca gttcctccca aagaccactc ctaatcacct ctggcctcag gcgggagggg
      601 aactaacacc cacccacccc tgccctccct gcaaatggga acatcaaggt tcccagtgct
      661 taactgaggg acaagtgaca atttagcaga gaggcaagat ttgaatccag actgtcttcc
      721 agactcagga cctaccttaa aataatatct gagttgctta tggaggcaga cctgcctgca
      781 aagcccagca ctcagcaagt gctcaataaa tatttgattt gaattctt
//
